Explanipedia

T-PGI: an engineered STITCHR system for scarless, programmable genome integration Open

Joo‐Hyung Lee, Jonathan D. Finn, Sandeep Kumar, K. Daneshvar, Yizhao Ni , et al. · 2025

Scarless, programmable insertion of defined DNA remains a central goal for therapeutic genome editing. We introduce T-PGI (Transposon-mediated programmable genomic integration), an engineered implementation of STITCHR that preserves target…

CXCR5 engineered human and murine Tregs for targeted suppression in secondary and tertiary lymphoid organs Open

Matteo Doglio, Jyoti Rana, Adriana Stucchi, M J Llorente Melero, Alessia Ugolini , et al. · 2025

Introduction Secondary and tertiary lymphoid structures are a critical target of suppression in many autoimmune disorders, protein replacement therapies, and in transplantation. Although antigen-specific regulatory T cells (Tregs), such as…

Heterosis Studies for Yield and Fibre Quality Traits in GMS based Asiatic Cotton (Gossypium arboreum L.) Hybrids Open

Minakshi Jattan, Sandeep Kumar, Amit, Somveer Nimbal, Shiwani Mandhania , et al. · 2025

Background: Cotton is a natural fibre grown in over 100 countries worldwide and is a key agricultural crop that provides raw material for various industries (Radhakrishnan, 2017). One effective strategy to address yield and productivity is…

COMPARATIVE PHYTOCHEMICAL EVALUATION OF PSIDIUM GUAJAVA L. AND TERMINALIA ARJUNA ROXB. WHICH ARE USED IN THE MANAGEMENT OF HYPERTENSION Open

P. Srikanth, Sandeep Kumar · 2025

Evaluation of Sensory Properties and Short-Chain Fatty Acid Production in Fermented Soymilk on Addition of Fructooligosaccharides and Raffinose Family of Oligosaccharides Open

Minnu Sasi, Sandeep Kumar, Om Prakash, Veda Krishnan, Vinayaka Vinayaka , et al. · 2025

High potential is attributed to the concomitant use of probiotics and prebiotics in a single food product, called “synbiotics”, where the prebiotic component distinctly favours the growth and activity of probiotic microbes. This study impl…

Advancements in dairy technology: Innovations and trends in milk processing Open

Pooja Yadav, Sandeep Kumar, MU Tanpure, Ved Prakash Gupta, Veerendra Kumar , et al. · 2025

Gut MicrobiotAware: how much do we know about gut microbiota? An international questionnaire Open

Enriqueta García-Gutiérrez, Sara Arbulu, Charlotte Oliver, Sandeep Kumar, Sarita Dam , et al. · 2024

Over the past two decades, our understanding of human gut microbiota composition and function has grown significantly. The surge in studies and data has unveiled the profound influence of gut microbiota on host nutrition, health, and behav…

Regulatory Aspects of Antioxidants Open

Kiran Kumar Bellapu, Tejaswini Mergu, Nikhil Vinod Shirsath, Pooja Anil Shende, Pavankumar Yashvantrao Vasu , et al. · 2024

Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell Responses in AAV1 Muscle Gene Transfer Open

Ning Li, Sandeep Kumar, Di Cao, Maite Muñoz-Melero, Sreevani Arisa , et al. · 2024

While adeno-associated viral (AAV) vectors are successfully used in a variety of in vivo gene therapy applications, they continue to be hampered by the immune system. Here, we sought to identify innate and cytokine signaling pathways that …

Redundancy in Innate Immune Pathways that Promote CD8+ T cell Responses in AAV Muscle Gene Transfer Open

Ning Li, Sandeep Kumar, Di Cao, Maite Muñoz-Melero, Sreevani Arisa , et al. · 2024

While adeno-associated viral (AAV) vectors are successfully used in a variety of in vivo gene therapy applications, they continue to be hampered by the immune system. Here, we sought to identify innate and cytokine signaling pathways that …

Innate Immune Sensing of Adeno-Associated Virus Vectors Open

Di Cao, Barry J. Byrne, Ype P. de Jong, Cox Terhorst, Dongsheng Duan , et al. · 2024

