Liping Zhao
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View article: Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy
Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy Open
CD5‐ and CD7‐directed chimeric antigen receptor T‐cell (5CAR and 7CAR) therapies for T‐cell malignancies carry the risk of life‐threatening infection. Although depletion of target‐positive lymphocytes is expected, the contribution of resid…
View article: The anti-allergic effect of Lactobacillus plantarum GUANKE on allergic rhinitis induced by either ragweed pollen or house dust mites in mice
The anti-allergic effect of Lactobacillus plantarum GUANKE on allergic rhinitis induced by either ragweed pollen or house dust mites in mice Open
Background Current treatment strategies for Allergic rhinitis (AR) are often limited by adverse effects and less efficacy. This study aims to evaluate the therapeutic effect of Lactobacillus plantarum GUANKE in either ragweed pollen (RAGW)…
View article: Supplementary Table 2 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency
Supplementary Table 2 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency Open
Prevalent IgH VDJ sequences of MLN B cells in aging M-Traf3-/- mice
View article: Figures S1-S9 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency
Figures S1-S9 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency Open
Supplementary Figure S1. Analysis of ERV reactivation in aging M-Traf3-/- mice with BCL and WT mice. Supplementary Figure S2. Assessment of gut barrier integrity and commensal bacterial transmigration in aging WT and MTraf3-/- mice. Supple…
View article: Supplementary Table 1 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency
Supplementary Table 1 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency Open
IgH VDJ sequence characteristics of dominant malignant B-cell clones spontaneously developed in aging M-Traf3-/- mice
View article: Ulinastatin protects against cisplatin-induced ovarian damage via Nrf2/Keap1 pathway
Ulinastatin protects against cisplatin-induced ovarian damage via Nrf2/Keap1 pathway Open
The administration of chemotherapeutic agents such as cisplatin frequently results in ovarian damage and premature ovarian failure (POF), severely compromising fertility and quality of life in young women. This study aimed to investigate t…
View article: Incorporating microbiomes into the One Health Joint Plan of Action
Incorporating microbiomes into the One Health Joint Plan of Action Open
The One Health Joint Plan of Action (2022–2026), developed by the United Nations Quadripartite (FAO, UNEP, WHO, and WOAH), provides a comprehensive framework to address global health risks at the human-animal-plant-environment interface. H…
View article: Data from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency
Data from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency Open
Myeloid cells are central players in innate immunity and inflammation. Their function is regulated by the adapter protein TRAF3. We previously reported that aging myeloid cell–specific TRAF3-deficient (M-Traf3−/−) mice sp…
View article: Figures S1-S9 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency
Figures S1-S9 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency Open
Supplementary Figure S1. Analysis of ERV reactivation in aging M-Traf3-/- mice with BCL and WT mice. Supplementary Figure S2. Assessment of gut barrier integrity and commensal bacterial transmigration in aging WT and MTraf3-/- mice. Supple…
View article: Supplementary Table 2 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency
Supplementary Table 2 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency Open
Prevalent IgH VDJ sequences of MLN B cells in aging M-Traf3-/- mice
View article: Supplementary Table 1 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency
Supplementary Table 1 from Commensal Bacteria Drive B-cell Lymphomagenesis in the Setting of Innate Immunodeficiency Open
IgH VDJ sequence characteristics of dominant malignant B-cell clones spontaneously developed in aging M-Traf3-/- mice
View article: Exploring the sheen: a review of research advances on fruit glossiness
Exploring the sheen: a review of research advances on fruit glossiness Open
Fruit glossiness is a visually appealing trait that positively influences consumer preferences and market value. Despite its commercial importance, the biological basis of fruit glossiness has only recently gained attention. This review pr…
View article: Predicting habitat suitability for an endangered medicinal plant, Saussurea medusa: insights from ensemble species distribution models
Predicting habitat suitability for an endangered medicinal plant, Saussurea medusa: insights from ensemble species distribution models Open
Introduction Global climate change has profound impacts on alpine ecosystems, and with climate warming, alpine plants often face a substantial risk of habitat loss. Saussurea medusa Maxim., known for its significant medicinal value, is a t…
View article: Continuous versus intermittent cuff pressure monitoring in preventing ventilator-associated pneumonia: a multicentre randomised controlled trial
Continuous versus intermittent cuff pressure monitoring in preventing ventilator-associated pneumonia: a multicentre randomised controlled trial Open
View article: Genome-Wide Identification and Expression Analysis of AT-Hook Motif Nuclear Localized Gene Family in Birch
Genome-Wide Identification and Expression Analysis of AT-Hook Motif Nuclear Localized Gene Family in Birch Open
The AT-hook motif nuclear localized (AHL) gene family encodes transcription factors pivotal in regulating plant growth, development, and responses to abiotic stimuli, including low temperature, salinity, darkness, and drought. In this stud…
