Explanipedia

The association of HIV status with triple-negative breast cancer in patients with breast cancer in South Africa: a cross-sectional analysis of case-only data from a prospective cohort study Open

Jacob Dubner, A. I. Neugut, Maureen Joffe, Daniel S. O’Neil, Oluwatosin Ayeni , et al. · 2024

The clinicopathological landscape of thyroid cancer in South Africa—A multi‐institutional review Open

W Conradie, Thifhelimbilu Emmanuel Luvhengo, Jeanne Lübbe, Amir Afrogheh, Aneldi Bestbier , et al. · 2024

Background In South Africa (SA), data on the incidence of thyroid cancer is limited. Papillary thyroid carcinoma is by far the most common malignancy in developed countries; however, a preponderance of follicular thyroid cancer in developi…

Review of: "Effect of Ethnic Differences on Breast Cancer Presentation and Prognosis in Singapore" Open

Sharon Čačala · 2024

The Association of HIV Status with Triple-Negative Breast Cancer in South African Breast Cancer Patients Open

Jacob Dubner, A. I. Neugut, Maureen Joffe, Daniel S. O’Neil, Oluwatosin Ayeni , et al. · 2024

The South African breast cancer and HIV outcomes study: Profiling the cancer centres and cohort characteristics, diagnostic pathways, and treatment approaches Open

Witness Mapanga, Oluwatosin Ayeni, Wenlong Carl Chen, Judith S. Jacobson, Alfred I. Neugut , et al. · 2023

The South African Breast Cancer and HIV Outcomes prospective cohort (SABCHO) study was established to investigate survival determinants among HIV-positive and HIV-negative SA women with breast cancer. This paper describes common and unique…

Case study: An unusual and fatal injury: stab wound of a bovine aortic arch anomaly Open

George Oosthuizen, Sergio AM Vieira, Ryan J Keet, Jacobus D Winter, Sharon Čačala · 2023

Penetrating trauma of the aortic arch is relatively uncommon, even at busy trauma centers. Such an injury is challenging, especially in a “crashing” patient in whom emergency surgery is undertaken. When this scenario is coupled with an aor…

The Impact of HIV Infection on Neoadjuvant and Adjuvant Chemotherapy Relative Dose Intensity in South African Patients with Breast Cancer Open

Daniel S. O’Neil, Oluwatosin Ayeni, Hayley A. Farrow, Wenlong Carl Chen, Georgia Demetriou , et al. · 2023

Introduction In the South African Breast Cancer and HIV Outcomes (SABCHO) study, we previously found that breast cancer patients living with HIV and treated with neoadjuvant chemotherapy achieve lower rates of complete pathologic response …

Drivers of disparities in stage at diagnosis among women with breast cancer: South African breast cancers and HIV outcomes cohort Open

Witness Mapanga, Shane A. Norris, Ashleigh Craig, Oluwatosin Ayeni, Wenlong Carl Chen , et al. · 2023

Objective In low- and middle-income countries (LMICs), advanced-stage diagnosis of breast cancer (BC) is common, and this contributes to poor survival. Understanding the determinants of the stage at diagnosis will aid in designing interven…

Correction: Multimorbidity and overall survival among women with breast cancer: results from the South African Breast Cancer and HIV Outcomes Study Open

Oluwatosin Ayeni, Maureen Jofe, Witness Mapanga, Wenlong Carl Chen, Daniel S. O’Neil , et al. · 2023

Multimorbidity and overall survival among women with breast cancer: results from the South African Breast Cancer and HIV Outcomes Study Open

Oluwatosin Ayeni, Maureen Joffe, Witness Mapanga, Wenlong Carl Chen, Daniel S. O’Neil , et al. · 2023

Background Breast cancer survival in South Africa is low, but when diagnosed with breast cancer, many women in South Africa also have other chronic conditions. We investigated the impact of multimorbidity (≥ 2 other chronic conditions) on …

A Retrospective Study of the Severity of Injury following Potassium Permanganate Ingestion in Teenagers and Adults in KwaZulu Natal, South Africa Open

Samantha J. Beningfield, Emily A. Webber, George Oosthuizen, Sharon Čačala · 2023

Introduction: Potassium Permanganate (KMnO4) is an uncommon cause of caustic ingestion in teenagers and adults; only case reports are found in the recent literature. At Ngwelezana Hospital in South Africa, KMnO4 ingestion is not an uncommo…

Multimorbidity and overall survival among women with breast cancer: Results from the South African breast cancer and HIV outcomes study Open

Oluwatosin Ayeni, Maureen Joffe, Witness Mapanga, Wenlong Carl Chen, Daniel S. O’Neil , et al. · 2022

Background Breast cancer survival in sub-Saharan Africa (SSA) is low, but when diagnosed with breast cancer, many women in SSA also have other chronic conditions. We investigated the impact of multimorbidity (≥ 2 other chronic conditions) …

Impact of HIV infection on survival among women with stage I‐III breast cancer: Results from the South African breast cancer and HIV outcomes study Open

Oluwatosin Ayeni, Daniel S. O’Neil, Yoanna S Pumpalova, Wenlong Carl Chen, Sarah Nietz , et al. · 2022

In some countries of sub‐Saharan Africa, the prevalence of HIV exceeds 20%; in South Africa, 20.4% of people are living with HIV. We examined the impact of HIV infection on the overall survival (OS) of women with nonmetastatic breast cance…

