Surya P. Bhatt
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View article: Linking deliveries to newborns using nationwide Medicaid data
Linking deliveries to newborns using nationwide Medicaid data Open
Background Linking mothers to their newborns in health records is crucial for understanding the impact of policies, programs, and medical treatments on intergenerational health outcomes. While previous studies have used shared identifiers …
View article: MiniBEE: A New Form Factor for Compact Bimanual Dexterity
MiniBEE: A New Form Factor for Compact Bimanual Dexterity Open
Bimanual robot manipulators can achieve impressive dexterity, but typically rely on two full six- or seven- degree-of-freedom arms so that paired grippers can coordinate effectively. This traditional framework increases system complexity w…
View article: Dupilumab Versus Mepolizumab for COPD: Evaluating Efficacy Outcomes Using Placebo-Adjusted Indirect Treatment Comparison
Dupilumab Versus Mepolizumab for COPD: Evaluating Efficacy Outcomes Using Placebo-Adjusted Indirect Treatment Comparison Open
This ITC suggests potential clinical benefits of dupilumab over mepolizumab in reducing exacerbations and improving lung function, respiratory symptoms, and quality of life in patients with COPD and type 2 inflammation. Direct head-to-head…
View article: A Metabolomic Severity Score for Airflow Obstruction and Emphysema
A Metabolomic Severity Score for Airflow Obstruction and Emphysema Open
Chronic obstructive pulmonary disease (COPD) is a disease with marked metabolic disturbance. Previous studies have shown the association between single metabolites and lung function for COPD, but whether a combination of metabolites could …
View article: Assessment of the Applications of Agriculturally Important Microorganism in Food, Pharmaceutical and Agricultural Sector
Assessment of the Applications of Agriculturally Important Microorganism in Food, Pharmaceutical and Agricultural Sector Open
Microorganisms are a cornerstone of sustainable development due to their versatility and adaptability across diverse ecological niches. Their applications span agriculture, food processing, and pharmaceuticals, where they provide scalable,…
View article: Molecular Recognition and Signaling Cascades in Plant Immunity: PTI, ETI and beyond
Molecular Recognition and Signaling Cascades in Plant Immunity: PTI, ETI and beyond Open
Plants are constantly exposed to broad spectrum of pathogens, ranging from bacteria and fungi to viruses and nematodes. Unlike animals, plants lack an adaptive immune system and instead depend on a complex, multilayered innate defense fram…
View article: Light Convolutional Neural Network to Detect Chronic Obstructive Pulmonary Disease (COPDxNet): A Multicenter Model Development and External Validation Study
Light Convolutional Neural Network to Detect Chronic Obstructive Pulmonary Disease (COPDxNet): A Multicenter Model Development and External Validation Study Open
Background Approximately 70% of adults with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Opportunistic screening using chest computed tomography (CT) scans, commonly acquired in clinical practice, may be used to improve…
View article: Type 2 inflammation biomarkers and their association with response to dupilumab in COPD (BOREAS): an analysis of a randomised, placebo-controlled, phase 3 trial
Type 2 inflammation biomarkers and their association with response to dupilumab in COPD (BOREAS): an analysis of a randomised, placebo-controlled, phase 3 trial Open
Sanofi and Regeneron Pharmaceuticals.
View article: Deep Learning of Suboptimal Spirometry to Predict Respiratory Outcomes and Mortality
Deep Learning of Suboptimal Spirometry to Predict Respiratory Outcomes and Mortality Open
View article: Respiratory Exacerbations Increase with Chronic PM<sub>2.5</sub> Exposure in Current and Former Smokers
Respiratory Exacerbations Increase with Chronic PM<sub>2.5</sub> Exposure in Current and Former Smokers Open
Rationale Short-term exposure to fine particulates (PM 2.5 ) transiently increases the risk of respiratory exacerbations, but the contribution of chronic, long-term particulate exposure to respiratory exacerbations is poorly defined. Objec…
View article: Not All Tele-Pulmonary Rehabilitation Models for Chronic Respiratory Disease Are Created Equal
Not All Tele-Pulmonary Rehabilitation Models for Chronic Respiratory Disease Are Created Equal Open
View article: Quality Assurance of Drug Information Services in a Tertiary Care Hospital
Quality Assurance of Drug Information Services in a Tertiary Care Hospital Open
Introduction: The concept of drug information by clinical pharmacists in our setting is still in growing phase. Lack of awareness on pharmacists’ role, late installation of clinical pharmacy education and service, shortage of skills and po…
View article: Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area
Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area Open
View article: Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD
Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD Open
Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally. Gastroesophageal reflux disease (GERD) is a common comorbidity in COPD associated with worse pulmonary symptoms, reduced quality of life, and increased exac…
View article: Dupilumab Improves Health-Related Quality of Life and Respiratory Symptoms in Patients With COPD and Type 2 Inflammation: BOREAS and NOTUS
Dupilumab Improves Health-Related Quality of Life and Respiratory Symptoms in Patients With COPD and Type 2 Inflammation: BOREAS and NOTUS Open
gov.
