Sin‐Yeang Teow
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View article: Electrospun Carboxymethylcellulose as a Scaffold for Biomedical Applications
Electrospun Carboxymethylcellulose as a Scaffold for Biomedical Applications Open
Electrospinning of pure carboxymethylcellulose (CMC) and its derivatives for biomedical applications is attractive due to their interesting biology and biomimetic properties. However, the main challenges in electrospinning pure CMC are str…
View article: Association of SEPT9 Gene Methylation with the Clinicopathologic Features and Fusobacterium nucleatum Infection in Colorectal Cancer Patients
Association of SEPT9 Gene Methylation with the Clinicopathologic Features and Fusobacterium nucleatum Infection in Colorectal Cancer Patients Open
Background/Objectives: Colorectal cancer (CRC) is a significant global health issue. The identification of methylated Septin 9 (mSEPT9) as a biomarker for CRC represents a significant advancement in cancer diagnostics. On the other hand, F…
View article: Dual ionotropic crosslinked biopolymer magnetic nanocomposites as <scp>5‐Fluorouracil</scp> nanocarrier for potential colorectal cancer treatment
Dual ionotropic crosslinked biopolymer magnetic nanocomposites as <span>5‐Fluorouracil</span> nanocarrier for potential colorectal cancer treatment Open
This study aimed to synthesize dual‐crosslinked chitosan‐alginate nanocomposites (Cs‐Alg/IO NCs) using green‐synthesized iron oxide nanoparticles (IO, Fe 3 O 4 NPs) for drug delivery application. The NCs, formed via ionotropic gelation wit…
View article: Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity
Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity Open
In this study, zinc oxide nanoparticles (ZnO‐NPs) are synthesized and combined with chitosan (Cs) to create Cs/ZnO‐NPs nanomicelles, aiming to investigate their potential as a novel cancer treatment. The ZnO‐NPs are produced through a sint…
View article: Role of sirtuin 1 (SIRT1) in regulation of autophagy and nuclear factor-kappa Beta (NF-ĸβ) pathways in sorafenib-resistant hepatocellular carcinoma (HCC)
Role of sirtuin 1 (SIRT1) in regulation of autophagy and nuclear factor-kappa Beta (NF-ĸβ) pathways in sorafenib-resistant hepatocellular carcinoma (HCC) Open
Hepatocellular carcinoma (HCC) remains a major global health problem with high incidence and mortality. Diagnosis of HCC at late stages and tumour heterogeneity in patients with different genetic profiles are known factors that complicate …
View article: Soft X-Ray Spectra of High Temperature Argon Plasma for Potential Cell Treatment
Soft X-Ray Spectra of High Temperature Argon Plasma for Potential Cell Treatment Open
A plasma pinch is created when the current sheath collapses onto the axis in a plasma focus discharge. The plasma focus produces a high temperature and high density plasma, emitting soft x-ray with energy in the range of kiloelectronvolt. …
View article: Enhanced antibacterial and anticancer activities of plant extract mediated green synthesized zinc oxide-silver nanoparticles
Enhanced antibacterial and anticancer activities of plant extract mediated green synthesized zinc oxide-silver nanoparticles Open
This study presents a green synthesis approach for the fabrication of zinc oxide-silver nanoparticles (ZnO-Ag-NPs) using Punica granatum fruit peels extract as a natural reducing and stabilizing agent. This eco-friendly method offers a sus…
View article: How Magnetic Composites are Effective Anticancer Therapeutics? A Comprehensive Review of the Literature
How Magnetic Composites are Effective Anticancer Therapeutics? A Comprehensive Review of the Literature Open
Chemotherapy is the most prominent route in cancer therapy for prolonging the lifespan of cancer patients. However, its non-target specificity and the resulting off-target cytotoxicities have been reported. Recent in vitro and in vivo stud…
View article: Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice
Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice Open
The role of inulin in alleviating obesity-related disorders has been documented; yet, its underlying mechanisms still need to be further investigated. This study attempted to elucidate the causative link between the gut microbiota and the …
View article: Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance
Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance Open
There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Physiologically, they regulate tissue differentiation, signal transduction pathways, cellular activation, proliferation, mot…
View article: Potential use of gold-silver core-shell nanoparticles derived from Garcinia mangostana peel for anticancer compound, protocatechuic acid delivery
Potential use of gold-silver core-shell nanoparticles derived from Garcinia mangostana peel for anticancer compound, protocatechuic acid delivery Open
