Samuel Yang
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View article: Institutional changes in the eaeu and their impact on logistics and economic indicators of the china-belarus industrial park“Great stone”
Institutional changes in the eaeu and their impact on logistics and economic indicators of the china-belarus industrial park“Great stone” Open
This study analyzes the impact of institutional and policy changes within the Eurasian Economic Union (EAEU) on the logistics and adaptation strategies of the China-Belarus Industrial Park “Great Stone.” The dynamics of the park’s economic…
View article: α-Glucosidase inhibitory activity of polyphenol-rich sugarcane extract: screening and mechanistic insights based on biolayer interferometry-mass spectrometry
α-Glucosidase inhibitory activity of polyphenol-rich sugarcane extract: screening and mechanistic insights based on biolayer interferometry-mass spectrometry Open
Introduction Polyphenol-rich sugarcane extract (PRSE) contains bioactive compounds with potential hypoglycemic properties, but its direct interaction with α-glucosidase has not been explored. Methods This study investigated the inhibitory …
View article: Disease diagnostics using machine learning of B cell and T cell receptor sequences
Disease diagnostics using machine learning of B cell and T cell receptor sequences Open
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen exposures encoded by receptors on B cel…
View article: Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection
Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection Open
At this stage in the COVID-19 pandemic, most infections are “breakthrough” infections that occur in individuals with prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. To refine long-term vaccine strategies agains…
View article: Neutrophil extracellular traps have active DNAzymes that promote bactericidal activity
Neutrophil extracellular traps have active DNAzymes that promote bactericidal activity Open
The mechanisms of bacterial killing by neutrophil extracellular traps (NETs) are unclear. DNA, the largest component of NETs was believed to merely be a scaffold with antimicrobial activity only through the charge of the backbone. Here, we…
View article: Interferon-mediated NK cell activation is associated with limited neutralization breadth during SARS-CoV-2 infection
Interferon-mediated NK cell activation is associated with limited neutralization breadth during SARS-CoV-2 infection Open
Best known for their ability to kill infected or malignant cells, natural killer (NK) cells are also underappreciated regulators of the antibody response to viral infection. In mice, NK cells can kill T follicular helper (Tfh) cells, decre…
View article: Students’, parents’ and teachers’ perspectives on comprehensive school-based sleep promotion
Students’, parents’ and teachers’ perspectives on comprehensive school-based sleep promotion Open
Objective: Sleep deprivation is common among children and schools are ideal settings in which to influence children’s sleep. Children spend a significant amount of time at school during key developmental periods, and programmes that influe…
View article: Host heterogeneity in humoral bactericidal activity can be complement independent
Host heterogeneity in humoral bactericidal activity can be complement independent Open
Background Humoral bactericidal activity was first recognized nearly a century ago. However, the extent of inter-individual heterogeneity and the mechanisms underlying such heterogeneity beyond antibody or complement systems have not been …
View article: Bridging Computational Predictions and Empirical Data: Insights into SARS-CoV-2 Mutational Impacts and Evolution
Bridging Computational Predictions and Empirical Data: Insights into SARS-CoV-2 Mutational Impacts and Evolution Open
The emergence of SARS-CoV-2 has unleashed a global health crisis, demanding advanced research into its genomic mutations and their consequences. Our study combines computational models and empirical validation to predict the effects of the…
View article: Prognostic value of systemic immune-inflammation index and systemic inflammation response index for oral cancers: A systematic review and meta-analysis
Prognostic value of systemic immune-inflammation index and systemic inflammation response index for oral cancers: A systematic review and meta-analysis Open
Acknowledging the limitations of current evidence, it seems that both SII and SIRI can predict the prognosis of oral cancers. High SII and SIRI are both associated with worse OS while high SII also predicts worse DFS.
View article: Comparative study of encoded and alignment-based methods for virus taxonomy classification
Comparative study of encoded and alignment-based methods for virus taxonomy classification Open
View article: Neutrophil Extracellular Traps have DNAzyme activity that drives bactericidal potential
Neutrophil Extracellular Traps have DNAzyme activity that drives bactericidal potential Open
The mechanisms of bacterial killing by neutrophil extracellular traps (NETs) are unclear. DNA, the largest component of NETs is believed to merely be a scaffold with minimal antimicrobial activity through the charge of the backbone. Here, …
View article: Study of β1-transferrin and β2-transferrin using microprobe-capture in-emitter elution and high-resolution mass spectrometry
Study of β1-transferrin and β2-transferrin using microprobe-capture in-emitter elution and high-resolution mass spectrometry Open
View article: Evaluation of the Impact of Peer-Created Academic Resources on Student Satisfaction and Utilization
Evaluation of the Impact of Peer-Created Academic Resources on Student Satisfaction and Utilization Open
To evaluate the impact of customized peer-created education resources on student pharmacists' perceived satisfaction and utilization of the materials.
