Zhe‐Sheng Chen
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View article: HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment
HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment Open
Targeted protein degradation (TPD) represents a transformative therapeutic paradigm that harnesses the cellular degradation machinery to pharmacologically eliminate disease‐causing proteins with aberrant expression. This work here reports …
View article: Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy
Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy Open
Antitumor immunotherapy has become a pillar therapy by activating the immune system to recognize and attack tumor cells. Yet its efficacy is limited by the immunosuppressive tumor microenvironment (TME) and related mechanisms like hypoxia,…
View article: PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8 <sup>+</sup> T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma
PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8 <sup>+</sup> T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) demonstrates suboptimal responses to current immune checkpoint inhibitors (ICIs), with objective response rates (ORRs) of merely 15–20%. The molecular mechanisms underlying these low ORRs remai…
View article: Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer
Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer Open
Despite the established clinical efficacy of oxaliplatin in colorectal cancer (CRC), resistance to this platinum‑based agent continues to pose a significant therapeutic challenge. Increased exportin 1 (XPO1) expression in CRC has been link…
View article: The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure
The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure Open
Diet provides essential metals, which are required for the growth, development, and well‐functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodie…
View article: Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics
Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics Open
Gankyrin (PSMD10) is a 25 kDa oncogenic protein and regulatory subunit of the 26S proteasome, characterized by a sevenfold ankyrin repeat domain. Gankyrin is overexpressed in various malignancies, particularly gastrointestinal (GI) cancers…
View article: Dual‐Pedicle Tissue‐Engineered Trachea Promotes Biomimetic Cartilaginous Framework, Vascularization, and Epithelial Lining for Long‐Segment Tracheal Reconstruction
Dual‐Pedicle Tissue‐Engineered Trachea Promotes Biomimetic Cartilaginous Framework, Vascularization, and Epithelial Lining for Long‐Segment Tracheal Reconstruction Open
Long‐segment tracheal reconstruction remains a formidable clinical challenge due to failures of conventional tissue‐engineered trachea (TET) grafts, stemming from inadequate vascularization, compromised cartilaginous framework, and epithel…
View article: Tumor-Derived CTHRC1 Mediates ITGB3-Dependent Osteoclast Differentiation to Promote Prostate Cancer Bone Metastasis
Tumor-Derived CTHRC1 Mediates ITGB3-Dependent Osteoclast Differentiation to Promote Prostate Cancer Bone Metastasis Open
Background: Bone metastasis represents the most common and fatal stage of advanced prostate cancer (PCa) with the poor prognosis. This study aims to elucidate the mechanisms underlying the development and progression of bone-metastatic PCa…
View article: Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance
Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance Open
Advanced renal cell carcinoma (RCC) primarily relies on targeted and immune‐based therapies, yet these treatments often face limitations due to inefficacy and drug resistance. Branched‐chain α‐keto‐acid dehydrogenase kinase (BCKDK) has bee…
View article: Correction: Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206)
Correction: Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206) Open
[This corrects the article DOI: 10.3389/fphar.2025.1606857.].
