Sylvie Renaud
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View article: Fascicle-selective kilohertz-frequency neural conduction block with longitudinal intrafascicular electrodes
Fascicle-selective kilohertz-frequency neural conduction block with longitudinal intrafascicular electrodes Open
Objective. Electrical stimulation of peripheral nerves is used to treat a variety of disorders and conditions. While conventional biphasic pulse stimulation typically induces neural activity in fibers, kilohertz (kHz) continuous stimulatio…
View article: A microfluidic twin islets-on-chip device for on-line electrophysiological monitoring
A microfluidic twin islets-on-chip device for on-line electrophysiological monitoring Open
Pancreatic islets play a major role in glucose homeostasis and diabetes. We have now developed microfluidic islets-on-chip for combined electrophysiology and hormone monitoring with twin chambers long-term monitoring in two islet populatio…
View article: Comparative Study of Data Processing Techniques for Pancreatic Islets in Organ-on-Chip Applications
Comparative Study of Data Processing Techniques for Pancreatic Islets in Organ-on-Chip Applications Open
International audience
View article: Continuous monitoring of glucose levels<i>in vivo</i>with a micro-organ based microfluidic biosensor
Continuous monitoring of glucose levels<i>in vivo</i>with a micro-organ based microfluidic biosensor Open
Continuous monitoring of glucose levels has improved diabetes therapy. Current approaches rely on enzyme-linked electrochemical probes but do not allow a fully autonomous artificial pancreas. In contrast, monitoring the activity of a few e…
View article: Islets-on-Chip: A Tool for Real-Time Assessment of Islet Function Prior to Transplantation
Islets-on-Chip: A Tool for Real-Time Assessment of Islet Function Prior to Transplantation Open
Islet transplantation improves metabolic control in patients with unstable type 1 diabetes. Clinical outcomes have been improving over the last decade, and the widely used beta-score allows the evaluation of transplantation results. Howeve…
View article: Towards the Integration of an Islet-Based Biosensor in Closed-Loop Therapies for Patients With Type 1 Diabetes
Towards the Integration of an Islet-Based Biosensor in Closed-Loop Therapies for Patients With Type 1 Diabetes Open
In diabetes mellitus (DM) treatment, Continuous Glucose Monitoring (CGM) linked with insulin delivery becomes the main strategy to improve therapeutic outcomes and quality of patients’ lives. However, Blood Glucose (BG) regulation with CGM…
View article: Vertical Organic Electrochemical Transistors and Electronics for Low Amplitude Micro‐Organ Signals
Vertical Organic Electrochemical Transistors and Electronics for Low Amplitude Micro‐Organ Signals Open
Electrical signals are fundamental to key biological events such as brain activity, heartbeat, or vital hormone secretion. Their capture and analysis provide insight into cell or organ physiology and a number of bioelectronic medical devic…
View article: Bioimpedance Spectroscopy Helps Monitor the Impact of Electrical Stimulation on Muscle Cells
Bioimpedance Spectroscopy Helps Monitor the Impact of Electrical Stimulation on Muscle Cells Open
In this study, we present a first-of-a-kind biological-hardware-software tool to evaluate the physiological condition of in vitro myotubes in response to electrical stimulation. We demonstrate that impedance spectroscopy on a microelectrod…
View article: In vitro impedance spectroscopy: A MEA-based measurement bench for myoblasts cultures monitoring
In vitro impedance spectroscopy: A MEA-based measurement bench for myoblasts cultures monitoring Open
International audience
View article: Evaluation of Stimulation Waveforms for Safe and Efficient Peripheral Nervous System Activation
Evaluation of Stimulation Waveforms for Safe and Efficient Peripheral Nervous System Activation Open
International audience
View article: IC-Based Neuro-Stimulation Environment for Arbitrary Waveform Generation
IC-Based Neuro-Stimulation Environment for Arbitrary Waveform Generation Open
Electrical stimulation of the nervous system is commonly based on biphasic stimulation waveforms, which limits its relevance for some applications, such as selective stimulation. We propose in this paper a stimulator capable of delivering …
View article: Dynamic uni- and multicellular patterns encode biphasic activity in pancreatic islets
Dynamic uni- and multicellular patterns encode biphasic activity in pancreatic islets Open
