Sean R. Williamson
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View article: Molecularly defined renal cell carcinomas: practical approaches for surgical pathologists
Molecularly defined renal cell carcinomas: practical approaches for surgical pathologists Open
Molecularly defined renal carcinomas (MDRC) represent a heterogeneous group of tumours characterized by disease‐defining genetic alterations, and the documentation of these mutations is necessary for their diagnosis. This group includes TF…
View article: Mapping Molecular Diversity in Prostate Cancer With a Combined Multiplex IHC and RNA‐ISH Assay
Mapping Molecular Diversity in Prostate Cancer With a Combined Multiplex IHC and RNA‐ISH Assay Open
Background Molecular heterogeneity in prostate cancer is defined by distinct gene fusions and expression profiles involving ERG, SPINK1, ETV1, and ETV4. These markers are typically mutually exclusive and represent biologically distinct mol…
View article: The Genitourinary Pathology Society and International Society of Urological Pathology Joint Expert Consultation Recommendations on intraductal carcinoma of the prostate
The Genitourinary Pathology Society and International Society of Urological Pathology Joint Expert Consultation Recommendations on intraductal carcinoma of the prostate Open
Conflicting practice recommendations regarding the grading of intraductal carcinoma of the prostate (IDCP) from two leading uropathology societies, the Genitourinary Pathology Society (GUPS) and the International Society of Urological Path…
View article: Adult granulosa cell tumours of the testis analogous to ovarian counterparts are exceptionally rare: analysis of a multicentric series and review of the literature
Adult granulosa cell tumours of the testis analogous to ovarian counterparts are exceptionally rare: analysis of a multicentric series and review of the literature Open
Aims Testicular adult granulosa cell tumours (AGCTs) are rare and show several clinical–pathological differences with their ovarian counterparts. In a limited number of prior studies, FOXL2 p.Cys134Trp, the hallmark molecular alteration of…
View article: Perivascular epithelioid cell tumors of the urinary bladder: a multi-institutional clinicopathologic and molecular analysis of 21 cases
Perivascular epithelioid cell tumors of the urinary bladder: a multi-institutional clinicopathologic and molecular analysis of 21 cases Open
While perivascular epithelioid cell tumor (PEComas) have been described in most organ systems, only a few bladder PEComas have been reported. Although most behave in an indolent fashion, a subset may develop metastasis. Herein, we describe…
View article: Mapping Molecular Diversity in Prostate Cancer with a Combined Multiplex IHC and RNA-ISH Assay
Mapping Molecular Diversity in Prostate Cancer with a Combined Multiplex IHC and RNA-ISH Assay Open
Combining multiplex Immunohistochemistry (mIHC) and RNA in situ hybridization (RNA-ISH) in a single assay allows for the simultaneous detection of multiple markers in tissue sections. This approach can be a powerful tool for understanding …
View article: Assessment and classification of sex cord‐stromal tumours of the testis: recommendations from the testicular sex cord‐stromal tumour (<scp>TESST</scp>) group, an Expert Panel of the Genitourinary Pathology Society (<scp>GUPS</scp>) and International Society of Urological Pathology (<scp>ISUP</scp>)
Assessment and classification of sex cord‐stromal tumours of the testis: recommendations from the testicular sex cord‐stromal tumour (<span>TESST</span>) group, an Expert Panel of the Genitourinary Pathology Society (<span>GUPS</span>) and International Society of Urological Pathology (<span>ISUP</span>) Open
Aims Testicular sex cord‐stromal tumours (TSCSTs) are relatively rare, accounting for ~5% of all testicular neoplasms. They were historically classified into Leydig cell tumour, Sertoli cell tumour, granulosa cell tumour, and unclassified …
View article: Observer Variation in the Diagnosis of Testicular Sex Cord-Stromal Tumors by a Genitourinary Pathology Society and International Society of Urological Pathology Panel: Paving the Way for a New Classification
Observer Variation in the Diagnosis of Testicular Sex Cord-Stromal Tumors by a Genitourinary Pathology Society and International Society of Urological Pathology Panel: Paving the Way for a New Classification Open
The diagnosis of sex cord-stromal tumors is challenging. They show a wide spectrum of behaviors and associations with clinically important pathogenic germline variants. In view of recent advances in molecular subtyping and risk factors, we…
View article: Artificial Intelligence–Based Digital Histologic Classifier for Prostate Cancer Risk Stratification: Independent Blinded Validation in Patients Treated With Radical Prostatectomy
Artificial Intelligence–Based Digital Histologic Classifier for Prostate Cancer Risk Stratification: Independent Blinded Validation in Patients Treated With Radical Prostatectomy Open
PURPOSE Artificial intelligence (AI) tools that identify pathologic features from digitized whole-slide images (WSIs) of prostate cancer (CaP) generate data to predict outcomes. The objective of this study was to evaluate the clinical vali…
View article: Current practices in prostate pathology reporting: results from a survey of genitourinary and general pathologists
Current practices in prostate pathology reporting: results from a survey of genitourinary and general pathologists Open
Aims Standardizing pathology reporting protocols through peer consensus review is critical for the best quality of care metrics. Reporting heterogeneity due to discrepancies among professional societies and practice patterns may lead to he…
View article: Interobserver reproducibility of a hybrid three‐tier grading system of papillary nonmuscle invasive urothelial carcinoma: an international Uropathology study
Interobserver reproducibility of a hybrid three‐tier grading system of papillary nonmuscle invasive urothelial carcinoma: an international Uropathology study Open
