Sumathy Rangarajan
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View article: The burden of cardiovascular events according to cardiovascular risk profile in adults from high-income, middle-income, and low-income countries (PURE): a cohort study
The burden of cardiovascular events according to cardiovascular risk profile in adults from high-income, middle-income, and low-income countries (PURE): a cohort study Open
The funding bodies are listed in the appendix (p 29).
View article: Association of health knowledge with adoption of heart healthy behaviours: a cross-sectional analysis using data from the PURE study
Association of health knowledge with adoption of heart healthy behaviours: a cross-sectional analysis using data from the PURE study Open
Aims This study aims to assess aspects of health knowledge: (i) awareness of health effect of tobacco smoking and (ii) awareness of preventive actions for heart disease and stroke, and their relationships with adoption of heart healthy beh…
View article: Social factors, health policy, and environment: implications for cardiovascular disease across the globe
Social factors, health policy, and environment: implications for cardiovascular disease across the globe Open
Cardiovascular disease (CVD) is the leading cause of deaths worldwide, with 80% occurring in low- and middle-income countries. These countries are characterized by rapid urbanization, poorly funded health systems, poor access to prevention…
View article: Self-Reported Prevalence of Chronic Non-Communicable Diseases Concerning Socioeconomic and Educational Factors: Analysis of the PURE-Ecuador Cohort
Self-Reported Prevalence of Chronic Non-Communicable Diseases Concerning Socioeconomic and Educational Factors: Analysis of the PURE-Ecuador Cohort Open
Background: The changing epidemiological landscape, marked by the increasing prominence of Non-Communicable Chronic Diseases (NCDs), underscores the need for studies that identify and analyze these conditions and their associated risk fact…
View article: Secondary Prevention Medications in 17 Countries Grouped by Income Level (PURE)
Secondary Prevention Medications in 17 Countries Grouped by Income Level (PURE) Open
Globally and in most country income-level groups, the use of medications for secondary CVD prevention has been low, with little improvement over time.
View article: Use of Cardiovascular Disease Secondary Prevention Medications in Four Middle East Countries in a Community Setting
Use of Cardiovascular Disease Secondary Prevention Medications in Four Middle East Countries in a Community Setting Open
Background: Evidence-based International clinical practice guidelines, universally recommend secondary prevention medications for those with previous cardiovascular disease (CVD). There is limited data on the community use of these medicat…
View article: External validation and comparison of six cardiovascular risk prediction models in the Prospective Urban Rural Epidemiology (PURE)-Colombia study
External validation and comparison of six cardiovascular risk prediction models in the Prospective Urban Rural Epidemiology (PURE)-Colombia study Open
Aims To externally validate the SCORE2, AHA/ACC pooled cohort equation (PCE), Framingham Risk Score (FRS), Non-Laboratory INTERHEART Risk Score (NL-IHRS), Globorisk-LAC, and WHO prediction models and compare their discrimination and calibr…
View article: Mortality and Morbidity in Adults With Rheumatic Heart Disease
Mortality and Morbidity in Adults With Rheumatic Heart Disease Open
Importance Rheumatic heart disease (RHD) remains a public health issue in low- and middle-income countries (LMICs). However, there are few large studies enrolling individuals from multiple endemic countries. Objective To assess the risk an…
View article: Associations of perceived built environment characteristics using NEWS questionnaires with all-cause mortality and major cardiovascular diseases: The prospective urban rural epidemiology (PURE)-China study
Associations of perceived built environment characteristics using NEWS questionnaires with all-cause mortality and major cardiovascular diseases: The prospective urban rural epidemiology (PURE)-China study Open
Favorable perceived BE characteristics were linked with a lower risk of all-cause mortality and major CVD events in Chinese population, especially in urban areas and females. Our findings can be used by policymakers to take action to mitig…
View article: Pre‐morbid sleep disturbance and its association with stroke severity: results from the international <scp>INTERSTROKE</scp> study
Pre‐morbid sleep disturbance and its association with stroke severity: results from the international <span>INTERSTROKE</span> study Open
Background and purpose Whilst sleep disturbances are associated with stroke, their association with stroke severity is less certain. In the INTERSTROKE study, the association of pre‐morbid sleep disturbance with stroke severity and functio…
View article: Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case–control study
Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case–control study Open
The Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, Canadian Stroke Network, Swedish Research Council, Swedish Heart and Lung Foundation, The Health & Medical Care Committee of the Regional Executive Board, R…
View article: Sex Differences in Cardiovascular Disease Risk Factor Prevalence, Morbidity, and Mortality in Colombia: Findings from the Prospective Urban Rural Epidemiology (PURE) Study
Sex Differences in Cardiovascular Disease Risk Factor Prevalence, Morbidity, and Mortality in Colombia: Findings from the Prospective Urban Rural Epidemiology (PURE) Study Open
Background: Controversies exist on whether the presence of cardiovascular risk factors and their association with major cardiovascular events (MACE) is different between men and women. Most of the evidence comes from high-income countries,…
