Isuru Ranasinghe
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View article: National trends in stroke hospitalisations, mortality, and recurrent stroke in Australia and New Zealand
National trends in stroke hospitalisations, mortality, and recurrent stroke in Australia and New Zealand Open
Robust data on trends in stroke hospitalisation rate and outcomes are needed to improve stroke care, yet are sparse and show conflicting results. We investigated the trends in hospitalisation rate, survival, and risk of stroke recurrence f…
View article: Timing, Diagnosis, and Potential Preventability of 30-Day Unplanned Readmissions After a Heart Failure Hospitalisation: Implications for Care Quality
Timing, Diagnosis, and Potential Preventability of 30-Day Unplanned Readmissions After a Heart Failure Hospitalisation: Implications for Care Quality Open
The peak risk of unplanned readmission occurred in the first few days after discharge, often for potentially preventable reasons such as hospital-acquired complications and recurrent heart failure. Such early and potentially preventable re…
View article: Differences between sexes in STEMI treatment and outcomes with contemporary primary PCI
Differences between sexes in STEMI treatment and outcomes with contemporary primary PCI Open
Background Historically, differences in timely reperfusion and outcomes have been described in females who suffer ST‐segment elevation myocardial infarction (STEMI). However, there have been improvements in the treatment of STEMI patients …
View article: Hospital costs for unplanned re‐admissions within 30 days of hospitalisations with heart failure, Australia, 2013–2017: a retrospective cohort study
Hospital costs for unplanned re‐admissions within 30 days of hospitalisations with heart failure, Australia, 2013–2017: a retrospective cohort study Open
Objectives To assess the direct hospital costs for unplanned re‐admissions within 30 days of hospitalisations with heart failure in Australia; to estimate the proportion of these costs attributable to potentially preventable re‐admissions.…
View article: Clinical characteristics and outcomes of Australian and Indian ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI)
Clinical characteristics and outcomes of Australian and Indian ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI) Open
Significant differences in demographics and presentation characteristics exist between Indian and Australian STEMI patients treated with pPCI. Indian patients had significantly longer pre-hospital delays and lower achievement of TIMI III f…
View article: Long-term outcomes after hospitalization for atrial fibrillation or flutter
Long-term outcomes after hospitalization for atrial fibrillation or flutter Open
Background and Aims Atrial fibrillation (AF) and flutter are common causes of hospitalizations but contemporary long-term outcomes following these episodes are uncertain. This study assessed outcomes up to 10 years after an acute AF or flu…
View article: Spot urinary sodium-guided titration of intravenous diuretic therapy in acute heart failure: a pilot randomized controlled trial
Spot urinary sodium-guided titration of intravenous diuretic therapy in acute heart failure: a pilot randomized controlled trial Open
Background Spot urinary sodium concentration (UNa) is advocated in guidelines to assess diuretic response and titrate dosage in acute heart failure (AHF). However, no randomized controlled trial data exist to support this approach. We perf…
View article: Excess Bed Days and Hospitalization Costs Associated With 30‐Day Complications Following Catheter Ablation of Atrial Fibrillation
Excess Bed Days and Hospitalization Costs Associated With 30‐Day Complications Following Catheter Ablation of Atrial Fibrillation Open
Background The incidence and type of complications following catheter ablation of atrial fibrillation have been extensively examined, but the impact associated with these complications on the length of stay and hospitalization costs is unk…
View article: Pericardial infiltration and constriction due to cardiac actinomycosis—case report
Pericardial infiltration and constriction due to cardiac actinomycosis—case report Open
Background Constrictive pericarditis associated with actinomycosis infection is a rare and challenging diagnosis due to its insidious manifestation. We describe the successful treatment of pericardial infiltration and constriction due to a…
View article: Prehospital Activation of the Cardiac Catheterization Laboratory in ST‐Segment–Elevation Myocardial Infarction for Primary Percutaneous Coronary Intervention
Prehospital Activation of the Cardiac Catheterization Laboratory in ST‐Segment–Elevation Myocardial Infarction for Primary Percutaneous Coronary Intervention Open
Background Prehospital activation of the cardiac catheter laboratory is associated with significant improvements in ST‐segment–elevation myocardial infarction (STEMI) performance measures. However, there are equivocal data, particularly wi…
