Sonja Vučković
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View article: Effects of NMDA receptor antagonists on acute postoperative pain
Effects of NMDA receptor antagonists on acute postoperative pain Open
Introduction: Pain represents a multifactorial process with detrimental effects on the entire organism. This randomized, open-label pilot study investigated the effect of preemptive administration of ketamine and magnesium-sulfate on the i…
View article: Pharmacological management of postoperative pain
Pharmacological management of postoperative pain Open
Postoperative pain is a widespread and underestimated problem both in Serbia and globally. Numerous studies conducted in countries with advanced healthcare systems have shown that even in the 21st century, postoperative pain is not adequat…
View article: Ketamine, an Old–New Drug: Uses and Abuses
Ketamine, an Old–New Drug: Uses and Abuses Open
Ketamine as an old–new drug has a variety of clinical implications. In the last 30 years, ketamine has become popular for acute use in humans. Ketamine in standard doses is principally utilized for the induction and maintenance of surgical…
View article: Ketamine, an Old–New Drug: Uses and Abuses
Ketamine, an Old–New Drug: Uses and Abuses Open
Ketamine as an old - new drug has variety of clinical implications. In the last 30 years, ketamine has become popular for acute use in humans. Ketamine at standard doses is principally utilized for the induction and maintenance in surgical…
View article: Oxidative Stress and Inflammation Biomarkers in Postoperative Pain Modulation in Surgically Treated Patients with Laryngeal Cancer—Pilot Study
Oxidative Stress and Inflammation Biomarkers in Postoperative Pain Modulation in Surgically Treated Patients with Laryngeal Cancer—Pilot Study Open
(1) Background: Surgical treatment of laryngeal carcinoma includes different types of laryngectomies with neck dissection. Surgical tissue damage triggers an inflammatory response, leading to the release of pro-inflammatory molecules. This…
View article: The Interactions of Magnesium Sulfate and Cromoglycate in a Rat Model of Orofacial Pain; The Role of Magnesium on Mast Cell Degranulation in Neuroinflammation
The Interactions of Magnesium Sulfate and Cromoglycate in a Rat Model of Orofacial Pain; The Role of Magnesium on Mast Cell Degranulation in Neuroinflammation Open
Mast cell degranulation impacts the development of pain and inflammation during tissue injury. We investigated the antinociceptive effect of a combination of cromoglycate and magnesium in the orofacial model of pain and the histological pr…
View article: Infections of the extremities as a complications of the intravenous use of psychoactive substances
Infections of the extremities as a complications of the intravenous use of psychoactive substances Open
Introduction: Infections on the extremities are a common occurrence in psychoactive substance addicts who use the drug intravenously. A significant risk of infection is present due to non-sterile conditions and/or incorrect injection of su…
View article: Magnesium Sulfate Reduces Carrageenan-Induced Rat Paw Inflammatory Edema Via Nitric Oxide Production
Magnesium Sulfate Reduces Carrageenan-Induced Rat Paw Inflammatory Edema Via Nitric Oxide Production Open
Background Magnesium is an antagonist of the N-methyl-D-aspartate receptor. This study aimed to investigate the anti-edematous effect of magnesium sulfate (MS) in different protocols of use and the possible mechanism of its action. Methods…
View article: Revising the role of magnesium in epilepsy research and management
Revising the role of magnesium in epilepsy research and management Open
Magnesium is a bioessential mineral with multiple neuroactive effects. Mg2+ ion stabilizes excitable membranes. Epilepsy is the third most frequent chronic neurological condition characterized by spontaneous reappearance of unprovoked epil…
View article: Chloroquine Attenuates Oxidative Stress in Gentamicin-Induced Nephrotoxicity in Rats
Chloroquine Attenuates Oxidative Stress in Gentamicin-Induced Nephrotoxicity in Rats Open
The wider application of gentamicin is limited by potential adverse effects (nephrotoxicity and ototoxicity). The goal of our study was to investigate the effects of chloroquine on biochemical and oxidative stress parameters in gentamicin-…
View article: Correlation of Ionized Magnesium with the Parameters of Oxidative Stress as Potential Biomarkers in Patients with Anxiety and Depression: A Pilot Study
Correlation of Ionized Magnesium with the Parameters of Oxidative Stress as Potential Biomarkers in Patients with Anxiety and Depression: A Pilot Study Open
Background Magnesium (Mg) is the second most abundant intracellular cation. Ionized Mg is the only active form of Mg. The concentration of ionized Mg could be a potentially novel biomarker for anxiety and depression. Aim The aim of this st…
View article: Investigation of the Antinociceptive Activity of the Hydroethanolic Extract of <i>Junglas nigra</i> Leaf by the Tail-Immersion and Formalin Pain Tests in Rats
Investigation of the Antinociceptive Activity of the Hydroethanolic Extract of <i>Junglas nigra</i> Leaf by the Tail-Immersion and Formalin Pain Tests in Rats Open
Background Juglans (J.) nigra leaf is obtained from a plant that is used in traditional medicine in some countries to alleviate inflammatory diseases. Aim The aim of this study was to compare the effects of J. nigra extract on acute nocice…
View article: The effects of subchronic intake of magnesium hydrocarbonate-rich mineral water on body weight and cardiovascular variables in rats with streptozotocin: Induced diabetes
The effects of subchronic intake of magnesium hydrocarbonate-rich mineral water on body weight and cardiovascular variables in rats with streptozotocin: Induced diabetes Open
