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View article: Symbiotic bacteria Sodalis glossinidius, Spiroplasma sp and Wolbachia do not favour Trypanosoma grayi coexistence in wild population of tsetse flies collected in Bobo-Dioulasso, Burkina Faso
Symbiotic bacteria Sodalis glossinidius, Spiroplasma sp and Wolbachia do not favour Trypanosoma grayi coexistence in wild population of tsetse flies collected in Bobo-Dioulasso, Burkina Faso Open
Background. Tsetse flies, the biological vectors of African trypanosomes, have established symbiotic associations with different bacteria. Their vector competence is suggested to be affected by bacterial endosymbionts. The current study pr…
View article: Transient Exposure of Humans to Animal Trypanosomes in Communities Highly Exposed to Tsetse Fly Bite
Transient Exposure of Humans to Animal Trypanosomes in Communities Highly Exposed to Tsetse Fly Bite Open
Case reports of some Trypanosomes (Trypanosoma congolense, Trypanosoma evansi, Trypanosoma brucei brucei, and Trypanosoma vivax) thought to be natural parasites only to animals have been reported to cause “atypical human trypanosomiasis” (…
View article: The Transmission of Animal African Trypanosomiasis in Two Districts in the Forest Zone of Ghana
The Transmission of Animal African Trypanosomiasis in Two Districts in the Forest Zone of Ghana Open
Animal African trypanosomiasis, also known as nagana, is caused by Trypanosoma species, which cause significant clinical diseases and lead to losses in animal production. We carried out a cross-sectional survey to investigate the compositi…
View article: Towards More Sustainable Food Systems
Towards More Sustainable Food Systems Open
Food systems are under increasing pressure. They must meet the food requirements of a growing world population, and socio-economic changes also influence the type of foods which are under demand. At the same time, food systems are a major …
View article: Molecular detection of Sodalis glossinidius, Spiroplasma species and Wolbachia endosymbionts in wild population of tsetse flies collected in Cameroon, Chad and Nigeria
Molecular detection of Sodalis glossinidius, Spiroplasma species and Wolbachia endosymbionts in wild population of tsetse flies collected in Cameroon, Chad and Nigeria Open
Background Tsetse flies are cyclical vectors of African trypanosomiasis (AT). The flies have established symbiotic associations with different bacteria that influence certain aspects of their physiology. Vector competence of tsetse flies f…
View article: Molecular Detection of Trypanosomes and Xenomonitoring of Host Range from the Feeding Patterns of Glossina Species Collected from Northern Guinea Savannah of Nigeria
Molecular Detection of Trypanosomes and Xenomonitoring of Host Range from the Feeding Patterns of Glossina Species Collected from Northern Guinea Savannah of Nigeria Open
Background Trypanosomiasis is a vector-borne protozoan disease that is widespread in sub-Saharan Africa. In Nigeria, efforts to control trypanosomiasis include vector control, diagnosis, and treatment of the infection. These efforts exclud…
View article: Molecular detection of Sodalis glossinidius, Spiroplasma and Wolbachia endosymbionts in wild population of tsetse flies collected in Cameroon, Chad and Nigeria
Molecular detection of Sodalis glossinidius, Spiroplasma and Wolbachia endosymbionts in wild population of tsetse flies collected in Cameroon, Chad and Nigeria Open
Background Tsetse flies are cyclical vectors of African trypanosomiasis. They have established symbiotic associations with different bacteria, which influence certain aspects of their physiology. The vector competence of tsetse flies for d…
View article: N-glycosylation modulates enzymatic activity of Trypanosoma congolense trans-sialidase
N-glycosylation modulates enzymatic activity of Trypanosoma congolense trans-sialidase Open
