Sebastian Zimmer
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View article: An improved porcine model of infrarenal abdominal aortic aneurysm
An improved porcine model of infrarenal abdominal aortic aneurysm Open
Abdominal aortic aneurysm (AAA) remains a significant public health challenge, primarily due to its high mortality rate and the lack of effective preventive and causal strategies. This study aims to establish an improved translational trip…
View article: Cyclodextrin reduces cholesterol crystal uptake by circulating monocytes in patients undergoing coronary angiography
Cyclodextrin reduces cholesterol crystal uptake by circulating monocytes in patients undergoing coronary angiography Open
Background Atherosclerosis is a chronic inflammatory disease driven by endothelial dysfunction, cholesterol accumulation, and immune activation leading to thrombosis and vascular stenosis. While LDL-lowering therapies are firmly establishe…
View article: Advanced Imaging Preparation for Endoscopic Mitral Valve Surgery—Analysis of Circumflex Anatomy and Associated Procedural Risks
Advanced Imaging Preparation for Endoscopic Mitral Valve Surgery—Analysis of Circumflex Anatomy and Associated Procedural Risks Open
Objectives Iatrogenic injury to the circumflex artery (CX) during mitral valve (MV) surgery occurs in 0.3%-1.8% of cases. This study analysed the CX’s anatomical relationship to the mitral annulus using advanced imaging to predict peri-ope…
View article: Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock
Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock Open
Importance Microaxial flow pump treatment improves survival in selected patients with infarct-related cardiogenic shock; however, treatment carries substantial risks, and benefit may vary by patient subgroup. Systolic blood pressure (SBP) …
View article: Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk
Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk Open
Calcific aortic valve disease (CAVD) is one of the leading causes of cardiovascular death in the elderly population worldwide. MicroRNAs (miRNAs) are highly dysregulated in patients with CAVD undergoing surgical aortic valve replacement (S…
View article: Long‐Term Impact of Guselkumab on Skin, Sexuality, and Perceived Stigmatization in Patients With Psoriasis in Routine Clinical Practice: Week 76 Effectiveness and Safety Results From the Prospective German Multicenter G‐<scp>EPOSS</scp> Study
Long‐Term Impact of Guselkumab on Skin, Sexuality, and Perceived Stigmatization in Patients With Psoriasis in Routine Clinical Practice: Week 76 Effectiveness and Safety Results From the Prospective German Multicenter G‐<span>EPOSS</span> Study Open
Background G‐EPOSS is a prospective, non‐interventional, German multicenter study evaluating the effects of guselkumab, an interleukin‐23 inhibitor, in patients with moderate‐to‐severe plaque psoriasis in real‐world clinical practice. Obje…
View article: Sex differences in a murine model of infective endocarditis
Sex differences in a murine model of infective endocarditis Open
View article: Clonal haematopoiesis of indeterminate potential is associated with progression of aortic valve stenosis
Clonal haematopoiesis of indeterminate potential is associated with progression of aortic valve stenosis Open
View article: Aortic valve stenosis and osteoporosis: insights from a mouse model
Aortic valve stenosis and osteoporosis: insights from a mouse model Open
View article: Cardiovascular magnetic resonance characteristics of focal takotsubo syndrome
Cardiovascular magnetic resonance characteristics of focal takotsubo syndrome Open
CMR revealed a distinctive pattern of transient RWMA and myocardial edema in focal TTS, primarily affecting the anterior segments, suggesting that it may be classified as "anterior" TTS. Given its clinical similarity to typical TTS and oth…
View article: EASIX as a predictor of 3-year mortality in aortic stenosis patients undergoing TAVR
EASIX as a predictor of 3-year mortality in aortic stenosis patients undergoing TAVR Open
Background Endothelial dysfunction plays a crucial role in the progression of aortic stenosis (AS), and the Endothelial Activation and Stress Index (EASIX) has been proposed as a biomarker for predicting mortality in various clinical setti…
