Pei‐Shan Tsai
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View article: Multimodal single-cell transcriptomics with patient-specific iPSC-derived airway organoids as a drug screening approach for cystic fibrosis with nonsense mutations
Multimodal single-cell transcriptomics with patient-specific iPSC-derived airway organoids as a drug screening approach for cystic fibrosis with nonsense mutations Open
Cystic fibrosis arises from loss-of-function mutations in the CFTR gene, disrupting epithelial ion homeostasis and impairing airway mucus clearance. While missense mutations typically lead to minor conformational alterations that can be re…
View article: Chronotype and Sleep Quality in College Students Undergoing Clinical Placement: A Moderated Moderation Model of Sleep Reactivity and Resilience
Chronotype and Sleep Quality in College Students Undergoing Clinical Placement: A Moderated Moderation Model of Sleep Reactivity and Resilience Open
Background: Chronotype, also referred to as morningness and eveningness, describes the natural preference of the body for wakefulness or sleep at different times during a 24-hour period. Individuals demonstrating late chronotypes and low r…
View article: Prevalence and risk factors for loneliness among individuals with diabetes: a systematic review and meta-analysis
Prevalence and risk factors for loneliness among individuals with diabetes: a systematic review and meta-analysis Open
Background Loneliness is more pronounced in individuals with diabetes; however, limited studies have investigated loneliness and its risk factors. This study estimated the pooled prevalence of loneliness and identified its risk factors in …
View article: Impact of social media addiction on anxiety symptoms as modified by social support and its subscales
Impact of social media addiction on anxiety symptoms as modified by social support and its subscales Open
Objectives We aimed to investigate the moderating effect of social support and its subscales on the relationship between social media addiction (SMA) and anxiety symptoms in young Taiwanese adults. Methods A cross-sectional study was condu…
View article: Effects of Digital Sleep Interventions on Sleep Among College Students and Young Adults: Systematic Review and Meta-Analysis
Effects of Digital Sleep Interventions on Sleep Among College Students and Young Adults: Systematic Review and Meta-Analysis Open
Background College students and young adults (18-25 years) frequently experience poor sleep quality, with insomnia being particularly prevalent among this population. Given the widespread use of digital devices in the modern world, electro…
View article: Predicting complications and morbidities in PAD patients through lower extremity compositions with dual-energy CT and material decomposition: a 2-year follow-up observational study
Predicting complications and morbidities in PAD patients through lower extremity compositions with dual-energy CT and material decomposition: a 2-year follow-up observational study Open
View article: Effects of Digital Sleep Interventions on Sleep Among College Students and Young Adults: Systematic Review and Meta-Analysis (Preprint)
Effects of Digital Sleep Interventions on Sleep Among College Students and Young Adults: Systematic Review and Meta-Analysis (Preprint) Open
BACKGROUND College students and young adults (18-25 years) frequently experience poor sleep quality, with insomnia being particularly prevalent among this population. Given the widespread use of digital devices in the modern world, electr…
View article: The effect of health education on symptom severity in patients with fibromyalgia: a systematic review and meta-analysis
The effect of health education on symptom severity in patients with fibromyalgia: a systematic review and meta-analysis Open
Fibromyalgia (FM) is a complex chronic disorder characterized by widespread pain as the primary symptom. To evaluate the effect of health education on the severity of various symptoms in patients with FM, seven databases were searched from…
View article: Association Between Social Jetlag and Components of Metabolic Syndrome: A Systematic Review and Meta-Analysis
Association Between Social Jetlag and Components of Metabolic Syndrome: A Systematic Review and Meta-Analysis Open
Background A mismatch between biological and social time, often referred to as social jetlag (SJL), can lead to inadequate sleep and activities or taking meals at times that do not align with our biological rhythms, increasing the risk of …
View article: P.034 Cost-effectiveness of treatment strategies for medically refractory pediatric epilepsy: a systematic review
P.034 Cost-effectiveness of treatment strategies for medically refractory pediatric epilepsy: a systematic review Open
Background: Medically refractory pediatric epilepsy is a disorder that can cause significant financial and physical burden. Although multiple treatments exist, cost-effectiveness remains unclear. We conducted a systematic review to assess …
View article: Humoral responses to multiple SARS-CoV-2 variants after two doses of vaccine in kidney transplant patients
Humoral responses to multiple SARS-CoV-2 variants after two doses of vaccine in kidney transplant patients Open
