Simin Liu
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View article: Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity Open
Chaperone-mediated autophagy (CMA) is a selective autophagic process essential for maintaining cellular quality and responding to stress. Dysregulation of the CMA pathway is increasingly recognized in various cancers, yet the mechanisms be…
View article: Non-apoptotic death of the <i>C. elegans</i> linker cell is primed by MYRF-1 activation of <i>pqn-41</i> /polyQ
Non-apoptotic death of the <i>C. elegans</i> linker cell is primed by MYRF-1 activation of <i>pqn-41</i> /polyQ Open
Linker cell-type death (LCD) is a morphologically conserved non-apoptotic cell-death process with features resembling polyglutamine-dependent neurodegeneration. In C. elegans development, LCD eliminates the male-specific linker cell follow…
View article: Association Between Over-the-Counter Magnesium Supplement Use and Health Outcomes in Veterans with Newly Diagnosed Heart Failure
Association Between Over-the-Counter Magnesium Supplement Use and Health Outcomes in Veterans with Newly Diagnosed Heart Failure Open
Background: Individuals with heart failure (HF) are at increased risk of magnesium deficiency. Magnesium supplements are widely available and being used without clear evidence of efficacy in HF. Methods: We emulated a target trial to asses…
View article: Effects of yucca extract on dynamic nutrient change, greenhouse gas emissions, and microbial community during chicken manure storage
Effects of yucca extract on dynamic nutrient change, greenhouse gas emissions, and microbial community during chicken manure storage Open
Liquid manure storage contributes substantially to environmental emissions within manure management systems. This study evaluated Yucca schidigera extract (YE) as a sustainable microbial modulator for mitigating ammonia (NH3) and greenhous…
View article: Community based cohort studies in China: critical insights for shaping the future of population and public health
Community based cohort studies in China: critical insights for shaping the future of population and public health Open
Dongfeng Gu and colleagues review community based cohort studies in China, finding strategies to improve the quality and scale of these studies in China and beyond
View article: Oral magnesium and outcomes in US veterans with heart failure
Oral magnesium and outcomes in US veterans with heart failure Open
Background and Aims Magnesium deficiency is associated with poor outcomes in patients with heart failure (HF), but less is known about the impact of oral magnesium therapy. This study aimed to examine the association of oral magnesium with…
View article: SARS-CoV-2 Positivity, Indicators of COVID-19 Severity, COVID-19 Hospitalization, and Diabetes Risk in the Women’s Health Initiative
SARS-CoV-2 Positivity, Indicators of COVID-19 Severity, COVID-19 Hospitalization, and Diabetes Risk in the Women’s Health Initiative Open
Objective: To examine prospective associations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test positivity, coronavirus disease 2019 (COVID-2019) symptom severity, and COVID-2019 hospitalization with incident clinical d…
View article: Ultrasound-Assisted Deep Eutectic Solvent Extraction of Flavonoids from Cercis chinensis Seeds: Optimization, Kinetics and Antioxidant Activity
Ultrasound-Assisted Deep Eutectic Solvent Extraction of Flavonoids from Cercis chinensis Seeds: Optimization, Kinetics and Antioxidant Activity Open
This study establishes an efficient and eco-friendly ultrasound-assisted extraction (UAE) method for total flavonoids present in Cercis chinensis seeds using natural deep eutectic solvents (NADES). Among nine NADES formulations screened, c…
View article: Bronchodilator Response Assessed by Surface Respiratory Muscle EMG in Children
Bronchodilator Response Assessed by Surface Respiratory Muscle EMG in Children Open
Surface respiratory muscle EMG could be feasible and useful to assess bronchodilator response to differentiate children with uncontrolled asthma from healthy subjects.
