Shoji Takeuchi
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View article: Intercalant Aggregation Promotes Nanoscopic Depletion in Droplet Interface Bilayers
Intercalant Aggregation Promotes Nanoscopic Depletion in Droplet Interface Bilayers Open
Free volume within lipid bilayers plays a crucial role in determining membrane properties, such as fluidity, permeability, and domain organization, which in turn modulate the functions of membrane proteins and cellular processes. The prese…
View article: Association of thermal perceptions, metabolic rate, clothing, and local skin temperature in people with cold constitution in air-conditioned office environments
Association of thermal perceptions, metabolic rate, clothing, and local skin temperature in people with cold constitution in air-conditioned office environments Open
Cold constitution refers to a phenomenon in which individuals have a higher sensitivity to cold and feel colder than others. This research aimed to examine the associations of morphological characteristics, personal factors, thermal percep…
View article: Shape‐Encoded Hydrogel Sensor Particles Enable Multiplex Odorant Detection Through Deep‐learning Classification
Shape‐Encoded Hydrogel Sensor Particles Enable Multiplex Odorant Detection Through Deep‐learning Classification Open
Simultaneous detection of multiple odorants is a major challenge in the development of portable, cell‐based biohybrid sensors, primarily due to the difficulty of distinguishing between different sensor cell types. Here, a strategy that enc…
View article: Cell-based multisensor array for detecting cancer biomarkers in human urine
Cell-based multisensor array for detecting cancer biomarkers in human urine Open
Detecting volatile urinary biomarkers offers a compelling strategy for noninvasive diagnosis of diseases such as cancer. Biohybrid sensors employing sensor cells that express olfactory receptors—with finely tuned molecular recognition capa…
View article: Tetanus-driven biohybrid multijoint robots powered by muscle rings with enhanced contractile force
Tetanus-driven biohybrid multijoint robots powered by muscle rings with enhanced contractile force Open
Biohybrid actuators using muscle rings have been limited to twitching movements and are unsuitable for sustained contractile force applications. In this study, we developed muscle rings capable of generating high contractile forces under t…
View article: Biohybrid Actuators in Compact Arrangement with Embedded X Electrode
Biohybrid Actuators in Compact Arrangement with Embedded X Electrode Open
Selective control of multimuscle biohybrid actuators is crucial for achieving complex movements of biohybrid robots. In this study, an embedded X electrode to selectively control multiple muscles for the realization of the robotic finger's…
View article: Association of thermal perceptions, metabolic rate, clothing and local skin temperature in people with cold constitution in air-conditioned office environments
Association of thermal perceptions, metabolic rate, clothing and local skin temperature in people with cold constitution in air-conditioned office environments Open
Cold constitution refers to a phenomenon in which individuals have a higher sensitivity to cold and feel colder than others. This research aimed to examine the associations of morphological characteristics, personal factors, thermal percep…
View article: Nuclear Assembly in Giant Unilamellar Vesicles Encapsulating <i>Xenopus</i> Egg Extract
Nuclear Assembly in Giant Unilamellar Vesicles Encapsulating <i>Xenopus</i> Egg Extract Open
The reconstitution of a cell nucleus in a lipid bilayer‐enclosed synthetic cell makes great strides in bottom‐up synthetic biology. In this study, a method for assembling a nucleus in giant unilamellar vesicles (GUVs) is proposed. To induc…
View article: Skin‐Covered Biohybrid Robotic Finger with Bilayered Permeable Subcutaneous Support for Internal Hydration Supplement
Skin‐Covered Biohybrid Robotic Finger with Bilayered Permeable Subcutaneous Support for Internal Hydration Supplement Open
Integrating living tissues with robotic systems presents unique opportunities for developing next‐generation robots. This study addresses a critical challenge in skin‐covered biohybrid robots: maintaining a hydration supply to prevent rapi…
View article: 3D Wiring Microelectrodes in a PMMA Microfluidic Device by Vacuum Filling Method
3D Wiring Microelectrodes in a PMMA Microfluidic Device by Vacuum Filling Method Open
In order to establish a detection and actuation system for 3D printed microfluidics, it is necessary to fabricate the 3D wiring microelectrodes. In this paper, a method is proposed that enables the fabrication of 3D wiring microelectrodes …
View article: Electrophysiological Characterization of Monoolein-Fatty Acid Bilayers
Electrophysiological Characterization of Monoolein-Fatty Acid Bilayers Open
Understanding the evolution of protocells, primitive compartments that distinguish self from nonself, is crucial for exploring the origin of life. Fatty acids and monoglycerides have been proposed as key components of protocell membranes d…
View article: Sensor‐Embedded Muscle for Closed‐Loop Controllable Actuation in Proprioceptive Biohybrid Robots