Trypanosomes cause the devastating disease trypanosomiasis, in which the action of trans-sialidase (TS) enzymes harbored on their surface is a key virulence factor. TS enzymes are N-glycosylated, but the biological functions of their glyca…
View article: Anti SARS-CoV-2 seroprevalence in Zanzibar in 2021 before the Omicron wave
Anti SARS-CoV-2 seroprevalence in Zanzibar in 2021 before the Omicron wave Open
The antibody levels observed were most likely due to previous infections with SARS-CoV-2, since vaccination was generally not available before the survey. Therefore, this study offers the first insights into how many Zanzibari had COVID-19…
View article: Anti SARS-CoV2 seroprevalence in Zanzibar in 2021 before the Omicron wave
Anti SARS-CoV2 seroprevalence in Zanzibar in 2021 before the Omicron wave Open
Objectives For Tanzania including Zanzibar, the development of the COVID-19 pandemic has remained unclear, since reporting cases was suspended during 2020/21. The present study provides first data on the COVID-19 seroprevalence among Zanzi…
View article: Cooperativity of catalytic and lectin-like domain of Trypanosoma congolense trans-sialidase modulates its catalytic activity
Cooperativity of catalytic and lectin-like domain of Trypanosoma congolense trans-sialidase modulates its catalytic activity Open
Trans-sialidases (TS) represent a multi-gene family of unusual enzymes, which catalyse the transfer of terminal sialic acids (Sia) from sialoglycoconjugates to terminal galactose or N -acetylgalactosamine residues of oligosaccharides witho…
View article: Sugar-decorated carbon dots: a novel tool for targeting immunomodulatory receptors
Sugar-decorated carbon dots: a novel tool for targeting immunomodulatory receptors Open
Interactions between sialic acid (Sia) and sialic acid-binding immunoglobulin-like lectins (siglecs) regulate the immune system, with aberrations contributing to pathologies such as autoimmunity, infectious disease and cancer.
View article: <i>N</i>-glycosylation modulates enzymatic activity of<i>Trypanosoma congolense</i>trans-sialidase
<i>N</i>-glycosylation modulates enzymatic activity of<i>Trypanosoma congolense</i>trans-sialidase Open
Trypanosomes cause the devastating disease trypanosomiasis, in which the action of trans-sialidase (TS) enzymes harbored on their surface is a key virulence factor. TS are N -glycosylated, but the biological functions of their glycans has …
View article: The role of sialic acid-binding immunoglobulin-like-lectin-1 (siglec-1) in immunology and infectious disease
The role of sialic acid-binding immunoglobulin-like-lectin-1 (siglec-1) in immunology and infectious disease Open
Siglec-1, also known as Sialoadhesin (Sn) and CD169 is highly conserved among vertebrates and with 17 immunoglobulin-like domains is Siglec-1 the largest member of the Siglec family. Expression of Siglec-1 is found primarily on dendritic c…
View article: The transmission of African Animal Trypanosomiasis (Nagana) in two districts in the forest zone of Ghana
The transmission of African Animal Trypanosomiasis (Nagana) in two districts in the forest zone of Ghana Open
The African Animal Trypanosomiasis (nagana) is caused by several species of trypanosome species which results in significant clinical diseases. This consequently leads to huge economic losses. We carried out a cross-sectional survey to inv…
View article: Replication Data for: The transmission of African Animal Trypanosomiasis (nagana) in two districts in the forest zone of Ghana
Replication Data for: The transmission of African Animal Trypanosomiasis (nagana) in two districts in the forest zone of Ghana Open
Transmission of Trypanosomiasis, data on parasite prevalence among Tsetse fly, Pigs and Cattle
View article: Diversity of trypanosomes in humans and cattle in the HAT foci Mandoul and Maro, Southern Chad—A matter of concern for zoonotic potential?