Background/Aim: Optimal intake of magnesium minerals is essential in maintaining the coordinated physiological functions of cells, tissues and organs. The importance of this element is reflected in the fact that it is the fourth most abund…
View article: The effects of subchronic intake of magnesium hydro-carbonate-rich mineral water on cardiometabolic markers and electrolytes in rats with streptozotocin-induced diabetes
The effects of subchronic intake of magnesium hydro-carbonate-rich mineral water on cardiometabolic markers and electrolytes in rats with streptozotocin-induced diabetes Open
Background/Aim: Hypomagnesaemia is one of the most detected electrolyte abnormalities in diabetics. Modulation of numerous cardiovascular pathophysiological processes is a potential goal for anti-diabetic therapy. Magnesium supplementation…
View article: Pharmacology, from Rudolf Buchheim to Arnold Holste: The founding of the Institute of Pharmacology at the Faculty of Medicine, University of Belgrade
Pharmacology, from Rudolf Buchheim to Arnold Holste: The founding of the Institute of Pharmacology at the Faculty of Medicine, University of Belgrade Open
The School of Medicine at the University of Belgrade celebrates its centennial anniversary. The Institute of Pharmacology and Toxicology, founded in 1924, played an important role in the School's life and development. It is not just about …
View article: Editorial: Mechanisms and New Targets for the Treatment of Chronic Pain
Editorial: Mechanisms and New Targets for the Treatment of Chronic Pain Open
EDITORIAL article Front. Pharmacol., 29 September 2020Sec. Neuropharmacology Volume 11 - 2020 | https://doi.org/10.3389/fphar.2020.600037
View article: Pharmacotherapy of Rare Diseases in Serbia: The Current State of Art
Pharmacotherapy of Rare Diseases in Serbia: The Current State of Art Open
Rare diseases affect less than 1 in 2000 or 5 in 10,000 people by definition.Most of those diseases have genetic basis (80% of cases) and first symptoms appear in early childhood (50% of cases).Most of these diseases are chronic and degene…
View article: μ-opioid/D2 dopamine receptor pharmacophore containing ligands: Synthesis and pharmacological evaluation
μ-opioid/D2 dopamine receptor pharmacophore containing ligands: Synthesis and pharmacological evaluation Open
Herein, the synthesis and pharmacological evaluation of 13 novel compounds, designed as potential heterobivalent ligands for ?-opioid receptor (MOR) and dopamine D2 receptors (D2DAR), are reported. The compounds consisted of anilido piperi…
View article: Takotsubo Cardiomyopathy Precipitated By Thyroidectomy - A Case Report
Takotsubo Cardiomyopathy Precipitated By Thyroidectomy - A Case Report Open
Takotsubo cardiomyopathy (TC) is an acute cardiac condition triggered by emotional or physical stress. General anesthesia and sympathetic activation are possible triggers for TC. However, little is known about the role of sympathovagal act…
View article: Pain Management After Surgical Tonsillectomy: Is There a Favorable Analgesic?
Pain Management After Surgical Tonsillectomy: Is There a Favorable Analgesic? Open
The aim of this study was to examine how ibuprofen and paracetamol prevent pain after cold-steel extracapsular tonsillectomy in children. Also, we examined the relation between age, gender, nausea, postoperative bleeding, antibiotic use, t…
View article: Role of magnesium sulfate in the treatment of acute postoperative pain
Role of magnesium sulfate in the treatment of acute postoperative pain Open
Co-analgesics are often combined with opioids to reduce the prevalence of opioid adverse effects while maintaining or even improve the quality of analgesia. Magnesium is an essential mineral which modulates nociceptive processing by action…
View article: Evaluation of Prophylactic and Therapeutic Effects of Tramadol and Tramadol Plus Magnesium Sulfate in an Acute Inflammatory Model of Pain and Edema in Rats
Evaluation of Prophylactic and Therapeutic Effects of Tramadol and Tramadol Plus Magnesium Sulfate in an Acute Inflammatory Model of Pain and Edema in Rats Open
Background: Inflammatory pain is the most commonly treated clinical pain, since it develops following trauma or surgery, and accompanies rheumatic or arthritic diseases. Tramadol is one of the most frequently used opioid analgesics in acut…
View article: Cannabinoids and Pain: New Insights From Old Molecules
Cannabinoids and Pain: New Insights From Old Molecules Open
Cannabis has been used for medicinal purposes for thousands of years. The prohibition of cannabis in the middle of the 20th century has arrested cannabis research. In recent years there is a growing debate about the use of cannabis for med…
View article: Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain
Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain Open
Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist. Magnesium is an endogenous non-competitive NMDA antagonist that ca…
View article: Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test
Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test Open
Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine al…
View article: Pharmacotherapy of Pain in the Older Population: The Place of Opioids
Pharmacotherapy of Pain in the Older Population: The Place of Opioids Open
Pain is a common symptom in older people. It is possible that pain is underreported in older persons due to an incorrect belief that it is an inevitable part of aging. Opioid analgesics are potent medications, with confirmed efficacy for t…
View article: L-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat
L-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat Open
This study investigated whether the L-arginine-NO system participates in the analgesic effect of flunixin meglumine in the rat. Hyperalgesia was induced by intraplantar (i.pl.) administration of carrageenan (500 μg) into the rat’s hind paw…