View article: Grape polyphenols reduce fasting glucose and increase hyocholic acid in healthy humans: a meta-omics study
Grape polyphenols reduce fasting glucose and increase hyocholic acid in healthy humans: a meta-omics study Open
Grape polyphenols (GPs) are rich in B-type proanthocyanidins, which promote metabolic resilience. Longitudinal metabolomic, metagenomic, and metaproteomic changes were measured in 27 healthy subjects supplemented with soy protein isolate (…
View article: Nitraria sibirica Pall.: A Halophytic Resource for Antioxidant-Rich Functional Foods and Ecological Resilience
Nitraria sibirica Pall.: A Halophytic Resource for Antioxidant-Rich Functional Foods and Ecological Resilience Open
Nitraria sibirica Pall., a halophytic shrub native to arid and saline–alkaline ecosystems, represents a dual-purpose resource for ecological stabilization and functional food development. This review synthesizes current knowledge of its bi…
View article: Serum Methylmalonic Acid Is Associated With Gut Microbial Co-Abundance Guilds and Circulating Propionate in Healthy Adults
Serum Methylmalonic Acid Is Associated With Gut Microbial Co-Abundance Guilds and Circulating Propionate in Healthy Adults Open
View article: Animal models of post-acute COVID-19 syndrome: a call for longitudinal animal studies
Animal models of post-acute COVID-19 syndrome: a call for longitudinal animal studies Open
Animal models are indispensable for unraveling the mechanisms underlying post-acute sequelae of COVID-19 (PASC). This review evaluates recent research on PASC-related perturbations in animal models, drawing comparisons with clinical findin…
View article: TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma
TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma Open
Rationale: TFEB activation is associated with prolonged survival in LUAD patients, suggesting potential benefits of TFEB agonists in LUAD treatment. In this study, we identify ginkgetin (GK), derived from Ginkgo folium, as a …
View article: Relational Stability: A New Strategy for Defining the Human Core Microbiome
Relational Stability: A New Strategy for Defining the Human Core Microbiome Open
View article: Erratum for Guo et al., “Guild-Level Microbiome Signature Associated with COVID-19 Severity and Prognosis”
Erratum for Guo et al., “Guild-Level Microbiome Signature Associated with COVID-19 Severity and Prognosis” Open
View article: Effects of dietary energy levels on production and absorption of hindgut short-chain fatty acids in two sheep breeds
Effects of dietary energy levels on production and absorption of hindgut short-chain fatty acids in two sheep breeds Open
Hindgut fermentation is a crucial process in the production of short-chain fatty acids (SCFAs) and the provision of energy for ruminants. However, hindgut fermentation is not well-researched and has only recently received more attention. T…
View article: Bacterial guilds, not genus-level taxa, mediate the protective effects of time-restricted feeding against high-fat diet–induced obesity in mice
Bacterial guilds, not genus-level taxa, mediate the protective effects of time-restricted feeding against high-fat diet–induced obesity in mice Open
The gut microbiota functions as a complex adaptive system where microbes form structural modules known as “guilds.” Each guild comprises taxonomically distinct microbes that work together as cohesive functional units, contributing to overa…
View article: Causal effect of serum lipopolysaccharide activity levels and inflammatory proteins on Alzheimer's disease: A Mendelian randomization study combined with meta-analysis in a large-scale cohort
Causal effect of serum lipopolysaccharide activity levels and inflammatory proteins on Alzheimer's disease: A Mendelian randomization study combined with meta-analysis in a large-scale cohort Open
Background Neuroinflammation represents a central pathological mechanism in Alzheimer's disease (AD). Lipopolysaccharide (LPS) is a potent inducer of neuroinflammation and demonstrates elevated circulating levels in AD patients. Objective …
View article: Identification of novel ferroptosis-related biomarkers associated with the oxidative stress pathways in ischemic cardiomyopathy
Identification of novel ferroptosis-related biomarkers associated with the oxidative stress pathways in ischemic cardiomyopathy Open
Ferroptosis exists in ICM and and is associated with oxidative stress. This association suggests that ferroptosis may facilitate the progression of ICM.
View article: A core microbiome signature as an indicator of health
A core microbiome signature as an indicator of health Open
The gut microbiota is crucial for human health, functioning as a complex adaptive system akin to a vital organ. To identify core health-relevant gut microbes, we followed the systems biology tenet that stable relationships signify core com…
View article: Guild-based approach for mitigating information loss and distortion issues in microbiome analysis
Guild-based approach for mitigating information loss and distortion issues in microbiome analysis Open
View article: Comparative analysis of physical traits, mineral compositions, antioxidant contents, and metabolite profiles in five cherry tomato cultivars
Comparative analysis of physical traits, mineral compositions, antioxidant contents, and metabolite profiles in five cherry tomato cultivars Open
Cherry tomatoes (Solanum lycopersicum var. cerasiforme) are cultivated and consumed worldwide. While numerous cultivars have been bred to enhance fruit quality, few studies have comprehensively evaluated the fruit quality of cherry tomato …
View article: A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori
A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori Open
Helicobacter pylori ( H. pylori ) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neural network-based deep lea…