Vikas Patil
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View article: BIOM-31. PLASMA CELL-FREE DNA METHYLOME PREDICTS RESPONSE TO COMBINED PARP AND IMMUNE CHECKPOINT INHIBITION IN IDH-MUTANT GLIOMA
BIOM-31. PLASMA CELL-FREE DNA METHYLOME PREDICTS RESPONSE TO COMBINED PARP AND IMMUNE CHECKPOINT INHIBITION IN IDH-MUTANT GLIOMA Open
INTRODUCTION Recurrent IDH-mutant gliomas pose a significant therapeutic challenge, with limited treatment options following progression after standard therapy. Combining PARP inhibitors with immune checkpoint blockade has been proposed as…
View article: BIOM-08. CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA
BIOM-08. CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA Open
The CNS WHO grade of meningioma was updated in 2021 to include rare molecular features, namely homozygous deletions of CDKN2A or CDKN2B and TERT promotor mutations. Previous work including the cIMPACT-NOW update 8 have discussed the potent…
View article: STEM-24. SINGLE CELL CRISPR/CAS-9 LINEAGE TRACING REVEALS EVOLUTIONARY FITNESS, EXPANSION AND PLASTICITY AXES IN ADULT DIFFUSE GLIOMAS
STEM-24. SINGLE CELL CRISPR/CAS-9 LINEAGE TRACING REVEALS EVOLUTIONARY FITNESS, EXPANSION AND PLASTICITY AXES IN ADULT DIFFUSE GLIOMAS Open
A major barrier in understanding adult diffuse gliomas lies in the inability to track tumor evolution in real time. To address this, we employed a novel method known as continuous lineage tracing, which integrates CRISPR/Cas9-based express…
View article: BIOM-113. TERT EXPRESSION IN MENINGIOMAS PREDICTS PROGRESSION-FREE SURVIVAL INDEPENDENT OF TERT PROMOTER MUTATION
BIOM-113. TERT EXPRESSION IN MENINGIOMAS PREDICTS PROGRESSION-FREE SURVIVAL INDEPENDENT OF TERT PROMOTER MUTATION Open
INTRODUCTION While TERT promoter mutation (TPM) has been established as a marker of clinically aggressive meningiomas, this alteration is rare and found in less than 5% of all cases. However, a larger subset of meningiomas may exhibit aber…
View article: Biomass‐Derived Hetero Atom‐Doped Porous Carbon for Enhanced CO <sub>2</sub> Adsorption
Biomass‐Derived Hetero Atom‐Doped Porous Carbon for Enhanced CO <sub>2</sub> Adsorption Open
The emission of carbon dioxide (CO 2 ) and its impact on global warming have shown exponential growth in recent decades. Hence, the mitigation of CO 2 emissions is indeed important. Among the developed protocols, the selective and effectiv…
View article: Synthesis and characterization of bio-based furan-imine diol derived polyurethane composites from 5-HMF
Synthesis and characterization of bio-based furan-imine diol derived polyurethane composites from 5-HMF Open
Polyurethanes are the most important polymer generally prepared through the curing of diols and isocyanates. Here we have prepared Furan-Imine diol compounds from the reaction of bio-waste-derived 5-HMF and different diamines (1,2-phenylen…
View article: 33 TERT EXPRESSION PREDICTS PROGRESSION-FREE SURVIVAL IN MENINGIOMAS
33 TERT EXPRESSION PREDICTS PROGRESSION-FREE SURVIVAL IN MENINGIOMAS Open
BACKGROUND TERT promoter mutation (TPM) is a rare but established biomarker in meningiomas associated with aberrant TERT expression and reduced progression-free survival (PFS). While TERT is highly expressed in meningiomas with TPMs, it ha…
View article: 55 INSIGHTS INTO MENINGIOMA BIOLOGY AND RADIOTHERAPY RESPONSE THROUGH MOLECULAR CHARACTERIZATION OF RTOG-0539 CLINICAL TRIAL
55 INSIGHTS INTO MENINGIOMA BIOLOGY AND RADIOTHERAPY RESPONSE THROUGH MOLECULAR CHARACTERIZATION OF RTOG-0539 CLINICAL TRIAL Open
Brain Tumour Foundation of Canada Travel Award Recipient BACKGROUND Meningiomas are the most common primary intracranial tumors. Radiotherapy (RT) is an adjunct treatment following surgical resection, but response varies. RTOG-0539 is the …
View article: 17 CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA
17 CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA Open
BACKGROUND The CNS WHO grade of meningioma was updated in 2021 to include rare molecular features, namely homozygous deletions of CDKN2A or CDKN2B and TERT promotor mutations. Previous work including the recent cIMPACT-NOW statement have d…
