Stephen Naylor
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View article: Breaking the vicious cycle in sickle cell disease: Redox stress impairs red blood cell rheology and promotes lung vasocongestion
Breaking the vicious cycle in sickle cell disease: Redox stress impairs red blood cell rheology and promotes lung vasocongestion Open
Sickle cell disease (SCD) is characterized by impaired red blood cell (RBC) rheology, including increased hemoglobin S (HbS) polymerization, reduced sickle RBC deformability, and elevated blood viscosity, all features that promote lung vas…
View article: The Destructive Cycle in Bronchopulmonary Dysplasia: The Rationale for Systems Pharmacology Therapeutics
The Destructive Cycle in Bronchopulmonary Dysplasia: The Rationale for Systems Pharmacology Therapeutics Open
Bronchopulmonary dysplasia (BPD) remains a significant complication of premature birth and neonatal intensive care. While much is known about the drivers of lung injury, few studies have addressed the interrelationships between oxidative s…
View article: Endoplasmic Reticulum Stress in Bronchopulmonary Dysplasia: Contributor or Consequence?
Endoplasmic Reticulum Stress in Bronchopulmonary Dysplasia: Contributor or Consequence? Open
Bronchopulmonary dysplasia (BPD) is the most common complication of prematurity. Oxidative stress (OS) and inflammation are the major contributors to BPD. Despite aggressive treatments, BPD prevalence remains unchanged, which underscores t…
View article: Temporal Dynamics of Oxidative Stress and Inflammation in Bronchopulmonary Dysplasia
Temporal Dynamics of Oxidative Stress and Inflammation in Bronchopulmonary Dysplasia Open
Bronchopulmonary dysplasia (BPD) is the most common lung complication of prematurity. Despite extensive research, our understanding of its pathophysiology remains limited, as reflected by the stable prevalence of BPD. Prematurity is the pr…
View article: Role of Myeloperoxidase, Oxidative Stress, and Inflammation in Bronchopulmonary Dysplasia
Role of Myeloperoxidase, Oxidative Stress, and Inflammation in Bronchopulmonary Dysplasia Open
Bronchopulmonary dysplasia (BPD) is a lung complication of premature births. The leading causes of BPD are oxidative stress (OS) from oxygen treatment, infection or inflammation, and mechanical ventilation. OS activates alveolar myeloid ce…
View article: Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia
Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia Open
Oxidative stress, inflammation, and endoplasmic reticulum (ER) stress sequentially occur in bronchopulmonary dysplasia (BPD), and all result in DNA damage. When DNA damage becomes irreparable, tumor suppressors increase, followed by apopto…
View article: Role of endoplasmic reticulum stress in impaired neonatal lung growth and bronchopulmonary dysplasia
Role of endoplasmic reticulum stress in impaired neonatal lung growth and bronchopulmonary dysplasia Open
Myeloperoxidase (MPO), oxidative stress (OS), and endoplasmic reticulum (ER) stress are increased in the lungs of rat pups raised in hyperoxia, an established model of bronchopulmonary dysplasia (BPD). However, the relationship between OS,…
View article: Inhibition of myeloperoxidase increases revascularization and improves blood flow in a diabetic mouse model of hindlimb ischaemia
Inhibition of myeloperoxidase increases revascularization and improves blood flow in a diabetic mouse model of hindlimb ischaemia Open
Objective: Diabetes mellitus is a significant risk factor for peripheral artery disease. Diabetes mellitus induces chronic states of oxidative stress and vascular inflammation that increase neutrophil activation and release of myeloperoxid…