Adeno-associated virus (AAV) based viral vectors are widely used in human gene therapy and form the basis of approved treatments for several genetic diseases. Immune responses to vector and transgene products, however, substantially compli…

Genetic variability and association studies for yield and its attributes in cultivated potato (Solanum tuberosum L.) Open

Jagmeet Singh, Dharminder Kumar, Salej Sood, Vinay Bhardwaj, Ramesh Kumar , et al. · 2024

Sufficient genetic variability on the basis of various parameters of variability was recorded in 357 tetraploid potato genotypes, including varieties, advanced breeding lines and exotic germplasm. The estimates of heritability and genetic …

Spatio-temporal expression of polyphenol oxidase unveils the dynamics of L-DOPA accumulation in faba bean (Vicia faba L.) Open

Sradhanjali Jena, Rajarshi Sanyal, Danish Md. Jawed, Kaustav Sengupta, Bhubaneswar Pradhan , et al. · 2024

Primary microgliopathy presenting as degenerative dementias: A case series of novel gene mutations from India Open

Subasree Ramakrishnan, Faheem Arshad, Keerthana Bs, Arun Gokul Pon, Susan Bosco , et al. · 2024

Introduction Microglia exert a crucial role in homeostasis of white matter integrity and several studies highlight the role of microglial dysfunctions in neurodegeneration. Primary microgliopathy are disorders where the pathogenic abnormal…

B cell focused transient immune suppression protocol for efficient AAV readministration to the liver Open

Jyoti Rana, Roland W. Herzog, Maite Muñoz-Melero, Kentaro Yamada, Sandeep Kumar , et al. · 2024

Adeno-associated virus (AAV) vectors are used for correcting multiple genetic disorders. Although the goal is to achieve lifelong correction with a single vector administration, the ability to redose would enable the extension of therapy i…

Optimization for nutritional fortification of wheat–millet composite flour mixture by response surface methodology Open

Gaurav Chaudhary, Monu Kumar, Anita R. Sehrawat, Sandeep Kumar, Sachidanand Tripathi · 2024

This study intends to optimize the production and evaluation of the nutritional quality of composite flour comprising wheat and millet. The experimental design for the composite flour was laid down using the I-optimal mixture design of res…

TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling Open

Sandeep Kumar, Moanaro Biswas, Di Cao, Sreevani Arisa, Maite Muñoz-Melero , et al. · 2023

Isoflavones Play a Potential Role in Off-Flavour Scavenging, with a Key Role of IFS2 in Isoflavone Accumulation in Soybean Seeds Open

Sandeep Kumar, Sagar Banerjee, Amandeep Kaur, Minnu Sasi, Sweta Kumari , et al. · 2023

Research background. Soybean (Glycine max (L.) Merr) is a nutrient-rich crop with a high protein content and various bioactive compounds with health-promoting properties. Nevertheless, it is poorly accepted as a food by consumers due to it…

Distinct functions and transcriptional signatures in orally induced regulatory T cell populations Open

Moanaro Biswas, Kaman So, Thaís B. Bertolini, Preethi Krishnan, Jyoti Rana , et al. · 2023

Oral administration of antigen induces regulatory T cells (Treg) that can not only control local immune responses in the small intestine, but also traffic to the central immune system to deliver systemic suppression. Employing murine model…

Research trends and approaches for the nutritional and bio-functionality enhancement of fermented soymilk Open

Muzaffar Hasan, S R Arpitha, Chandrika Das, Rosalin Laishram, Minnu Sasi , et al. · 2023

The rising interest in plant-based formulations and ethical concerns associated with animal-based products has led to an increased consumption of soymilk. This review explores research trends in soymilk and its fermentation to enhance our …

Fermentative Bioconversion of β-Glucoside Like Isoflavones is a Better Indicator of β-Glucoside Hydrolysing Capability in Probiotic Lactic Acid Bacteria (LAB) Due to the Predominant Phosphoglucosidase Activity Open

Sandeep Kumar, Minnu Sasi, Sweta Kumari, Navita Bansal, Rajeev Mohan Kaushik , et al. · 2023

