Sumihare Noji
YOU?
Author Swipe
View article: Establishment of CRISPR/Cas9-based knock-in in a hemimetabolous insect: targeted gene tagging in the cricket <i>Gryllus bimaculatus</i>
Establishment of CRISPR/Cas9-based knock-in in a hemimetabolous insect: targeted gene tagging in the cricket <i>Gryllus bimaculatus</i> Open
Studies of traditional model organisms such as the fruit fly Drosophila melanogaster have contributed immensely to our understanding of the genetic basis of developmental processes. However, the generalizability of these findings cannot be…
View article: Combinatorial expression of ebony and tan generates body color variation from nymph through adult stages in the cricket, Gryllus bimaculatus
Combinatorial expression of ebony and tan generates body color variation from nymph through adult stages in the cricket, Gryllus bimaculatus Open
Insect body colors and patterns change markedly during development in some species as they adapt to their surroundings. The contribution of melanin and sclerotin pigments, both of which are synthesized from dopamine, to cuticle tanning has…
View article: Establishment of CRISPR/Cas9-based knock-in in a hemimetabolous insect: targeted gene tagging in the cricket<i>Gryllus bimaculatus</i>
Establishment of CRISPR/Cas9-based knock-in in a hemimetabolous insect: targeted gene tagging in the cricket<i>Gryllus bimaculatus</i> Open
Studies of traditional model organisms like the fruit fly Drosophila melanogaster have contributed immensely to our understanding of the genetic basis of developmental processes. However, the generalizability of these findings cannot be co…
View article: Insights into the genomic evolution of insects from cricket genomes
Insights into the genomic evolution of insects from cricket genomes Open
Most of our knowledge of insect genomes comes from Holometabolous species, which undergo the complete metamorphosis and have genomes under 2Gb with little signs of DNA methylation. In contrast, Hemiemetabolous insects undergo the ancestral…
View article: Photoperiod and temperature separately regulate nymphal development through JH and insulin/TOR signaling pathways in an insect
Photoperiod and temperature separately regulate nymphal development through JH and insulin/TOR signaling pathways in an insect Open
Insects living in the temperate zone enter a physiological state of arrested or slowed development to overcome an adverse season, such as winter. Developmental arrest, called diapause, occurs at a species-specific developmental stage, and …
View article: Regulatory mechanisms underlying the specification of the pupal-homologous stage in a hemimetabolous insect
Regulatory mechanisms underlying the specification of the pupal-homologous stage in a hemimetabolous insect Open
Juvenile hormones and the genetic interaction between the transcription factors Krüppel homologue 1 ( Kr-h1 ) and Broad ( Br ) regulate the transformation of insects from immature to adult forms in both types of metamorphosis (holometaboly…
View article: Supplementary material from "Regulatory mechanisms underlying the specification of the pupal-homologous stage in a hemimetabolous insect"
Supplementary material from "Regulatory mechanisms underlying the specification of the pupal-homologous stage in a hemimetabolous insect" Open
Juvenile hormones and the genetic interaction between the transcription factors Krüppel homologue 1 (Kr-h1) and Broad (Br) regulate the transformation of insects from immature to adult forms in both types of metamorphosis (holometaboly wit…
View article: The Singularity for the Insect
The Singularity for the Insect Open
人工知能（AI）が発達し，やがて人類の知能を超える転換点（技術的特異点：シンギュラリティ）が来ると予測している科学者もいます。私は，昆虫，特にコオロギを用いて，その発生と再生のメカニズムについて研究を行ってきました。昆虫を機械であると考えると現在の技術でそれを
View article: Bone morphogenetic protein signaling in distal patterning and intercalation during leg regeneration of the cricket, <i>Gryllus bimaculatus</i>
Bone morphogenetic protein signaling in distal patterning and intercalation during leg regeneration of the cricket, <i>Gryllus bimaculatus</i> Open
The cricket, Gryllus bimaculatus , is a classic model of leg regeneration following amputation. We previously demonstrated that Gryllus decapentaplegic ( Gb ’ dpp ) is expressed during leg regeneration, although it remains unclear whether …
View article: Molecular mechanisms of limb regeneration: insights from regenerating legs of the cricket Gryllus bimaculatus
Molecular mechanisms of limb regeneration: insights from regenerating legs of the cricket Gryllus bimaculatus Open
This review summarizes recent advances in leg regeneration research, focusing on the cricket Gryllus bimaculatus. Recent studies have revealed molecular mechanisms on blastema formation, establishment of positional information, and epigene…
View article: Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development
Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development Open
Several mutations, located mainly in the MSX1 homeodomain, have been identified in non-syndromic tooth agenesis predominantly affecting premolars and third molars. We identified a novel frameshift mutation of the highly conserved C-termina…
View article: Somatic cell reprogramming-free generation of genetically modified pigs
Somatic cell reprogramming-free generation of genetically modified pigs Open
A new and highly efficient method for generating mutant pigs by electroporating the CRISPR/Cas9 system into zygotes.
