Andreas Sturm
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Variational Quantum Algorithms for Differential Equations on a Noisy Quantum Computer Open
The role of differential equations (DEs) in science and engineering is of paramount importance, as they provide the mathematical framework for a multitude of natural phenomena. Since quantum computers promise significant advantages over cl…
Diagnostic delay in inflammatory bowel diseases in a German population Open
BACKGROUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease (IBD). Risk factor analyses linked with delayed diagnosis in European IBD patients are scarce and no data in German IBD patients exists. AIM To identif…
Residual Disease Burden Among European Patients With Inflammatory Bowel Disease: A Real-World Survey Open
Background Understanding disease burden is imperative for improving inflammatory bowel disease (IBD) management. This real-world survey investigated residual disease burden and treatment satisfaction among European patients with moderate-t…
Variational Quantum Algorithms for Differential Equations on a Noisy Quantum Computer Open
The role of differential equations (DEs) in science and engineering is of paramount importance, as they provide the mathematical framework for a multitude of natural phenomena. Since quantum computers promise significant advantages over cl…
Unlocking Quantum Optimization: A Use Case Study on NISQ Systems Open
The major advances in quantum computing over the last few decades have sparked great interest in applying it to solve the most challenging computational problems in a wide variety of areas. One of the most pronounced domains here are optim…
Glutaryl-CoA Dehydrogenase Misfolding in Glutaric Acidemia Type 1 Open
Glutaric acidemia type 1 (GA1) is a neurotoxic metabolic disorder due to glutaryl-CoA dehydrogenase (GCDH) deficiency. The high number of missense variants associated with the disease and their impact on GCDH activity suggest that disturbe…
Electrophoretic deposition of gentamicin and chitosan into titanium nanotubes to target periprosthetic joint infection Open
Periprosthetic joint infection (PJI) occurs in 1%–2% of primary total hip and knee arthroplasties; the rate can reach 20% in individuals at risk. Due to the low local bioavailability of systemic antibiotics and possible off‐target effects,…
Data from Systematic High-Content Proteomic Analysis Reveals Substantial Immunologic Changes in Colorectal Cancer Open
The immune system is a significant determinant of epithelial tumorigenesis, but its role in colorectal cancer pathogenesis is not well understood. The function of the immune system depends upon the integrity of the protein network environm…
Data from Systematic High-Content Proteomic Analysis Reveals Substantial Immunologic Changes in Colorectal Cancer Open
The immune system is a significant determinant of epithelial tumorigenesis, but its role in colorectal cancer pathogenesis is not well understood. The function of the immune system depends upon the integrity of the protein network environm…
Supplementary Table 1 from Systematic High-Content Proteomic Analysis Reveals Substantial Immunologic Changes in Colorectal Cancer Open
Supplementary Table 1 from Systematic High-Content Proteomic Analysis Reveals Substantial Immunologic Changes in Colorectal Cancer
Supplementary Table 1 from Systematic High-Content Proteomic Analysis Reveals Substantial Immunologic Changes in Colorectal Cancer Open
Supplementary Table 1 from Systematic High-Content Proteomic Analysis Reveals Substantial Immunologic Changes in Colorectal Cancer
P624 Investigating the symptom burden among European patients with moderate-to-severe Crohn’s disease using a real-world survey Open
Background Despite treatment, patients with Crohn’s disease (CD) experience symptoms that affect their health-related quality of life (HRQoL). Understanding how CD affects HRQoL reveals valuable insight into disease impact. We aimed to exa…
Theory and Implementation of the Quantum Approximate Optimization Algorithm: A Comprehensible Introduction and Case Study Using Qiskit and IBM Quantum Computers Open
The present tutorial aims to provide a comprehensible and easily accessible introduction into the theory and implementation of the famous Quantum Approximate Optimization Algorithm (QAOA). We lay our focus on practical aspects and step-by-…
Laser-equipped gas reaction chamber for probing environmentally sensitive materials at near atomic scale Open
