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View article: Multistain multicompartment automatic segmentation in renal biopsies with thrombotic microangiopathies and other vasculopathies
Multistain multicompartment automatic segmentation in renal biopsies with thrombotic microangiopathies and other vasculopathies Open
Automatic tissue segmentation is a necessary step for the bulk analysis of whole slide images (WSIs) from paraffin histology sections in kidney biopsies. However, existing models often fail to generalize across the main nephropathological …
View article: Anti‐Phosphatidylserine/Prothrombin Antibodies Identify a Distinct Form of ITP
Anti‐Phosphatidylserine/Prothrombin Antibodies Identify a Distinct Form of ITP Open
Introduction Immune thrombocytopenia (ITP) and antiphospholipid syndrome (APS) are distinct autoimmune disorders with clinical intersections. While APS is marked by thrombosis and pregnancy complications, ITP typically presents as isolated…
View article: Green teams drive sustainability: a European Rare Kidney Disease Reference Network Survey on dialysis environmental practices
Green teams drive sustainability: a European Rare Kidney Disease Reference Network Survey on dialysis environmental practices Open
Background the environmental impact of healthcare is a growing concern, and nephrology, particularly dialysis, is a resource-intensive field. Dialysis involves high energy use, water consumption, significant waste generation, and transport…
View article: Optimizing antiphospholipid antibody testing: a real-world analysis of appropriateness and resource utilization
Optimizing antiphospholipid antibody testing: a real-world analysis of appropriateness and resource utilization Open
View article: EULAR recommendations for a core dataset to support clinical care and translational and observational research in systemic lupus erythematosus
EULAR recommendations for a core dataset to support clinical care and translational and observational research in systemic lupus erythematosus Open
View article: Development of the 2023 <scp>ACR</scp>/<scp>EULAR</scp> Antiphospholipid Syndrome Classification Criteria, Phase <scp>III</scp>‐C Report: Assessment of Patient Scenarios (Derivation Cohort) and Refinement of Definitions
Development of the 2023 <span>ACR</span>/<span>EULAR</span> Antiphospholipid Syndrome Classification Criteria, Phase <span>III</span>‐C Report: Assessment of Patient Scenarios (Derivation Cohort) and Refinement of Definitions Open
Objective The 2023 ACR/EULAR Antiphospholipid Syndrome (APS) Classification criteria aim to identify patients with high likelihood of APS for research. Phases I/II of our four‐phase methodological approach resulted in 27 candidate criteria…
View article: Unmet needs and challenges in the diagnosis and management of antiphospholipid syndrome: a qualitative stakeholder study within the ReCONNET framework
Unmet needs and challenges in the diagnosis and management of antiphospholipid syndrome: a qualitative stakeholder study within the ReCONNET framework Open
Objective Antiphospholipid syndrome (APS) is a rare autoimmune condition characterised by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies. Despite the publication of updated American College of Rheumato…
View article: Administration of belimumab prior to standard immunosuppression in patients with early active lupus hinders accrual of new EULAR/ACR criteria within the first 12 months of treatment
Administration of belimumab prior to standard immunosuppression in patients with early active lupus hinders accrual of new EULAR/ACR criteria within the first 12 months of treatment Open
Objective To evaluate the effect of early belimumab administration on disease progression in patients with early active SLE. Methods This multicentre observational study included patients with early active SLE, defined as being diagnosed ≤…
View article: Impact of conflicting information on the use of antirheumatic drugs in pregnancy and breastfeeding: perspectives of healthcare providers from the global PRAISE survey
Impact of conflicting information on the use of antirheumatic drugs in pregnancy and breastfeeding: perspectives of healthcare providers from the global PRAISE survey Open
Background: Treating rheumatic musculoskeletal diseases (RMDs) during pregnancy and breastfeeding presents significant complexities, mainly due to inconsistencies between the clinical guidance documents and the reference safety information…
