Rizwana Chaudhri
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View article: ANALYSIS OF CAESAREAN SECTION RATES USING THE ROBSON’S TEN GROUP CLASSIFICATION SYSTEM (TGCS) AT TERTIARY LEVEL HEALTHCARE FACILITIES IN RAWALPINDI, PAKISTAN: A CROSS-SECTIONAL STUDY
ANALYSIS OF CAESAREAN SECTION RATES USING THE ROBSON’S TEN GROUP CLASSIFICATION SYSTEM (TGCS) AT TERTIARY LEVEL HEALTHCARE FACILITIES IN RAWALPINDI, PAKISTAN: A CROSS-SECTIONAL STUDY Open
Background: Robson’s Ten Group Classification System (TGCS) is recommended as a global standard for assessing, monitoring, and comparing Cesarean Section rates at all levels. This study was conducted to audit CS deliveries using the Robson…
View article: Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial
Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial Open
Background Each year world-wide about 65 million people sustain a mild traumatic brain injury (mTBI). Fatigue is a common and distressing symptom after mTBI. We examine the effect of tranexamic acid (TXA) on fatigue in patients with mTBI u…
View article: Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial
Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial Open
Background Each year world-wide about 65 million people sustain a mild traumatic brain injury (mTBI). Fatigue is a common and distressing symptom after mTBI. We examine the effect of tranexamic acid (TXA) on fatigue in patients with mTBI u…
View article: Tranexamic acid by the intramuscular or intravenous route for the prevention of postpartum haemorrhage in women at increased risk: a randomised placebo-controlled trial (I’M WOMAN)
Tranexamic acid by the intramuscular or intravenous route for the prevention of postpartum haemorrhage in women at increased risk: a randomised placebo-controlled trial (I’M WOMAN) Open
Background: . Postpartum haemorrhage (PPH) causes about 70,000 maternal deaths every year. Tranexamic acid (TXA) is a lifesaving treatment for women with PPH. Intravenous (IV) TXA reduces deaths due to PPH by one third when given within 3 …
View article: Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: Statistical analysis plan for the WOMAN-2 trial: an international, randomised, placebo-controlled trial
Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: Statistical analysis plan for the WOMAN-2 trial: an international, randomised, placebo-controlled trial Open
Background: Postpartum haemorrhage (PPH) is responsible for over 50,000 maternal deaths every year. Most of these deaths are in low- and middle-income countries. Tranexamic acid (TXA) reduces bleeding by inhibiting the enzymatic breakdown …
View article: Maternal anaemia and the risk of postpartum haemorrhage: a cohort analysis of data from the WOMAN-2 trial
Maternal anaemia and the risk of postpartum haemorrhage: a cohort analysis of data from the WOMAN-2 trial Open
The WOMAN-2 trial is funded by Wellcome and the Bill & Melinda Gates Foundation.
View article: Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: Statistical analysis plan for the WOMAN-2 trial: an international, randomised, placebo-controlled trial
Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: Statistical analysis plan for the WOMAN-2 trial: an international, randomised, placebo-controlled trial Open
Background: Postpartum haemorrhage (PPH) is responsible for over 50,000 maternal deaths every year. Most of these deaths are in low- and middle-income countries. Tranexamic acid (TXA) reduces bleeding by inhibiting the enzymatic breakdown …
View article: Tranexamic acid for the prevention of postpartum bleeding: Protocol for a systematic review and individual patient data meta-analysis
Tranexamic acid for the prevention of postpartum bleeding: Protocol for a systematic review and individual patient data meta-analysis Open
Background: Tranexamic acid (TXA) reduces the risk of death and is recommended as a treatment for women with severe postpartum bleeding. There is hope that giving TXA shortly before or immediately after birth could prevent postpartum bleed…
View article: Alternative routes for tranexamic acid treatment in obstetric bleeding (<scp>WOMAN‐PharmacoTXA</scp>trial): a randomised trial and pharmacological study in caesarean section births
Alternative routes for tranexamic acid treatment in obstetric bleeding (<span>WOMAN‐PharmacoTXA</span>trial): a randomised trial and pharmacological study in caesarean section births Open
Objective To examine the safety, efficacy and pharmacology of intravenous (IV), intramuscular (IM) and oral tranexamic acid (TXA) use in pregnant women. Design Randomised, open‐label trial. Setting Hospitals in Pakistan and Zambia. Populat…
View article: Tranexamic acid for the prevention of postpartum bleeding: Protocol for a systematic review and individual patient data meta-analysis
Tranexamic acid for the prevention of postpartum bleeding: Protocol for a systematic review and individual patient data meta-analysis Open
Background: Tranexamic acid (TXA) reduces the risk of death and is recommended as a treatment for women with severe postpartum bleeding. There is hope that giving TXA shortly before or immediately after birth could prevent postpartum bleed…
View article: Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial
Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial Open
Background: Each year world-wide about 65 million people sustain a mild traumatic brain injury (mTBI). Fatigue is a common and distressing symptom after mTBI. We examine the effect of tranexamic acid (TXA) on fatigue in patients with mTBI…