View article: Freedom from atrial arrhythmia and other clinical outcomes at 5 years and beyond after catheter ablation of atrial fibrillation: a systematic review and meta-analysis
Freedom from atrial arrhythmia and other clinical outcomes at 5 years and beyond after catheter ablation of atrial fibrillation: a systematic review and meta-analysis Open
Aims Catheter ablation of atrial fibrillation (AF) is now a mainstream procedure although long-term outcomes are uncertain. We performed a systematic review and meta-analysis of procedural outcomes at 5 years and beyond. Methods and result…
View article: Prehospital activation of the cardiac catheterisation laboratory in ST-segment elevation myocardial infarction (STEMI) for primary percutaneous coronary intervention (PCI)
Prehospital activation of the cardiac catheterisation laboratory in ST-segment elevation myocardial infarction (STEMI) for primary percutaneous coronary intervention (PCI) Open
Background Prehospital activation of the cardiac catheter laboratory is associated with significant improvements in ST-segment elevation myocardial infarction (STEMI) performance measures. However, there is equivocal data, particularly wit…
View article: The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction
The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction Open
Background. When compared to left ventricular ejection fraction (LVEF), previous studies have suggested the superiority of wall motion score index (WMSI) in predicting cardiac events in patients who have suffered acute myocardial infarctio…
View article: Single High-Sensitivity Point-of-Care Whole-Blood Cardiac Troponin I Measurement to Rule Out Acute Myocardial Infarction at Low Risk
Single High-Sensitivity Point-of-Care Whole-Blood Cardiac Troponin I Measurement to Rule Out Acute Myocardial Infarction at Low Risk Open
Background: High-sensitivity cardiac troponin (hs-cTn) laboratory assays are used to rule out myocardial infarction (MI) on presentation, but prolonged result turnaround times can delay patient management. Our primary aim was to identify p…
View article: Novel Pulmonary Delivery of Drugs for the Management of Atrial Fibrillation
Novel Pulmonary Delivery of Drugs for the Management of Atrial Fibrillation Open
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, affecting approximately 335 million patients worldwide. Comprehensive pharmacological treatment of AF includes medications for rate or rhythm control and anticoagulants to …
View article: Sex differences in time to primary percutaneous coronary intervention and outcomes in patients presenting with ST‐segment elevation myocardial infarction
Sex differences in time to primary percutaneous coronary intervention and outcomes in patients presenting with ST‐segment elevation myocardial infarction Open
Objectives We assessed sex differences in treatment and outcomes in ST‐segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI). Background Historically, delays to timely reperf…
View article: Longitudinal risk of death, hospitalizations for atrial fibrillation, and cardiovascular events following catheter ablation of atrial fibrillation: a cohort study
Longitudinal risk of death, hospitalizations for atrial fibrillation, and cardiovascular events following catheter ablation of atrial fibrillation: a cohort study Open
Aims Population studies reporting contemporary long-term outcomes following catheter ablation of atrial fibrillation (AF) are sparse. We evaluated long-term clinical outcomes following AF ablation and examined variation in outcomes by age,…
View article: Long-Term Survival, Stroke Recurrence, and Life Expectancy After an Acute Stroke in Australia and New Zealand From 2008–2017: A Population-Wide Cohort Study
Long-Term Survival, Stroke Recurrence, and Life Expectancy After an Acute Stroke in Australia and New Zealand From 2008–2017: A Population-Wide Cohort Study Open
Background: Data on long-term outcomes following an acute stroke are sparse. We assessed survival, risk of recurrent stroke and loss in life expectancy following an acute stroke using population-wide data from Australia and New Zealand. Me…
View article: Association of hypertension with mortality in patients hospitalised with COVID-19
Association of hypertension with mortality in patients hospitalised with COVID-19 Open
Objective To assess whether hypertension is an independent risk factor for mortality among patients hospitalised with COVID-19, and to evaluate the impact of ACE inhibitor and angiotensin receptor blocker (ARB) use on mortality in patients…
View article: Incidence and causes of early unplanned readmission after hospitalisation with peripheral arterial disease in Australia and New Zealand
Incidence and causes of early unplanned readmission after hospitalisation with peripheral arterial disease in Australia and New Zealand Open
Unplanned readmissions within 30 days of hospitalisation for PAD are often for potentially preventable reasons. Their number should be reduced to improve clinical outcomes for people with PAD.