View article: POS0410-HPR GLOBAL AWARENESS AMONG HEALTHCARE PROVIDERS OF EULAR RECOMMENDATIONS ON CARDIOVASCULAR RISK MANAGEMENT IN PEOPLE WITH RHEUMATIC AND MUSCULOSKELETAL DISEASES - A SURVEY STUDY
POS0410-HPR GLOBAL AWARENESS AMONG HEALTHCARE PROVIDERS OF EULAR RECOMMENDATIONS ON CARDIOVASCULAR RISK MANAGEMENT IN PEOPLE WITH RHEUMATIC AND MUSCULOSKELETAL DISEASES - A SURVEY STUDY Open
View article: Epigenetic regulation of thrombo-inflammation in Behçet and antiphospholipid syndrome
Epigenetic regulation of thrombo-inflammation in Behçet and antiphospholipid syndrome Open
View article: EULAR RECOMMENDATIONS FOR A CORE DATA SET TO SUPPORT CLINICAL CARE AND TRANSLATIONAL AND OBSERVATIONAL RESEARCH IN SYSTEMIC LUPUS ERYTHEMATOSUS
EULAR RECOMMENDATIONS FOR A CORE DATA SET TO SUPPORT CLINICAL CARE AND TRANSLATIONAL AND OBSERVATIONAL RESEARCH IN SYSTEMIC LUPUS ERYTHEMATOSUS Open
PT004 / #704 Topic: AS13 - Guidelines and Recommendations POSTER TOUR 01: CLINICAL OUTCOMES IN SLE 22-05-2025 10:00 AM - 10:40 AM Background/Purpose To enhance clinical and multicenter research outcomes in systemic lupus erythematosus (SLE…
View article: INTRA-RENAL INVOLVEMENT IN PRIMARY ANTIPHOSPHOLIPID ANTIBODIES SYNDROME: DATA FROM 2 ITALIAN CENTERS
INTRA-RENAL INVOLVEMENT IN PRIMARY ANTIPHOSPHOLIPID ANTIBODIES SYNDROME: DATA FROM 2 ITALIAN CENTERS Open
PV020 / #573 Poster Topic: AS03 - Antiphospholipid Syndrome Background/Purpose Antiphospholipid antibodies nephropathy (aPL-N) is defined by thrombotic microangiopathy (TMA) early lesions and late lesions such fibro-intimal hyperplasia wit…
View article: Real-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohort
Real-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohort Open
This research was supported by the European Reference Network for Rare Kidney Diseases, funded by the European Union within the framework of the "EU4Health Programme 2021-2027".
View article: Biological therapies in thrombocytopenia and primary antiphospholipid syndrome: where are we now?
Biological therapies in thrombocytopenia and primary antiphospholipid syndrome: where are we now? Open
View article: Antiphospholipid IgG Certified Reference Material ERM<sup>®</sup>-DA477/IFCC: a tool for aPL harmonization?
Antiphospholipid IgG Certified Reference Material ERM<sup>®</sup>-DA477/IFCC: a tool for aPL harmonization? Open
Objectives The Certified Reference Material (CRM) ERM ® -DA477/IFCC is a new polyclonal IgG anti-beta2-glycoprotein I (anti-β2GPI) material for the harmonization of the laboratory diagnosis of antiphospholipid syndrome (APS). We evaluated …
View article: Cryfibrinogen-Associated Glomerulonephritis and Monoclonal Gammopathy of Renal Significance—Case Report and Literature Review
Cryfibrinogen-Associated Glomerulonephritis and Monoclonal Gammopathy of Renal Significance—Case Report and Literature Review Open
Background/Objectives: Cryofibrinogenemia, characterized by plasma cryoprecipitation of fibrinogen and related proteins, is a rare and often under-recognized entity that can present with significant renal involvement. Methods: we describe …
View article: A global survey about undiagnosed rare diseases: perspectives, challenges, and solutions
A global survey about undiagnosed rare diseases: perspectives, challenges, and solutions Open
Background Undiagnosed rare diseases (URDs) are a complex and multifaceted challenge, especially in low-and medium-income countries. They affect individuals with unique clinical features and lack a clear diagnostic label. Although the Undi…
View article: Problem Solved? An Individual Ratio between Point-of-Care and Venous International Normalized Ratio Values in Two Patients with Antiphospholipid Syndrome: Two Case Reports
Problem Solved? An Individual Ratio between Point-of-Care and Venous International Normalized Ratio Values in Two Patients with Antiphospholipid Syndrome: Two Case Reports Open
Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by thromboembolic and obstetric complications in the presence of persistent antiphospholipid antibodies (aPL). Treatment aims to prevent recurrent thrombosis, prim…
View article: The Italian Society for Rheumatology guidelines on reproductive health in patients with rheumatic diseases
The Italian Society for Rheumatology guidelines on reproductive health in patients with rheumatic diseases Open