Sensor‐Embedded Muscle for Closed‐Loop Controllable Actuation in Proprioceptive Biohybrid Robots Open
Biohybrid robots are soft robots that exploit unique characteristics of biological cells and tissues for motion generation. Skeletal muscle tissue‐based bioactuators respond to externally applied stimuli, such as electrical fields. However…
View article: Dynamic and Static Workout of In Vitro Skeletal Muscle Tissue through a Weight Training Device
Dynamic and Static Workout of In Vitro Skeletal Muscle Tissue through a Weight Training Device Open
Enhancing muscle strength through workouts is a key factor in improving physical activity and maintaining metabolic profiles. The controversial results concerning the impacts of weight training often arise from clinical experiments that re…
View article: Magicity versus superfluidity around $^{28}$O viewed from the study of\n $^{30}$F
Magicity versus superfluidity around $^{28}$O viewed from the study of\n $^{30}$F Open
The neutron-rich unbound fluorine isotope $^{30}$F$_{21}$ has been observed\nfor the first time by measuring its neutron decay at the SAMURAI spectrometer\n(RIBF, RIKEN) in the quasi-free proton knockout reaction of $^{31}$Ne nuclei at\n23…
View article: Effective Dissolution of a Gaseous Odorant in Liquid Using Gas Flow
Effective Dissolution of a Gaseous Odorant in Liquid Using Gas Flow Open
Olfactory receptors are known for their high specificity, sensitivity, and nanometer‐sized sensing element, making them ideal for in situ odorant sensor applications. However, one of the major limitations of these sensors is the requiremen…
View article: Harnessing the Propulsive Force of Microalgae with Microtrap to Drive Micromachines
Harnessing the Propulsive Force of Microalgae with Microtrap to Drive Micromachines Open
Microorganisms possess remarkable locomotion abilities, making them potential candidates for micromachine propulsion. Here, the use of Chlamydomonas Reinhardtii (CR) is explored, a motile green alga, as a micromotor by harnessing its propu…
View article: Nuclear assembly in giant unilamellar vesicles encapsulating<i>Xenopus</i>egg extract
Nuclear assembly in giant unilamellar vesicles encapsulating<i>Xenopus</i>egg extract Open
The reconstitution of a cell nucleus in a lipid bilayer-enclosed synthetic cell makes great strides in bottom-up synthetic biology. In this study, we propose a method for assembling a nucleus in giant unilamellar vesicles (GUVs). To induce…
View article: Perforation-type anchors inspired by skin ligament for robotic face covered with living skin
Perforation-type anchors inspired by skin ligament for robotic face covered with living skin Open
Skin equivalent, a living skin model composed of cells and extracellular matrix, possesses the potential to be an ideal covering material for robots due to its biological functionalities. To employ skin equivalents as covering materials fo…
View article: Pillar electrodes embedded in the skeletal muscle tissue for selective stimulation of biohybrid actuators with increased contractile distance
Pillar electrodes embedded in the skeletal muscle tissue for selective stimulation of biohybrid actuators with increased contractile distance Open
Electrodes are crucial for controlling the movements of biohybrid robots, but their external placement outside muscle tissue often leads to inefficient and non-selective stimulation of nearby biohybrid actuators. To address this, we propos…
View article: Culture insert device with perfusable microchannels enhances <i>in vitro</i> skin model development and barrier function assessment
Culture insert device with perfusable microchannels enhances <i>in vitro</i> skin model development and barrier function assessment Open
The ever-stricter regulations on animal experiments in the field of cosmetic testing have prompted a surge in skin-related research with a special focus on recapitulation of the in vivo skin structure in vitro. In vitro human skin models a…
View article: Controlled Self‐Assembly of Vesicles by Electrospray Deposition
Controlled Self‐Assembly of Vesicles by Electrospray Deposition Open
The self‐assembly of amphiphilic molecules produces structures of diverse dimensions, encompassing micelles, tubules, lamellae, and vesicles. This study focuses on elucidating the controllability of amphiphilic lipid molecule self‐assembly…
View article: Integrated Closed-loop Control of Bio-actuation for Proprioceptive Bio-hybrid Robots
Integrated Closed-loop Control of Bio-actuation for Proprioceptive Bio-hybrid Robots Open
Biohybrid robots are emergent soft robots that combine engineered artificial structures and living biosystems to exploit unique characteristics of biological cells and tissues. Skeletal muscle tissue-based bio-actuators can respond to exte…
View article: PERFORATION-TYPE ANCHORS INSPIRED BY SKIN LIGAMENT FOR THE ROBOTIC FACE COVERED WITH LIVING SKIN
PERFORATION-TYPE ANCHORS INSPIRED BY SKIN LIGAMENT FOR THE ROBOTIC FACE COVERED WITH LIVING SKIN Open
Skin equivalent, a living skin model composed of cells and extracellular matrix, possesses the potential as an ideal covering material for robots due to their biological functionalities. To employ skin equivalents as a coverage material fo…