View article: Development and external validation of a pretrained deep learning model for the prediction of non-accidental trauma
Development and external validation of a pretrained deep learning model for the prediction of non-accidental trauma Open
View article: Comparative Study of Encoded and Alignment-Based Methods for Virus Taxonomy Classification
Comparative Study of Encoded and Alignment-Based Methods for Virus Taxonomy Classification Open
The emergence of viruses and their variants has made virus taxonomy more important than ever before in controlling the spread of diseases. The creation of efficient treatments and cures that target particular virus properties can be aided …
View article: Phage diversity in cell-free DNA identifies bacterial pathogens in human sepsis cases
Phage diversity in cell-free DNA identifies bacterial pathogens in human sepsis cases Open
View article: Supplementary Figure 1 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Supplementary Figure 1 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
Kaplan-Meier (log-rank) analysis of MPP4 and SD3 showing the PFS and OS for stage III patients only. a. PFS for MPP4, **p=0.0017, b. OS for MPP4, *p=0.0117, c. PFS for SD3, ***p=0.0003 and d. OS for SD3, **p=0.0094.
View article: Supplementary Figure 3 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Supplementary Figure 3 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
Multiplex immunofluorescence staining quantification by Visiopharm Image Analytical System. DAPI nuclei were segmented defining the areas. Then each marker was quantified within this DAPI area. MPP4 low (MelR062) and MPP4 high (MelR166) ph…
View article: Supplementary Figure 1 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Supplementary Figure 1 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
Kaplan-Meier (log-rank) analysis of MPP4 and SD3 showing the PFS and OS for stage III patients only. a. PFS for MPP4, **p=0.0017, b. OS for MPP4, *p=0.0117, c. PFS for SD3, ***p=0.0003 and d. OS for SD3, **p=0.0094.
View article: Supplementary Figure 3 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Supplementary Figure 3 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
Multiplex immunofluorescence staining quantification by Visiopharm Image Analytical System. DAPI nuclei were segmented defining the areas. Then each marker was quantified within this DAPI area. MPP4 low (MelR062) and MPP4 high (MelR166) ph…
View article: Supplementary Tables 1-4 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Supplementary Tables 1-4 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
Table S1. Patient Characteristics. AJCC: American Joint Committee on Cancer Table S2. Clinical information including histology, stage and survival. Table S3. Univariate analysis of clinico-pathological and CT features. Log-rank (Mantel-Cox…
View article: Supplementary Tables 1-4 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Supplementary Tables 1-4 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
Table S1. Patient Characteristics. AJCC: American Joint Committee on Cancer Table S2. Clinical information including histology, stage and survival. Table S3. Univariate analysis of clinico-pathological and CT features. Log-rank (Mantel-Cox…
View article: Data from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Data from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
Treatment for metastatic melanoma includes targeted and/or immunotherapy. Although many patients respond, only a subset has complete response. As late-stage patients often have multiple tumors in difficult access sites, non-invasive techni…
View article: Supplementary Figure 2 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Supplementary Figure 2 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
The association between TMB and SD3/MPP4 is not statistically significant. A. MPP4, not significant, Fisher's exact. B. SD3, not significant, Fisher's exact.
View article: Supplementary Figure 2 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Supplementary Figure 2 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
The association between TMB and SD3/MPP4 is not statistically significant. A. MPP4, not significant, Fisher's exact. B. SD3, not significant, Fisher's exact.
View article: Data from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Data from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients Open
Treatment for metastatic melanoma includes targeted and/or immunotherapy. Although many patients respond, only a subset has complete response. As late-stage patients often have multiple tumors in difficult access sites, non-invasive techni…
View article: Rapid molecular phenotypic antimicrobial susceptibility test for<i>Neisseria gonorrhoeae</i>based on propidium monoazide viability PCR
Rapid molecular phenotypic antimicrobial susceptibility test for<i>Neisseria gonorrhoeae</i>based on propidium monoazide viability PCR Open
Neisseria gonorrhoeae (NG) is an urgent threat to antimicrobial resistance (AMR) worldwide. NG has acquired rapid resistance to all previously recommended treatments leaving ceftriaxone monotherapy as the first and last line of therapy for…
View article: Structural Elucidation of β<sub>1</sub>- and β<sub>2</sub>-Transferrin Using Microprobe-Capture In-Emitter Elution and High-Resolution Mass Spectrometry
Structural Elucidation of β<sub>1</sub>- and β<sub>2</sub>-Transferrin Using Microprobe-Capture In-Emitter Elution and High-Resolution Mass Spectrometry Open
Background Cerebrospinal fluid (CSF) leak is typically diagnosed by detecting a protein marker β 2 -transferrin (β 2 -Tf) in secretion samples. β 2 -Tf and β 1 -transferrin (β 1 -Tf) are glycoforms of human transferrin (Tf). A novel affini…
View article: Microprobe-Capture In-Emitter Elution: An Affinity Capture Technique to Directly Couple a Label-Free Optical Sensing Technology with Mass Spectrometry for Top-Down Protein Analysis
Microprobe-Capture In-Emitter Elution: An Affinity Capture Technique to Directly Couple a Label-Free Optical Sensing Technology with Mass Spectrometry for Top-Down Protein Analysis Open
Affinity capture of an analyte by a capture agent is one of the most effective sample preparation approaches for protein analytes. We describe a new affinity capture technique for top-down protein analysis, called microprobe-capture in-emi…