Tao Shen
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View article: Exosomal transfer of miR-375-3p from pancreatic β cells to hepatocytes impairs hepatic glycogenesis <i>via</i> Rbpj repression
Exosomal transfer of miR-375-3p from pancreatic β cells to hepatocytes impairs hepatic glycogenesis <i>via</i> Rbpj repression Open
BACKGROUND Glucotoxic pancreatic β cells impair glycogenesis of hepatocytes, with exosomes serving as novel mediators. miR-375-3p is the most abundant miRNA in the pancreas and critical for β-cell function, but whether it plays a role in p…
View article: Study on the Relationship between the Board of Directors and Principals in Private Schools: Governance Structure, Interaction Mechanism, and Support-Supervision
Study on the Relationship between the Board of Directors and Principals in Private Schools: Governance Structure, Interaction Mechanism, and Support-Supervision Open
This paper focuses on the core issue of private school governance, systematically explores the coupling relationship between the governance structure of the board of directors and principals’ leadership, conducts an in-depth analysis of th…
View article: Efficacy of digital interventions for smoking cessation by type and method: a systematic review and network meta-analysis
Efficacy of digital interventions for smoking cessation by type and method: a systematic review and network meta-analysis Open
Smoking cessation is the only evidence-based approach to reducing tobacco-related health risks, yet traditional interventions suffer from limited coverage. Although digital interventions show promise, their comparative efficacy across meth…
View article: Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast‐Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect
Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast‐Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect Open
Osteoarthritis (OA), the prevalent debilitating joint disorder, is accelerated by dysregulated intercellular crosstalk, yet the role of fibroblast‐like synoviocyte (FLS)‐derived extracellular vesicles and particles (EVPs) in disease progre…
View article: The gut-retina axis: association of dietary index for gut microbiota with diabetic retinopathy in diabetic patients—a cross-sectional study from NHANES 2009–2018
The gut-retina axis: association of dietary index for gut microbiota with diabetic retinopathy in diabetic patients—a cross-sectional study from NHANES 2009–2018 Open
Higher DI-GM scores are linked to lower DR risk, supporting dietary optimization (e.g., increased whole grains/vegetables, reduced processed meat) as a potential strategy for DR prevention through gut microbiota modulation. These findings …
View article: Divergent Upcycling of Polystyrene into Phenol and Hydroquinone Derivatives by Photocatalysis and Electrocatalysis
Divergent Upcycling of Polystyrene into Phenol and Hydroquinone Derivatives by Photocatalysis and Electrocatalysis Open
The selective upcycling of polystyrene (PS) waste into value‐added aromatics has emerged as a compelling strategy toward sustainable plastic valorization, drawing significant scientific and industrial interest. While most existing methods …
View article: The relationship between inspiratory muscle strength and exercise tolerance in patients with coronary heart disease
The relationship between inspiratory muscle strength and exercise tolerance in patients with coronary heart disease Open
After PCI, CHD patients exhibiting IMW, especially those with comorbid COPD, demonstrated reduced exercise tolerance and oxygen uptake efficiency.
