S. Wesley Long
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View article: Genomic and Patient Epidemiology of <i>Streptococcus dysgalactiae</i> Subspecies <i>equisimilis</i> in Houston, Texas
Genomic and Patient Epidemiology of <i>Streptococcus dysgalactiae</i> Subspecies <i>equisimilis</i> in Houston, Texas Open
Many countries have reported increased human infections caused by Streptococcus dysgalactiae subspecies equisimilis (SDSE) in the last 15 years. However, there is scant molecular epidemiology data for SDSE in the United States, especially …
View article: 44 Centralizing and Digitizing Bone Marrow Biopsy Ancillary Testing
44 Centralizing and Digitizing Bone Marrow Biopsy Ancillary Testing Open
For hematopathologists, cytogenetics, FISH, and molecular results are essential to establishing a final diagnosis and guiding appropriate treatment. In pathology departments where these tests are not performed in-house but have a significa…
View article: Intrahost Genomic Variation of Haemophilus influenzae Isolates from Asymptomatic Nasopharyngeal Carriers Involves Genes Encoding Proteins with Diverse Inferred Functions
Intrahost Genomic Variation of Haemophilus influenzae Isolates from Asymptomatic Nasopharyngeal Carriers Involves Genes Encoding Proteins with Diverse Inferred Functions Open
View article: Ciprofloxacin resistance in <i>Klebsiella pneumoniae</i>: phenotype prediction from genotype and global distribution of resistance determinants
Ciprofloxacin resistance in <i>Klebsiella pneumoniae</i>: phenotype prediction from genotype and global distribution of resistance determinants Open
BACKGROUND Ciprofloxacin resistant Klebsiella pneumoniae is common or emerging in many geographies, and knowledge of local resistance rates is important for empirical therapy. Whilst there are known K. pneumoniae ciprofloxacin resistance d…
View article: Analysis of <i>Streptococcus dysgalactiae</i> subspecies <i>equisimilis</i> gene transcripts during experimental primate necrotizing myositis
Analysis of <i>Streptococcus dysgalactiae</i> subspecies <i>equisimilis</i> gene transcripts during experimental primate necrotizing myositis Open
Streptococcus dysgalactiae subspecies equisimilis (SDSE) is a gram-positive bacterial pathogen capable of causing various infections in humans. Recently, isolates of SDSE emm type stG62647 have emerged as a cause of severe invasive infecti…
View article: Intra-host genomic variation of <i>Haemophilus influenzae</i> isolates from asymptomatic nasopharyngeal carriers involves genes encoding proteins with diverse inferred functions
Intra-host genomic variation of <i>Haemophilus influenzae</i> isolates from asymptomatic nasopharyngeal carriers involves genes encoding proteins with diverse inferred functions Open
Haemophilus influenzae is a human-specific pathogen that causes infections ranging in severity from otitis media to potentially fatal meningitis. It also asymptomatically colonizes the upper respiratory tract. Although intra-host genomic v…
View article: Intra-host genomic variation of serologically nontypeable <i>Haemophilus influenzae</i> isolates from otitis media
Intra-host genomic variation of serologically nontypeable <i>Haemophilus influenzae</i> isolates from otitis media Open
Serologically nontypeable Haemophilus influenzae is a human pathogen that causes infections ranging in severity from mild otitis media and sinusitis to life-threatening pneumonia, bacteremia, and meningitis. Although intra-host genomic var…
View article: Analysis of differential gene expression in the brain tissue transcriptome of Jiangkou radish piglets infected with porcine pseudorabies virus
Analysis of differential gene expression in the brain tissue transcriptome of Jiangkou radish piglets infected with porcine pseudorabies virus Open
Background: The research focused on the effects of pseudorabies virus on gene expression in piglet brain tissue. Objectives: The goal was to understand the changes in gene expression in piglet brains due to pseudorabies virus infection. De…
View article: Whole-Genome Identification and Expression Profiles of WRKY Genes Related to the Leaf Expansion Period in the Camphor Tree
Whole-Genome Identification and Expression Profiles of WRKY Genes Related to the Leaf Expansion Period in the Camphor Tree Open
