S A Mohammed
YOU?
Author Swipe
View article: Resurgence of Intestinal Parasitic Infections in the United Villages Region, Northern Khartoum state: Impact of armed conflict and water supply disruption
Resurgence of Intestinal Parasitic Infections in the United Villages Region, Northern Khartoum state: Impact of armed conflict and water supply disruption Open
View article: Unrecognized Febrile Illness due to Brucellosis with Atypical Manifestations: A Difficult Differential Diagnosis—a Case Report from Sudan
Unrecognized Febrile Illness due to Brucellosis with Atypical Manifestations: A Difficult Differential Diagnosis—a Case Report from Sudan Open
View article: Expression ratio of PD-1 on the T cell surface and TGF-β levels in acute and chronic brucellosis: A marker of immune evasion
Expression ratio of PD-1 on the T cell surface and TGF-β levels in acute and chronic brucellosis: A marker of immune evasion Open
Background: Brucellosis is considered a zoonotic disease characterized by the ability of Brucella spp. to evade host immune responses and establish chronic infections. Key immune-regulatory molecules, such as transforming growth factor-bet…
View article: #2366 Epigenetic and transcriptional landscape of the kidney in heart failure with preserved ejection fraction
#2366 Epigenetic and transcriptional landscape of the kidney in heart failure with preserved ejection fraction Open
Background and Aims Heart failure with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD) constitute a high-risk phenotype with significant morbidity and mortality and poor prognosis. Multiple proinflammatory comorbid con…
View article: miR-451 Is a Driver of Lipotoxic Injury in Patients with Diabetic Cardiomyopathy
miR-451 Is a Driver of Lipotoxic Injury in Patients with Diabetic Cardiomyopathy Open
MicroRNA 451 (miR-451) is emerging as a pivotal mediator of cardiac damage in experimental models of diabetic cardiomyopathy. Whether miR-451 plays a detrimental role in the human diabetic myocardium is unknown. The present study investiga…
View article: Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease
Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease Open
View article: Unlocking metabolic flexibility in heart failure with preserved ejection fraction: Bridging fundamental mechanisms to clinical innovation
Unlocking metabolic flexibility in heart failure with preserved ejection fraction: Bridging fundamental mechanisms to clinical innovation Open
Heart failure is often described as a condition of "energy depletion." However, in heart failure with preserved ejection fraction (HFpEF), particularly when associated with metabolic conditions such as obesity and diabetes, the heart may f…
View article: Genotypic and Phenotypic Detection of Carbapenemase Genes in Clinical and Environmental Isolates of Klebsiella pneumoniae ST23
Genotypic and Phenotypic Detection of Carbapenemase Genes in Clinical and Environmental Isolates of Klebsiella pneumoniae ST23 Open
Background and Objectives: The global rise of multidrug-resistant bacteria poses a major healthcare challenge. Carbapenemase-producing Klebsiella pneumoniae, especially ST23, has emerged as a significant hospital-acquired pathogen. This st…
View article: Metformin Beyond Diabetes: A Precision Gerotherapeutic and Immunometabolic Adjuvant for Aging and Cancer.
Metformin Beyond Diabetes: A Precision Gerotherapeutic and Immunometabolic Adjuvant for Aging and Cancer. Open
Metformin, a long-established antidiabetic agent, is undergoing a renaissance as a prototype gerotherapeutic and immunometabolic oncology adjuvant. Mechanistic advances reveal that metformin modulates an integrated network of metabolic, im…
View article: Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation
Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation Open
Aims Low-density lipoprotein (LDL)-cholesterol is causally involved in atherosclerotic cardiovascular disease (ASCVD) pathogenesis. Pharmacological activation of the intracellular NAD + -dependent deacetylase Sirtuin-1 (SIRT1) reduces plas…
View article: Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment
Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment Open
Heart failure with preserved ejection fraction (HFpEF) represents nearly half of all heart failure cases globally. The increased prevalence of cardiometabolic disease, driven by unhealthy lifestyles, has led to a growing population of peop…
View article: Mapping of the Antinuclear Autoantibodies in Sudanese patients infected with Human Immunodeficiency Virus after HAART receiving: A cross-sectional study
Mapping of the Antinuclear Autoantibodies in Sudanese patients infected with Human Immunodeficiency Virus after HAART receiving: A cross-sectional study Open
View article: Comparison of prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with metastatic and non-metastatic cancers
Comparison of prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with metastatic and non-metastatic cancers Open
Background Several studies have reported NLR as an independent prognostic factor in solid tumors. However, comparing the prognostic value among metastatic and non-metastatic cancers remains underexplored, which is the objective of this stu…
View article: Endothelial dysfunction in patients with type 2 diabetes: the truth is in the blood
Endothelial dysfunction in patients with type 2 diabetes: the truth is in the blood Open
Endothelial dysfunction remains a cornerstone of diabetic vascular complications. RBCs emerge as pivotal players in endothelial dysfunction, yet the underlying mechanisms remain elusive. In this issue of the JCI, Collado et al. show that t…
View article: Anti-tumor Necrosis Factor-Alpha (TNF-α)-Induced Hypertrophic Lichen Planus: A Case Report
Anti-tumor Necrosis Factor-Alpha (TNF-α)-Induced Hypertrophic Lichen Planus: A Case Report Open
