S. Ananth Karumanchi
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View article: Role of Diffusion Tensor Imaging-Derived Metrics for the Assessment of Deranged Myelination in Children With Developmental Delay: A Hospital-Based Observational Study
Role of Diffusion Tensor Imaging-Derived Metrics for the Assessment of Deranged Myelination in Children With Developmental Delay: A Hospital-Based Observational Study Open
View article: The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits
The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits Open
Aging disrupts physiological homeostasis, impairing thermoregulation, metabolism, and water balance, but the underlying neural mechanisms remain unclear. Here, we identify arginine vasopressin (AVP) neurons in the supraoptic nucleus (SON) …
View article: Antimicrobial treatment ameliorates delirium-like phenotypes in a murine model of urinary tract infection
Antimicrobial treatment ameliorates delirium-like phenotypes in a murine model of urinary tract infection Open
Practice guidelines recommend withholding antimicrobial therapy (ABX) in delirious patients with suspected urinary tract infection (UTI) who do not endorse classic genitourinary symptoms, citing both a lack of a causal relationship between…
View article: Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy
Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy Open
Background/Aims The placenta expresses and releases specific microRNAs (miRNAs) into the maternal circulation that may influence insulin secretion during pregnancy. We hypothesized that specific decidual/placental miRNAs are associated wit…
View article: Intramuscular Hydatid Cyst- A Rare Case Report
Intramuscular Hydatid Cyst- A Rare Case Report Open
Hydatid disease, caused by the Echinococcus species, commonly affects the liver and lungs. Muscular involvement is rare, accounting for less than 5% of cases due to factors such as muscle contractility and lactic acid content that make it …
View article: Adverse functions of neutrophils are regulated by neutrophilic angiotensin-converting enzyme in immune complex-mediated crescentic glomerulonephritis
Adverse functions of neutrophils are regulated by neutrophilic angiotensin-converting enzyme in immune complex-mediated crescentic glomerulonephritis Open
We recently reported that NeuACE mice that overexpress angiotensin-converting enzyme (ACE), specifically in neutrophils, alleviate glomerular injury in immune complex-mediated crescentic glomerulonephritis by the complement C3b-complement …
View article: Prenatal Diagnosis Of Complex Congenital Heart Disease With Right Atrial Isomerism And Double Outlet Right Ventricle: A Combined Case Report
Prenatal Diagnosis Of Complex Congenital Heart Disease With Right Atrial Isomerism And Double Outlet Right Ventricle: A Combined Case Report Open
Background: Congenital heart defects (CHDs) are the most frequently diagnosed prenatal anomalies, with complex subtypes such as double outlet right ventricle (DORV) and transposition of the great arteries (TGA) posing significant diagnosti…
View article: An Unusual Presentation of Bullous Skin Lesions During Pregnancy
An Unusual Presentation of Bullous Skin Lesions During Pregnancy Open
Here, we present a 33-years-old pregnant female who at 27-weeks gestation developed an unusual rash on her left knee after a spider bite. The rash rapidly became systemic requiring admission and treatment with high-dose steroids. Patient r…
View article: Fabrication and Characterization of Highly Porous Gyroid Scaffolds Composed of Deproteinized Bone Mineral
Fabrication and Characterization of Highly Porous Gyroid Scaffolds Composed of Deproteinized Bone Mineral Open
Current treatment methods for critical bone defects involve the implantation of large bone grafts, which are limited by tissue availability and failure to heal correctly with high complication rates. Bioengineered scaffolds have emerged, w…
View article: Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapse
Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapse Open
B7 costimulatory family member Butyrophilin 2A2 ( BTN2A2) is predominantly expressed by antigen presenting cells and regulates T cell immunity, but molecular mechanisms are unclear. Using immunoblots analyzing TCR-initiated signaling inter…
View article: Birthweight in a non-human primate model of placental ischaemia
Birthweight in a non-human primate model of placental ischaemia Open
Animal models for preeclampsia are mostly determined by the experimental induction of hypertension, proteinuria and latterly, endogenous production of anti-angiogenic factors (sFlt-1). The focus on maternal outcome measures is more immedia…
View article: Microglia ameliorate delirium-like phenotypes in a murine model of acute ventilator-induced lung injury
Microglia ameliorate delirium-like phenotypes in a murine model of acute ventilator-induced lung injury Open
This study demonstrates that microglia depletion exacerbates structural and functional delirium-like phenotypes after VILI, while subsequent repopulation of microglia restores these phenotypes. These findings suggest a neuroprotective role…
View article: Two decades of advances in preeclampsia research: molecular mechanisms and translational studies
Two decades of advances in preeclampsia research: molecular mechanisms and translational studies Open
View article: Data-driven prediction of continuous renal replacement therapy survival
