Stefano Puglisi‐Allegra
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View article: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease Open
View article: Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice
Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice Open
View article: Methamphetamine-Induced Blood Pressure Sensitization Correlates with Morphological Alterations within A1/C1 Catecholamine Neurons
Methamphetamine-Induced Blood Pressure Sensitization Correlates with Morphological Alterations within A1/C1 Catecholamine Neurons Open
Methamphetamine (METH) is a drug of abuse, which induces behavioral sensitization following repeated doses. Since METH alters blood pressure, in the present study we assessed whether systolic and diastolic blood pressure (SBP and DBP, resp…
View article: Methamphetamine Increases Tubulo-Vesicular Areas While Dissipating Proteins from Vesicles Involved in Cell Clearance
Methamphetamine Increases Tubulo-Vesicular Areas While Dissipating Proteins from Vesicles Involved in Cell Clearance Open
Cytopathology induced by methamphetamine (METH) is reminiscent of degenerative disorders such as Parkinson’s disease, and it is characterized by membrane organelles arranged in tubulo-vesicular structures. These areas, appearing as cluster…
View article: In situ stoichiometry amounts of p62 and poly-ubiquitin exceed the increase of alpha-synuclein during degeneration of catecholamine cells induced by autophagy inhibition in vitro
In situ stoichiometry amounts of p62 and poly-ubiquitin exceed the increase of alpha-synuclein during degeneration of catecholamine cells induced by autophagy inhibition in vitro Open
Neurodegenerative disorders are typically featured by the occurrence of neuronal inclusions. In the case of Parkinson’s disease (PD) these correspond to Lewy bodies (LBs), which are routinely defined as proteinaceous inclusions composed of…
View article: Is There a Place for Lewy Bodies before and beyond Alpha-Synuclein Accumulation? Provocative Issues in Need of Solid Explanations
Is There a Place for Lewy Bodies before and beyond Alpha-Synuclein Accumulation? Provocative Issues in Need of Solid Explanations Open
In the last two decades, alpha-synuclein (alpha-syn) assumed a prominent role as a major component and seeding structure of Lewy bodies (LBs). This concept is driving ongoing research on the pathophysiology of Parkinson’s disease (PD). In …
View article: Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration
Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration Open
The present investigation was designed based on the evidence that, in neurodegenerative disorders, such as Alzheimer’s dementia (AD) and Parkinson’s disease (PD), damage to the locus coeruleus (LC) arising norepinephrine (NE) axons (LC-NE)…
View article: Combined light and electron microscopy (CLEM) to quantify methamphetamine-induced alpha-synuclein-related pathology
Combined light and electron microscopy (CLEM) to quantify methamphetamine-induced alpha-synuclein-related pathology Open
Methamphetamine (METH) produces a cytopathology, which is rather specific within catecholamine neurons both in vitro and ex vivo, in animal models and chronic METH abusers. This led some authors to postulate a sort of parallelism between M…
View article: Pain in Parkinson's disease: a neuroanatomy-based approach
Pain in Parkinson's disease: a neuroanatomy-based approach Open
Parkinson's disease is a progressive neurodegenerative disorder characterized by the deposition of misfolded alpha-synuclein in different regions of the central and peripheral nervous system. Motor impairment represents the signature clini…
View article: Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players
Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players Open
Deficits in cognitive flexibility have been characterized in affective, anxiety, and neurodegenerative disorders. This paper reviews data, mainly from studies on animal models, that support the existence of a cortical–striatal brain circui…
View article: The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes
The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes Open
Tinnitus is the perception of noise in the absence of acoustic stimulation (phantom noise). In most patients suffering from chronic peripheral tinnitus, an alteration of outer hair cells (OHC) starting from the stereocilia (SC) occurs. Thi…
