Serhat Ünal
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View article: Fracture-Related Infections: Current Status and Perspectives from the International Society of Antimicrobial Chemotherapy
Fracture-Related Infections: Current Status and Perspectives from the International Society of Antimicrobial Chemotherapy Open
Fracture-related infections (FRIs) represent a significant complication in orthopedic trauma care, often leading to delayed bone healing, prolonged hospital stays, and increased patient morbidity. Pathogenesis involves microbial contaminat…
View article: Molecular epidemiological analysis and investigation of antiretroviral drug resistance profile, including capsid inhibitors, among treatment‐naïve individuals with <scp>HIV</scp> ‐1 in Türkiye
Molecular epidemiological analysis and investigation of antiretroviral drug resistance profile, including capsid inhibitors, among treatment‐naïve individuals with <span>HIV</span> ‐1 in Türkiye Open
Introduction Monitoring transmitted drug resistance is crucial for guiding first‐line antiretroviral therapy (ART) and controlling the rising HIV epidemic in Türkiye. This study aimed to determine the prevalence of transmitted antiretrovir…
View article: Phase Angle Is Lower in Older Adults Living with HIV Compared to Geriatric Outpatients: A Case–Control Study
Phase Angle Is Lower in Older Adults Living with HIV Compared to Geriatric Outpatients: A Case–Control Study Open
Background: Bioelectrical impedance analysis has been used to evaluate phase angle, which predicts cellular health and may even predict survival in people living with HIV. However, the relationship between the phase angle and geriatric syn…
View article: Global Trends in Pediatric Dentistry Research on Neurodevelopmental Disorders: A Bibliometric Study (2015–2024)
Global Trends in Pediatric Dentistry Research on Neurodevelopmental Disorders: A Bibliometric Study (2015–2024) Open
Neurodevelopmental disorders such as autism spectrum disorder (ASD), Down syndrome, and attention-deficit/hyperactivity disorder (ADHD) present significant challenges in pediatric dental care, often requiring specialized approaches to trea…
View article: A Phase 3 Randomized Trial Investigating the Safety, Tolerability, and Immunogenicity of V116, an Adult-Specific Pneumococcal Vaccine, Compared with PPSV23, in Adults ≥50 Years of Age (STRIDE-10)
A Phase 3 Randomized Trial Investigating the Safety, Tolerability, and Immunogenicity of V116, an Adult-Specific Pneumococcal Vaccine, Compared with PPSV23, in Adults ≥50 Years of Age (STRIDE-10) Open
Background: V116 is a 21-valent pneumococcal conjugate vaccine (PCV) designed for adults. It contains the most prevalent serotypes associated with invasive pneumococcal disease (IPD) in adults in regions with established pediatric vaccinat…
View article: The Global Influenza Hospital Surveillance Network: A Multicountry Public Health Collaboration
The Global Influenza Hospital Surveillance Network: A Multicountry Public Health Collaboration Open
Respiratory viruses represent a significant public health threat. There is the need for robust and coordinated surveillance to guide global health responses. Established in 2012, the Global Influenza Hospital Surveillance Network (GIHSN) a…
View article: A novel scale to define biopsychosocial aspects of people living with HIV: BETY-BQ
A novel scale to define biopsychosocial aspects of people living with HIV: BETY-BQ Open
AIM: To define the validity and reliability of a novel, biopsychosocial assessment scale (Cognitive Exercise Therapy Approach – Biopsychosocial Questionnaire (BETY-BQ)) in people living with HIV (PLWH). BACKGROUND: Problems such as pain, f…
View article: Evaluation of the impact of the COVID-19 pandemic on treatment response of newly diagnosed people living with HIV: Turkey experience
Evaluation of the impact of the COVID-19 pandemic on treatment response of newly diagnosed people living with HIV: Turkey experience Open
AIM: To evaluate the antiretroviral treatment (ART) in newly diagnosed people living with HIV (PLWH) and to determine treatment response in pre-pandemic and pandemic periods. BACKGROUND: The COVID-19 pandemic has negatively affected the tr…
View article: SARS-CoV-2 Still on the Stage: The Need to Pursue an Integrated Respiratory Virus Surveillance
SARS-CoV-2 Still on the Stage: The Need to Pursue an Integrated Respiratory Virus Surveillance Open
AIM: To demonstrate the importance of an integrated viral surveillance to tackle the changing epidemiology and the continuing disease burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). BACKGROUND: International institu…
View article: A Case of Relapsing Hyponatremia Associated with Fungal Sinusitis
A Case of Relapsing Hyponatremia Associated with Fungal Sinusitis Open
Introduction: Hyponatremia is one of the most common electrolyte abnormalities in clinical practice. Syndrome of inappropriate antidiuretic hormone (SIADH) accounts for the majority of hyponatremia cases. In some cases, it may be challengi…
View article: The Older Population’s Antibody Response to SARS-CoV-2 Inactivated Vaccine (CoronaVac) is Independent to Vitamin D Levels
The Older Population’s Antibody Response to SARS-CoV-2 Inactivated Vaccine (CoronaVac) is Independent to Vitamin D Levels Open