View article: Rationale and Design of the Alpha-1 Biomarkers Consortium Study
Rationale and Design of the Alpha-1 Biomarkers Consortium Study Open
This is the first cohort of AATD to incorporate such detailed metrics of disease, including quantitative emphysema measures, with the overarching goal of improving the understanding of disease heterogeneity in AATD and identifying factors …
View article: Endophytic microbial advancement through NGS technology: Unlocking the power of the genome
Endophytic microbial advancement through NGS technology: Unlocking the power of the genome Open
View article: Enhancing Artistic Style Transfer: Integrating CycleGAN, Diffusion Models, and Neural Painting for Monet-Inspired Image Generation
Enhancing Artistic Style Transfer: Integrating CycleGAN, Diffusion Models, and Neural Painting for Monet-Inspired Image Generation Open
This project explores various approaches to style transfer, specifically focusing on transforming natural images into the iconic style of Claude Monets paintings. We explored three methods: CycleGAN-based, neural painting-based, and diffus…
View article: Linking Newborns and Mothers to Enable the Study of Inter-generational Health Outcomes: Evidence from Nationwide Medicaid Data
Linking Newborns and Mothers to Enable the Study of Inter-generational Health Outcomes: Evidence from Nationwide Medicaid Data Open
View article: Uncertainty-Aware Test-Time Adaptation for Inverse Consistent Diffeomorphic Lung Image Registration
Uncertainty-Aware Test-Time Adaptation for Inverse Consistent Diffeomorphic Lung Image Registration Open
Diffeomorphic deformable image registration ensures smooth invertible transformations across inspiratory and expiratory chest CT scans. Yet, in practice, deep learning-based diffeomorphic methods struggle to capture large deformations betw…
View article: PiSlope: A New CT Metric for Quantifying Airway Remodeling in Chronic Obstructive Pulmonary Disease
PiSlope: A New CT Metric for Quantifying Airway Remodeling in Chronic Obstructive Pulmonary Disease Open
The new CT metric PiSlope quantified the amount of remodeling along the entire visualized airway and was associated with dyspnea, quality of life, functional capacity, exacerbations, lung function decline, and mortality.
View article: Dupilumab reduces exacerbations and improves lung function in patients with chronic obstructive pulmonary disease and emphysema: Phase 3 randomized trial (BOREAS)
Dupilumab reduces exacerbations and improves lung function in patients with chronic obstructive pulmonary disease and emphysema: Phase 3 randomized trial (BOREAS) Open
Dupilumab efficacy was similar in patients with COPD and type 2 inflammation, with or without investigator-reported emphysema.
View article: Airway tapering in COPD
Airway tapering in COPD Open
Background Luminal narrowing is a hallmark feature of airway remodelling in COPD, but current measures focus on airway wall remodelling. Quantification of the natural increase in cumulative cross-sectional area along the length of the huma…
View article: Deep Learning Estimation of Small Airways Disease from Inspiratory Chest CT is Associated with FEV<sub>1</sub>Decline in COPD
Deep Learning Estimation of Small Airways Disease from Inspiratory Chest CT is Associated with FEV<sub>1</sub>Decline in COPD Open
Rationale Quantifying functional small airways disease (fSAD) requires additional expiratory computed tomography (CT) scan, limiting clinical applicability. Artificial intelligence (AI) could enable fSAD quantification from chest CT scan a…
View article: A Research Agenda to Improve Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disease: An Official American Thoracic Society Research Statement
A Research Agenda to Improve Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disease: An Official American Thoracic Society Research Statement Open
Background: Individuals with chronic obstructive pulmonary disease (COPD) are often at risk for or have comorbid cardiovascular disease and are likely to die of cardiovascular-related causes. Objectives: To prioritize a list …
View article: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area
Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area Open
View article: Effect of ensifentrine on dyspnea in patients with moderate-to-severe chronic obstructive pulmonary disease: pooled analysis of the ENHANCE trials
Effect of ensifentrine on dyspnea in patients with moderate-to-severe chronic obstructive pulmonary disease: pooled analysis of the ENHANCE trials Open
www.clinicaltrials.gov identifiers are ENHANCE-1: NCT04535986; ENHANCE-2: NCT04542057.
View article: Breathing Is Bipartisan: An Appeal to Civic Action to Promote Telehealth Pulmonary Rehabilitation
Breathing Is Bipartisan: An Appeal to Civic Action to Promote Telehealth Pulmonary Rehabilitation Open
View article: Type 2 Inflammation Is Associated with Emphysema on Computed Tomography
Type 2 Inflammation Is Associated with Emphysema on Computed Tomography Open
"Type 2 Inflammation is Associated with Emphysema on Computed Tomography." Annals of the American Thoracic Society, 0(ja), pp.
View article: Non-cigarette tobacco products, aryl-hydrocarbon receptor repressor gene methylation and smoking-related health outcomes
Non-cigarette tobacco products, aryl-hydrocarbon receptor repressor gene methylation and smoking-related health outcomes Open
Introduction Cigarette smoking leads to altered DNA methylation at the aryl-hydrocarbon receptor repressor (AHRR) gene. However, it remains unknown whether pipe or cigar smoking is associated with AHRR methylation. We evaluated association…