View article: Risk factors for recognized and unrecognized SARS-CoV-2 infection: a seroepidemiologic analysis of the Prospective Urban Rural Epidemiology (PURE) study
Risk factors for recognized and unrecognized SARS-CoV-2 infection: a seroepidemiologic analysis of the Prospective Urban Rural Epidemiology (PURE) study Open
There are limited data on individual risk factors for SARS-CoV-2 infection (including unrecognized infection). In this seroepidemiologic substudy of an ongoing prospective cohort study of community-dwelling adults, participants were thorou…
View article: Associations of dietary copper intake with cardiovascular disease and mortality: findings from the Chinese Perspective Urban and Rural Epidemiology (PURE-China) Study
Associations of dietary copper intake with cardiovascular disease and mortality: findings from the Chinese Perspective Urban and Rural Epidemiology (PURE-China) Study Open
Background Previous in vitro and animal experiments have shown that copper plays an important role in cardiovascular health. Dietary copper is the main source of copper in the human body and the association between dietary copper and cardi…
View article: Socioeconomic disparity in mortality and the burden of cardiovascular disease: analysis of the Prospective Urban Rural Epidemiology (PURE)-China cohort study
Socioeconomic disparity in mortality and the burden of cardiovascular disease: analysis of the Prospective Urban Rural Epidemiology (PURE)-China cohort study Open
Funding sources are listed at the end of the Article.
View article: Association of physical activity intensity with cardiovascular disease and mortality in high-income, middle-income and low-income countries: the PURE study
Association of physical activity intensity with cardiovascular disease and mortality in high-income, middle-income and low-income countries: the PURE study Open
Background The WHO recommends adults get 150-300 minutes of moderate physical activity (MPA) and/or 75-150 minutes of vigorous physical activity (VPA) per week. Few studies have investigated the independent benefits of PA intensity. Those …
View article: Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia
Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia Open
Background Abdominal obesity (AO) indirectly represents visceral adiposity and can be assessed by waist circumference (WC) measurement. In Latin America, cut-off points for the diagnosis of AO are based on Asian population data. We aim to …
View article: The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses
The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses Open
Decline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive function is associated with increased dementia and stroke risk. The mechanisms underlying variation in cognitive function are uncertain. Here, we a…
View article: The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses
The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses Open
Decline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive function is associated with increased dementia and stroke risk. The mechanisms underlying variation in cognitive function are uncertain. Here, we a…
View article: Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk
Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk Open
Importance Cardiometabolic parameters are established risk factors for COVID-19 severity. The identification of causal or protective biomarkers for COVID-19 severity may facilitate the development of novel therapies. Objective To identify …
View article: Diet, cardiovascular disease, and mortality in 80 countries
Diet, cardiovascular disease, and mortality in 80 countries Open
Aims To develop a healthy diet score that is associated with health outcomes and is globally applicable using data from the Prospective Urban Rural Epidemiology (PURE) study and replicate it in five independent studies on a total of 245 00…
View article: How regional versus global thresholds for physical activity and grip strength influence physical frailty prevalence and mortality estimates in PURE: a prospective multinational cohort study of community-dwelling adults
How regional versus global thresholds for physical activity and grip strength influence physical frailty prevalence and mortality estimates in PURE: a prospective multinational cohort study of community-dwelling adults Open
Objectives Handgrip strength and physical activity are commonly used to evaluate physical frailty; however, their distribution varies worldwide. The thresholds that identify frail individuals have been established in high-income countries …
View article: Sleep Patterns and the Risk of Acute Stroke
Sleep Patterns and the Risk of Acute Stroke Open
We found that sleep disturbance symptoms were common and associated with a graded increased risk of stroke. These symptoms may be a marker of increased individual risk or represent independent risk factors. Future clinical trials are warra…
View article: Comparing estimates of household expenditures between pictorial diaries and surveys in three low- and middle-income countries
Comparing estimates of household expenditures between pictorial diaries and surveys in three low- and middle-income countries Open
In most low- and middle-income countries (LMICs), household out-of-pocket (OOP) health spending constitutes a major source of healthcare financing. Household surveys are commonly used to monitor OOP health spending, but are prone to recall…
View article: Household Air Pollution and Adult Lung Function Change, Respiratory Disease, and Mortality across Eleven Low- and Middle-Income Countries from the PURE Study
Household Air Pollution and Adult Lung Function Change, Respiratory Disease, and Mortality across Eleven Low- and Middle-Income Countries from the PURE Study Open
We observed modest associations between HAP exposure and lung function, lung function change, and respiratory disease and mortality. https://doi.org/10.1289/EHP11179.