Objective:The purpose of this study was to determine how the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) inactivated vaccine antibody response and vitamin D levels in the older population are related. Materials and Methods…
View article: The impact of previous SARS-CoV-2 infection on post-vaccine adverse events in individuals vaccinated with TURKOVAC or CoronaVac –inactivated COVID-19 vaccines
The impact of previous SARS-CoV-2 infection on post-vaccine adverse events in individuals vaccinated with TURKOVAC or CoronaVac –inactivated COVID-19 vaccines Open
This study- a secondary analysis of data from a randomized, observer-blinded, non-inferiority study among volunteers between 18-55 y old in Türkiye- evaluated the impact of previous SARS-CoV-2 infection before the first dose of inactive TU…
View article: Multimodal data fusion using sparse canonical correlation analysis and cooperative learning: a COVID-19 cohort study
Multimodal data fusion using sparse canonical correlation analysis and cooperative learning: a COVID-19 cohort study Open
Through technological innovations, patient cohorts can be examined from multiple views with high-dimensional, multiscale biomedical data to classify clinical phenotypes and predict outcomes. Here, we aim to present our approach for analyzi…
View article: Treatment of Pneumocystis jirovecii Pneumonia with Caspofungin and Clindamycin: An HIV Patient and Literature Review
Treatment of Pneumocystis jirovecii Pneumonia with Caspofungin and Clindamycin: An HIV Patient and Literature Review Open
The first-line treatment for Pneumocystis jirovecii pneumonia (PCP) is trimethoprim-sulfamethoxazole (TMP-SMZ).However, some cases require alternative agents due to the side effects of TMP-SMZ.Treatment with TMP-SMZ was initiated in an HIV…
View article: Preliminary Findings Regarding Nutrition Information Needs among Family Physicians in Turkey
Preliminary Findings Regarding Nutrition Information Needs among Family Physicians in Turkey Open
Background and objectives: Considering the information pollution in the field of nutrition and health in society, more than half of the community asks family physicians (FPs) as the closest counseling unit about healthy nutrition and relat…
View article: Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial
Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial Open
Background Tixagevimab and cilgavimab (AZD7442) are two monoclonal antibodies developed by AstraZeneca for the pre-exposure prophylaxis and treatment of patients infected by SARS-CoV-2. Its effectiveness and safety in patients hospitalized…
View article: Frailty as a Significant Predictor of COVID-19 Among Vaccinated Older Adults
Frailty as a Significant Predictor of COVID-19 Among Vaccinated Older Adults Open
Frailty is defined as a clinical syndrome of decreased reserve to stressors and is strongly associated with increased disability, hospitalization, and mortality rates (3).Frail older adults have a poor prognosis for COVID-19, and some guid…
View article: Chest wall resections for sulcus superior tumors
Chest wall resections for sulcus superior tumors Open
Chemoradiotherapy followed by surgical resection (trimodality therapy) is a guideline recommended treatment for sulcus superior tumors (SST). By definition, SSTs invade the chest wall and therefore require en-bloc chest wall resection with…
View article: Initial Empirical Antibiotic Treatment in Covid-19 Patients is Related with Excess Adverse Drug Reactions Without Clinical Benefit
Initial Empirical Antibiotic Treatment in Covid-19 Patients is Related with Excess Adverse Drug Reactions Without Clinical Benefit Open
Initial empirical antibiotic treatment is common among patients infected with SARS-CoV-2, although the coinfection rate is low. Empirical antibiotic(s) did not improve the clinical course in COVID-19 patients.
View article: Influenza
Influenza Open
İnfluenza virüsleri, Orthomyxovirida ailesine ait
View article: A retrospective study: Can dual ART mitigate the risk of potential drug-drug interactions among PLWH under stable ART?
A retrospective study: Can dual ART mitigate the risk of potential drug-drug interactions among PLWH under stable ART? Open
The results suggest that dual treatment regimens can reduce pDDIs, resulting in better tolerance and probably higher quality of life among PLWH.
View article: Superior Sulcus Tumors Invading the Spine: Multimodal Treatment Outcomes From the Preimmunotherapy Era
Superior Sulcus Tumors Invading the Spine: Multimodal Treatment Outcomes From the Preimmunotherapy Era Open
Multimodality treatment in selected patients with a superior sulcus tumor invading the spine is safe and results in good survival. Such patients should be referred to expert centers. Future research should focus on improving distant contro…
View article: Cessation of Rectal Screening for Vancomycin-Resistant Enterococci: Experience from a Tertiary Care Hospital from Türkiye
Cessation of Rectal Screening for Vancomycin-Resistant Enterococci: Experience from a Tertiary Care Hospital from Türkiye Open
Objective: Here, we compared the impact of different polices on the epidemiology of Vancomycin-resistant Enterococcus faecium bloodstream infections (VRE-BSIs) in a tertiary care hospital including two hospital buildings (oncology and adul…