Five atom probe datasets as featured in the PLOSone journal concerning the methodology of laser-assisted thermochemical gas treatments of atom probe needles, two comparing the deuterium charged and uncharged states of a steel and comparing…
Addendum to S3-Guidelines Crohn’s disease and ulcerative colitis: Management of Patients with Inflammatory Bowel Disease in the COVID-19 Pandemic – open questions and answers Open
The COVID-19 pandemic is a global outbreak of new onset infections with the SARS-CoV-2 virus. To date, more than 3.4 million people have been infected throughout the world. In Germany, approximately 450,000 patients suffer from inflammator…
The LUCID Study: Living With Ulcerative Colitis; Identifying the Socioeconomic Burden in Europe Open
BackgroundUlcerative Colitis (UC) is an inflammatory bowel disease with increasing prevalence worldwide. Current treatment strategies place considerable economic and humanistic burdens on patients. The aim of this study was to determine th…
Monitoring of Vedolizumab Infusion Therapy (MOVE-IT) Response With Fecal Inflammation Markers, Ultrasound, and Trough Serum Level in Patients With Ulcerative Colitis: Protocol for a Multicentric, Prospective, Noninterventional Study Open
Background Vedolizumab has been shown to induce clinical remission in patients with active ulcerative colitis. Treatment with anti-integrin vedolizumab leads to clinical remission in 16.9% and clinical response in 47.1% of cases after 6 we…
Monitoring of Vedolizumab Infusion Therapy (MOVE-IT) Response With Fecal Inflammation Markers, Ultrasound, and Trough Serum Level in Patients With Ulcerative Colitis: Protocol for a Multicentric, Prospective, Noninterventional Study (Preprint) Open
BACKGROUND Vedolizumab has been shown to induce clinical remission in patients with active ulcerative colitis. Treatment with anti-integrin vedolizumab leads to clinical remission in 16.9% and clinical response in 47.1% of cases after 6 we…
View article: The impact of technical and clinical factors on fecal microbiota transfer outcomes for the treatment of recurrent <i>Clostridioides difficile</i> infections in Germany
The impact of technical and clinical factors on fecal microbiota transfer outcomes for the treatment of recurrent <i>Clostridioides difficile</i> infections in Germany Open
Introduction Fecal microbiota transfer (FMT) is highly effective in the treatment and prevention of recurrent Clostridioides difficile infection (rCDI) with cure rates of about 80% after a single treatment. Nevertheless, the reasons for fa…
Emicizumab in the Treatment of Acquired Haemophilia: A Case Report Open
The prognosis of acquired haemophilia A (AHA) is severe and treatment options are limited. Emicizumab is a novel bispecific humanized monoclonal antibody in the treatment of inherited AHA with inhibitors. An 83-year-old AHA patient with co…
ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects Open
This new diagnostic consensus guideline is a joint project of the European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR] that now merges the former ECCO-ESGAR Imaging G…
Intestinal epithelial cells and T cells differentially recognize and respond to <i>Candida albicans</i> yeast and hypha Open
Inflammatory bowel diseases (IBD) are a multifactorial disorder. Our understanding of the role of bacteria in the pathogenesis of IBD has increased substantially; however, only scarce data exist regarding the role of commensal fungi in mai…
View article: ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications
ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications Open
This new diagnostic consensus guideline is a joint project of the European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR] that now merges the former ECCO-ESGAR Imaging G…
European Crohn’s and Colitis Organisation Topical Review on IBD in the Elderly: Table 1. Open
This ECCO topical review of the European Crohn's and Colitis Organisation [ECCO] focuses on the epidemiology, pathophysiology, diagnosis, management and outcome of the two most common forms of inflammatory bowel disease, Crohn's disease an…
Early Monitoring of Response (MORE) to Golimumab Therapy Based on Fecal Calprotectin and Trough Serum Levels in Patients With Ulcerative Colitis: A Multicenter Prospective Study Open
German Clinical Trials Register, Deutsches Register Klinischer Studien DRKS00005940; https://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00005940 (Archived by WebCite at http://www.webcitation.o…