View article: TGF-β signaling in insects regulates metamorphosis via juvenile hormone biosynthesis
TGF-β signaling in insects regulates metamorphosis via juvenile hormone biosynthesis Open
Significance Insects undergo a morphological transformation from nymph/larva to adult with or without pupal formation, processes referred to as “hemimetamorphosis” and “holometamorphosis,” respectively. Both processes are regulated by comm…
View article: Knockout crickets for the study of learning and memory: Dopamine receptor Dop1 mediates aversive but not appetitive reinforcement in crickets
Knockout crickets for the study of learning and memory: Dopamine receptor Dop1 mediates aversive but not appetitive reinforcement in crickets Open
Elucidation of reinforcement mechanisms in associative learning is an important subject in neuroscience. In mammals, dopamine neurons are thought to play critical roles in mediating both appetitive and aversive reinforcement. Our pharmacol…
View article: RNAi-mediated silencing and overexpression of the FaMYB1 gene and its effect on anthocyanin accumulation in strawberry fruit
RNAi-mediated silencing and overexpression of the FaMYB1 gene and its effect on anthocyanin accumulation in strawberry fruit Open
Strawberry (Fragaria × ananassa) contains anthocyanins which are important secondary metabolites and key contributors to the antioxidant capacity and nutritional value of the fruit. Anthocyanin biosynthetic genes have been identified. Howe…
View article: Short germ insects utilize both the ancestral and derived mode of Polycomb group-mediated epigenetic silencing of Hox genes
Short germ insects utilize both the ancestral and derived mode of Polycomb group-mediated epigenetic silencing of Hox genes Open
In insect species that undergo long germ segmentation, such as Drosophila, all segments are specified simultaneously at the early blastoderm stage. As embryogenesis progresses, the expression boundaries of Hox genes are established by repr…
View article: Nonviral Reprogramming of Human Wharton's Jelly Cells Reveals Differences Between <i>ATOH1</i> Homologues
Nonviral Reprogramming of Human Wharton's Jelly Cells Reveals Differences Between <i>ATOH1</i> Homologues Open
The transcription factor atonal homolog 1 (ATOH1) has multiple homologues that are functionally conserved across species and is responsible for the generation of sensory hair cells. To evaluate potential functional differences between homo…
View article: Involvement of dachshund and Distal-less in distal pattern formation of the cricket leg during regeneration
Involvement of dachshund and Distal-less in distal pattern formation of the cricket leg during regeneration Open
Cricket nymphs have the remarkable ability to regenerate a functional leg following amputation, indicating that the regenerating blastemal cells contain information for leg morphology. However, the molecular mechanisms that underlie regene…
View article: Regenerated leg segment patterns are regulated epigenetically by histone H3K27 methylation in the cricket <i>Gryllus bimaculatus</i>
Regenerated leg segment patterns are regulated epigenetically by histone H3K27 methylation in the cricket <i>Gryllus bimaculatus</i> Open
Hemimetabolous insects such as the cricket Gryllus bimaculatus regenerate lost tissue parts using blastemal cells, which is a population of dedifferentiated-proliferating cells. The gene expression of several epigenetic factors is upregula…