The camphor tree (Cinnamomum camphora) is of great economic and ecological value, and the WRKY transcription factor (TF) family plays a crucial role in regulating plant growth and development as well as the responses toward environmental c…
View article: P-889. Therapeutic Failures of High Inoculum Infections with Cefazolin: Role of A Rapid Test and Prevalence of the Cefazolin Inoculum Effect in Methicillin-Susceptible <i>Staphylococcus aureus</i> (MSSA) Bloodstream Infections
P-889. Therapeutic Failures of High Inoculum Infections with Cefazolin: Role of A Rapid Test and Prevalence of the Cefazolin Inoculum Effect in Methicillin-Susceptible <i>Staphylococcus aureus</i> (MSSA) Bloodstream Infections Open
Background Cefazolin (CFZ) remains a key therapy for MSSA bloodstream infections (BSIs), yet some studies suggest poorer outcomes when CFZ is used in the presence of cefazolin inoculum effect (CzIE). We developed a rapid colorimetric test …
View article: New taxa of Xylariales from Karst Ecosystems in Southwestern China
New taxa of Xylariales from Karst Ecosystems in Southwestern China Open
The order Xylariales consists of fungi that are widely distributed and commonly found on decaying wood, fallen branches, and trunks. Despite the taxonomic and morphological challenges in accurately identifying species within this group, in…
View article: Using intrahost single nucleotide variant data to predict SARS-CoV-2 detection cycle threshold values
Using intrahost single nucleotide variant data to predict SARS-CoV-2 detection cycle threshold values Open
Over the last four years, each successive wave of the COVID-19 pandemic has been caused by variants with mutations that improve the transmissibility of the virus. Despite this, we still lack tools for predicting clinically important featur…
View article: Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae
Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae Open
Interpreting the phenotypes of bla SHV alleles in Klebsiella pneumoniae genomes is complex. Whilst all strains are expected to carry a chromosomal copy conferring resistance to ampicillin, they may also carry mutations in chromosomal bla S…
View article: Integrative genomic, virulence, and transcriptomic analysis of emergent <i>Streptococcus dysgalactiae</i> subspecies <i>equisimilis</i> (SDSE) <i>emm</i> type <i>stG62647</i> isolates causing human infections
Integrative genomic, virulence, and transcriptomic analysis of emergent <i>Streptococcus dysgalactiae</i> subspecies <i>equisimilis</i> (SDSE) <i>emm</i> type <i>stG62647</i> isolates causing human infections Open
Streptococcus dysgalactiae subspecies equisimilis (SDSE) is a Gram-positive bacterial pathogen that infects humans and is closely related to group A streptococcus (GAS). Compared with GAS, far less is known about SDSE pathobiology. Increas…
View article: Diagnostic testing and laboratory equity in clinical microbiology
Diagnostic testing and laboratory equity in clinical microbiology Open
View article: Diversity, functional classification and genotyping of SHV β-lactamases in<i>Klebsiella pneumoniae</i>
Diversity, functional classification and genotyping of SHV β-lactamases in<i>Klebsiella pneumoniae</i> Open
Interpreting phenotypes of bla SHV alleles in Klebsiella pneumoniae genomes is complex. While all strains are expected to carry a chromosomal copy conferring resistance to ampicillin, they may also carry mutations in chromosomal bla SHV al…
View article: Increase in invasive Streptococcus pyogenes M1 infections with close evolutionary genetic relationship, Iceland and Scotland, 2022 to 2023
Increase in invasive Streptococcus pyogenes M1 infections with close evolutionary genetic relationship, Iceland and Scotland, 2022 to 2023 Open
Group A Streptococcus isolates of the recently described M1 UK clade have emerged to cause human infections in several European countries and elsewhere. Full-genome sequence analysis of M1 isolates discovered a close genomic relationship b…
View article: Unveiling fungal diversity in China: New species and records within the Xylariaceae
Unveiling fungal diversity in China: New species and records within the Xylariaceae Open
