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View article: Reproductive Life Stages and Female Sex-Specific Patterns in Uveitis Activity: Data From the AIDA Network Uveitis Registry
Reproductive Life Stages and Female Sex-Specific Patterns in Uveitis Activity: Data From the AIDA Network Uveitis Registry Open
RLS are clinically relevant modifiers of uveitis activity and should guide patient education, risk stratification, and therapy. Early puberty and perimenopause increase relapse risk; pediatric cases show more severe anterior inflammation a…
View article: Modulation of cellular senescence in psoriatic arthritis: exploring the potential impact of bDMARDs on telomere length, mtDNA copy number, and oxidative damage
Modulation of cellular senescence in psoriatic arthritis: exploring the potential impact of bDMARDs on telomere length, mtDNA copy number, and oxidative damage Open
Inflammation and cellular senescence are two interconnected biological processes critical for several chronic diseases. Pro-inflammatory factors promote the accumulation of reactive oxygen species, which synergistically accelerate the dete…
View article: The Risk of Developing Ocular Involvement Among Behçet’s Disease Patients Presenting with Mucocutaneous Involvement at Disease Onset: Data from the International AIDA Network Behçet’s Disease Registry
The Risk of Developing Ocular Involvement Among Behçet’s Disease Patients Presenting with Mucocutaneous Involvement at Disease Onset: Data from the International AIDA Network Behçet’s Disease Registry Open
Major oral aphthosis, genital aphthous attacks with more than five concurrent ulcers, erythema nodosum coexisting with pseudofolliculitis, a positive family history of BD, and Arab ethnicity are associated with a higher risk of ocular invo…
View article: Sjögren’s disease and concomitant Fibromyalgia: clinical profile and implications for disease activity assessment
Sjögren’s disease and concomitant Fibromyalgia: clinical profile and implications for disease activity assessment Open
Objectives: Fibromyalgia (FM) is more prevalent in patients with Sjögren’s disease (SjD) than in the general population and a bidirectional association between the two conditions has been proposed. However, the clinical profile of patients…
View article: EULAR points to consider and consensus definitions for difficult-to-manage and treatment-refractory psoriatic arthritis
EULAR points to consider and consensus definitions for difficult-to-manage and treatment-refractory psoriatic arthritis Open
EULAR proposes 2 consensus definitions to identify a D2M PsA population, including a TR subgroup. These definitions should now be tested in research studies to understand disease pathogenesis and improve care for people living with PsA.
View article: Macrovascular Involvement in Systemic Sclerosis: Association Between Carotid Ultrasound Hemodynamics Parameters and Digital Ulcers
Macrovascular Involvement in Systemic Sclerosis: Association Between Carotid Ultrasound Hemodynamics Parameters and Digital Ulcers Open
Background: Digital ulcers (DUs) are among the most debilitating vascular complications in SSc and are commonly attributed to microvascular damage. However, recent evidence suggests a potential involvement of macrovascular abnormalities, i…
View article: Metabolic challenges of glucose and lipid dysregulation in psoriatic arthritis: a narrative review from pathogenesis to clinical practice
Metabolic challenges of glucose and lipid dysregulation in psoriatic arthritis: a narrative review from pathogenesis to clinical practice Open
Emerging evidence highlights a complex interconnection between metabolic dysfunction and chronic inflammation in psoriatic arthritis (PsA), positioning glucose and lipid abnormalities not only as comorbidities but as active contributors to…
View article: Sex differences in systemic sclerosis: from pathogenesis to clinical manifestations and treatment
Sex differences in systemic sclerosis: from pathogenesis to clinical manifestations and treatment Open
Systemic sclerosis (SSc) exhibits sex-related disparities in prevalence, clinical features, and outcomes. While women are more frequently affected, men often experience a more severe disease course, including diffuse cutaneous involvement,…
View article: Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry
Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry Open
Objectives To detect factors capable of predicting the development of macular edema (ME) throughout the disease course in patients affected by non-infectious uveitis (NIU). Methods Predictive factors leading to the development of ME were a…
View article: Guselkumab Efficacy in Biologic-Naïve Participants with Psoriatic Arthritis and Severe Disease Activity: Post Hoc Analysis of a Phase 3 Study
Guselkumab Efficacy in Biologic-Naïve Participants with Psoriatic Arthritis and Severe Disease Activity: Post Hoc Analysis of a Phase 3 Study Open
ClinicalTrials.gov, NCT03158285.
View article: Validation of “Clinical Red Flags” for RA-ILD in an Italian cohort
Validation of “Clinical Red Flags” for RA-ILD in an Italian cohort Open
Introduction Rheumatoid arthritis (RA) is a systemic inflammatory disease, characterized by articular and extra-articular manifestations, including Interstitial Lung Disease (ILD). An early diagnosis of ILD can be essential in improving di…
View article: Violações e violência sexual na campanha de Alexandre
Violações e violência sexual na campanha de Alexandre Open
This article aims to offer a preliminary exploration of sexual violence and violence against women during the Macedonian campaign of conquest in Asia (334–232 BCE) and the reign of Alexander the Great (336–323 BCE). To address the troublin…
View article: Italian Multicenter Real-World Study on the Twelve-Month Effectiveness, Safety, and Retention Rate of Guselkumab in Psoriatic Arthritis Patients
Italian Multicenter Real-World Study on the Twelve-Month Effectiveness, Safety, and Retention Rate of Guselkumab in Psoriatic Arthritis Patients Open
Background/Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory condition that primarily affects the musculoskeletal system and skin. While biologic and targeted synthetic DMARDs have improved treatment, many patients still fail…
View article: Upadacitinib for the treatment of radiographic axial spondyloarthritis — case series and review of the literature
Upadacitinib for the treatment of radiographic axial spondyloarthritis — case series and review of the literature Open
Upadacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of different rheumatic diseases, including axial spondyloarthritis (axSpA). In phase III clinical trials, upadacitinib was associated with rapid and significant impr…
View article: Anti-SARS-CoV-2 B and T-Cell Immune Responses Persist 12 Months After mRNA Vaccination with BNT162b2 in Systemic Lupus Erythematosus Patients Independently of Immunosuppressive Therapies
Anti-SARS-CoV-2 B and T-Cell Immune Responses Persist 12 Months After mRNA Vaccination with BNT162b2 in Systemic Lupus Erythematosus Patients Independently of Immunosuppressive Therapies Open
Background: In response to the SARS-CoV-2 pandemic, a massive vaccination campaign was launched. Nonetheless, concerns arose regarding some peculiar groups of patients, including those affected by Systemic Lupus Erythematosus (SLE), becaus…