Background: The COVID-19 pandemic has led to millions of fatalities globally. Kidney transplant (KT) patients, given their comorbidities and under immunosuppressant drugs, are identified as a high-risk group. Though vaccination rema…
View article: Shaping the Future of Nursing
Shaping the Future of Nursing Open
View article: Pain Catastrophizing as a Mediator Between Pain Self-Efficacy and Disease Severity in Patients with Fibromyalgia
Pain Catastrophizing as a Mediator Between Pain Self-Efficacy and Disease Severity in Patients with Fibromyalgia Open
Pain catastrophizing independently predicts FM severity and mediates the association between pain self-efficacy and FM severity. Pain catastrophizing should be monitored through interventions aimed at improving pain self-efficacy to reduce…
View article: Effectiveness of Cold Therapy for Pain and Anxiety Associated with Chest Tube Removal: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Effectiveness of Cold Therapy for Pain and Anxiety Associated with Chest Tube Removal: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
View article: Machine learning combined with radiomics and deep learning features extracted from CT images: a novel AI model to distinguish benign from malignant ovarian tumors
Machine learning combined with radiomics and deep learning features extracted from CT images: a novel AI model to distinguish benign from malignant ovarian tumors Open
Background To develop an artificial intelligence (AI) model with radiomics and deep learning (DL) features extracted from CT images to distinguish benign from malignant ovarian tumors. Methods We enrolled 149 patients with pathologically c…
View article: Psychometric properties of Indonesian version of sleep condition indicator for screening poststroke insomnia
Psychometric properties of Indonesian version of sleep condition indicator for screening poststroke insomnia Open
View article: Profiling Humoral Immunity After Mixing and Matching COVID-19 Vaccines Using SARS-CoV-2 Variant Protein Microarrays
Profiling Humoral Immunity After Mixing and Matching COVID-19 Vaccines Using SARS-CoV-2 Variant Protein Microarrays Open
In November 2022, 68% of the population received at least one dose of COVID-19 vaccines. Owing to the ongoing mutations, especially for the variants of concern (VOCs), it is important to monitor the humoral immune responses after different…
View article: Rituximab, but not other biologics, impairs humoral immunity in patients with rheumatoid arthritis—a study using CoVariant protein arrays
Rituximab, but not other biologics, impairs humoral immunity in patients with rheumatoid arthritis—a study using CoVariant protein arrays Open
Objectives RA is an autoimmune disease characterized by chronic inflammation and joint destruction. Biologics are crucial to achieving treat-to-target goals in patients with RA. The global spread and continuous variation of severe acute re…
View article: Plasmapheresis for a Patient with Catatonia and Systemic Lupus Erythematosus: A Case Report and Literature Review
Plasmapheresis for a Patient with Catatonia and Systemic Lupus Erythematosus: A Case Report and Literature Review Open
Neuropsychiatric systemic lupus erythematous (NPSLE) encompasses various psychiatric and neurological manifestations that develop in patients with systemic lupus erythematous (SLE), secondary to the involvement of the central nervous syste…
View article: Effects of health qigong on sleep quality: A systematic review and meta-analysis of randomized controlled trials
Effects of health qigong on sleep quality: A systematic review and meta-analysis of randomized controlled trials Open
Our study results suggest that Health Qigong is beneficial for improving sleep quality in adults with and without disease. However, the effects of Health Qigong could be partially due to nonspecific effects as half of the included studies …
View article: Adjunct diagnostic value of radiological findings in mucopolysaccharidosis type IVa-related thoracic spinal abnormalities: a pilot study
Adjunct diagnostic value of radiological findings in mucopolysaccharidosis type IVa-related thoracic spinal abnormalities: a pilot study Open
Background In patients with mucopolysaccharidosis (MPS), systematic assessment and management of cervical instability, cervicomedullary and thoracolumbar junction spinal stenosis and spinal cord compression averts or arrests irreversible n…
View article: Beneficial effects of preoperative oral nutrition supplements on postoperative outcomes in geriatric hip fracture patients
Beneficial effects of preoperative oral nutrition supplements on postoperative outcomes in geriatric hip fracture patients Open
Background: Geriatric hip fracture patients often present malnutrition during admission, which leads to higher morbidity and mortality. Protein-based oral nutrition supplements may improve nutritional status. We conducted this systematic r…
View article: Beneficial effects of preoperative oral nutrition supplements on postoperative outcomes in geriatric hip fracture patients: A PRISMA-compliant systematic review and meta-analysis of randomized controlled studies.
