Serena Pedron
YOU?
Author Swipe
View article: Stimulator of interferon genes immunohistochemical expression in the spectrum of extrarenal perivascular epithelioid cell lesions
Stimulator of interferon genes immunohistochemical expression in the spectrum of extrarenal perivascular epithelioid cell lesions Open
Angiomyolipoma is the prototype of the perivascular epithelioid cells (PEC) lesions whose pathogenesis is usually determined by mutations of the TSC1/2 genes, with eventual deregulation of the mTOR pathway, whereas a small subset of PEComa…
View article: P13.04.A CHROMOSOME 1P DELETION AND MCM2 IMMUNOEXPRESSION ARE PROGNOSTICALLY INFORMATIVE IN CHORDOID MENINGIOMAS
P13.04.A CHROMOSOME 1P DELETION AND MCM2 IMMUNOEXPRESSION ARE PROGNOSTICALLY INFORMATIVE IN CHORDOID MENINGIOMAS Open
BACKGROUND The chordoid subtype of meningioma is histologically characterized by epithelioid or spindle cells with eosinophilic cytoplasm arranged in cords within a myxoid matrix. Owing to its tendency to recur, it is currently classified …
View article: Gene therapy device-based delivery of progranulin, prosaposin, and GDNF as a combined precision and neurorestorative therapy in the rat 6-OHDA model of parkinsonism
Gene therapy device-based delivery of progranulin, prosaposin, and GDNF as a combined precision and neurorestorative therapy in the rat 6-OHDA model of parkinsonism Open
Parkinson's disease (PD) is a complex, multifactorial neurodegenerative disorder, characterized by a progressive degeneration of dopaminergic neurons, leading to significant motor impairments frequently associated with cognitive dysfunctio…
View article: HER2-Driven Breast Cancer: Role of the Chaperonin HSP90 in Modulating Response to Trastuzumab-Based Therapeutic Combinations
HER2-Driven Breast Cancer: Role of the Chaperonin HSP90 in Modulating Response to Trastuzumab-Based Therapeutic Combinations Open
Mechanistic relationships between heat shock protein 90 (HSP90) and human epidermal growth factor receptor 2 (HER2) are complex and clinical correlations in breast cancer remain inconsistent. We investigated the role of HSP90 expression in…
View article: Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization
Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization Open
Mucinous cystic neoplasms (MCNs) of the pancreas are macroscopic precursors of pancreatic cancer. A similar cystic lesion but lacking the ovarian‐type subepithelial stroma has been recently defined as a simple mucinous cyst (SMC); however,…
View article: SFPQ::TFE3-rearranged PEComa: Differences and analogies with renal cell carcinoma carrying the same translocation
SFPQ::TFE3-rearranged PEComa: Differences and analogies with renal cell carcinoma carrying the same translocation Open
Among perivascular epithelioid cell neoplasms (PEComas), some tumors have been found to carry rearrangements of the TFE3 gene. Such tumors can rarely occur in the kidney, closely resembling TFE3-rearranged renal cell carcinoma. This study …
View article: MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC Open
Intratumour heterogeneity and phenotypic plasticity drive tumour progression and therapy resistance1,2. Oncogene dosage variation contributes to cell-state transitions and phenotypic heterogeneity3, thereby providing a substrate for somati…
View article: P19.05.B CHROMOSOME 1P DELETION IS A NEGATIVE, INDEPENDENT, PROGNOSTIC FACTOR IN ATYPICAL MENINGIOMAS
P19.05.B CHROMOSOME 1P DELETION IS A NEGATIVE, INDEPENDENT, PROGNOSTIC FACTOR IN ATYPICAL MENINGIOMAS Open
BACKGROUND The treatment of patients with meningiomas is based on the degree of surgical excision and the tumor histological grade, which is determined according to the World Health Organization (WHO) classification of tumors of the centra…
View article: Comparison of Primary and Metastatic Fumarate Hydratase-Deficient Renal Cell Carcinomas Documents Morphologic Divergence and Potential Diagnostic Pitfall With Peritoneal Mesothelioma
Comparison of Primary and Metastatic Fumarate Hydratase-Deficient Renal Cell Carcinomas Documents Morphologic Divergence and Potential Diagnostic Pitfall With Peritoneal Mesothelioma Open
Fumarate hydratase (FH)-deficient renal cell carcinomas are rare neoplasms characterized by wide morphologic heterogeneity and pathogenetic mutations in the FH gene. They often show aggressive behavior with rapid diffusion to distant organ…
View article: ecDNA amplification of<i>MYC</i>drives intratumor copy-number heterogeneity and adaptation to stress in PDAC
ecDNA amplification of<i>MYC</i>drives intratumor copy-number heterogeneity and adaptation to stress in PDAC Open
Intratumor heterogeneity and phenotypic plasticity drive tumour progression and therapy resistance. Oncogene dosage variation contributes to cell state transitions and phenotypic heterogeneity, thereby providing a substrate for somatic evo…
View article: Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in non-functional pancreatic neuroendocrine tumors
Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in non-functional pancreatic neuroendocrine tumors Open
DAXX/ATRX expression and ALT status can be accurately evaluated in a preoperative setting on EUS-FNB samples, potentially improving the identification of patients with increased risk and poorer prognosis.