View article: Current status and recent trends in innovative tactics and the One Health approach to address the challenge of methicillin-resistant Staphylococcus aureus infections: a comprehensive review
Current status and recent trends in innovative tactics and the One Health approach to address the challenge of methicillin-resistant Staphylococcus aureus infections: a comprehensive review Open
View article: Leptin: Biological Functions and Metabolic Regulation in Type 2 Diabetes Mellitus
Leptin: Biological Functions and Metabolic Regulation in Type 2 Diabetes Mellitus Open
View article: NAD+ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice
NAD+ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice Open
High-dose NR supplementation in mice did not decrease but increase both aortic plaque lesions and systemic inflammation. These effects may be mediated by increased CD38 expression in macrophages, with NAD+ metabolism shifted fro…
View article: The effect of calcium and vitamin A in patients with metabolic-associated fatty liver diseases
The effect of calcium and vitamin A in patients with metabolic-associated fatty liver diseases Open
Background Non-alcoholic fatty liver disease (NAFLD) is a condition where there is an excessive accumulation of fat in the liver. Non-alcoholic steatohepatitis is a chronic liver injury that may result from benign steatosis, which is a com…
View article: Study of Obstructive Sleep Apnea in patients with Type 2 Diabetes Mellitus in Damietta
Study of Obstructive Sleep Apnea in patients with Type 2 Diabetes Mellitus in Damietta Open
Background: The relationship between sleep disorders and diabetes is bidirectional; sleep disorders can raise the risk of developing insulin resistance, while diabetes would worsen sleep quality. Aim of our study: The aim of this study is …
View article: <b>Targeting SETD7 Rescues Diabetes-induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin 3G</b>
<b>Targeting SETD7 Rescues Diabetes-induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin 3G</b> Open
Revascularization strategies failed to improve outcome in diabetic (DM) patients with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role in angiogenic response. This study inv…
View article: WCN25-3915 ENDOTHELIAL MICROPARTICLES IN MALARIA ASSOCIATED ACUTE KIDNEY INJURY
WCN25-3915 ENDOTHELIAL MICROPARTICLES IN MALARIA ASSOCIATED ACUTE KIDNEY INJURY Open
View article: A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related?
A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related? Open
Membranoproliferative glomerulonephritis (MPGN) has previously been used as an umbrella term to describe a spectrum of hypocomplementemic glomerular diseases, which are rare causes of end stage kidney disease (ESKD). We present a 22‐year‐o…
View article: Cover Image
Cover Image Open
The cover image is based on the article A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related? by Ayman Azhary et al., https://doi.org/10.1002/ccr3.70088.[Image: see text]
View article: Changes in immunofluorescence staining during islet regeneration in a cystic fibrosis-related diabetes (CFRD) ferret model
Changes in immunofluorescence staining during islet regeneration in a cystic fibrosis-related diabetes (CFRD) ferret model Open
CF ferret islets revealed significant immunofluorescent staining changes compared to WT during various phases of disease, providing insights into CRFD pathophysiology.
View article: Study of Some Apoptotic Protein Expration in Human Mesenchymal Stem Cells During Toxoplasma Gondii Infection
Study of Some Apoptotic Protein Expration in Human Mesenchymal Stem Cells During Toxoplasma Gondii Infection Open
Background: Toxoplasma gondii (T. gondii) infection is a significant health concern, particularly during pregnancy, as it can lead to fetal harm and birth abnormalities. Specific Background: The role of apoptosis in managing T. gondii infe…
View article: Chromatin Remodeling by the Histone Methyltransferase SETD2 Drives Lipotoxic Injury in Cardiometabolic Heart Failure with Preserved Ejection Fraction
Chromatin Remodeling by the Histone Methyltransferase SETD2 Drives Lipotoxic Injury in Cardiometabolic Heart Failure with Preserved Ejection Fraction Open
Background Cardiometabolic heart failure with preserved ejection fraction (cHFpEF) is highly prevalent and associates with a poor outcome. Pathological gene expression in heart failure is accompanied by changes in active histone marks with…
View article: Inhibition of <i>de novo</i> ceramide synthesis by sirtuin-1 improves beta-cell function and glucose metabolism in type 2 diabetes
Inhibition of <i>de novo</i> ceramide synthesis by sirtuin-1 improves beta-cell function and glucose metabolism in type 2 diabetes Open
Aims Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular (CV) diseases. Dysregulated pro-apoptotic ceramide synthesis reduces β-cell insulin secretion, thereby promoting hyperglycaemic states that may manifest as T2…
View article: Targeting the histone methyltransferase SETD7 rescues diabetes-induced impairment of angiogenic response by transcriptional repression of semaphorin 3G
Targeting the histone methyltransferase SETD7 rescues diabetes-induced impairment of angiogenic response by transcriptional repression of semaphorin 3G Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Swiss National Science Foundation (n. 310030_197557), the Swiss Heart Foundation (n. FF19045) Background Peripheral artery disease (PAD) is hi…
View article: Long non-coding RNA PANDA drives diabetic vascular dysfunction by promoting endothelial senescence and oxidative damage
Long non-coding RNA PANDA drives diabetic vascular dysfunction by promoting endothelial senescence and oxidative damage Open
Funding Acknowledgements None. Background ROS and inflammation are major features of diabetic vasculopathy, yet the underlying mechanisms remain elusive. Long non-coding RNAs (lncRNAs) are emerging as important players in the pathogenesis …