Objective. To date, there is no shared national guideline in Italy for the management of reproductive health in rheumatic diseases (RHRD). The Italian Society for Rheumatology (SIR) has committed to developing clinical practice recommendat…
View article: Promuovere la ricerca e l’innovazione: l’analisi della prima mappatura dell’organizzazione e delle attività in ambito di ricerca sanitaria e biomedica delle aziende sanitarie piemontesi
Promuovere la ricerca e l’innovazione: l’analisi della prima mappatura dell’organizzazione e delle attività in ambito di ricerca sanitaria e biomedica delle aziende sanitarie piemontesi Open
La ricerca sanitaria, intesa come parte integrante delle attività del Servizio Sanitario Nazionale (SSN), è fondamentale per garantire una sanità efficiente e rispondente ai reali bisogni di assistenza e cura del Paese. La Regione Piemonte…
View article: How We Treat ANCA-Associated Vasculitis: A Focus on the Maintenance Therapy
How We Treat ANCA-Associated Vasculitis: A Focus on the Maintenance Therapy Open
Recent progress has notably improved outcomes for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), namely granulomatosis with polyangiitis and microscopic polyangiitis. Since 2021, several international scien…
View article: Thrombocytopenia in Antiphospholipid Syndrome: Predictors, Prognostic Implications, and Thrombotic Risk in a Large Cohort Study
Thrombocytopenia in Antiphospholipid Syndrome: Predictors, Prognostic Implications, and Thrombotic Risk in a Large Cohort Study Open
View article: Syndemic approach to chronic kidney disease, cardiovascular disease and educational level: a longitudinal cohort study in northwest Italy
Syndemic approach to chronic kidney disease, cardiovascular disease and educational level: a longitudinal cohort study in northwest Italy Open
Introduction Chronic kidney disease (CKD) and end-stage renal disease (ESRD) represent significant public health challenges, linked to an elevated risk of cardiovascular disease (CVD) and influenced by socioeconomic disparities. This longi…
View article: The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance—A Patient-Driven, Multistep-Approach Study
The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance—A Patient-Driven, Multistep-Approach Study Open
Background/Objectives: Inflammation and immunological dysregulation are central to systemic lupus erythematosus (SLE), a complex autoimmune disease. Recently, there has been increasing interest in the potential role of dietary factors in S…
View article: From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases
From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases Open
The transition from a comorbidity-based to a multimorbidity-focused to ultimately a network medicine approach in people with rheumatic diseases might mark a significant shift in how we understand and manage these complex conditions. Multim…
View article: Why should we teach about sustainability in medical schools? The MedInTo initiative
Why should we teach about sustainability in medical schools? The MedInTo initiative Open
View article: Is it time for treat-to-target in antiphospholipid syndrome?
Is it time for treat-to-target in antiphospholipid syndrome? Open
A treat-to-target (T2T) approach aims to the identification of a clinically relevant therapeutic target and applies tight control (periodic visits at prespecified time-points and treatment adjustments) to achieve it with the goal of improv…
View article: ANA-positive <i>versus</i> ANA-negative Antiphospholipid Antibody-positive Patients: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Clinical Database and Repository (“Registry”)
ANA-positive <i>versus</i> ANA-negative Antiphospholipid Antibody-positive Patients: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Clinical Database and Repository (“Registry”) Open
Objectives This study focused on the prevalence and impact of ANA in aPL-positive patients without concomitant systemic autoimmune rheumatic diseases (SARDs). Methods Data from aPL-positive patients with or without Revised Sapporo APS clas…
View article: How to treat patients with thrombotic antiphospholipid syndrome in 2024?
How to treat patients with thrombotic antiphospholipid syndrome in 2024? Open
Antiphospholipid syndrome (APS) encompasses a range of clinical conditions, particularly thrombotic or obstetrical manifestations, associated with the presence of antiphospholipid antibodies. Managing thrombotic APS in daily clinical pract…