Soraya S. Smaili
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View article: Tetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling Pathways
Tetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling Pathways Open
SARS-CoV-2 exploits multiple host cellular processes, including autophagy—a critical intracellular degradation pathway—to facilitate viral replication and evade immune detection. Tetrandrine, a natural bis-benzylisoquinoline alkaloid deriv…
View article: Encontros no exílio
Encontros no exílio Open
The text revisits the trajectory of Al Mahjar project, conceived by Aziz Ab’Saber within the framework of the Arab Culture Institute (ICArabe), as a response to the growing stigmatization of Arab culture and the historical erasure of its c…
View article: Remission conversion drives outcomes after CAR T-cell therapy for multiple myeloma: a registry analysis from the DRST
Remission conversion drives outcomes after CAR T-cell therapy for multiple myeloma: a registry analysis from the DRST Open
Cellular therapies targeting B-cell maturation antigen have shown promise in controlled clinical trials, but their impact in broader, diverse patient populations remains underexplored. This study examines the real-world efficacy and safety…
View article: Preventive beneficial effects of cannabidiol in a reserpine-induced progressive model of parkinsonism
Preventive beneficial effects of cannabidiol in a reserpine-induced progressive model of parkinsonism Open
Introduction: Parkinson's disease (PD) is characterized by motor and non-motor symptoms such as tremors, difficulty in initiating movements, depression, and cognitive deficits. The pathophysiology of PD involves a gradual decrease in dopam…
View article: Public perception of the persistence of COVID-19 symptoms and potential strategies to address Long COVID
Public perception of the persistence of COVID-19 symptoms and potential strategies to address Long COVID Open
Long COVID is characterized by symptoms that persist for more than 12 weeks after a SARS-CoV-2 infection. This study investigated public perceptions of long COVID in Brazil. Interviews were conducted with 1,295 participants selected based …
View article: Brazilian Public Universities’ Contributions to Global COVID-19 Research: Publications, International Collaboration, and Impact
Brazilian Public Universities’ Contributions to Global COVID-19 Research: Publications, International Collaboration, and Impact Open
The Brazilian scientific community, primarily composed of public universities and research institutes, played a fundamental role in combating the COVID-19 pandemic. This study investigates Brazil’s contribution to the global body of knowle…
View article: Cannabidiol induces autophagy via CB1 receptor and reduces α-synuclein cytosolic levels
Cannabidiol induces autophagy via CB1 receptor and reduces α-synuclein cytosolic levels Open
Numerous studies have explored the role of cannabinoids in neurological conditions, chronic pain and neurodegenerative diseases. Restoring autophagy has been proposed as a potential target for the treatment of neurodegenerative diseases. I…
View article: Natural Language Processing method to Unravel Long COVID's clinical condition in hospitalized patients
Natural Language Processing method to Unravel Long COVID's clinical condition in hospitalized patients Open
Long COVID is characterized by persistent symptoms beyond established timeframes, presenting a significant challenge in understanding its clinical manifestations and implications. In this study, we present a novel application of natural la…
View article: Astroglial S100B Secretion Is Mediated by Ca2+ Mobilization from Endoplasmic Reticulum: A Study Using Forskolin and DMSO as Secretagogues
Astroglial S100B Secretion Is Mediated by Ca2+ Mobilization from Endoplasmic Reticulum: A Study Using Forskolin and DMSO as Secretagogues Open
S100B, a homodimeric Ca2+-binding protein, is produced and secreted by astrocytes, and its extracellular levels have been used as a glial marker in brain damage and neurodegenerative and psychiatric diseases; however, its mechanism of secr…
View article: NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes Open
Huntington’s disease (HD) is a progressive neurodegenerative disease characterized by mutations in the huntingtin gene (mHtt), causing an unstable repeat of the CAG trinucleotide, leading to abnormal long repeats of polyglutamine (poly-Q) …
View article: The pro-science wave in times of denialism: Brazilian society’s perception of science, scientists, and universities during the COVID-19 pandemic
The pro-science wave in times of denialism: Brazilian society’s perception of science, scientists, and universities during the COVID-19 pandemic Open
This article presents the results of our study on the public perception of science during the COVID-19 pandemic in Brazil, carried out at the Centro de Estudos SoU_Ciência, from Universidade Federal de São Paulo (UNIFESP). To answer the qu…
View article: α-Synuclein Interactions in Mitochondria-ER Contacts: A Possible Role in Parkinson's Disease
α-Synuclein Interactions in Mitochondria-ER Contacts: A Possible Role in Parkinson's Disease Open
Endoplasmic reticulum-mitochondria contact sites regulate various biological processes, such as mitochondrial dynamics, calcium homeostasis, autophagy and lipid metabolism. Notably, dysfunctions in these contact sites are closely related t…
View article: Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19
Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19 Open