Data-driven prediction of continuous renal replacement therapy survival Open
Continuous renal replacement therapy (CRRT) is a form of dialysis prescribed to severely ill patients who cannot tolerate regular hemodialysis. However, as the patients are typically very ill to begin with, there is always uncertainty whet…
View article: Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human Open
Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute to both diseases, suggesting a common underlying pathop…
View article: Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes
Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes Open
View article: High-throughput mRNA sequencing of human placenta shows sex differences across gestation
High-throughput mRNA sequencing of human placenta shows sex differences across gestation Open
View article: Glycated Albumin and Adverse Clinical Outcomes in Patients With CKD: A Prospective Cohort Study
Glycated Albumin and Adverse Clinical Outcomes in Patients With CKD: A Prospective Cohort Study Open
Hemoglobin A1c (HbA1c) is widely used to estimate glycemia, yet it is less reliable in patients with chronic kidney disease (CKD). There is growing interest in the complementary use of glycated albumin (GA) to improve…
View article: SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys
SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys Open
The steps governing healing with or without fibrosis within the same microenvironment are unclear. After acute kidney injury (AKI), injured proximal tubular epithelial cells activate SOX9 for self-restoration. Using a multimodal approach f…
View article: Lipid droplets in the endothelium: The missing link between metabolic syndrome and cardiovascular disease?
Lipid droplets in the endothelium: The missing link between metabolic syndrome and cardiovascular disease? Open
The physiology of lipid droplets (LDs) has been most extensively characterized in adipocytes, but LDs also accumulate in endothelial cells lining blood vessels in response to changing levels of triglycerides. In recent issues of the JCI, t…
View article: High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester
High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester Open
The placenta, composed of chorionic villi, changes dramatically across gestation. Understanding differences in ongoing pregnancies are essential to identify the role of chorionic villi at specific times in gestation and develop biomarkers …
View article: Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death
Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death Open
The vast majority of membrane phospholipids (PLs) include two asymmetrically positioned fatty acyls: oxidizable polyunsaturated fatty acids (PUFA) attached predominantly at the sn2 position, and non‐oxidizable saturated/monounsaturated aci…
View article: Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death
Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death Open
The vast majority of membrane phospholipids (PLs) include two asymmetrically positioned fatty acyls: oxidizable polyunsaturated fatty acids (PUFA) attached predominantly at the sn2 position, and non‐oxidizable saturated/monounsaturated aci…
View article: 1059 Maternal Angiogenic Imbalance & Placental Sexual Dimorphism
1059 Maternal Angiogenic Imbalance & Placental Sexual Dimorphism Open
View article: Tail-Cuff Versus Radiotelemetry to Measure Blood Pressure in Mice and Rats
Tail-Cuff Versus Radiotelemetry to Measure Blood Pressure in Mice and Rats Open
View article: Data-driven prediction of continuous renal replacement therapy survival
Data-driven prediction of continuous renal replacement therapy survival Open
Continuous renal replacement therapy (CRRT) is a form of dialysis prescribed to severely ill patients who cannot tolerate regular hemodialysis. However, as the patients are typically very ill to begin with, there is always uncertainty as t…
View article: Placental RNA sequencing implicates IGFBP1 in insulin sensitivity during pregnancy and in gestational diabetes
Placental RNA sequencing implicates IGFBP1 in insulin sensitivity during pregnancy and in gestational diabetes Open
Reduced insulin sensitivity (or greater insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes mellitus (GDM) pathophysiology. We conducted transcriptomic profiling of 434 human pla…
View article: Higher Maternal Body Mass Index Is Associated With Lower Placental Expression of<i>EPYC:</i>A Genome-Wide Transcriptomic Study
Higher Maternal Body Mass Index Is Associated With Lower Placental Expression of<i>EPYC:</i>A Genome-Wide Transcriptomic Study Open
Context Elevated body mass index (BMI) in pregnancy is associated with adverse maternal and fetal outcomes. The placental transcriptome may elucidate molecular mechanisms underlying these associations. Objective We examined the association…
View article: Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor
Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor Open
Most cases of preterm labor have unknown cause, and the burden of preterm birth is immense. Placental aging has been proposed to promote labor onset, but specific mechanisms remain elusive. We report findings stemming from unbiased transcr…
View article: Author Response: Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor
Author Response: Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Metrics Abstract Most cases of …