View article: Ultrasound-assisted deep eutectic solvent extraction of polysaccharides from Cercis chinensis bark: Optimization, kinetics and antioxidant activities
Ultrasound-assisted deep eutectic solvent extraction of polysaccharides from Cercis chinensis bark: Optimization, kinetics and antioxidant activities Open
This study pioneers a green, efficient ultrasound-assisted extraction (UAE) technique using a deep eutectic solvent (DES) to isolate polysaccharides from Cercis chinensis bark, overcoming limitations of conventional methods. Through system…
View article: Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone
Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone Open
Introduction Several aquaporins (AQPs) are involved in the influx of water to form follicular fluid, and AQP2 may play a crucial role in follicular growth. However, the specific roles of Aquaporin (AQP) 2 and AQP6 in granulosa cells (GCs) …
View article: Dietary Patterns, Circulating Metabolome, and Risk of Type 2 Diabetes
Dietary Patterns, Circulating Metabolome, and Risk of Type 2 Diabetes Open
Circulating metabolites may reflect biological homeostasis and have been linked to dietary intakes and human health, and may hold the promises to facilitate objective assessments of intakes and metabolic response to diets. Here, we integra…
View article: 3D visualization of uterus and ovary: tissue clearing techniques and biomedical applications
3D visualization of uterus and ovary: tissue clearing techniques and biomedical applications Open
Recent advancements in tissue clearing and three-dimensional (3D) visualization technologies have enabled subcellular-level examination of entire organs, particularly in complex structures such as the ovary and uterus. Traditional histolog…
View article: Proton Pump Inhibitor Use and Incident Hypertension in Menopausal Women
Proton Pump Inhibitor Use and Incident Hypertension in Menopausal Women Open
Background Proton pump inhibitors (PPIs) could affect blood pressure regulation by suppressing gastric acid required for the conversion of oral nitrite into nitric oxide. Whether PPI use is associated with incident hypertension remains unk…
View article: Multi-omics analysis of chlorogenic acid in alleviating oxidative damage from heat stress in prepubertal boar testes
Multi-omics analysis of chlorogenic acid in alleviating oxidative damage from heat stress in prepubertal boar testes Open
Background: Heat stress (HS) can impair boar testicular function, leading to reproductive issues. While chlorogenic acid (CGA) has shown function in mitigating HS-induced damage in various livestock and poultry species. Prepuberty is an im…
View article: Serum Magnesium, Prescribed Magnesium Replacement and Cardiovascular Events in Adults with Type 2 Diabetes: A National Cohort Study in U.S. Veterans
Serum Magnesium, Prescribed Magnesium Replacement and Cardiovascular Events in Adults with Type 2 Diabetes: A National Cohort Study in U.S. Veterans Open
Objectives: To investigate the relationship between serum magnesium levels, prescribed oral magnesium replacement, and major adverse cardiovascular events (MACE) in type-2 diabetes mellitus (T2D). Research design and methods: This nationwi…
View article: Parental dysfunction and adolescent mental health: AI-aided content analysis of suicide notes on social media
Parental dysfunction and adolescent mental health: AI-aided content analysis of suicide notes on social media Open
Adolescent suicide represents a critical global health issue. While research has identified numerous risk factors, the specific impact of parental dysfunction on adolescent suicide remains understudied, especially in Chinese contexts. This…
View article: Serum Magnesium, Prescribed Magnesium Replacement and Cardiovascular Events in Adults with Type 2 Diabetes: A National Cohort Study in U.S. Veterans
Serum Magnesium, Prescribed Magnesium Replacement and Cardiovascular Events in Adults with Type 2 Diabetes: A National Cohort Study in U.S. Veterans Open
OBJECTIVE To investigate the relationship between serum magnesium levels, prescribed oral magnesium replacement, and major adverse cardiovascular events (MACE) in type-2 diabetes (T2D). RESEARCH DESIGN AND METHODS This national-wide retros…
View article: The portfolio dietary pattern and risk of cardiovascular disease mortality during 1988–2019 in US adults: a prospective cohort study
The portfolio dietary pattern and risk of cardiovascular disease mortality during 1988–2019 in US adults: a prospective cohort study Open
Background The Portfolio Diet, a dietary pattern of cholesterol-lowering foods, has been shown to reduce cardiovascular disease (CVD) risk factors in clinical trials and lower CVD risk in observational cohorts of mainly white men and women…
View article: A study on the ecological environment influenced by the sex ratio of lampreys based on logistic and dynamic analysis model
A study on the ecological environment influenced by the sex ratio of lampreys based on logistic and dynamic analysis model Open
Lamprey sex determination is influenced by factors such as larval growth rate and food availability. When food is plentiful, males make up approximately half of the population. However, in conditions of food scarcity, the proportion of mal…