Colorectal cancer is one of the most killing cancers and this has become a global problem. Current treatment and anticancer drugs cannot specifically target the cancerous cells, thus causing toxicity towards surrounding non-cancer cells. H…
View article: Sonochemical synthesis of a copper reduced graphene oxide nanocomposite using honey and evaluation of its antibacterial and cytotoxic activities
Sonochemical synthesis of a copper reduced graphene oxide nanocomposite using honey and evaluation of its antibacterial and cytotoxic activities Open
The combination of graphene-based materials and inorganic nanoparticles for the enhancement of the nanomaterial properties is extensively explored nowadays. In the present work, we used a sonochemical method to synthesize a copper/reduced …
View article: Preparation and Application of Cross-linked Alginate Nanoparticles as Drug Carrier: A Review
Preparation and Application of Cross-linked Alginate Nanoparticles as Drug Carrier: A Review Open
Nanotechnology also called as nanotech is referring to the science, technology and engineering to synthesis, manipulation and investigation of materials and devices at nanoscales. Nanoparticles (NPs) owns a special place in nanotechnology …
View article: Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update
Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update Open
Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suit…
View article: Short Review: Phytofabrication of Zinc Oxide Nanoparticles for Anticancer Applications
Short Review: Phytofabrication of Zinc Oxide Nanoparticles for Anticancer Applications Open
Zinc oxide nanoparticles (ZnO NPs) are one of the most well-known materials in the field of nanotechnology. Adopting a more environmentally friendly synthesis methods of ZnO NPs have been the focus in the last few decades. Of all green syn…
View article: 5-Fluorouracil Encapsulated Chitosan-Cellulose Fiber Bionanocomposites: Synthesis, Characterization and In Vitro Analysis towards Colorectal Cancer Cells
5-Fluorouracil Encapsulated Chitosan-Cellulose Fiber Bionanocomposites: Synthesis, Characterization and In Vitro Analysis towards Colorectal Cancer Cells Open
Cellulose and chitosan with remarkable biocompatibility and sophisticated physiochemical characteristics can be a new dawn to the advanced drug nano-carriers in cancer treatment. This study aims to synthesize layer-by-layer bionanocomposit…
View article: Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update
Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update Open
With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug de…
View article: Interplay of autophagy and cancer stem cells in hepatocellular carcinoma
Interplay of autophagy and cancer stem cells in hepatocellular carcinoma Open
Liver cancer is the sixth most common cancer and the fourth leading cause of cancer deaths in the world. The most common type of liver cancers is hepatocellular carcinoma (HCC). Autophagy is the cellular digestion of harmful components by …
View article: Green Synthesis of Fe3O4 Nanoparticles Stabilized by a Garcinia mangostana Fruit Peel Extract for Hyperthermia and Anticancer Activities
Green Synthesis of Fe3O4 Nanoparticles Stabilized by a Garcinia mangostana Fruit Peel Extract for Hyperthermia and Anticancer Activities Open
This research, therefore, introduced a new stabilizer of Garcinia mangostana fruit peel extract for the biosynthesis of Fe3O4 NPs with desirable physiochemical properties for potential magnetic hyperthermia and colon cancer treatment.
View article: Modulating carboxymethylcellulose-based hydrogels with superior mechanical and rheological properties for future biomedical applications
Modulating carboxymethylcellulose-based hydrogels with superior mechanical and rheological properties for future biomedical applications Open
Herein, a grafted copolymer composed of carboxymethylcellulose (CMC) and polyethylene-glycol-aminated (PEG-NH2) was successfully synthesized via a facile ionic interaction and scalable route in the presence of EDC/NHS (N-ethyl-N′-(3-dimeth…
View article: CCDC 2022654: Experimental Crystal Structure Determination
CCDC 2022654: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2022659: Experimental Crystal Structure Determination
CCDC 2022659: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Crystal structure of chlorido-(<i>O</i>-methyl phenylcarbamothioamide-κ<i>S</i>)-bis(triphenylphosphane-κ<i>P</i>)silver(I), C<sub>44</sub>H<sub>39</sub>AgClNOP<sub>2</sub>S
Crystal structure of chlorido-(<i>O</i>-methyl phenylcarbamothioamide-κ<i>S</i>)-bis(triphenylphosphane-κ<i>P</i>)silver(I), C<sub>44</sub>H<sub>39</sub>AgClNOP<sub>2</sub>S Open
C 44 H 39 AgClNOP 2 S, triclinic, P 1̄ (no. 2), a = 10.2520(3) Å, b = 13.2252(4) Å, c = 14.9378(3) Å, α = 78.424(2)°, β = 78.388(2)°, γ = 84.534(3)°, V = 1940.35(9) Å 3 , Z = 2, R gt ( F ) = 0.0382, wR ref ( F 2 ) = 0.0807, T = 100(2) K.