Biphasic secretion is an autonomous feature of many endocrine micro-organs to fulfill physiological demands. The biphasic activity of islet β-cells maintains glucose homeostasis and is altered in type-2 diabetes. Nevertheless, underlying c…
View article: Dynamic Uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets
Dynamic Uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets Open
Biphasic secretion is an autonomous feature of many endocrine micro-organs to fulfill physiological demands. The biphasic activity of islet β-cells maintains glucose homeostasis and is altered in type 2 diabetes. Nevertheless, underlying c…
View article: Dynamic uni- and multicellular patterns encode biphasic activity in pancreatic islets
Dynamic uni- and multicellular patterns encode biphasic activity in pancreatic islets Open
Biphasic secretion is an autonomous feature of many endocrine micro-organs to fulfill physiological demands. The biphasic activity of islet β-cells maintains glucose homeostasis and is altered in type-2 diabetes. Nevertheless, underlying c…
View article: A Robust H∞ Control Approach for Blood Glucose Regulation in Type-1 Diabetes
A Robust H∞ Control Approach for Blood Glucose Regulation in Type-1 Diabetes Open
The paper addresses the design of a H∞ closed-loop dedicated to Blood Glucose (BG) regulation for patients affected by Type-1 Diabetes Mellitus (T1DM). The closed-loop setup is standard, i.e. the H∞ feedback controller uses the information…
View article: Restoring Ventilatory Control Using an Adaptive Bioelectronic System
Restoring Ventilatory Control Using an Adaptive Bioelectronic System Open
Ventilatory pacing by electrical stimulation of the phrenic nerve or of the diaphragm has been shown to enhance quality of life compared to mechanical ventilation. However, commercially available ventilatory pacing devices require initial …
View article: Restoring ventilatory control using an adaptive bioelectronic system
Restoring ventilatory control using an adaptive bioelectronic system Open
Ventilatory pacing via electrical stimulation of the phrenic nerve or of the diaphragm has been shown to enhance quality of life compared to mechanical ventilation. However, commercially-available ventilatory pacing devices require initial…
View article: Preliminary Investigation Towards Embedded Impedance Spectroscopy in Implanted Stimulators
Preliminary Investigation Towards Embedded Impedance Spectroscopy in Implanted Stimulators Open
International audience
View article: Multimed: An Integrated, Multi-Application Platform for the Real-Time Recording and Sub-Millisecond Processing of Biosignals
Multimed: An Integrated, Multi-Application Platform for the Real-Time Recording and Sub-Millisecond Processing of Biosignals Open
Enhanced understanding and control of electrophysiology mechanisms are increasingly being hailed as key knowledge in the fields of modern biology and medicine. As more and more excitable cell mechanics are being investigated and exploited,…
View article: A versatile electrode sorting module for MEAs: Implementation in a FPGA-based real-time system
A versatile electrode sorting module for MEAs: Implementation in a FPGA-based real-time system Open
International audience
View article: Bio-Inspired Controller on an FPGA Applied to Closed-Loop Diaphragmatic Stimulation
Bio-Inspired Controller on an FPGA Applied to Closed-Loop Diaphragmatic Stimulation Open
Cervical spinal cord injury can disrupt connections between the brain respiratory network and the respiratory muscles which can lead to partial or complete loss of ventilatory control and require ventilatory assistance. Unlike current open…
View article: Generation of Locomotor-Like Activity in the Isolated Rat Spinal Cord Using Intraspinal Electrical Microstimulation Driven by a Digital Neuromorphic CPG
Generation of Locomotor-Like Activity in the Isolated Rat Spinal Cord Using Intraspinal Electrical Microstimulation Driven by a Digital Neuromorphic CPG Open
Neural prostheses based on electrical microstimulation offer promising perspectives to restore functions following lesions of the central nervous system (CNS). They require the identification of appropriate stimulation sites and the coordi…
View article: Theoretical study and optimisation of a standard deviation estimator circuit for adaptive threshold spike detection
Theoretical study and optimisation of a standard deviation estimator circuit for adaptive threshold spike detection Open
Summary This paper presents a theoretical study and the resulting architecture of an analogue‐based standard deviation (SD) estimator, typically used in biomedical spike detectors to assess the noise level of bioelectrical recordings onlin…