Sheila Sprague
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View article: The Surveillance After Extremity Tumor Surgery (SAFETY) Pilot International Multi-Center Randomized Controlled Trial
The Surveillance After Extremity Tumor Surgery (SAFETY) Pilot International Multi-Center Randomized Controlled Trial Open
Soft-tissue sarcomas (STSs) are rare malignancies predominantly found in the extremities. Surgery and radiation are standard treatments, but post-operative pulmonary surveillance, involving clinical visits and thoracic imaging, is crucial …
View article: Infection and Nonunion Rates in Open Fractures
Infection and Nonunion Rates in Open Fractures Open
Background: Infection and nonunion are common sequelae of open fractures. Studies have shown infection and nonunion rates ranging from 2% to 52% and 12% to 17%, respectively. The present article describes the rates of surgical site infecti…
View article: Retraction notice to Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: the TOGETHER randomized platform clinical trial [The Lancet Regional Health–Americas Volume 6, February 2022, 100142]
Retraction notice to Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: the TOGETHER randomized platform clinical trial [The Lancet Regional Health–Americas Volume 6, February 2022, 100142] Open
[This retracts the article DOI: 10.1016/j.lana.2021.100142.].
View article: Help seeking for intimate partner violence in a resource-constrained setting: A latent class analysis of the Nigerian demographic health survey dataset
Help seeking for intimate partner violence in a resource-constrained setting: A latent class analysis of the Nigerian demographic health survey dataset Open
Help seeking for intimate partner violence (IPV) is a complex process that involves reaching out to an external party. Women in resource constrained settings face unique constraints when seeking help for IPV but the latent classes of their…
View article: Job Satisfaction of Research Personnel in Orthopaedic Trauma Surgery
Job Satisfaction of Research Personnel in Orthopaedic Trauma Surgery Open
Background: The role of research personnel (e.g., research assistants, research coordinators, research managers, etc.) is critical to the success of clinical trials in orthopaedic surgery. Retention of research personnel is a challenge fac…
View article: Revisiting the FAITH Trial: A Secondary Analysis Yielding Novel Insights with the Win Ratio
Revisiting the FAITH Trial: A Secondary Analysis Yielding Novel Insights with the Win Ratio Open
Background: Many orthopaedic trials use any unplanned reoperation as the primary outcome, but this overlooks how patients experience those outcomes. Using a high-quality hip fracture trial, we demonstrate how the relative importance of mul…
View article: Perceptions of barriers and facilitators to opioid reduction after total joint arthroplasty among orthopedic surgeons practicing in Canada, Japan, and the Netherlands: A qualitative description study
Perceptions of barriers and facilitators to opioid reduction after total joint arthroplasty among orthopedic surgeons practicing in Canada, Japan, and the Netherlands: A qualitative description study Open
Opioid analgesics are commonly prescribed after total knee and hip arthroplasty to manage pain. Rates of opioid prescribing after arthroplasty differ by country, suggesting differences in policies or surgeons’ practices. We adopted a quali…
View article: Efficacy of biomarkers in the endochondral phase of fracture repair and healing in long bones: A clinical observational studys
Efficacy of biomarkers in the endochondral phase of fracture repair and healing in long bones: A clinical observational studys Open
Background Clinical determination of bone fracture healing remains qualitative, typically determined through the combination of plain film radiographs, clinical assessment, and patient-reported pain. Importantly, standard radiographs can o…
View article: Orthopaedic surgeons' perspectives on peripheral nerve blocks for surgical fixation of hip fractures in older adults
Orthopaedic surgeons' perspectives on peripheral nerve blocks for surgical fixation of hip fractures in older adults Open
Objectives: This study aimed to identify factors influencing orthopaedic surgeons' decision to request peripheral nerve blocks (PNBs) for older adults undergoing hip fracture surgery and to assess the need for further research. Design: A c…
View article: When would orthopaedic surgeons perform arthroplasty for a femoral neck fracture in an older adult?
When would orthopaedic surgeons perform arthroplasty for a femoral neck fracture in an older adult? Open
Purpose Minimally displaced femoral neck fractures (FNFs) in older adults have traditionally been managed with internal fixation (IF). However, emerging evidence suggests arthroplasty may provide better outcomes. We sought to determine sur…
View article: The Design of a Patient-Centered Hierarchal Composite Outcome for a Multi-Center Randomized Controlled Trial in Metastatic Bone Disease
The Design of a Patient-Centered Hierarchal Composite Outcome for a Multi-Center Randomized Controlled Trial in Metastatic Bone Disease Open
The proximal femur represents the most frequent site in the appendicular skeleton for metastatic bone disease (MBD) to occur, with a high risk for pathologic fracture. While surgical stabilization is typically used to manage fractures, rec…
View article: How does internal fixation compared with arthroplasty affect quality of life for patients who have suffered femoral neck fractures?