Aims A hybrid‐three tier system with low grade (LG), high grade‐ G2 (HG‐G2), high grade‐ G3 (HG‐G3) has been proposed in recognition of, and to help address, the clinical heterogeneity within high grade WHO 2004/2022. We assessed interobse…
View article: Artificial Intelligence–Based Classification of Renal Oncocytic Neoplasms: Advancing From a 2-Class Model of Renal Oncocytoma and Low-Grade Oncocytic Tumor to a 3-Class Model Including Chromophobe Renal Cell Carcinoma
Artificial Intelligence–Based Classification of Renal Oncocytic Neoplasms: Advancing From a 2-Class Model of Renal Oncocytoma and Low-Grade Oncocytic Tumor to a 3-Class Model Including Chromophobe Renal Cell Carcinoma Open
Context.— Distinguishing between renal oncocytic tumors, such as renal oncocytoma (RO), and a subset of tumors with overlapping characteristics, including the recently identified low-grade oncocytic tumor (LOT), can present a diagnostic ch…
View article: Unexpectedly high variability in determining tumour extent in prostatic biopsies: implications for active surveillance
Unexpectedly high variability in determining tumour extent in prostatic biopsies: implications for active surveillance Open
AIMS: Tumour content in prostatic biopsies is an important indicator of prostate cancer volume and patient prognosis. Consequently, guidelines typically recommend reporting it as a percentage or linear length (mm). This study aimed to dete…
View article: Unexpectedly high variability in determining tumour extent in prostatic biopsies: implications for active surveillance
Unexpectedly high variability in determining tumour extent in prostatic biopsies: implications for active surveillance Open
Aims Tumour content in prostatic biopsies is an important indicator of prostate cancer volume and patient prognosis. Consequently, guidelines typically recommend reporting it as a percentage or linear length (mm). This study aimed to deter…
View article: Diagnostic incidence and pitfalls of rete testis hyperplasia and hyaline globules in a multi-institutional study of 348 testicular germ cell tumors
Diagnostic incidence and pitfalls of rete testis hyperplasia and hyaline globules in a multi-institutional study of 348 testicular germ cell tumors Open
Objectives The concept of rete hyperplasia with hyaline globules simulating testicular yolk sac tumor was first reported in a mostly retrospective review over 30 years ago. Nonetheless, we continue to encounter examples where this scenario…
View article: Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer
Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer Open
The aggressiveness of prostate cancer, the most common cancer in men worldwide, is primarily assessed based on histopathological data using the Gleason scoring system. While artificial intelligence (AI) has shown promise in accurately pred…
View article: TFE3‐rearranged nonmelanotic renal PEComa: a case series expanding their phenotypic and fusion landscape
TFE3‐rearranged nonmelanotic renal PEComa: a case series expanding their phenotypic and fusion landscape Open
Aims A subset of exceptionally rare primary renal perivascular epithelioid cell tumours (PEComas) that harbour Xp11.2 translocation have been reported, but no larger series devoted to this topic have been published. Methods and Results We …
View article: Unveiling Prostate Cancer's Molecular Tapestry: Ethnic Disparities and Prognostic Insights from Whole-Mount Prostatectomy Tissue Analysis
Unveiling Prostate Cancer's Molecular Tapestry: Ethnic Disparities and Prognostic Insights from Whole-Mount Prostatectomy Tissue Analysis Open
Background: Prostate cancer is a complex and heterogeneous disease with multiple tumor foci, each potentially harboring distinct driver molecular aberrations. This complexity poses challenges to effective management. We took an innovative …
View article: "Unveiling Prostate Cancer’s Molecular Tapestry: Ethnic Disparities and Prognostic Insights from Whole-Mount Prostatectomy Tissue Analysis"
"Unveiling Prostate Cancer’s Molecular Tapestry: Ethnic Disparities and Prognostic Insights from Whole-Mount Prostatectomy Tissue Analysis" Open
Background Prostate cancer is a complex and heterogeneous disease with multiple tumor foci, each potentially harboring distinct driver molecular aberrations. This complexity poses challenges to effective management. We took an innovative a…
View article: Impact of pathologic re-review on grade, clinical stage, and risk stratification for patients with nonmuscle invasive bladder cancer
Impact of pathologic re-review on grade, clinical stage, and risk stratification for patients with nonmuscle invasive bladder cancer Open
Re-review of TURBT pathology by a dedicated GU pathologist led to change in AUA NMIBC risk stratification in over one-fifth of patients, with potential for changing management.
View article: Patterns of B‐cell lymphocyte expression changes in pre‐ and post‐malignant prostate tissue are associated with prostate cancer progression
Patterns of B‐cell lymphocyte expression changes in pre‐ and post‐malignant prostate tissue are associated with prostate cancer progression Open
Backround Inflammation characterized by the presence of T and B cells is often observed in prostate cancer, but it is unclear how T‐ and B‐cell levels change during carcinogenesis and whether such changes influence disease progression. Met…
View article: International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members
International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members Open
Grading of non-muscle-invasive bladder cancer (NMIBC) is a matter of ongoing debate and lacks international consensus. We surveyed urologists and pathologists of European Association of Urology and International Society of Urological Patho…
View article: Clear cell renal cell carcinoma with focal psammomatous calcifications: a rare occurrence mimicking translocation carcinoma
Clear cell renal cell carcinoma with focal psammomatous calcifications: a rare occurrence mimicking translocation carcinoma Open
Aims Renal cell carcinoma (RCC) with clear cells and psammoma‐like calcifications would often raise suspicion for MITF family translocation RCC. However, we have rarely encountered tumours consistent with clear cell RCC that contain focal …