View article: 4 CTDNA METHYLATION PREDICTS RESPONSE TO PARP AND PD-1 BLOCKADE IN IDH-MUTANT GLIOMA
4 CTDNA METHYLATION PREDICTS RESPONSE TO PARP AND PD-1 BLOCKADE IN IDH-MUTANT GLIOMA Open
The combination of PARP and immune checkpoint inhibitors has been proposed as a synergistic treatment strategy for IDH-mutant high-grade glioma, targeting homologous recombination repair deficiencies. This study evaluated circulating tumor…
View article: 17 CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA
17 CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA Open
Brain Tumour Foundation of Canada Travel Award Recipient The CNS WHO grade of meningioma was updated in 2021 to include rare molecular features, namely homozygous deletions of CDKN2A or CDKN2B and TERT promotor mutations. Previous work inc…
View article: The “Lelli Test” a modern and new clinical test for the diagnosis of anterior cruciate ligament lesions
The “Lelli Test” a modern and new clinical test for the diagnosis of anterior cruciate ligament lesions Open
Objectives: Over the past decade, Dr. Alessandro Lelli’s new functional clinical test, the Lelli Test or the Lever Sign Test, has supplemented traditional clinical tests and magnetic resonance imaging (MRI) investigations to diagnose parti…
View article: Using Open-Source Large Language Models to Identify Access to Germline Genetic Testing in Veterans With Breast Cancer From Unstructured Text
Using Open-Source Large Language Models to Identify Access to Germline Genetic Testing in Veterans With Breast Cancer From Unstructured Text Open
PURPOSE The ability of large language models (LLMs) to identify access to germline genetic testing from unstructured text remains unknown. The Department of Veterans Affairs (VA) assessed access in Veterans with breast cancer by implementi…
View article: P.157 TERT expression predicts progression-free survival in meningiomas
P.157 TERT expression predicts progression-free survival in meningiomas Open
Background: TERT promoter mutation (TPM) is an established biomarker in meningiomas associated with aberrant TERT expression and reduced progression-free survival (PFS). TERT expression, however, has also been observed even in tumours with…
View article: F.2 Single cell CRISPR/Cas-9 lineage tracing reveals fitness axis in glioblastoma
F.2 Single cell CRISPR/Cas-9 lineage tracing reveals fitness axis in glioblastoma Open
Background: We’ve adopted a novel approach that combines cellular barcoding with CRISPR/Cas-9 technology and single-cell RNA sequencing known as continuous lineage tracing to track the development, treatment and inevitable recurrence of gl…
View article: P.158 Molecular characterization of RTOG-0539 risk groups in meningioma: insights into radiotherapy response and tumor biology
P.158 Molecular characterization of RTOG-0539 risk groups in meningioma: insights into radiotherapy response and tumor biology Open
Background: Meningiomas are the most common intracranial tumors. Radiotherapy (RT) serves as an adjunct following surgical resection; however, response varies. RTOG-0539 is a prospective, phase 2, trial that stratified patients risk groups…
View article: Boosting Open Set Recognition Performance through Modulated Representation Learning
Boosting Open Set Recognition Performance through Modulated Representation Learning Open
The open set recognition (OSR) problem aims to identify test samples from novel semantic classes that are not part of the training classes, a task that is crucial in many practical scenarios. However, the existing OSR methods use a constan…
View article: Chromosome 1p Loss and 1q Gain for Grading of Meningioma
Chromosome 1p Loss and 1q Gain for Grading of Meningioma Open
Importance The World Health Organization (WHO) classification of central nervous system tumors (CNS) grading for meningioma was updated in 2021 to include rare molecular features, namely homozygous deletions of CDKN2A or CDKN2B and TERT pr…
View article: Metabolic profiling of meningioma reveals novel subgroup-specific biologic insights and outcome dependencies