View article: Global and Regional Temporal Changes in Cross‐Country Inequalities of Site‐Specific Osteoarthritis Burden, 1990 to 2021
Global and Regional Temporal Changes in Cross‐Country Inequalities of Site‐Specific Osteoarthritis Burden, 1990 to 2021 Open
Objective This study examined the global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis (OA) burden from 1990 to 2021. Methods Age‐standardized years lived with disability rates (ASYRs) for site…
View article: Immunoregulatory mechanisms in the aging microenvironment: Targeting the senescence-associated secretory phenotype for cancer immunotherapy
Immunoregulatory mechanisms in the aging microenvironment: Targeting the senescence-associated secretory phenotype for cancer immunotherapy Open
The aging microenvironment, as a key driver of tumorigenesis and progression, plays a critical role in tumor immune regulation through one of its core features-the senescence-associated secretory phenotype (SASP). SASP consists of a variet…
View article: Application of biomarkers in the assessment and treatment of cancer-related fatigue
Application of biomarkers in the assessment and treatment of cancer-related fatigue Open
Cancer-related fatigue (CRF) is a common side effect experienced by cancer patients and disease-free survivors, significantly impacting their quality of life. This review summarizes the application of biomarkers in assessment and treatment…
View article: Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206)
Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206) Open
Introduction Multidrug resistance (MDR) in cancer therapy, frequently driven by overexpression of ATP-binding cassette (ABC) transporters—particularly ABCG2—continues to undermine the efficacy of chemotherapeutic regimens. Tinodasertib (ET…
View article: Real‐Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis
Real‐Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis Open
The molecular mechanism by which tumor cells and their microenvironment evolve during lung squamous cell carcinoma (LUSC) carcinogenesis remains unclear, greatly limiting its early diagnosis and treatment effectiveness in patients. To repl…
View article: CircPLK1 upregulates ETS1 to confer anthracycline resistance in triple-negative breast cancer
CircPLK1 upregulates ETS1 to confer anthracycline resistance in triple-negative breast cancer Open
Background and Objectives Circular RNAs play a vital role in developing triple-negative breast cancer (TNBC). Likewise, the function of circRNAs in TNBC resistance to chemotherapy remains largely unknown. Here, we aimed to investigate whet…
View article: Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction
Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction Open
Ischemic/hypoxic injury significantly damages vascular function, detrimentally impacting patient outcomes. Changes in mitochondrial structure and function are closely associated with ischemia/hypoxia-induced vascular dysfunction. The mecha…
View article: Apoptozole Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer
Apoptozole Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Open
Lung cancer is a widespread malignant tumor with a highmortality rate, often difficult to treat effectively due to chemoresistance. Given the close association between ABCG2 overexpression and cancer multidrug resistance, overcoming the is…
View article: Advancing Cancer Treatment: Innovative Materials in PDT and Diagnostic Integration
Advancing Cancer Treatment: Innovative Materials in PDT and Diagnostic Integration Open
The diagnosis and treatment of cancers have become a significant challenge in overcoming malignant diseases. Early detection of tumors and timely targeted therapy can greatly impede the rapid deterioration of cancers. In recent years, nano…
View article: Application of cancer organoids: The forefront of personalized oncology and preclinical testing
Application of cancer organoids: The forefront of personalized oncology and preclinical testing Open
Cancer remains one of the most pressing medical problems in the world. Recent years have seen a gradual rise in utilization of “organoids,” a novel in vitro three-dimensional culture technology, in cancer research. Organoids ar…
View article: Machine Learning‐Based Radiomics in Malignancy Prediction of Pancreatic Cystic Lesions: Evidence from Cyst Fluid Multi‐Omics
Machine Learning‐Based Radiomics in Malignancy Prediction of Pancreatic Cystic Lesions: Evidence from Cyst Fluid Multi‐Omics Open
The malignant potential of pancreatic cystic lesions (PCLs) varies dramatically, leading to difficulties when making clinical decisions. This study aimed to develop noninvasive clinical‐radiomic models using preoperative CT images to predi…
View article: CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer
CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense, immunosuppressive tumor microenvironment (TME) that limits therapeutic efficacy. This study investigates the role of cellular communication network factor 1 (CCN1, also k…
View article: Transient intracellular expression of PD-L1 and VEGFR2 bispecific nanobody in cancer cells inspires long-term T cell activation and infiltration to combat tumor and inhibit cancer metastasis
Transient intracellular expression of PD-L1 and VEGFR2 bispecific nanobody in cancer cells inspires long-term T cell activation and infiltration to combat tumor and inhibit cancer metastasis Open
PD-L1 and VEGFR2- bispecific VH intracellular nanobody was highly biocompatible and showed the potential for combined anti-cancer therapy through long-term immune activation mediated by PD-L1/PD-1 checkpoint blockade and anti-metastasis me…