View article: Screening and Evaluation of tRF-Glu-CTC-013 as a Biomarker and Key Regulator in the Development of Cardiac Hypertrophy
Screening and Evaluation of tRF-Glu-CTC-013 as a Biomarker and Key Regulator in the Development of Cardiac Hypertrophy Open
tRNA-derived small RNAs (tsRNAs) are a newly recognized class of non-coding RNAs involved in regulating RNA processing and translational control. Pathological cardiac hypertrophy, characterized by left ventricular remodeling under chronic …
View article: NHE7 drives endometrial cancer progression by delaying senescence through cAMP/CREB/GRIN2B axis-mediated Ca²⁺ influx
NHE7 drives endometrial cancer progression by delaying senescence through cAMP/CREB/GRIN2B axis-mediated Ca²⁺ influx Open
Endometrial cancer (EC) remains a lethal gynecological malignancy with limited therapeutic options owing to unresolved pathogenesis. Cellular senescence acts as a key barrier against tumorigenesis in cancer cells, thus investigating its ro…
View article: Universal Joint Orthosis (UJO): Assistive and Resistive Movement Device for Astronauts and Medical Rehabilitation
Universal Joint Orthosis (UJO): Assistive and Resistive Movement Device for Astronauts and Medical Rehabilitation Open
One of the foremost challenges for astronauts is maintaining their health in the low-gravity environment of space and providing necessary assistance in tasks. Similarly, on Earth, many individuals require rehabilitation technologies to aid…
View article: Sphaeropsidin A covalently binds to Cys 151 of Keap1 to attenuate LPS-induced acute pneumonia in mice
Sphaeropsidin A covalently binds to Cys 151 of Keap1 to attenuate LPS-induced acute pneumonia in mice Open
View article: Sphaeropsidin a Covalently Binds to Cys 151 of Keap1 to Attenuate Lps-Induced Acute Pneumonia in Mice
Sphaeropsidin a Covalently Binds to Cys 151 of Keap1 to Attenuate Lps-Induced Acute Pneumonia in Mice Open
View article: LLMs are Also Effective Embedding Models: An In-depth Overview
LLMs are Also Effective Embedding Models: An In-depth Overview Open
Large language models (LLMs) have revolutionized natural language processing by achieving state-of-the-art performance across various tasks. Recently, their effectiveness as embedding models has gained attention, marking a paradigm shift f…
View article: Relevance of the oxidative balance score and red cell distribution width/albumin ratio in diabetic retinopathy: A mediation analysis in the NHANES
Relevance of the oxidative balance score and red cell distribution width/albumin ratio in diabetic retinopathy: A mediation analysis in the NHANES Open
Background: As a comprehensive indicator of the body's overall oxidative stress status, the oxidative balance score (OBS) can reflect the body's antioxidant capacity and is associated with a myriad of diabetes-related complications. The re…
View article: Biofluid GPNMB/osteoactivin as a potential biomarker of ageing: A cross-sectional study
Biofluid GPNMB/osteoactivin as a potential biomarker of ageing: A cross-sectional study Open
The biofluid GPNMB was a strong clinical biomarker candidate for estimating biological aging.
View article: Mechanical loading on osteocytes regulates thermogenesis homeostasis of brown adipose tissue by influencing osteocyte-derived exosomes
Mechanical loading on osteocytes regulates thermogenesis homeostasis of brown adipose tissue by influencing osteocyte-derived exosomes Open
This study provides a biological rationale for using osteocyte exosomes as potential agents to modulate BAT and even whole-body homeostasis. It also provides a new pathological basis and a new treatment approach for mechanical unloading co…
View article: Integrating network pharmacology and computational biology to propose Yiqi Sanjie formula’s mechanisms in treating NSCLC: molecular docking, ADMET, and molecular dynamics simulation
Integrating network pharmacology and computational biology to propose Yiqi Sanjie formula’s mechanisms in treating NSCLC: molecular docking, ADMET, and molecular dynamics simulation Open
Our research demonstrates the potential of integrating network pharmacology and computational biology to elucidate the mechanisms of the Yiqi Sanjie formula in NSCLC treatment. The identified compounds could lead to novel targeted therapie…
View article: DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure Open
DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understood. We generated cardiomyocyte…
View article: Inflammatory Fibroblast‐Like Synoviocyte‐Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis (Adv. Sci. 14/2024)
Inflammatory Fibroblast‐Like Synoviocyte‐Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis (Adv. Sci. 14/2024) Open
Fibroblast‐Like Synoviocytes The cover shows blooming lotus flowers, with the pollen from one flower being spread to another by butterflies, which is a metaphor for the phenomenon the authors discovered in the synovium of osteoarthritis. I…