How does internal fixation compared with arthroplasty affect quality of life for patients who have suffered femoral neck fractures? Open
Objectives: To evaluate functional outcomes amongst femoral neck fracture trial participants who did not undergo reoperation. Design: Secondary analysis of 2 randomized controlled trials. Setting: Ninety hospitals in 5 continents. Particip…
View article: An Evidence Map of the Women Veterans’ Health Literature, 2016 to 2023
An Evidence Map of the Women Veterans’ Health Literature, 2016 to 2023 Open
Importance Women veterans are the fastest-growing veteran subpopulation in the US. Women veterans often experience military service–related health issues in addition to conditions common to all women. Because women veterans are more likely…
View article: Reasons for declining to participate in a trial of online cognitive behavioural therapy following orthopaedic trauma: A mixed methods study
Reasons for declining to participate in a trial of online cognitive behavioural therapy following orthopaedic trauma: A mixed methods study Open
The timely enrollment of study participants is critical to the success of clinical trials. Understanding factors that contribute to patients’ decision to participate in trials involving online cognitive behavioural therapy for pain managem…
View article: Cognitive Behavioural Therapy to Optimize Post-Operative Recovery (COPE): a randomized controlled feasibility trial in extremity fracture patients
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery (COPE): a randomized controlled feasibility trial in extremity fracture patients Open
gov/ct2/show/NCT04274530 .
View article: Predictors of Response to Medical Cannabis for Chronic Pain: A Retrospective Review of Real-Time Observational Data
Predictors of Response to Medical Cannabis for Chronic Pain: A Retrospective Review of Real-Time Observational Data Open
Objective: People living with chronic pain increasingly use medical cannabis for symptom relief. We conducted a retrospective cohort study examining cannabis for chronic pain relief using anonymous archival data obtained from the medicinal…
View article: The ROADS project: Road observational assessment of driving distractions
The ROADS project: Road observational assessment of driving distractions Open
This data can be applied towards driver education programs counseling drivers on dangerous distracting behaviors, as well as influencing legislature, informing, and providing law enforcement insight into worrisome patterns of distracted dr…
View article: Nutritional Indicators of Bone Nonunion: A Systematic Review
Nutritional Indicators of Bone Nonunion: A Systematic Review Open
Background/Objectives: Bone nonunion remains a clinical challenge in orthopedic surgery with significant impacts on mental and physical wellbeing for patients. There are several previously established risk factors of nonunion that are conn…
View article: Osteochondroplasty with or without labral repair is more cost-effective than arthroscopic lavage with or without labral repair for treatment of young adults with femoroacetabular impingement: A cost-utility analysis based on data from a randomized controlled trial
Osteochondroplasty with or without labral repair is more cost-effective than arthroscopic lavage with or without labral repair for treatment of young adults with femoroacetabular impingement: A cost-utility analysis based on data from a randomized controlled trial Open
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View article: Time from injury to hip-fracture surgery in low-income and middle-income regions: a secondary analysis of data from the International Orthopaedic Multicentre Study in Fracture Care (INORMUS)
Time from injury to hip-fracture surgery in low-income and middle-income regions: a secondary analysis of data from the International Orthopaedic Multicentre Study in Fracture Care (INORMUS) Open
The National Health and Medical Research Council of Australia, the Canadian Institutes of Health Research, McMaster Surgical Associates, Hamilton Health Sciences, and the US National Institutes of Health.
View article: The response of Canada’s clinical health research ecosystem to the COVID-19 pandemic
The response of Canada’s clinical health research ecosystem to the COVID-19 pandemic Open
A minority of Canadian hospitals enrolled the majority of participants in CIHR-funded studies on COVID-19. This analysis sheds light on the Canadian health research ecosystem and provides information for multiple key partners to consider w…
View article: A Pilot Feasibility Randomized Controlled Trial of Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit: The Lessening Organ Dysfunction with Vitamin C-India (LOVIT-India) Trial
A Pilot Feasibility Randomized Controlled Trial of Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit: The Lessening Organ Dysfunction with Vitamin C-India (LOVIT-India) Trial Open
Vijayaraghavan BKT, Venkataraman R, Ramanathan Y, Margabandhu S, Jayakumar D, Ramachandran P, et al. A Pilot Feasibility Randomized Controlled Trial of Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit: The Lessening O…
View article: Cost-effectiveness analysis of the Geriatric Fracture Center (GFC) concept: a prospective multicentre cohort study
Cost-effectiveness analysis of the Geriatric Fracture Center (GFC) concept: a prospective multicentre cohort study Open
Introduction Geriatric Fracture Centers (GFCs) are dedicated treatment units where care is tailored towards elderly patients who have suffered fragility fractures. The primary objective of this economic analysis was to determine the cost-u…
View article: Pragmatic design and inclusion of patient–partner representatives improves participant experience in clinical research
Pragmatic design and inclusion of patient–partner representatives improves participant experience in clinical research Open
Objectives: Patient engagement in the design and implementation of clinical trials is necessary to ensure that the research is relevant and responsive to patients. The PREP-IT trials, which include 2 pragmatic trials that evaluate differen…
View article: Reamed compared with unreamed nailing of tibial shaft fractures: Does the initial method of nail insertion influence outcome in patients requiring reoperations?
Reamed compared with unreamed nailing of tibial shaft fractures: Does the initial method of nail insertion influence outcome in patients requiring reoperations? Open
gov, no. NCT00038129.