The family of coronaviruses (CoVs) uses the autophagy machinery of host cells to promote their growth and replication; thus, this process stands out as a potential target to combat COVID-19. Considering the different roles of autophagy dur…
View article: Lack of Autophagy Induction by Lithium Decreases Neuroprotective Effects in the Striatum of Aged Rats
Lack of Autophagy Induction by Lithium Decreases Neuroprotective Effects in the Striatum of Aged Rats Open
The pharmacological modulation of autophagy is considered a promising neuroprotective strategy. While it has been postulated that lithium regulates this cellular process, the age-related effects have not been fully elucidated. Here, we eva…
View article: 17β‐estradiol reduces SARS‐CoV‐2 infection in vitro
17β‐estradiol reduces SARS‐CoV‐2 infection in vitro Open
The COVID-19 has originated from Wuhan, China, in December 2019 and has been affecting the public health system, society, and economy in an unheard-of manner. There is no specific treatment or vaccine available for COVID-19. Previous data …
View article: Effects of ICI 182,780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells
Effects of ICI 182,780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells Open
Objective To investigate if ICI 182,780 (fulvestrant), a selective estrogen receptor alpha/beta (ERα/ERβ) antagonist, and G-1, a selective G-protein-coupled receptor (GPER) agonist, can potentially induce autophagy in breast cancer cell li…
View article: Effective Synergy of Sorafenib and Nutrient Shortage in Inducing Melanoma Cell Death through Energy Stress
Effective Synergy of Sorafenib and Nutrient Shortage in Inducing Melanoma Cell Death through Energy Stress Open
Skin melanoma is one of the most aggressive and difficult-to-treat human malignancies, characterized by poor survival rates, thus requiring urgent novel therapeutic approaches. Although metabolic reprogramming has represented so far, a can…
View article: Effects of ICI 182,780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells
Effects of ICI 182,780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells Open
The effect of ICI 182,780 on increasing acidic vesicular organelles in estrogen receptor-positive breast cancer cells appears to be associated with its inhibitory effect on estrogen receptors, and GPER does notseem to be involved. Understa…
View article: The Interplay between Ca2+ Signaling Pathways and Neurodegeneration
The Interplay between Ca2+ Signaling Pathways and Neurodegeneration Open
Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in many physiological processes. For example, the spatial and temporal organization of Ca2+ signaling in the central nervous system is fundamental for…
View article: FAM129A regulates autophagy in thyroid carcinomas in an oncogene-dependent manner
FAM129A regulates autophagy in thyroid carcinomas in an oncogene-dependent manner Open
We previously proposed that high expression of FAM129A can be used as a thyroid carcinoma biomarker in preoperative diagnostic exams of thyroid nodules. Here, we identify that FAM129A expression is increased under nutrient and growth facto…
View article: PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for calreticulin exposure in melanoma cells
PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for calreticulin exposure in melanoma cells Open
The immunogenic cell death (ICD) process represents a novel therapeutic approach to treat tumours, in which cytotoxic compounds promote both cancer cell death and the emission of damage-associated molecular patterns (DAMPs) from dying cell…
View article: Effects of Aging in the Striatum and Substantia Nigra of a Parkinson’s Disease Animal Model
Effects of Aging in the Striatum and Substantia Nigra of a Parkinson’s Disease Animal Model Open
Aging is a multifactorial process associated with functional deficits, and the brain is more prone to developing chronic degenerative diseases such as Parkinson’s disease. Several groups have tried to correlate the age-related ultrastructu…
View article: Galectin-3 sensitized melanoma cell lines to vemurafenib (PLX4032) induced cell death through prevention of autophagy
Galectin-3 sensitized melanoma cell lines to vemurafenib (PLX4032) induced cell death through prevention of autophagy Open
Melanoma is a current worldwide problem, as its incidence is increasing. In the last years, several studies have shown that melanoma cells display high levels of autophagy, a self-degradative process that can promote survival leading to dr…
View article: Autophagy and intermittent fasting: the connection for cancer therapy?
Autophagy and intermittent fasting: the connection for cancer therapy? Open
Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Th…
View article: Reduction in skeletal muscle fibrosis of spontaneously hypertensive rats after laceration by microRNA targeting angiotensin II receptor
Reduction in skeletal muscle fibrosis of spontaneously hypertensive rats after laceration by microRNA targeting angiotensin II receptor Open
Regeneration of injured skeletal muscles is affected by fibrosis, which can be improved by the administration of angiotensin II (AngII) receptor (ATR) blockers in normotensive animals. However, the role of ATR in skeletal muscle fibrosis i…
View article: Glutamate induces autophagy via the two-pore channels in neural cells
Glutamate induces autophagy via the two-pore channels in neural cells Open
NAADP (nicotinic acid adenine dinucleotide phosphate) has been proposed as a second messenger for glutamate in neuronal and glial cells via the activation of the lysosomal Ca2+ channels TPC1 and TPC2. However, the activities of glutamate t…