View article: Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence
Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence Open
View article: Creation and Evaluation of a Clinical Informatics Match: Initial Findings
Creation and Evaluation of a Clinical Informatics Match: Initial Findings Open
Background Clinical Informatics (CI) fellowship programs utilize the Electronic Residency Application Service (ERAS) to gather applications but until recently used an American Medical Informatics Association (AMIA) member-developed, simult…
View article: CCDC 2280201: Experimental Crystal Structure Determination
CCDC 2280201: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2280192: Experimental Crystal Structure Determination
CCDC 2280192: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2280200: Experimental Crystal Structure Determination
CCDC 2280200: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Analysis of the Genomics and Mouse Virulence of an Emergent Clone of Streptococcus dysgalactiae Subspecies <i>equisimilis</i>
Analysis of the Genomics and Mouse Virulence of an Emergent Clone of Streptococcus dysgalactiae Subspecies <i>equisimilis</i> Open
Our studies addressed a critical knowledge gap in understanding the genomics and virulence of the bacterial pathogen Streptococcus dysgalactiae subsp. equisimilis . S. dysgalactiae subsp. equisimilis strains are responsible for a recent in…
View article: Using Genome Sequence Data to Predict SARS-CoV-2 Detection Cycle Threshold Values
Using Genome Sequence Data to Predict SARS-CoV-2 Detection Cycle Threshold Values Open
The continuing emergence of SARS-CoV-2 variants of concern (VOCs) presents a serious public health threat, exacerbating the effects of the COVID19 pandemic. Although millions of genomes have been deposited in public archives since the star…
View article: Rapid Analysis and Integration of Patient Clinical Data with SARS-CoV-2 Genome Sequence Data
Rapid Analysis and Integration of Patient Clinical Data with SARS-CoV-2 Genome Sequence Data Open
Objectives The COVID-19 pandemic has evolved the importance of monitoring viral evolution and correlated clinical outcomes in directing patient care and health policy. Our institution sequences the viral genome from essentially all SARS-Co…
View article: Making Complex Cancer Reports Easier Using Self-Built Interactive Templates
Making Complex Cancer Reports Easier Using Self-Built Interactive Templates Open
Surgical pathology reports are becoming increasingly complex, especially with neoplastic cases. Pathologists need to verify all elements are addressed in the CAP synoptics, order proper reflex molecular testing or immunohistochemistry depe…
View article: RecutClub 2.0: Deployment of a Trainee-Led, Didactic-Centered Whole Slide Imaging Platform
RecutClub 2.0: Deployment of a Trainee-Led, Didactic-Centered Whole Slide Imaging Platform Open
Objectives The Houston Methodist Pathology training program encourages trainee participation in quality improvement (QI) projects for improving the didactics experience. One of these initiatives is RecutClub, a whole slide imaging (WSI) we…
View article: Within-host genetic diversity of SARS-CoV-2 in the context of large-scale hospital-associated genomic surveillance
Within-host genetic diversity of SARS-CoV-2 in the context of large-scale hospital-associated genomic surveillance Open
The COVID-19 pandemic has resulted in extensive surveillance of the genomic diversity of SARS-CoV-2. Sequencing data generated as part of these efforts can also capture the diversity of the SARS-CoV-2 virus populations replicating within i…
View article: Signals of significantly increased vaccine breakthrough, decreased hospitalization rates, and less severe disease in patients with COVID-19 caused by the Omicron variant of SARS-CoV-2 in Houston, Texas
Signals of significantly increased vaccine breakthrough, decreased hospitalization rates, and less severe disease in patients with COVID-19 caused by the Omicron variant of SARS-CoV-2 in Houston, Texas Open
Genetic variants of SARS-CoV-2 continue to dramatically alter the landscape of the COVID-19 pandemic. The recently described variant of concern designated Omicron (B.1.1.529) has rapidly spread worldwide and is now responsible for the majo…