Beneficial effects of preoperative oral nutrition supplements on postoperative outcomes in geriatric hip fracture patients: A PRISMA-compliant systematic review and meta-analysis of randomized controlled studies. Open
Preoperative protein-based oral nutrition supplements exert beneficial, but limited, effects on postoperative outcomes in geriatric patients with hip fracture undergoing surgery.
View article: Testicular torsion–detorsion causes dysfunction of mitochondrial oxidative phosphorylation
Testicular torsion–detorsion causes dysfunction of mitochondrial oxidative phosphorylation Open
Background : Semen quality impairment is a serious consequence of testicular torsion–detorsion. Adequate germ‐cell mitochondrial oxidative phosphorylation plays a crucial role in male fertility. Changes in cellular oxidative phosphorylatio…
View article: The Varied and Multifaceted Professional Roles of Today’s Nurses
The Varied and Multifaceted Professional Roles of Today’s Nurses Open
The nursing profession is evolving rapidly to meet the challenges and opportunities presented by the constant, technology-driven changes in healthcare delivery and the ever-changing landscape of healthcare needs. In this issue of The Journ…
View article: Prenatal diagnosis of abdominal lymphatic malformations
Prenatal diagnosis of abdominal lymphatic malformations Open
View article: Different impacts of various tocolytic agents on increased risk of postoperative hemorrhage in preterm labor women undergoing Cesarean delivery
Different impacts of various tocolytic agents on increased risk of postoperative hemorrhage in preterm labor women undergoing Cesarean delivery Open
Tocolytic agents, commonly used for inhibiting preterm labor, pose the risk of uterine atony, leading to postpartum hemorrhage. This study elucidated the effects of different tocolytic agents on postoperative hemorrhage among women in pret…
View article: Comparative efficacy and safety of hypnotics for insomnia in older adults: a systematic review and network meta-analysis
Comparative efficacy and safety of hypnotics for insomnia in older adults: a systematic review and network meta-analysis Open
Study Objectives To compare the efficacy and safety of various hypnotics for identifying the best treatments for insomnia in older adults. Methods We searched the EMBASE, PubMed, ClinicalTrials.gov, and ProQuest Dissertations and Theses A&…
View article: Hyperlipidemia is a risk factor for bladder cancer in young adult men: a population-based cohort study
Hyperlipidemia is a risk factor for bladder cancer in young adult men: a population-based cohort study Open
Background: A high-cholesterol diet increases the risk of bladder cancer. This study investigated whether hyperlipidemia is a risk factor for bladder cancer.Methods: Data from Taiwan National Health Insurance Database were analyzed. The pr…
View article: Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats
Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats Open
We investigated whether magnesium sulfate (MgSO4) mitigated pulmonary hypertension progression in rats. Pulmonary hypertension was induced by a single intraperitoneal injection of monocrotaline (60 mg/kg). MgSO4 (100 mg/kg) was intraperito…