View article: Postpartum Haemorrhage in Anaemic Women: Assessing Outcome Measures for Clinical Trials
Postpartum Haemorrhage in Anaemic Women: Assessing Outcome Measures for Clinical Trials Open
Background: Post-partum haemorrhage (PPH) is a leading cause of maternal mortality worldwide. Maternal anaemia greatly increases the risk of PPH and over a third of all pregnant women are anaemic. Because anaemia reduces the oxygen-carryin…
View article: A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT
A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT Open
Background Tranexamic acid reduces blood loss in surgery and the risk of death in trauma patients. Meta-analyses of small trials suggest that tranexamic acid decreases the number of deaths from gastrointestinal bleeding, but these meta-ana…
View article: P374 Characteristics of pregnant women, partners, and partner treatment preferences among women undergoing sexually transmitted infection screening, Rawalpindi, Pakistan
P374 Characteristics of pregnant women, partners, and partner treatment preferences among women undergoing sexually transmitted infection screening, Rawalpindi, Pakistan Open
Background This study sought to characterize dyads of pregnant women and their partners in Rawalpindi, Pakistan, and to understand STI partner notification and treatment preferences in this population. Methods We enrolled pregnant women se…
View article: WOMAN-PharmacoTXA trial: Study protocol for a randomised controlled trial to assess the pharmacokinetics and pharmacodynamics of intramuscular, intravenous and oral administration of tranexamic acid in women giving birth by caesarean section
WOMAN-PharmacoTXA trial: Study protocol for a randomised controlled trial to assess the pharmacokinetics and pharmacodynamics of intramuscular, intravenous and oral administration of tranexamic acid in women giving birth by caesarean section Open
Background: Intravenous tranexamic acid (TXA) within 3 hours of birth significantly reduces death due to bleeding in women with postpartum haemorrhage (PPH). Most PPH deaths occur in the first hours after giving birth and treatment delay d…
View article: Development of a patient reported outcome questionnaire to measure the impact of postpartum blood loss in women with moderate and severe anaemia: A study using a multi-faceted approach
Development of a patient reported outcome questionnaire to measure the impact of postpartum blood loss in women with moderate and severe anaemia: A study using a multi-faceted approach Open
Background: Globally, over one-third of pregnant women are anaemic and are at increased risk of postpartum haemorrhage (PPH). Tranexamic acid (TXA) given within 3 hours of birth significantly reduces death due to bleeding in women with PPH…
View article: Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT
Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT Open
Background Tranexamic acid safely reduces mortality in traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury and can cause brain herniation and death. We assessed the effects of tranexamic acid in tr…
View article: WOMAN-PharmacoTXA Trial: Pharmacokinetics and pharmacodynamics of tranexamic acid in women having caesarean section birth - Extended data
WOMAN-PharmacoTXA Trial: Pharmacokinetics and pharmacodynamics of tranexamic acid in women having caesarean section birth - Extended data Open
Supplementary information that supports the manuscript, “WOMAN-PharmacoTXA trial: Study protocol for a randomised controlled trial to assess the pharmacokinetics and pharmacodynamics of intramuscular, intravenous and oral administration of…
View article: Guidelines for Management of Hyperglycemia in Pregnancy (HIP) by Society of Obstetricians & Gynaecologists of Pakistan (SOGP)#
Guidelines for Management of Hyperglycemia in Pregnancy (HIP) by Society of Obstetricians & Gynaecologists of Pakistan (SOGP)# Open
Hyperglycemia in pregnancy (HIP) is an important component of primary prevention of diabetes both globally and in Pakistan. To ensure that the opportunity of primary prevention is not missed it is important to diagnose hyperglycemia early …
View article: Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial
Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial Open
Background The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracranial bleeding after traumatic brain injury (TBI). To explore the mechanism of action of TXA in TBI, we examined the timi…
View article: Cost-effectiveness analysis of tranexamic acid for the treatment of traumatic brain injury, based on the results of the CRASH-3 randomised trial: a decision modelling approach
Cost-effectiveness analysis of tranexamic acid for the treatment of traumatic brain injury, based on the results of the CRASH-3 randomised trial: a decision modelling approach Open
Introduction An estimated 69 million traumatic brain injuries (TBI) occur each year worldwide, with most in low-income and middle-income countries. The CRASH-3 randomised trial found that intravenous administration of tranexamic acid withi…
View article: Risk factors for blood transfusion in traumatic and postpartum hemorrhage patients: Analysis of the CRASH-2 and WOMAN trials
Risk factors for blood transfusion in traumatic and postpartum hemorrhage patients: Analysis of the CRASH-2 and WOMAN trials Open
CRASH-2 is registered as ISRCTN86750102, ClinicalTrials.gov NCT00375258 and South African Clinical Trial Register DOH-27-0607-1919. WOMAN is registered as ISRCTN76912190, ClinicalTrials.gov NCT00872469, PACTR201007000192283, and EudraCT nu…