Stephan Windecker
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View article: Obstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement
Obstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement Open
Importance Aortic stenosis (AS) and obstructive coronary artery disease (CAD) often coexist, yet the impact of obstructive CAD on clinical and patient-reported outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) r…
View article: Association of Body Mass Index on 10-Year Outcomes in Patients Treated with Percutaneous Coronary Intervention and Drug-Eluting Stents (the DECADE Cooperation)
Association of Body Mass Index on 10-Year Outcomes in Patients Treated with Percutaneous Coronary Intervention and Drug-Eluting Stents (the DECADE Cooperation) Open
Aim To assess the association between body mass index (BMI) and 10-year clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation. Methods This is a pooled analysis of 5 ra…
View article: Transcatheter Treatment of Bicuspid Aortic Valve Stenosis: From Observational Studies to Randomized Clinical Trials
Transcatheter Treatment of Bicuspid Aortic Valve Stenosis: From Observational Studies to Randomized Clinical Trials Open
Bicuspid aortic valve (BAV) disease is the most common congenital heart abnormality, which affects up to 2% of the population and significantly increases the lifetime risk of aortic stenosis and the need for valve replacement. While surgic…
View article: Left Atrial Appendage Occlusion Using the Amplatzer Amulet Device in High-Risk Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Intervention: A Randomized Pilot Study
Left Atrial Appendage Occlusion Using the Amplatzer Amulet Device in High-Risk Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Intervention: A Randomized Pilot Study Open
View article: Revascularization in Ischemic Left Ventricular Dysfunction: a pathophysiology-guided, evidence-based approach
Revascularization in Ischemic Left Ventricular Dysfunction: a pathophysiology-guided, evidence-based approach Open
Ischemic left ventricular dysfunction (iLVD) is the most prevalent cause of heart failure with reduced ejection fraction and is associated with higher mortality than non-ischemic cardiomyopathy. Coronary revascularization was once routinel…
View article: Long-Term Outcomes in Moderate and Severe Aortic Stenosis According to Extent of Cardiac Damage
Long-Term Outcomes in Moderate and Severe Aortic Stenosis According to Extent of Cardiac Damage Open
Ten-year mortality in patients with moderate and severe AS is importantly determined by CD extent. AVR was associated with lower mortality in patients with moderate AS and advanced CD.
View article: Recommended methodologies for clinical investigations of high-risk medical devices—Conclusions from the European Union CORE–MD Project
Recommended methodologies for clinical investigations of high-risk medical devices—Conclusions from the European Union CORE–MD Project Open
The CORE-MD project was funded as a Coordination and Support action from the European UnionHorizon 2020 research and innovation programme, under grant agreement 965246.
View article: Noninvasive Anatomical and Functional Imaging for Hemodynamic Relevance in Right Coronary Artery Anomalies
Noninvasive Anatomical and Functional Imaging for Hemodynamic Relevance in Right Coronary Artery Anomalies Open
Importance Right anomalous aortic origin of a coronary artery (R-AAOCA) is a rare congenital condition increasingly diagnosed with the growing use of cardiac imaging. Due to dynamic compression of the anomalous vessel, invasive fractional …
View article: CT assessment of right heart anatomy across tricuspid regurgitation severity grades: implications for transcatheter interventions
CT assessment of right heart anatomy across tricuspid regurgitation severity grades: implications for transcatheter interventions Open
Purpose A five-grade severity scheme has been introduced for echocardiographic grading of tricuspid regurgitation (TR). Although higher TR grades have been associated with worse prognosis, it is unknown whether they can help determining pa…
View article: Management of bicuspid aortic stenosis
Management of bicuspid aortic stenosis Open
Aims Bicuspid aortic valve (BAV) disease is the most common congenital heart lesion and is associated with premature leaflet degeneration, aortic stenosis (AS), aortic regurgitation (AR), endocarditis, and ascending aortic pathologies. Thi…
View article: Intake of high-intensity statin after acute myocardial infarction assessed by direct drug concentration measurement: association with LDL-C response and coronary plaque modifications in the PACMAN-AMI trial
Intake of high-intensity statin after acute myocardial infarction assessed by direct drug concentration measurement: association with LDL-C response and coronary plaque modifications in the PACMAN-AMI trial Open
Background In real-world settings, adherence to preventive cardiovascular medications is often suboptimal. However, in clinical trials, adherence is crucial for ensuring the validity and generalizability of study results, and their clinica…
View article: Interdisciplinary Periprocedural Management of Patients Undergoing Transapical TMVI with the Tendyne System: A Narrative Review and Institutional Experience
Interdisciplinary Periprocedural Management of Patients Undergoing Transapical TMVI with the Tendyne System: A Narrative Review and Institutional Experience Open
Objectives Mitral regurgitation (MR) represents the most common valvular heart disease (VHD) in the Western world. While transcatheter mitral valve repair (M-TEER) is the leading interventional treatment for surgically high-risk patients, …
View article: Educational level, clinical outcomes and quality of care in a Swiss cohort of patients with acute coronary syndromes
Educational level, clinical outcomes and quality of care in a Swiss cohort of patients with acute coronary syndromes Open
Background Despite universal coverage, inequities persist in acute coronary syndrome (ACS) care. This study examines how educational levels impact the quality and outcomes of health care. Methods A cohort of ACS patients hospitalized in fi…
View article: Colchicine in patients with aortic stenosis undergoing transcatheter aortic valve replacement: a double-blind randomized trial
Colchicine in patients with aortic stenosis undergoing transcatheter aortic valve replacement: a double-blind randomized trial Open
An inflammatory process may increase the risk of arrhythmias after transcatheter aortic valve replacement (TAVR). In this single-centre, double-blind, placebo-controlled, randomized trial we investigated the efficacy of colchicine to reduc…
View article: 72355 | Long-Term Continuous Rhythm Monitoring in Patients Undergoing Transcatheter Tricuspid Valve Replacement
72355 | Long-Term Continuous Rhythm Monitoring in Patients Undergoing Transcatheter Tricuspid Valve Replacement Open
View article: Impact of Noncoaxial Transcatheter Aortic Valve Implantation on Clinical Outcomes
Impact of Noncoaxial Transcatheter Aortic Valve Implantation on Clinical Outcomes Open
Noncoaxial THV deployment is associated with impaired valve early safety and increased risk of bioprosthetic valve failure 1 year after TAVR.