Isoflavones provide multiple health benefits, such as the potential for prevention of cancer and osteoporosis. Isoflavones are naturally present as β-glucosides, rendering them unavailable for uptake in the human gut. In the present study,…

Comparative analysis of the prebiotic effect of Fructooligosaccharides and Raffinose oligosaccharides on nutraceutical and sensory properties of soymilk fermented with mixed cultures of Lacticaseibacillus rhamnosus and Weissella confusa 30082b Open

Minnu Sasi, Sandeep Kumar, Govind Singh Tomar, Jigni Mishra, Arpitha , et al. · 2023

High potential is attributed to the concomitant use of probiotics and prebiotics in a single food product, called "synbiotics," where the prebiotic component distinctly favours the growth and activity of probiotic microbes. This study impl…

Immune Responses to Muscle-Directed Adeno-Associated Viral Gene Transfer in Clinical Studies Open

Sandeep Kumar, Dongsheng Duan, Roland W. Herzog · 2023

Muscle-directed gene therapy with adeno-associated viral (AAV) vectors is undergoing clinical development for treating neuromuscular disorders and for systemic delivery of therapeutic proteins. Although these approaches show considerable t…

Optimizing raffinose family oligosaccharides content in plants: A tightrope walk Open

Rajarshi Sanyal, Sandeep Kumar, A. Pattanayak, Abhijit Kar, Sujit Kumar Bishi · 2023

Plants synthesize various compounds for their growth, metabolism, and stress mitigation, and one such group of compounds is the raffinose family of oligosaccharides (RFOs). RFOs are non-reducing oligosaccharides having galactose residues a…

Suppression of anti-drug antibody formation against coagulation factor VIII by oral delivery of anti-CD3 monoclonal antibody in hemophilia A mice Open

Thaís B. Bertolini, Roland W. Herzog, Sandeep Kumar, Alexandra Sherman, Jyoti Rana , et al. · 2023

Soybean (Glycine max) isoflavone conjugate hydrolysing β-glucosidase (GmICHG): a promising candidate for soy isoflavone bioavailability enhancement Open

Sandeep Kumar, Monika Awana, Khushboo Rani, Sweta Kumari, Minnu Sasi , et al. · 2023

Estimation Of Radon, Thoron, And Their Progeny Concentration In Selected Dwellings Near The Sugar Mills Of Uttar Pradesh And Uttarakhand, India Open

Sandeep Kumar, Rajnish Kumar, Pankaj Kumar, Anil Kumar, Surander kumar , et al. · 2022

Radon gas is the prime contributor to natural radiation and poses a significant human health risk. Radon is the second leading cause of cancer after smoking. The estimation of the level of naturally occurring gases become important for det…

IL-15 blockade and rapamycin rescue multifactorial loss of factor VIII from AAV-transduced hepatocytes in hemophilia A mice Open

John S. Butterfield, Kentaro Yamada, Thaís B. Bertolini, Farooq Syed, Sandeep Kumar , et al. · 2022

Isoflavones have a potential role in off-flavour scavenging, with isoflavone synthase 2 (IFS2) as a key player in determining isoflavone accumulation in soybean seeds Open

Sandeep Kumar, Sagar Banerjee, Amandeep Kaur, Minnu Sasi, Sweta Kumari , et al. · 2022

Soybean ( Glycine max (L.) Merr) is a nutrient-rich crop with limited consumer acceptability because of the presence of off-flavour. Owing to the ubiquity of isoflavones in soybean, their inherent antioxidant potential, and their inhibitor…

Isoflavones have a potential role to play in off-flavour scavenging, with Isoflavone synthase 2 (IFS2) as a key player determining isoflavone accumulation in soybean seeds Open

Sandeep Kumar, Sagar Banerjee, Amandeep Kaur, Minnu Sasi, Sweta Kumari , et al. · 2022

Soybean ( Glycine max (L.) Merr) is a nutrient-rich crop with limited consumer acceptability because of the presence of off-flavour. Owing to the ubiquity of isoflavones in soybean, their inherent antioxidant potential, and inhibitory effe…

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