Diversity of trypanosomes in humans and cattle in the HAT foci Mandoul and Maro, Southern Chad—A matter of concern for zoonotic potential? Open
Background African trypanosomes are parasites mainly transmitted by tsetse flies. They cause trypanosomiasis in humans (HAT) and animals (AAT). In Chad, HAT/AAT are endemic. This study investigates the diversity and distribution of trypano…
View article: Diversity of tsetse flies and trypanosome species circulating in the area of Lake Iro in southeastern Chad
Diversity of tsetse flies and trypanosome species circulating in the area of Lake Iro in southeastern Chad Open
Background African trypanosomiases are vector-borne diseases that affect humans and livestock in sub-Saharan Africa. Although data have been collected on tsetse fauna as well as trypanosome infections in tsetse flies and mammals in foci of…
View article: Cooperativity of catalytic and lectin-like domain of<i>T. congolense</i>trans-sialidase modulates its catalytic activity
Cooperativity of catalytic and lectin-like domain of<i>T. congolense</i>trans-sialidase modulates its catalytic activity Open
Trans-sialidases (TS) represent a multi-gene family of unusual enzymes, which catalyse the transfer of terminal sialic acids from sialoglycoconjugates to terminal galactose or N -acetylgalactosamine residues of oligosaccharides without the…
View article: Sodalis Glossinidius and Wolbachia Infections in Wild Population of Glossina Morsitans Submorsitans Caught in the Area of Lake Iro in the South of Chad
Sodalis Glossinidius and Wolbachia Infections in Wild Population of Glossina Morsitans Submorsitans Caught in the Area of Lake Iro in the South of Chad Open
Background: To improve vector control of tsetse transmitted trypanosomiases through a better understanging of the vectorial competence of tsetse flies, investigations have been undertaken on the bacterial fauna of different tsetse species.…
View article: The association between leptin and inflammatory markers with obesity indices in Zanzibari children, adolescents, and adults
The association between leptin and inflammatory markers with obesity indices in Zanzibari children, adolescents, and adults Open
Background Research from Western populations describes abdominal obesity as a low‐grade inflammatory disease; less is known from tropical areas with high pathogen burden. Objectives This cross‐sectional study investigated whether obesity c…
View article: Molecular and morphological characterization of Glossina sp. and identification of associated Trypanosoma sp. in Nigeria including analysis for sialidase activity
Molecular and morphological characterization of Glossina sp. and identification of associated Trypanosoma sp. in Nigeria including analysis for sialidase activity Open
These data sets include morphological and molecular data generated from a tsetse (Glossina sp.) collection carried out in Nigeria between 2014 and 2016. Traps were employed for one to three days in four different National Parks (Kainji Lak…
View article: Anthropometric and Biochemical Predictors for Hypertension in a Cross-Sectional Study in Zanzibar, Tanzania
Anthropometric and Biochemical Predictors for Hypertension in a Cross-Sectional Study in Zanzibar, Tanzania Open
Background: Aim of this study was to describe the proportion of hypertension among Zanzibari of different age-groups and to detect possible correlates of this non-communicable disease. Methods: In 2013 a cross-sectional survey was conducte…
View article: Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin
Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin Open
Inflammatory processes in the skin augment collagen degradation due to the up-regulation of matrix metalloproteinases (MMPs). The aim of the present project was to study the specific impact of MMP-3 on collagen loss in skin and its interpl…
View article: Widespread co-endemicity of Trypanosoma species infecting cattle in the Sudano-Sahelian and Guinea Savannah zones of Cameroon
Widespread co-endemicity of Trypanosoma species infecting cattle in the Sudano-Sahelian and Guinea Savannah zones of Cameroon Open
Background African animal trypanosomosis remains the major constraint of livestock production and livelihood of pastoral communities in Cameroon. Despite several decades of vector and parasite control efforts, it has not been eradicated. A…
View article: Genetic diversity of trypanosome species in tsetse flies (Glossina spp.) in Nigeria
Genetic diversity of trypanosome species in tsetse flies (Glossina spp.) in Nigeria Open
Background Trypanosomes cause disease in humans and livestock in sub-Saharan Africa and rely on tsetse flies as their main insect vector. Nigeria is the most populous country in Africa; however, only limited information about the occurrenc…