View article: Curcumin as a Perspective Protection for Retinal Pigment Epitheliumduring Autophagy Inhibition in the Course of Retinal Degeneration
Curcumin as a Perspective Protection for Retinal Pigment Epitheliumduring Autophagy Inhibition in the Course of Retinal Degeneration Open
Defective autophagy in the retinal pigment epithelium (RPE) is involved in retinal degeneration, mostly in the course of age-related macular degeneration (AMD), which is an increasingly prevalent retinal disorder, eventually leading to bli…
View article: Autophagy Activation Promoted by Pulses of Light and Phytochemicals Counteracting Oxidative Stress during Age-Related Macular Degeneration
Autophagy Activation Promoted by Pulses of Light and Phytochemicals Counteracting Oxidative Stress during Age-Related Macular Degeneration Open
The seminal role of autophagy during age-related macular degeneration (AMD) lies in the clearance of a number of reactive oxidative species that generate dysfunctional mitochondria. In fact, reactive oxygen species (ROS) in the retina gene…
View article: Lithium engages autophagy for neuroprotection and neuroplasticity: Translational evidence for therapy
Lithium engages autophagy for neuroprotection and neuroplasticity: Translational evidence for therapy Open
View article: Autophagy Activation Associates with Suppression of Prion Protein and Improved Mitochondrial Status in Glioblastoma Cells
Autophagy Activation Associates with Suppression of Prion Protein and Improved Mitochondrial Status in Glioblastoma Cells Open
Cells from glioblastoma multiforme (GBM) feature up-regulation of the mechanistic Target of Rapamycin (mTOR), which brings deleterious effects on malignancy and disease course. At the cellular level, up-regulation of mTOR affects a number …
View article: Chronic treatment with corticosterone increases the number of tyrosine hydroxylase-expressing cells within specific nuclei of the brainstem reticular formation
Chronic treatment with corticosterone increases the number of tyrosine hydroxylase-expressing cells within specific nuclei of the brainstem reticular formation Open
Cushing's syndrome is due to increased glucocorticoid levels in the body, and it is characterized by several clinical alterations which concern both vegetative and behavioral functions. The anatomical correlates of these effects remain lar…
View article: Bacopa Protects against Neurotoxicity Induced by MPP+ and Methamphetamine
Bacopa Protects against Neurotoxicity Induced by MPP+ and Methamphetamine Open
The neurotoxins methamphetamine (METH) and 1-methyl-4-phenylpyridinium (MPP+) damage catecholamine neurons. Although sharing the same mechanism to enter within these neurons, METH neurotoxicity mostly depends on oxidative species, while MP…
View article: Within the Ischemic Penumbra, Sub-Cellular Compartmentalization of Heat Shock Protein 70 Overlaps with Autophagy Proteins and Fails to Merge with Lysosomes
Within the Ischemic Penumbra, Sub-Cellular Compartmentalization of Heat Shock Protein 70 Overlaps with Autophagy Proteins and Fails to Merge with Lysosomes Open
The brain area which surrounds the frankly ischemic region is named the area penumbra. In this area, most cells are spared although their oxidative metabolism is impaired. area penumbra is routinely detected by immunostaining of a molecule…
View article: In Pancreatic Adenocarcinoma Alpha-Synuclein Increases and Marks Peri-Neural Infiltration
In Pancreatic Adenocarcinoma Alpha-Synuclein Increases and Marks Peri-Neural Infiltration Open
α-Synuclein (α-syn) is a protein involved in neuronal degeneration. However, the family of synucleins has recently been demonstrated to be involved in the mechanisms of oncogenesis by selectively accelerating cellular processes leading to …
View article: Locus Coeruleus magnetic resonance imaging: a comparison between native-space and template-space approach
Locus Coeruleus magnetic resonance imaging: a comparison between native-space and template-space approach Open
View article: Spreading of Alpha Synuclein from Glioblastoma Cells towards Astrocytes Correlates with Stem-like Properties
Spreading of Alpha Synuclein from Glioblastoma Cells towards Astrocytes Correlates with Stem-like Properties Open
