Stefan Jakob Wimmer
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View article: Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care
Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care Open
Background Clonidine and midazolam are routinely used in the pediatric intensive care unit for pain and sedation management, but target concentration and optimal dose are poorly defined for both drugs. The CloSed study is a multicenter, do…
Has corporate greed driven inflation in the European Union? An analysis of the food and beverage industry Open
The EU has recently experienced high inflation rates, particularly in food prices. This observation led to claims in the news and by retailers that large food and beverage manufacturers take advantage of high inflation, and increase prices…
The “Scribal Turn” from Egyptian Hieratic to the Alphabet Open
The cultural contact between Canaanite and Egyptian hieratic scribes in Late Bronze Age southern Canaan promoted the consolidation and refinement of the Early Alphabet, which had hitherto been mainly modeled after hieroglyphic sign shapes.…
Impact of a computerized physician order entry system on medication safety in pediatrics—The <span>AVOID</span> study Open
Background One of the most critical steps in the medication process on pediatric wards is the medical prescription. This study aims to investigate the impact of a computerized physician order entry (CPOE) system on Adverse Drug Events (ADE…
Development and Evaluation of a Web-Based Paediatric Drug Information System for Germany Open
Background: Off-label use is frequent in paediatrics but that does not necessarily mean that the risk-benefit ratio is negative. Nevertheless, evidence-based data is essential for safe drug therapy. In Germany, there is no publicly availab…
User-Centered Development of an Online Platform for Drug Dosing Recommendations in Pediatrics Open
Background Drug therapy in pediatric patients is a complex process. Children are subject to continuous growth and variation in drug-metabolizing enzyme activity, requiring continuous adaption of dosages. In Germany, currently no publicly a…
O01 Drug-related hospital admissions in paediatrics – what is preventable? Open
Background Safety of paediatric pharmacotherapy is of major concern. Due to high off-label use (about 46–64% of patients in primary care are affected), missing paediatric dosage forms and complex dosage calculations, adverse drug reactions…
View article: P101 Extending the Dutch Paediatric Formulary across Europe: successful development of country specific, parallel, paediatric drug formularies
P101 Extending the Dutch Paediatric Formulary across Europe: successful development of country specific, parallel, paediatric drug formularies Open
Backgrounds As many drugs in paediatrics are used of off-label, prescribers across Europe face a lack of evidence-based dosing guidelines. The Dutch Paediatric Formulary (DPF) was developed to provide dosing guidelines based on best availa…
P106 Impact of a computerised physician order entry system on medication safety in paediatrics Open
Background One of the most critical steps in the medication process on paediatric wards is the drug prescription. 1 Studies have shown that the use of electronic systems may improve the quality of prescribing and reduces medication errors …