View article: CrossBind: Collaborative Cross-Modal Identification of Protein Nucleic-Acid-Binding Residues
CrossBind: Collaborative Cross-Modal Identification of Protein Nucleic-Acid-Binding Residues Open
Accurate identification of protein nucleic acid binding residues poses a significant challenge with important implications for various biological processes and drug design. Many typical computational methods for protein analysis rely on a …
View article: Inflammatory Fibroblast‐Like Synoviocyte‐Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis
Inflammatory Fibroblast‐Like Synoviocyte‐Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis Open
The severity of osteoarthritis (OA) and cartilage degeneration is highly associated with synovial inflammation. Although recent investigations have revealed a dysregulated crosstalk between fibroblast‐like synoviocytes (FLSs) and macrophag…
View article: Shock Wave Therapy Alleviates Hypoxia/Reoxygenation‐Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Ferroptosis
Shock Wave Therapy Alleviates Hypoxia/Reoxygenation‐Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Ferroptosis Open
Shock wave therapy (SWT) is a new alternative therapy for patients with severe coronary artery disease that improves myocardial ischemic symptoms by delivering low‐energy shock wave stimulation to ischaemic myocardium with low‐energy pulse…
View article: The dual functions of the pentacyclic triterpenoid madecassic acid in ameliorating doxorubicin-induced cardiotoxicity and enhancing the antitumor efficacy of doxorubicin
The dual functions of the pentacyclic triterpenoid madecassic acid in ameliorating doxorubicin-induced cardiotoxicity and enhancing the antitumor efficacy of doxorubicin Open
Doxorubicin (DOX) is an anthracycline that has excellent anticancer effects during tumor chemotherapy, but it can cause cardiotoxic effects and its clinical use has been limited. Therefore, finding new drugs or methods to prevent or revers…
View article: A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement
A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement Open
Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent among the elderly population. Urgent attention is required to prioritize preventive and management strategies for age-related cardiovascular conditio…
View article: Chronic unpredictable mild stress promotes atherosclerosis <i>via</i> adipose tissue dysfunction in ApoE<sup>-/-</sup> mice
Chronic unpredictable mild stress promotes atherosclerosis <i>via</i> adipose tissue dysfunction in ApoE<sup>-/-</sup> mice Open
Background Chronic unpredictable mild stress (CUMS) has been shown to exacerbate atherosclerosis, but the underlying mechanism remains unknown. Adipose tissue is an energy storage organ and the largest endocrine organ in the human body, pl…
View article: Identification of the Immune Landscapes and Follicular Helper T Cell-Related Genes for the Diagnosis of Age-Related Macular Degeneration
Identification of the Immune Landscapes and Follicular Helper T Cell-Related Genes for the Diagnosis of Age-Related Macular Degeneration Open
Background: Age-related macular degeneration (AMD) is a progressive ocular ailment causing age-associated vision deterioration, characterized by dysregulated immune cell activity. Notably, follicular helper T (Tfh) cells have emerged as pi…
View article: Corrigendum: DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression
Corrigendum: DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression Open
[This corrects the article DOI: 10.3389/fonc.2022.943032.].
View article: Enhancing the Protein Tertiary Structure Prediction by Multiple Sequence Alignment Generation
Enhancing the Protein Tertiary Structure Prediction by Multiple Sequence Alignment Generation Open
The field of protein folding research has been greatly advanced by deep learning methods, with AlphaFold2 (AF2) demonstrating exceptional performance and atomic-level precision. As co-evolution is integral to protein structure prediction, …
View article: AF2-Mutation: Adversarial Sequence Mutations against AlphaFold2 on Protein Tertiary Structure Prediction
AF2-Mutation: Adversarial Sequence Mutations against AlphaFold2 on Protein Tertiary Structure Prediction Open
Deep learning-based approaches, such as AlphaFold2 (AF2), have significantly advanced protein tertiary structure prediction, achieving results comparable to real biological experimental methods. While AF2 has shown limitations in predictin…
View article: Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability
Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability Open
Background The objective response rate of microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) patients with first-line anti-programmed cell death protein-1 (PD-1) monotherapy is only 40–45%. Single-cell RNA sequenci…