Drivers of Disparities in Stage at Diagnosis Among Women With Breast Cancer: South African Breast Cancers and HIV Outcomes Cohort Open

Witness Mapanga, Shane A. Norris, Ashleigh Craig, Oluwatosin Ayeni, Wenlong Carl Chen , et al. · 2022

Objective In low- and middle-income countries (LMICs), advanced stage diagnosis of breast cancer (BC) is common, and this contributes to poor survival. By understanding the determinants of the stage at diagnosis will aid in designing inter…

The Impact of Breast Cancer Treatment Delays on Survival Among South African Women Open

Yoanna S Pumpalova, Oluwatosin Ayeni, Wenlong Carl Chen, Ines Buccimazza, Sharon Čačala , et al. · 2022

Background In high-income settings, delays from breast cancer (BC) diagnosis to initial treatment worsen overall survival (OS). We examined how time to BC treatment initiation (TTI) impacts OS in South Africa (SA). Methods We evaluated wom…

Oesophageal Transection for Bleeding Varices: Case Report and Literature Review Open

Zandri Pienaar, Zandri Pienaar, Sharon Čačala, George Oosthuizen · 2021

Surgical oesophageal transection for uncontrolled variceal bleeding is a last resort measure that is rarely needed due to modern endoscopic advancements. Since it is infrequently required, most of the younger General Surgeons have not been…

Impact of HIV infection on overall survival among women with stage IV breast cancer in South Africa Open

Yoanna S Pumpalova, Oluwatosin Ayeni, Wenlong Carl Chen, Daniel S. O’Neil, Sarah Nietz , et al. · 2021

The Value of Navigators in Breast Cancer Management in a South African Hospital Open

Sharon Čačala, Hayley A. Farrow, S. Makhanya, D. G. Couch, Maureen Joffe , et al. · 2021

Background Specialist breast cancer nurses (BCNs) have improved the psychological care and follow‐up rates of breast cancer (BC) patients. This study sought to determine if breast cancer research workers (BCRWs) as de facto BCNs impacted p…

Quality of Histopathological Reporting in Breast Cancer: Results From Four South African Breast Units Open

Armand Toma, Daniel S. O’Neil, Maureen Joffe, Oluwatosin Ayeni, Carolina Nel , et al. · 2021

PURPOSE High-quality histopathology reporting forms the basis for treatment decisions. The quality indicator for pathology reports from the European Society of Breast Cancer Specialists was applied to a cohort from four South African breas…

A comparison of complete pathologic response rates following neoadjuvant chemotherapy among South African breast cancer patients with and without concurrent HIV infection Open

Sarah Nietz, Daniel S. O’Neil, Oluwatosin Ayeni, Wenlong Carl Chen, Maureen Joffe , et al. · 2020

Breast Cancer Care Quality in South Africa’s Public Health System: An Evaluation Using American Society of Clinical Oncology/National Quality Forum Measures Open

Daniel S. O’Neil, Wenlong Carl Chen, Oluwatosin Ayeni, Sarah Nietz, Ines Buccimazza , et al. · 2019

PURPOSE The quality of breast cancer care in sub-Saharan Africa contributes to the region’s dismal breast cancer mortality. ASCO has issued quality measures focusing on delivery of adjuvant chemotherapy, radiotherapy, and endocrine therapy…

The multimorbidity profile of South African women newly diagnosed with breast cancer Open

Oluwatosin Ayeni, Shane A. Norris, Maureen Joffe, Herbert Cubasch, Sarah Nietz , et al. · 2019

Multimorbidity in women with breast cancer may delay presentation, affect treatment decisions and outcomes. We described the multimorbidity profile of women with breast cancer, its determinants, associations with stage at diagnosis and tre…

Bert Myburgh Research Forum Open

Kuruvilla Thomas, Cameron J. Mitchell, Edward J. Miller, Markus Schamm, Martin Hale , et al. · 2019

Introduction: Indications for parathyroidectomy include primary, secondary and tertiary hyperparathyroidism.Challenges in management of primary hyperparathyroidism include inability to conclusively differentiate a single adenoma from multi…

Neoadjuvant Chemotherapy Use for Nonmetastatic Breast Cancer at Five Public South African Hospitals and Impact on Time to Initial Cancer Therapy Open

Daniel S. O’Neil, Sarah Nietz, Ines Buccimazza, Urishka Singh, Sharon Čačala , et al. · 2018

Background In the U.S., neoadjuvant chemotherapy (NAC) for nonmetastatic breast cancer (BC) is used with extensive disease and aggressive molecular subtypes. Little is known about the influence of demographic characteristics, clinical fact…

Factors Relating to Late Presentation of Patients With Breast Cancer in Area 2 KwaZulu-Natal, South Africa Open

Sharon Čačala, José Gilart · 2017

Purpose Patients with breast cancer (BC) in Area 2 KwaZulu-Natal, South Africa, often present with advanced disease. We performed a review of the patients’ sociodemographic characteristics and their reasons for late presentation to identif…

South African Breast Cancer and HIV Outcomes Study: Methods and Baseline Assessment Open

Herbert Cubasch, Paul Ruff, Maureen Joffe, Shane A. Norris, Tobias Chirwa , et al. · 2016

Purpose In low- and middle-income, HIV-endemic regions of sub-Saharan Africa, morbidity and mortality from the common epithelial cancers of the developed world are rising. Even among HIV-infected individuals, access to antiretroviral thera…

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