Sandra A. Rempel
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View article: LOSS OF SPARC IN P53-NULL ASTROCYTES PROMOTES MACROPHAGE ACTIVATION AND PHAGOCYTOSIS RESULTING IN DECREASED TUMOR SIZE AND TUMOR CELL SURVIVAL
LOSS OF SPARC IN P53-NULL ASTROCYTES PROMOTES MACROPHAGE ACTIVATION AND PHAGOCYTOSIS RESULTING IN DECREASED TUMOR SIZE AND TUMOR CELL SURVIVAL Open
BACKGROUND: Both enhanced SPARC expression and the loss of p53 tumor suppressor gene are changes that occur early in glioma development. Both SPARC and p53 regulate glioma cell survival by inverse effects on apoptotic signaling. Therefore,…
View article: Loss of <i>Sparc</i> in <scp><i>p</i></scp><i>53</i>‐null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival
Loss of <i>Sparc</i> in <span><i>p</i></span><i>53</i>‐null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival Open
Both the induction of SPARC expression and the loss of the p53 tumor suppressor gene are changes that occur early in glioma development. Both SPARC and p53 regulate glioma cell survival by inverse effects on apoptotic signaling. Therefore,…
View article: Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal
Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal Open
MicroRNAs (miRNAs) have emerged as potential cancer therapeutics; however, their clinical use is hindered by lack of effective delivery mechanisms to tumor sites. Mesenchymal stem cells (MSCs) have been shown to migrate to experimental gli…
View article: MicroRNA-145 Is Downregulated in Glial Tumors and Regulates Glioma Cell Migration by Targeting Connective Tissue Growth Factor
MicroRNA-145 Is Downregulated in Glial Tumors and Regulates Glioma Cell Migration by Targeting Connective Tissue Growth Factor Open
Glioblastomas (GBM), the most common and aggressive type of malignant glioma, are characterized by increased invasion into the surrounding brain tissues. Despite intensive therapeutic strategies, the median survival of GBM patients has rem…
View article: PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma
PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma Open
These data describe a novel mechanism whereby PTEN inhibits SPARC-induced migration through suppression and differential regulation of pAkt and the P38 MAPK-MAPKAPK2-HSP27 signaling pathway.
View article: TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo
TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo Open
Glioblastomas (GBM) are characterized by resistance to chemotherapy and radiotherapy, and therefore, alternative therapeutic approaches are needed. TRAIL induces apoptosis in cancer but not in normal cells and is considered to be a promisi…
View article: Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival
Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival Open
Background The current treatment regimen for glioma patients is surgery, followed by radiation therapy plus temozolomide (TMZ), followed by 6 months of adjuvant TMZ. Despite this aggressive treatment regimen, the overall survival of all su…
View article: Correlation of Perfusion Parameters with Genes Related to Angiogenesis Regulation in Glioblastoma: A Feasibility Study
Correlation of Perfusion Parameters with Genes Related to Angiogenesis Regulation in Glioblastoma: A Feasibility Study Open
Our findings are provocative, with some of the proangiogenic genes showing a positive correlation and some of the antiangiogenic genes showing an inverse correlation with tumor perfusion parameters, suggesting a molecular basis for these i…
View article: Deletion of the SPARC acidic domain or EGF-like module reduces SPARC-induced migration and signaling through p38 MAPK/HSP27 in glioma
Deletion of the SPARC acidic domain or EGF-like module reduces SPARC-induced migration and signaling through p38 MAPK/HSP27 in glioma Open
We previously demonstrated that secreted protein acidic and rich in cysteine (SPARC) increases heat shock protein 27 (HSP27) expression and phosphorylation and promotes glioma cell migration through the p38 mitogen-activated protein kinase…
View article: PRECLINICAL EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY
PRECLINICAL EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY Open
Temozolomide (TMZ) provides significant benefits in the treatment of malignant glioma, but many patients continue to suffer from progressive or recurrent disease because of the intrinsic or acquired resistance of their tumors to TMZ. In th…