Evidence has been recently provided showing that, in baseline conditions, GBM cells feature high levels of α-syn which are way in excess compared with α-syn levels measured within control astrocytes. These findings are consistent along var…
View article: Combined pulses of light and sound in the retina with nutraceuticals may enhance the recovery of foveal holes
Combined pulses of light and sound in the retina with nutraceuticals may enhance the recovery of foveal holes Open
The present manuscript stems from evidence, which indicates that specific wavelength produce an activation of the autophagy pathway in the retina. These effects were recently reported to synergize with the autophagy-inducing properties of …
View article: Noradrenergic substrates sensing light within brainstem reticular formation as targets for light-induced behavioral and cardiovascular plasticity
Noradrenergic substrates sensing light within brainstem reticular formation as targets for light-induced behavioral and cardiovascular plasticity Open
The occurrence of pure light exerts a variety of effects in the human body, which span from behavioral alterations, such as light-driven automatic motor activity, cognition and mood to more archaic vegetative functions, which encompass mos…
View article: Inhibition of Autophagy In Vivo Extends Methamphetamine Toxicity to Mesencephalic Cell Bodies
Inhibition of Autophagy In Vivo Extends Methamphetamine Toxicity to Mesencephalic Cell Bodies Open
Methamphetamine (METH) is a widely abused psychostimulant and a stress-inducing compound, which leads to neurotoxicity for nigrostriatal dopamine (DA) terminals in rodents and primates including humans. In vitro studies indicate that autop…
View article: The Autophagy-Related Organelle Autophagoproteasome Is Suppressed within Ischemic Penumbra
The Autophagy-Related Organelle Autophagoproteasome Is Suppressed within Ischemic Penumbra Open
The peri-infarct region, which surrounds the irreversible ischemic stroke area is named ischemic penumbra. This term emphasizes the borderline conditions for neurons placed within such a critical region. Area penumbra separates the ischemi…
View article: Norepinephrine Protects against Methamphetamine Toxicity through β2-Adrenergic Receptors Promoting LC3 Compartmentalization
Norepinephrine Protects against Methamphetamine Toxicity through β2-Adrenergic Receptors Promoting LC3 Compartmentalization Open
Norepinephrine (NE) neurons and extracellular NE exert some protective effects against a variety of insults, including methamphetamine (Meth)-induced cell damage. The intimate mechanism of protection remains difficult to be analyzed in viv…
View article: Translational evidence for lithium-induced brain plasticity and neuroprotection in the treatment of neuropsychiatric disorders
Translational evidence for lithium-induced brain plasticity and neuroprotection in the treatment of neuropsychiatric disorders Open
View article: Stoichiometric Analysis of Shifting in Subcellular Compartmentalization of HSP70 within Ischemic Penumbra
Stoichiometric Analysis of Shifting in Subcellular Compartmentalization of HSP70 within Ischemic Penumbra Open
The heat shock protein (HSP) 70 is considered the main hallmark in preclinical studies to stain the peri-infarct region defined area penumbra in preclinical models of brain ischemia. This protein is also considered as a potential disease m…
View article: Morphology, clearing efficacy, and mTOR dependency of the organelle autophagoproteasome
Morphology, clearing efficacy, and mTOR dependency of the organelle autophagoproteasome Open
The interplay between autophagy (ATG) and ubiquitin proteasome (UP) cell-clearing systems was recently evidenced at biochemical and morphological levels, where subunits belonging to both pathways co-localize within a novel organelle named …
View article: The connections of Locus Coeruleus with hypothalamus: potential involvement in Alzheimer’s disease
The connections of Locus Coeruleus with hypothalamus: potential involvement in Alzheimer’s disease Open
The hypothalamus and Locus Coeruleus (LC) share a variety of functions, as both of them take part in the regulation of the sleep/wake cycle and in the modulation of autonomic and homeostatic activities. Such a functional interplay takes pl…