Sheetal Hardikar
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View article: Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer Open
The incidence of colorectal cancer in young adults (age of diagnosis <50 years) has been rapidly increasing. Although ∼20% of early-onset colorectal cancer (EOCRC) cases are due to germline mutations, the etiology of the majority of EOC…
View article: Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort
Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort Open
These results establish obesity-associated adipose tissue dysregulation as a key intertissue modulator of biology, with concordant cross-species effects on tumor cell-intrinsic inflammatory and metabolic programs.
View article: <i>Candida albicans</i> infiltrates colon and rectal cancers causing therapeutic resistance and decreased survival
<i>Candida albicans</i> infiltrates colon and rectal cancers causing therapeutic resistance and decreased survival Open
The microbiome is increasingly recognized as a modifier of cancer progression and therapy response, yet the role of intratumoral fungi remains poorly defined. Here, we identify Candida albicans colonization within human colorectal tumors a…
View article: Pre-surgery gut microbial diversity and abundance are associated with post-surgery onset of cachexia in colorectal cancer patients: the ColoCare Study
Pre-surgery gut microbial diversity and abundance are associated with post-surgery onset of cachexia in colorectal cancer patients: the ColoCare Study Open
Background Cachexia accounts for about 20% of all cancer-related deaths and it is indicative of poor prognosis and progressive functional impairment. The role of the gut microbiome in the development of cachexia in colorectal cancer (CRC) …
View article: Genetic risk factors modulate the association between physical activity and colorectal cancer
Genetic risk factors modulate the association between physical activity and colorectal cancer Open
Background Physical activity (PA) is an established protective factor for colorectal cancer (CRC), but it is unclear if genetic variants modify this effect. To investigate this possibility, we conducted a genome-wide gene–PA interaction an…
View article: Associations of Biomarkers of Systemic Inflammation, Angiogenesis, and Cell‐to‐Cell Adhesion With Tumor Budding Among Early‐Onset and Later‐Onset Colorectal Cancer Patients
Associations of Biomarkers of Systemic Inflammation, Angiogenesis, and Cell‐to‐Cell Adhesion With Tumor Budding Among Early‐Onset and Later‐Onset Colorectal Cancer Patients Open
Background High tumor budding and elevated systemic inflammation are adverse prognostic indicators in colorectal cancer. Its underlying mechanisms remain poorly understood. It is unclear whether systemic inflammation, angiogenesis, and cel…
View article: Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer
Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer Open
Background Cancer-related fatigue (fatigue) is a common and persistent symptom after cancer treatment, yet the role of genetic susceptibility remains unclear. Methods We used data from a prospective cohort study called the ColoCare Study, …
View article: Obesity promotes conserved inflammatory and metabolic transcriptional programs in mouse and human colon tumors
Obesity promotes conserved inflammatory and metabolic transcriptional programs in mouse and human colon tumors Open
Background: The global prevalence of obesity, an established risk and progression factor for colon cancer, is high and rising. Unfortunately, the mechanisms underlying the obesity-colon cancer association are incompletely understood, and n…
View article: Primary tumor microbiomes predict distant metastasis of colorectal cancer
Primary tumor microbiomes predict distant metastasis of colorectal cancer Open
Metastasis causes most cancer-related deaths in colorectal carcinoma (CRC), and microbiome markers may have prognostic value. We hypothesized that primary tumor microbiomes predict distant metastases. We analyzed 5-year metastasis-free sur…
View article: Subclinical Atherosclerosis and Cardiovascular Events Among Patients With Colorectal Cancer
Subclinical Atherosclerosis and Cardiovascular Events Among Patients With Colorectal Cancer Open
Background Prior studies have documented that patients with colorectal cancer (CRC) are at an increased risk of cardiovascular disease (CVD). Objectives To examine coronary artery calcium (CAC) as a marker of subclinical atherosclerosis an…
View article: Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer
Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer Open
Background: The incidence of colorectal cancer (CRC) in young adults (age of diagnosis < 50 years old) has been rapidly increasing. Although ~20% of early-onset (EO) CRC cases are due to germline mutations, the etiology of the majority of …
View article: Table S2 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors
Table S2 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors Open
Modeling results for gene expression differences between responders and non-responders
View article: Table S5 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors
Table S5 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors Open
Correlations between microbe abundances and MSigDB Hallmark gene sets average Z scores
View article: Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Cox proportional hazards model results for the interaction terms between hypoxia (binary, low or high) with microbe relative abundance in COADREAD tumors treated with radiotherapy.
View article: Table S3 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors
Table S3 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors Open
Model performance of 31 published gene expression signatures for predicting immunotherapy treatment response
View article: Table S1 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors
Table S1 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors Open
The list of published gene signatures compared between treatment responders and non-responders and to tumor microbe abundances.
View article: Figure S5 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors
Figure S5 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors Open
Comparison of alternate machine learning methods
View article: Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Numbers at risk for the association between survival and Fusobacterium canifelinum abundance in COADREAD tumors treated with radiation.
View article: Supplementary Tables Legend from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplementary Tables Legend from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Legend for Supplementary Tables
View article: Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Selected log2 fold change results for microbes found to be significantly enriched in hypoxic tumors in both mice and human subjects.
View article: Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Log2 fold changes of annotated Cutibacterium genes between hypoxic and normoxic tumors in nude and BALB/c mice.
View article: Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Correlations between tumor microbes enriched in hypoxic tumors in both mice and humans and deconvolved immune cell abundances.
View article: Figure S4 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors
Figure S4 from The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors Open
Comparison with TCGA for microbes most significantly enriched in response groups
View article: Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Fold-changes and adjusted p-values for all microbes associated with hypoxic or normoxic tumors in the ORIEN and TCGA datasets (associated with Figure 2A). Results of survival analyses of interactions between microbes and hypoxia in COADREA…
View article: Supplemental Figure S1 from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplemental Figure S1 from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Hypoxia scores by stage (A) or sex (B) for the ORIEN radiation-treated cohort.
View article: Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Differences in the tumor microbes in low and high hypoxia mouse tumors.
View article: Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Differences in the immune cell populations, estimated by RNAseq, within high and low hypoxia mouse tumors, combining the nude and BALB/c mice.
View article: Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplementary Data from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Numbers at risk for the association between low and high hypoxia in COAD and READ tumors (associated with the Kaplan-Meier curve shown in Figure 1D).
View article: Supplemental Figure S2 from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
Supplemental Figure S2 from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer Open
Boxplots comparing immune fractions in low and high hypoxia groups in the ORIEN radiation cohort, displaying cells with significantly different abundance with an adjusted p-value <0.05.