View article: Atypical meningiomas with an immunohistochemical profile consistent with hypermetabolic or proliferative molecular groups show high mitotic index, chromosomal instability, and higher recurrence risk
Atypical meningiomas with an immunohistochemical profile consistent with hypermetabolic or proliferative molecular groups show high mitotic index, chromosomal instability, and higher recurrence risk Open
The use of adjuvant radiotherapy is controversial for atypical meningiomas undergoing gross total resection. It has recently been proposed that meningiomas may be classified into four molecular groups (MG): immunogenic (MG1), benign NF2 -w…
View article: Supplementary Figure 1 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome
Supplementary Figure 1 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome Open
Prognostic significance of the combined variable p16INK4a/p21CIP1/WAF1 in patients with cHL.
View article: Data from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome
Data from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome Open
Purpose: There is evidence that Hodgkin Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) could display some molecular and morphologic markers of cellular senescence (CS). We hypothesized that CS mechanisms may have potential …
View article: Supplementary Methods, Supplementary Tables 1-2 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome
Supplementary Methods, Supplementary Tables 1-2 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome Open
Table S1. Multivariate analysis for event occurrence in 132/147* patients. Table S2. Probability of EFS (95%CI) according sCD30 and p16INK4a/p21CIP1/WAF1 expression at diagnosis.
View article: Data from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome
Data from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome Open
Purpose: There is evidence that Hodgkin Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) could display some molecular and morphologic markers of cellular senescence (CS). We hypothesized that CS mechanisms may have potential …
View article: Supplementary Figure 1 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome
Supplementary Figure 1 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome Open
Prognostic significance of the combined variable p16INK4a/p21CIP1/WAF1 in patients with cHL.
View article: Supplementary Methods, Supplementary Tables 1-2 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome
Supplementary Methods, Supplementary Tables 1-2 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome Open
Table S1. Multivariate analysis for event occurrence in 132/147* patients. Table S2. Probability of EFS (95%CI) according sCD30 and p16INK4a/p21CIP1/WAF1 expression at diagnosis.
View article: Supplementary Table 3 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome
Supplementary Table 3 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome Open
MARQ analysis for common gene expression signatures of Hodgkin's lymphoma.
View article: Supplementary Table 3 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome
Supplementary Table 3 from Cellular Senescence Markers p16<sup>INK4a</sup> and p21<sup>CIP1/WAF</sup> Are Predictors of Hodgkin Lymphoma Outcome Open
MARQ analysis for common gene expression signatures of Hodgkin's lymphoma.
View article: TFE3 and TFEB-rearranged renal cell carcinomas: an immunohistochemical panel to differentiate from common renal cell neoplasms
TFE3 and TFEB-rearranged renal cell carcinomas: an immunohistochemical panel to differentiate from common renal cell neoplasms Open
TFE3/TFEB-rearranged renal cell carcinomas are characterized by translocations involving TFE3 and TFEB genes. Despite the initial description of typical morphology, their histological spectrum is wide, mimicking common subtypes of renal ce…
View article: <scp>pRB</scp> immunostaining in the differential diagnosis between pleomorphic xanthoastrocytoma and glioblastoma with giant cells
<span>pRB</span> immunostaining in the differential diagnosis between pleomorphic xanthoastrocytoma and glioblastoma with giant cells Open
Aims Pleomorphic xanthoastrocytoma (PXA) is a rare circumscribed glioma, characterized by frequent BRAF p. V600E mutation, and classified as grade 2 or 3. Owing to overlapping clinical–pathological features, the histological distinction fr…
View article: The Immunohistochemical Loss of H3K27me3 in Intracranial Meningiomas Predicts Shorter Progression-Free Survival after Stereotactic Radiosurgery
The Immunohistochemical Loss of H3K27me3 in Intracranial Meningiomas Predicts Shorter Progression-Free Survival after Stereotactic Radiosurgery Open
The immunohistochemical loss of histone H3 trimethylated in lysine 27 (H3K27me3) was recently shown to predict recurrence of meningiomas after surgery. However, its association with tumor progression after stereotactic radiosurgery (SRS) i…
View article: Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles
Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles Open
Extrahepatic cholangiocarcinoma (ECC) is classified into two subtypes based on anatomic origin: distal extrahepatic (DECC) and perihilar (PHCC) cholangiocarcinoma. This study aimed to shed light on its genomic and transcriptomic profiles. …