View article: Cilengitide induces autophagy-mediated cell death in glioma cells
Cilengitide induces autophagy-mediated cell death in glioma cells Open
We studied the effect of the integrin inhibitor cilengitide in glioma cells. Cilengitide induced cell detachment and decreased cell viability, and induction of autophagy followed by cell apoptosis. In addition, cilengitide decreased the ce…
View article: Proteolysis of the matricellular protein hevin by matrix metalloproteinase‐3 produces a SPARC‐like fragment (SLF) associated with neovasculature in a murine glioma model
Proteolysis of the matricellular protein hevin by matrix metalloproteinase‐3 produces a SPARC‐like fragment (SLF) associated with neovasculature in a murine glioma model Open
The matricellular SPARC‐family member hevin (Sparc‐like 1/SPARCL‐1/SC1/Mast9) contributes to neural development and alters tumor progression in a range of mammalian models. Based on sequence similarity, we hypothesized that proteolytic dig…
View article: GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis Open
We characterized the expression and function of the endoplasmic reticulum protein GRP78 in glial tumors. GRP78 is highly expressed in glioblastomas but not in oligodendrogliomas, and its expression is inversely correlated with median patie…
View article: SPARC‐induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion
SPARC‐induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion Open
Glioblastomas are heterogeneous tumors displaying regions of necrosis, proliferation, angiogenesis, apoptosis and invasion. SPARC, a matricellular protein that negatively regulates angiogenesis and cell proliferation, but enhances cell dea…
View article: SPARC Regulates Extracellular Matrix Organization through Its Modulation of Integrin-linked Kinase Activity
SPARC Regulates Extracellular Matrix Organization through Its Modulation of Integrin-linked Kinase Activity Open
SPARC, a 32-kDa matricellular glycoprotein, mediates interactions between cells and their extracellular matrix, and targeted deletion of Sparc results in compromised extracellular matrix in mice. Fibronectin matrix provides provisional tis…
View article: SPARC affects glioma cell growth differently when grown on brain ECMproteins in vitro under standard versus reduced-serum stress conditions
SPARC affects glioma cell growth differently when grown on brain ECMproteins in vitro under standard versus reduced-serum stress conditions Open
Secreted protein acidic and rich in cysteine (SPARC) has a suppressive effect on U87 glioma cell proliferation when assessed in vitro and in vivo using parental U87T2 and U87T2-derived SPARC-transfected clones. Since SPARCinteracts with ex…
View article: Studying the heterogeneity of brain tumors using medium throughput LOH analysis
Studying the heterogeneity of brain tumors using medium throughput LOH analysis Open
The theory of tumor progression by clonal evolution posits that a succession of increasingly malignant clones arise, in turn, driven by the step-wise accumulation of mutations (1). At each point in this process it is thought that one cell …
View article: Use of horizontal ultrathin gel electrophoresis to analyze allelicdeletions in chromosome band 11p15.5 in gliomas
Use of horizontal ultrathin gel electrophoresis to analyze allelicdeletions in chromosome band 11p15.5 in gliomas Open
The prognosis for most patients with astrocytic glioma is poor, and postoperative life expectancy has not significantly improved in the last decade despite advances in diagnosis, surgery, and adjuvant therapy. Progress has been made, howev…
View article: Expression of Transforming Growth Factor-β Complex in Arteriovenous Malformations
Expression of Transforming Growth Factor-β Complex in Arteriovenous Malformations Open
The factors responsible for the development of cerebral arteriovenous malformations (AVMs) are not well known. Patients with hereditary hemorrhagic telangiectasia (HHT) have cutaneous vascular dysplasia and a high propensity to develop sys…
View article: Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells.
Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells. Open
Mutation of the p53 tumor suppressor gene is one of the earliest identified genetic lesions during malignant progression of human astrocytomas. To assess the functional significance of these mutations, wild-type (WT) p53 genes were introdu…