Paul S. Uster
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View article: Targeted radiosensitisation by pegylated liposome-encapsulated 3′, 5′-O-dipalmitoyl 5-iodo-2′-deoxyuridine in a head and neck cancer xenograft model
Targeted radiosensitisation by pegylated liposome-encapsulated 3′, 5′-O-dipalmitoyl 5-iodo-2′-deoxyuridine in a head and neck cancer xenograft model Open
5-Iodo-2'-deoxyuridine (IUdR) is an effective radiosensitiser but its clinical development has been limited by toxicity. Prolonged intravenous infusions of IUdR are necessary for optimal tumour uptake but cause dose-limiting myelosuppressi…
View article: Impact of aerosol particle size on drug deposition during mechanical ventilation: an in vitro evaluation
Impact of aerosol particle size on drug deposition during mechanical ventilation: an in vitro evaluation Open
Purpose: To describe the epidemiology of the acute respiratory distress syndrome (ARDS) in a Brazilian ICU.Methods: This prospective observational, non-interventional study, included all consecutive patients with ARDS criteria [1] admitted…
View article: Biodistribution and pharmacokinetics of 111In-DTPA-labelled pegylated liposomes in a human tumour xenograft model: implications for novel targeting strategies
Biodistribution and pharmacokinetics of 111In-DTPA-labelled pegylated liposomes in a human tumour xenograft model: implications for novel targeting strategies Open
The biodistribution and pharmacokinetics of 111In-DTPA-labelled pegylated liposomes in tumour-bearing nude mice was studied to examine possible applications of pegylated liposome-targeted anti-cancer therapies. Nude mice received an intrav…
View article: Inhibition of mouse mammary carcinoma development with doxorubicin in liposomes
Inhibition of mouse mammary carcinoma development with doxorubicin in liposomes Open
Monthly treatments with intravenous doxorubicin encapsulated in long circulating, sterically stabilized liposomes delayed the appearance of primary mammary carcinomas and reduced the final incidence from 49 in 50 untreated mice to 46 in 87…
View article: Insertion of poly(ethylene glycol) derivatized phospholipid into pre‐formed liposomes results in prolonged in vivo circulation time
Insertion of poly(ethylene glycol) derivatized phospholipid into pre‐formed liposomes results in prolonged in vivo circulation time Open
Transfer of MPEG 1900 ‐DSPE from micellar phase to pre‐formed liposomes imparts long in vivo circulation half‐life to an otherwise rapidly cleared lipid composition. MPEG 1900 ‐DSPE transfers efficiently and quickly in a time and temperatu…
View article: Resonance energy transfer microscopy: observations of membrane-bound fluorescent probes in model membranes and in living cells.
Resonance energy transfer microscopy: observations of membrane-bound fluorescent probes in model membranes and in living cells. Open
A conventional fluorescence microscope was modified to observe the sites of resonance energy transfer (RET) between fluorescent probes in model membranes and in living cells. These modifications, and the parameters necessary to observe RET…