Metabolic profiling of meningioma reveals novel subgroup-specific biologic insights and outcome dependencies Open
Background Our group and others have recently identified four molecular groups of meningioma, with unique underlying biology and outcomes. The relevance of group-specific metabolite profiles (particularly among hypermetabolic tumors), has …
View article: BIOM-72. INTEGRATION OF ULTRASENSITIVE ELECTROLUMINESCENT IMMUNOASSAY AND CELL-FREE DNAMETHYLATION ANALYSIS FOR NON-INVASIVE MONITORING OF ADULT DIFFUSE GLIOMAS
BIOM-72. INTEGRATION OF ULTRASENSITIVE ELECTROLUMINESCENT IMMUNOASSAY AND CELL-FREE DNAMETHYLATION ANALYSIS FOR NON-INVASIVE MONITORING OF ADULT DIFFUSE GLIOMAS Open
Gliomas are highly aggressive brain tumors with nearly universal recurrence rate. Despite this, the ability to accurately predict and identify tumor recurrence relies solely on serial MRI imaging, which is marred by treatment effects such …
View article: TMET-21. METABOLIC PROFILING OF MENINGIOMA REVEALS NOVEL SUBGROUP-SPECIFIC BIOLOGIC INSIGHTS AND OUTCOME DEPENDENCIES
TMET-21. METABOLIC PROFILING OF MENINGIOMA REVEALS NOVEL SUBGROUP-SPECIFIC BIOLOGIC INSIGHTS AND OUTCOME DEPENDENCIES Open
BACKGROUND Prior studies have elucidated the presence of four consensus molecular groups (MGs) of meningioma, with unique underlying biology and outcomes. The hyperactivation of metabolic pathways may be associated with tumour growth in so…
View article: Synthesis of self-curing bio-based eugenol-epoxy resin an application to metal surface coating
Synthesis of self-curing bio-based eugenol-epoxy resin an application to metal surface coating Open
Eugenol an active reagent extracted from the plant are being used as one of the composite materials for the preparation of monomer. In a course of successive reaction eugenol was reacted with the 1,4-butandiol diglycidyl ether yields the r…
View article: PL02.3.A MOLECULAR CLASSIFICATION TO REFINE SURGICAL AND RADIOTHERAPEUTIC DECISION MAKING IN MENINGIOMA
PL02.3.A MOLECULAR CLASSIFICATION TO REFINE SURGICAL AND RADIOTHERAPEUTIC DECISION MAKING IN MENINGIOMA Open
BACKGROUND Treatment of the tumor and dural margin, most commonly with surgery and sometimes radiation, are cornerstones of therapy for meningioma. Molecular classifications have provided insights into the biology of disease. However, resp…
View article: A Solar Air Receiver With Porous Ceramic Structures for Process Heat at Above 1000 °C—Heat Transfer Analysis
A Solar Air Receiver With Porous Ceramic Structures for Process Heat at Above 1000 °C—Heat Transfer Analysis Open
Concentrated solar energy can be used as the source of heat at above 1000 °C for driving key energy-intensive industrial processes, such as cement manufacturing and metallurgical extraction, contributing to their decarbonization. The corne…
View article: Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma Open
Treatment of the tumor and dural margin with surgery and sometimes radiation are cornerstones of therapy for meningioma. Molecular classifications have provided insights into the biology of disease; however, response to treatment remains h…
View article: QOL-27. EARLY CHEMOTHERAPY-INDUCED HEARING LOSS IN CHILDREN WITH MEDULLBLASTOMA AND EMBRYONAL BRAIN TUMOURS
QOL-27. EARLY CHEMOTHERAPY-INDUCED HEARING LOSS IN CHILDREN WITH MEDULLBLASTOMA AND EMBRYONAL BRAIN TUMOURS Open
BACKGROUND The purpose of this study was to examine the prevalence, severity and time to develop Chemotherapy-induced hearing loss (HL) in a cohort of embryonal brain tumors(ET) treated with cisplatin and cranial radiation(RT). METHODS Our…
View article: F.2 Comprehensively mapping transcriptionally relevant histone modifications in aggressive meningioma leads to novel biologic insights and therapeutic vulnerabilities
F.2 Comprehensively mapping transcriptionally relevant histone modifications in aggressive meningioma leads to novel biologic insights and therapeutic vulnerabilities Open
Background: We recently identified four molecular subgroups of meningioma with distinct biology and outcomes. While two (MG3/MG4) are associated with poor outcome, they display divergent transcriptional profiles (enriched in metabolic and …