Fabio Timeus
YOU?
Author Swipe
View article: Prevention of sudden unexpected postnatal collapse in wellbeing newborns by remote digital health technologies
Prevention of sudden unexpected postnatal collapse in wellbeing newborns by remote digital health technologies Open
Introduction To prevent the Sudden Unexpected Postnatal Collapse (SUPC) this approach was carried out. SUPC is a rare and devastating event for the child and their family. Currently, no diagnostic prediction model is available to calculate…
View article: Beyond genotype: challenges in predicting disease risk for carriers of biallelic perforin variants
Beyond genotype: challenges in predicting disease risk for carriers of biallelic perforin variants Open
Genetic screening for severe congenital immunohematological diseases offers potential for early intervention, particularly through preemptive allogeneic hematopoietic stem cell transplantation (HSCT). However, the clinical value of such sc…
View article: Outcome of primary hemophagocytic lymphohistiocytosis: a report on 143 patients from the Italian Registry
Outcome of primary hemophagocytic lymphohistiocytosis: a report on 143 patients from the Italian Registry Open
Primary hemophagocytic lymphohistiocytosis (pHLH) is a severe, life-threatening hyperinflammatory syndrome caused by defects in genes of the granule-dependent cytotoxic pathway. Here we investigated the clinical presentation and outcome in…
View article: Impact of SARS-CoV-2 Pandemic and Lockdown on the HRSV Circulation: Experience of Three Spoke Hospitals in Northern Italy
Impact of SARS-CoV-2 Pandemic and Lockdown on the HRSV Circulation: Experience of Three Spoke Hospitals in Northern Italy Open
The SARS-CoV-2 Pandemic affected the global epidemiology of respiratory infections, including Human Respiratory Syncytial Virus (HRSV), thanks to state governments’ implementation of mitigation strategies, like the promotion of face masks …
View article: Management of Acute Bronchiolitis in Spoke Hospitals in Northern Italy: Analysis and Outcome
Management of Acute Bronchiolitis in Spoke Hospitals in Northern Italy: Analysis and Outcome Open
Bronchiolitis is an acute viral infection of the lower respiratory tract that affects infants and young children. Respiratory syncytial virus (RSV) is the most common causative agent; however, other viruses can be involved in this disease.…
View article: Impact of SARS-CoV2 Pandemic and Lockdown on the RSV Circulation: Experience of Three Spoke Hospitals in Northern Italy
Impact of SARS-CoV2 Pandemic and Lockdown on the RSV Circulation: Experience of Three Spoke Hospitals in Northern Italy Open
The SARS-CoV2 Pandemic affected the global epidemiology of respiratory infections, including Respiratory Syncytial Virus (RSV), thanks to state governments’ implementation of mitigation strategies, like the promotion of face masks and lock…
View article: Management of Acute Bronchiolitis in Spoke Hospitals: Analysis and Outcome
Management of Acute Bronchiolitis in Spoke Hospitals: Analysis and Outcome Open
Bronchiolitis is an acute viral infection of the lower respiratory tract that affects infants and young children. Respiratory syncytial virus (RSV) is the most common causative agent, however other viruses can be the reason of the disease.…
View article: Secondary hemophagocytic lymphohistiocytosis in children (Review)
Secondary hemophagocytic lymphohistiocytosis in children (Review) Open
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening condition characterized by hyperinflammation in an uncontrolled and ineffective immune response. Despite great improvement in diagnosis and treatment, it still represents…
View article: The Importance of RSV Epidemiological Surveillance: A Multicenter Observational Study of RSV Infection during the COVID-19 Pandemic
The Importance of RSV Epidemiological Surveillance: A Multicenter Observational Study of RSV Infection during the COVID-19 Pandemic Open
The restrictive measures adopted worldwide against SARS-CoV-2 produced a drastic reduction in respiratory pathogens, including RSV, but a dramatic rebound was thereafter reported. In this multicenter retrospective observational study in 15…
View article: Possible association between Guillain‑Barré syndrome and SARS‑CoV‑2 infection in children: A case report and literature review
Possible association between Guillain‑Barré syndrome and SARS‑CoV‑2 infection in children: A case report and literature review Open
Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported in adults and in children, varying from mild to more debilitant symptoms, including fatigue, headache and dizziness. A…
View article: Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5
Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5 Open
Neuroblastoma (NB) is a common malignant solid tumor in children and accounts for 15% of childhood cancer mortality. Amplification of the N-Myc oncogene is a well-established poor prognostic marker in NB patients and strongly correlates wi…
View article: Outcome of relapsed/refractory acute promyelocytic leukaemia in children, adolescents and young adult patients — a 25‐year Italian experience
Outcome of relapsed/refractory acute promyelocytic leukaemia in children, adolescents and young adult patients — a 25‐year Italian experience Open
Acute promyelocytic leukaemia (APL) is a rare subtype ofchildhood acute myeloid leukaemia (AML), accounting for5–12% of all AML cases. Treatment with all-trans-retinoicacid (ATRA) and anthracyclines yields complete remission(CR) rates >…
View article: Chronic sclerosing sialadenitis IgG4-related in a boy with recurrent parotitis: a case report
Chronic sclerosing sialadenitis IgG4-related in a boy with recurrent parotitis: a case report Open
BackgroundIgG4-related diseases are a group of immune-mediated diseases characterized by a lymphoplasmacytic infiltrate with a prevalence of IgG4-positive plasma cells, storiform fibrosis, obliterative phlebitis. Autoimmune pancreatitis, s…
View article: Congenital Hypopigmentary Disorders with Multiorgan Impairment: A Case Report and an Overview on Gray Hair Syndromes
Congenital Hypopigmentary Disorders with Multiorgan Impairment: A Case Report and an Overview on Gray Hair Syndromes Open
The term congenital hypopigmentary disorders refers to a wide group of heterogeneous hereditary diseases, clinically characterized by inborn pigmentary defects of the iris, hair, and/or skin. They include Gray Hair Syndromes (GHSs), a rare…
View article: Reduction of CFU-GM and circulating hematopoietic progenitors in a subgroup of children with chronic neutropenia associated with severe infections and delayed recovery
Reduction of CFU-GM and circulating hematopoietic progenitors in a subgroup of children with chronic neutropenia associated with severe infections and delayed recovery Open
Myelopoiesis was evaluated in 66 pediatric patients with chronic neutropenia who were positive for anti-neutrophil antibodies (median age at diagnosis: 11 months, median neutrophil count at diagnosis: 419/μl). Other causes of neutropenia w…
View article: Hematopoietic stem cell transplantation in Niemann–Pick disease type B monitored by chitotriosidase activity
Hematopoietic stem cell transplantation in Niemann–Pick disease type B monitored by chitotriosidase activity Open
Here, we report a patient with Niemann–Pick disease type B, with early severe onset of disease and pulmonary involvement, treated with hematopoietic stem cell transplant (HSCT) from a bone marrow matched unrelated donor. We confirm that HS…