Sugantha Govindarajan
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View article: Peripheral Oxygen Saturation Levels: A Comparative Assessment among Different Fingers and between the 2 Most Commonly Used Pulse Oximetry Systems
Peripheral Oxygen Saturation Levels: A Comparative Assessment among Different Fingers and between the 2 Most Commonly Used Pulse Oximetry Systems Open
Background: The pocket pulse oximeter (PPO) has been noted to play a vital role in the pandemic due to hypoxemic status prevailing in COVID-19-affected patients. Attributing to its easier availability, cost-effectiveness, noninvasive appro…
View article: Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Genes associated with the twenty top-scored pathways of malignant hepatocytes of HDV-HCC.
View article: Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n = …
View article: Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with genes identified in malignant hepatocytes derived from HDV-, HBV- and HCV-HCC.
View article: Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Experimental design.
View article: Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Genes associated with the twenty top-scored pathways of malignant hepatocytes of HDV-HCC.
View article: Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
HBV DNA levels in tumorous and non-tumorous tissues of individual patients with HBV-associated HCC.
View article: Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with WLT-unique genes identified in the three tumors.
View article: Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Clusters of the 37 genes involved in the cell cycle and differentially expressed in malignant hepatocytes derived from HDV-HCC.
View article: Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
HBV DNA levels in tumorous and non-tumorous tissues of individual patients with HBV-associated HCC.
View article: Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Clusters of the 37 genes involved in the cell cycle and differentially expressed in malignant hepatocytes derived from HDV-HCC.
View article: Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Venn diagrams of differentially expressed genes obtained from laser capture microdissected hepatocytes and whole liver tissue of patients with HDV-, HBV-and HCV-associated HCC
View article: Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Venn diagrams of differentially expressed genes obtained from laser capture microdissected hepatocytes and whole liver tissue of patients with HDV-, HBV-and HCV-associated HCC
View article: Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with WLT-unique genes identified in the three tumors.
View article: Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Experimental design.
View article: Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with genes identified in malignant hepatocytes derived from HDV-, HBV- and HCV-HCC.
View article: Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n = …
View article: Data from Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma
Data from Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma Open
Background: Rats fed diets deficient in choline develop hepatocellular carcinoma. Tumor DNA from these animals is characteristically hypomethylated, suggesting that disruption of the one-carbon metabolism pathway is an underlying mechanism…
View article: Data from Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma
Data from Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma Open
Background: Rats fed diets deficient in choline develop hepatocellular carcinoma. Tumor DNA from these animals is characteristically hypomethylated, suggesting that disruption of the one-carbon metabolism pathway is an underlying mechanism…
View article: Supplementary Tables from Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma
Supplementary Tables from Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma Open
PDF file, 96K, Table S1. Mass transitions and method statistics for the determination of serum one-carbon metabolites Table S2. Linear regression ratio of prediagnostic serum levels of one-carbon metabolites in relation to baseline charact…
View article: Supplementary Tables from Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma
Supplementary Tables from Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma Open
PDF file, 96K, Table S1. Mass transitions and method statistics for the determination of serum one-carbon metabolites Table S2. Linear regression ratio of prediagnostic serum levels of one-carbon metabolites in relation to baseline charact…
View article: Chitinase 3-like 1 is a profibrogenic factor overexpressed in the aging liver and in patients with liver cirrhosis
Chitinase 3-like 1 is a profibrogenic factor overexpressed in the aging liver and in patients with liver cirrhosis Open
Significance Older age at the time of hepatitis virus infection and age of liver donors are major determinants of liver fibrosis progression and disease severity. Our study demonstrates that aging is accompanied by significant changes in g…
View article: A hepatitis A virus deletion mutant which lacks the first pyrimidine-rich tract of the 5' nontranslated RNA remains virulent in primates after direct intrahepatic nucleic acid transfection.
A hepatitis A virus deletion mutant which lacks the first pyrimidine-rich tract of the 5' nontranslated RNA remains virulent in primates after direct intrahepatic nucleic acid transfection. Open
Cell culture-adapted variants of hepatitis A virus (HAV) in which the first pyrimidine-rich tract (pY1; nucleotides 99 to 138) of the 5' nontranslated region has been deleted (delta 96-137 or delta 96-139) replicate as well as parental vir…
View article: Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans
Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans Open
Transmission to chimpanzees of a precore hepatitis B virus (HBV) mutant implicated in acute liver failure (ALF) in humans did not cause ALF nor the classic form of acute hepatitis B (AHB) seen upon infection with the wild-type HBV strain, …
View article: Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n = …
View article: Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy
Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy Open
The clinical presentation of alcoholic hepatitis (AH) can be mimicked by other alcoholic liver diseases. The aim of this study was to identify clinical features that predict AH on liver biopsy. Biopsies from patients hospitalized for presu…
View article: Is intracranial hemorrhage increased in cirrhosis?: An autopsy-based case control study
Is intracranial hemorrhage increased in cirrhosis?: An autopsy-based case control study Open
Background: Patients with cirrhosis are perceived to be at increased risk for bleeding given the presence of coagulopathy leading to unnecessary head imaging studies. Our aim is to determine the prevalence of intracranial hemorrhage (ICH) …
View article: Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue
Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue Open
Significance Hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) infection is the fastest-rising cause of cancer-related death in the United States. The level of intratumor HCV replication and the molecular interactions …
View article: The Use of Vaccinia Hyperimmune Gammaglobulin in the Prophylaxis of Smallpox
The Use of Vaccinia Hyperimmune Gammaglobulin in the Prophylaxis of Smallpox Open
This paper records an attempt to assess the prophylactic value of immune gamma-globulin, prepared from the serum of recently vaccinated adults, in the protection of close contacts of smallpox in Madras. The results serve to confirm finding…