View article: Clinical Outcomes in Patients With Acute Pulmonary Embolism Undergoing Ultrasound‐Assisted Catheter‐Directed Thrombolysis
Clinical Outcomes in Patients With Acute Pulmonary Embolism Undergoing Ultrasound‐Assisted Catheter‐Directed Thrombolysis Open
Background Ultrasound‐assisted catheter‐directed thrombolysis (USAT) for acute pulmonary embolism (PE) has garnered specific interest and is commonly employed in intermediate‐risk PE to prevent cardiac decompensation and death. However, ev…
View article: Smoking Status at Baseline and 10-Year Outcomes After Drug-Eluting Stent Implantation
Smoking Status at Baseline and 10-Year Outcomes After Drug-Eluting Stent Implantation Open
In patients undergoing PCI with DES, smoking at baseline is associated with an increased risk of death, MI, and ST, but a lower risk of repeat revascularization through to 10 years.
View article: Impacto de la tortuosidad de las arterias coronarias en los resultados del implante de stent farmacoactivo de nueva generación: un análisis de los estudios aleatorizados BIOFLOW
Impacto de la tortuosidad de las arterias coronarias en los resultados del implante de stent farmacoactivo de nueva generación: un análisis de los estudios aleatorizados BIOFLOW Open
View article: Treatment of Mitral and Tricuspid Atrioventricular Valve Disease by Double Transcatheter Valve Replacement
Treatment of Mitral and Tricuspid Atrioventricular Valve Disease by Double Transcatheter Valve Replacement Open
This case report illustrates a novel staged transcatheter approach for managing concomitant mitral and tricuspid valve disease in a high-risk surgical patient. A 79-year-old man with severe mitral regurgitation and secondary tricuspid regu…
View article: Simplified Outcome Prediction in Patients Undergoing Transcatheter Tricuspid Valve Intervention by Survival Tree-Based Modelling
Simplified Outcome Prediction in Patients Undergoing Transcatheter Tricuspid Valve Intervention by Survival Tree-Based Modelling Open
View article: Impact of coronary artery tortuosity on outcomes following stenting with newer-generation drug-eluting stents. An analysis of the randomized BIOFLOW trials
Impact of coronary artery tortuosity on outcomes following stenting with newer-generation drug-eluting stents. An analysis of the randomized BIOFLOW trials Open
Clinicaltrials.gov NCT01356888, NCT01939249, NCT02389946.
View article: Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antiplatelet strategy?
Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antiplatelet strategy? Open
Background and aims Due to the multitude of risk factors outlined in the guidelines, personalised dual antiplatelet therapy (DAPT) guidance after percutaneous coronary intervention (PCI) is complex. A simplified method was created to facil…
View article: Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland
Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland Open
Objectives To assess the association between the intensity of statin therapy and the level of physical activity in patients 1 year after an acute coronary syndrome (ACS). Design Prospective cohort study from the Special Program University …
View article: Hemodynamic Valve Deterioration After Transcatheter Aortic Valve Replacement
Hemodynamic Valve Deterioration After Transcatheter Aortic Valve Replacement Open
HVD occurred in up to 1 in 4 patients throughout 10-year post-TAVR and was associated with a 5-fold increase in the risk of aortic valve reintervention.
View article: Three‐Year Outcomes With a Supra‐Annular, Self‐Expanding Bioprosthesis and a Pericardial Wrap—The FORWARD PRO Study
Three‐Year Outcomes With a Supra‐Annular, Self‐Expanding Bioprosthesis and a Pericardial Wrap—The FORWARD PRO Study Open
Background The self‐expanding, supra‐annular Evolut valve is an established platform for Transcatheter Aortic Valve Implantation (TAVI). Evolut PRO introduced an outer sealing wrap to mitigate paravalvular leakage. We evaluated the 3‐year …
View article: Flow Status-Based Predicted Prosthesis-Patient Mismatch in Patients Undergoing Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve
Flow Status-Based Predicted Prosthesis-Patient Mismatch in Patients Undergoing Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve Open
View article: Abbreviated or Standard Antiplatelet Therapy After PCI in Diabetic Patients at High Bleeding Risk
Abbreviated or Standard Antiplatelet Therapy After PCI in Diabetic Patients at High Bleeding Risk Open
View article: Timing of Aortic Valve Intervention in the Management of Aortic Stenosis
Timing of Aortic Valve Intervention in the Management of Aortic Stenosis Open
Aortic stenosis (AS) affects about 12% of people aged ≥75 years. Accumulating evidence on the prognostic importance of cardiac damage in patients with asymptomatic and less than severe AS supports the proposition of advancing aortic valve …
View article: Apixaban and Limiting Aspirin for Patients With Atrial Fibrillation, Percutaneous Coronary Intervention, and Multimorbidity
Apixaban and Limiting Aspirin for Patients With Atrial Fibrillation, Percutaneous Coronary Intervention, and Multimorbidity Open