View article: Crystal structure of chlorido-(<i>O</i>-ethyl phenylcarbamothioamide-κ<i>S</i>)-bis(triphenylphosphane-κ<i>P</i>)-silver(I), C<sub>45</sub>H<sub>41</sub>AgClNOP<sub>2</sub>S
Crystal structure of chlorido-(<i>O</i>-ethyl phenylcarbamothioamide-κ<i>S</i>)-bis(triphenylphosphane-κ<i>P</i>)-silver(I), C<sub>45</sub>H<sub>41</sub>AgClNOP<sub>2</sub>S Open
C 45 H 41 AgClNOP 2 S, monoclinic, P 2 1 / c (no. 14), a = 10.1930(3) Å, b = 18.3087(6) Å, c = 21.3088(6) Å, β = 94.516(3)°, V = 3964.3(2) Å 3 , Z = 4, R gt ( F ) = 0.0353, wR ref ( F 2 ) = 0.0810, T = 100(2) K.
View article: Green Synthesized Montmorillonite/Carrageenan/Fe3O4 Nanocomposites for pH-Responsive Release of Protocatechuic Acid and Its Anticancer Activity
Green Synthesized Montmorillonite/Carrageenan/Fe3O4 Nanocomposites for pH-Responsive Release of Protocatechuic Acid and Its Anticancer Activity Open
Discovery of a novel anticancer drug delivery agent is important to replace conventional cancer therapies which are often accompanied by undesired side effects. This study demonstrated the synthesis of superparamagnetic magnetite nanocompo…
View article: <p>The Potential Anticancer Activity of 5-Fluorouracil Loaded in Cellulose Fibers Isolated from Rice Straw</p>
The Potential Anticancer Activity of 5-Fluorouracil Loaded in Cellulose Fibers Isolated from Rice Straw Open
This study, therefore, showed the strong potential anticancer activity of the novel CF/5-FU formulations, warranting their further investigation.
View article: Potential use of plasma focus radiation sources in superficial cancer therapy
Potential use of plasma focus radiation sources in superficial cancer therapy Open
The new multidisciplinary field of plasma medicine combines plasma physics, electrical engineering, life sciences and clinical medicine. Bekeschus et al. [Plasma Processes Polym. 16 , 1800033 (2019)]. Here we explore potential uses in medi…
View article: <p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>
Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications Open
Gold nanoparticles (AuNPs) are extensively studied nanoparticles (NPs) and are known to have profound applications in medicine. There are various methods to synthesize AuNPs which are generally categorized into two main types: chemical and…
View article: Current Update of Laboratory Molecular Diagnostics Advancement in Management of Colorectal Cancer (CRC)
Current Update of Laboratory Molecular Diagnostics Advancement in Management of Colorectal Cancer (CRC) Open
Colorectal cancer (CRC) continues to be one of the most common cancers globally. The incidence has increased in developing countries in the past few decades, this could be partly attributed to aging populations and unhealthy lifestyles. Wh…
View article: Bio-Mediated Synthesis and Characterisation of Silver Nanocarrier, and Its Potent Anticancer Action
Bio-Mediated Synthesis and Characterisation of Silver Nanocarrier, and Its Potent Anticancer Action Open
Discovery of a potent drug nanocarrier is crucial for cancer therapy in which drugs often face challenges in penetrating efficiently into solid tumours. Here, biosynthesis of silver nanoparticles (AgNPs) using a waste material, Garcinia ma…