Angus W. Thomson
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View article: Collaborative Synthesis for Neglected Diseases through the Open Synthesis Network: Structure–Activity Relationships of Arylaminopyrazoles as Chagas Disease Treatments
Collaborative Synthesis for Neglected Diseases through the Open Synthesis Network: Structure–Activity Relationships of Arylaminopyrazoles as Chagas Disease Treatments Open
Neglected tropical diseases (NTDs) make up a diverse group of debilitating illnesses disproportionately affecting impoverished communities in tropical and subtropical regions. Despite their significant global health burden, they are often …
View article: Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target
Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target Open
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. As an amplifier of the inflammatory response, TREM-1 is mainly involved in the production of inflammatory mediators and the regulation…
View article: Epigenetic signature of human vitamin D3 and IL-10-conditioned regulatory DCs
Epigenetic signature of human vitamin D3 and IL-10-conditioned regulatory DCs Open
During differentiation of precursor cells into their destination cell type, cell-fate decisions are enforced by a broad array of epigenetic modifications, including DNA methylation, which is reflected by the transcriptome. Thus, regulatory…
View article: Negative Vaccination Strategies for Promotion of Transplant Tolerance
Negative Vaccination Strategies for Promotion of Transplant Tolerance Open
Organ transplantation requires the use of immunosuppressive medications that lack antigen specificity, have many adverse side effects, and fail to induce immunological tolerance to the graft. The safe induction of tolerance to allogeneic t…
View article: Regulatory dendritic cell therapy in organ transplantation
Regulatory dendritic cell therapy in organ transplantation Open
Purpose of review Regulatory dendritic cells (DCregs; also ‘tolerogenic DCs’), innate immune cells that regulate the alloimmune response, are a novel cellular therapy for organ transplantation. Preliminary results from early-phase clinical…
View article: CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis Open
Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis form…
View article: IL-22BP controls the progression of liver metastasis in colorectal cancer
IL-22BP controls the progression of liver metastasis in colorectal cancer Open
Background The immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (…
View article: Tolerogenic dendritic cells protect against acute kidney injury
Tolerogenic dendritic cells protect against acute kidney injury Open
Ischemia reperfusion injury is a common precipitant of acute kidney injury that occurs following disrupted perfusion to the kidney. This includes blood loss and hemodynamic shock, as well as during retrieval for deceased donor kidney trans…
View article: SP03. Pharmacokinetics of Rapamycin and Tacrolimus in Swine Model of Vascularized Composite Allotransplantation
SP03. Pharmacokinetics of Rapamycin and Tacrolimus in Swine Model of Vascularized Composite Allotransplantation Open
PURPOSE: Tacrolimus (Tac) and Rapamycin (Rapa) are effective immunosuppressive drugs that has been widely used in experimental animals including minipigs; however, the pharmacokinetic properties of Tac and Rapa in minipigs have not been in…
View article: Meeting Report: The Fifth International Samuel Strober Workshop on Clinical Immune Tolerance
Meeting Report: The Fifth International Samuel Strober Workshop on Clinical Immune Tolerance Open
INTRODUCTION Chronic graft rejectionand toxicities of long-term immunosuppressive therapies impede the advancement of organ transplantation. Establishment of a state of tolerance, in which the immune system remains functional and competent…
View article: Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice
Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice Open
Immunomodulation holds therapeutic promise against brain injuries, but leveraging this approach requires a precise understanding of mechanisms. We report that CD8+CD122+CD49dlo T regulatory-like cells (CD8+ TRLs) are among the earliest lym…
View article: Activated-memory T cells influence naive T cell fate: A novel non-cytotoxic function of human CD8 T cells
Activated-memory T cells influence naive T cell fate: A novel non-cytotoxic function of human CD8 T cells Open
T cells are endowed with the capacity to sense their environment including other T cells around them. They do so to set their numbers and activation thresholds. This form of regulation has been well-studied within a given T cell population…
View article: Dendritic Cell-Mediated Regulation of Liver Ischemia-Reperfusion Injury and Liver Transplant Rejection
Dendritic Cell-Mediated Regulation of Liver Ischemia-Reperfusion Injury and Liver Transplant Rejection Open
Liver allograft recipients are more likely to develop transplantation tolerance than those that receive other types of organ graft. Experimental studies suggest that immune cells and other non-parenchymal cells in the unique liver microenv…
View article: A Comparison of Ex Vivo Expanded Human Regulatory T Cells Using Allogeneic Stimulated B Cells or Monocyte-Derived Dendritic Cells
A Comparison of Ex Vivo Expanded Human Regulatory T Cells Using Allogeneic Stimulated B Cells or Monocyte-Derived Dendritic Cells Open
Alloreactive regulatory T cells (arTregs) are more potent than polyclonal Tregs at suppressing immune responses to transplant antigens. Human arTregs can be expanded with allogeneic CD40L-stimulated B cells (sBcs) or stimulated-matured mon…
View article: Non-human Primate Regulatory T Cells and Their Assessment as Cellular Therapeutics in Preclinical Transplantation Models
Non-human Primate Regulatory T Cells and Their Assessment as Cellular Therapeutics in Preclinical Transplantation Models Open
Non-human primates (NHP) are an important resource for addressing key issues regarding the immunobiology of regulatory T cells (Treg), their in vivo manipulation and the translation of adoptive Treg therapy to clinical application. In addi…
View article: Ex Vivo Expanded Donor Alloreactive Regulatory T Cells Lose Immunoregulatory, Proliferation, and Antiapoptotic Markers After Infusion Into ATG-lymphodepleted, Nonhuman Primate Heart Allograft Recipients
Ex Vivo Expanded Donor Alloreactive Regulatory T Cells Lose Immunoregulatory, Proliferation, and Antiapoptotic Markers After Infusion Into ATG-lymphodepleted, Nonhuman Primate Heart Allograft Recipients Open
Background. Regulatory T cell (Treg) therapy is a promising approach to amelioration of allograft rejection and promotion of organ transplant tolerance. However, the fate of infused Treg, and how this relates to their therapeutic efficacy …
View article: Detection and Monitoring of Regulatory Immune Cells Following Their Adoptive Transfer in Organ Transplantation
Detection and Monitoring of Regulatory Immune Cells Following Their Adoptive Transfer in Organ Transplantation Open
Application of cell-based immunotherapy in organ transplantation to minimize the burden of immunosuppressive medication and promote allograft tolerance has expanded significantly over the past decade. Adoptively transferred regulatory immu…
View article: Transplantation Tolerance, Microchimerism, and the Two-Way Paradigm
Transplantation Tolerance, Microchimerism, and the Two-Way Paradigm Open
Melvin Cohn's points are exemplified by transplantation, which developed throughout much of its modern history in the absence of a unifying general principle. The microchimerism following organ transplantation has been studied extensively …