View article: Implications of monogenic bicuspid aortic valve (BAV) forms among sporadic BAV patients
Implications of monogenic bicuspid aortic valve (BAV) forms among sporadic BAV patients Open
View article: Prehospital thrombolytic treatment of high-risk acute pulmonary embolism
Prehospital thrombolytic treatment of high-risk acute pulmonary embolism Open
View article: Fighting time: the critical importance of pre-TAVR mortality risk prediction
Fighting time: the critical importance of pre-TAVR mortality risk prediction Open
Background Symptomatic severe aortic valve stenosis (AS) is a life-threatening condition requiring prompt medical attention. While transcatheter aortic valve replacement (TAVR) is an effective treatment, current scheduling practices often …
View article: The role of uremic toxin indoxyl sulfate in the pathophysiology of aortic valve stenosis
The role of uremic toxin indoxyl sulfate in the pathophysiology of aortic valve stenosis Open
Aims Chronic kidney disease (CKD) is closely associated with cardiovascular disease (CVD). This includes aortic valve stenosis (AS), one of the most common valve diseases among adults. CKD leads to the retention of uremic toxins such as in…
View article: Regional Cerebral Blood Flow Increase After Transcatheter Aortic Valve Replacement Is Related to Cardiac Output but Is Not Associated with Delirium: An Observational Cohort Study Using Transcranial Indocyanine Green Dye Dilution Technique
Regional Cerebral Blood Flow Increase After Transcatheter Aortic Valve Replacement Is Related to Cardiac Output but Is Not Associated with Delirium: An Observational Cohort Study Using Transcranial Indocyanine Green Dye Dilution Technique Open
Background: Despite the success of transcatheter aortic valve repair (TAVR) over the past years, its impact on global and cerebral hemodynamics remains largely unexplored. Changes in cerebral blood flow may be associated with delirium, whi…
View article: Prevalence and Management of Multiple Valvular Heart Disease in Patients Undergoing Transcatheter Aortic Valve Replacement: A Multicenter Study on the Impact of Staged Valvular Interventions on Outcomes
Prevalence and Management of Multiple Valvular Heart Disease in Patients Undergoing Transcatheter Aortic Valve Replacement: A Multicenter Study on the Impact of Staged Valvular Interventions on Outcomes Open
Background Multiple valvular heart disease correlates with poor outcomes following transcatheter aortic valve replacement. Previous studies have focused on mitral regurgitation (MR) or tricuspid regurgitation (TR) individually, without com…
View article: Ventricular Interaction and Clinical Outcomes in Patients Undergoing Transcatheter Tricuspid Valve Repair
Ventricular Interaction and Clinical Outcomes in Patients Undergoing Transcatheter Tricuspid Valve Repair Open
Ventricular interaction, assessed by LV eccentricity index, was associated with clinical outcomes after TTVr, and its postprocedural improvement was linked to better outcomes. Assessment of ventricular interaction may be helpful for risk s…
View article: Association between psoas muscle area and outcomes after transcatheter tricuspid valve repair
Association between psoas muscle area and outcomes after transcatheter tricuspid valve repair Open
Transcatheter tricuspid valve repair (TTVR) might be an alternative option to reduce tricuspid regurgitation (TR) in patients with sarcopenia. Psoas muscle area (PMA) measured using computed tomography (CT) is known as a marker of sarcopen…
View article: Predictive performance of the TRI-SCORE in patients with severe aortic stenosis and concomitant tricuspid regurgitation undergoing TAVR
Predictive performance of the TRI-SCORE in patients with severe aortic stenosis and concomitant tricuspid regurgitation undergoing TAVR Open
Background Tricuspid regurgitation (TR) is a common comorbidity in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) and represents a significant predictor of adverse outcomes. Precise risk …
View article: Mutational landscape and impact of clonal hematopoiesis of indeterminate potential in severe aortic valve stenosis
Mutational landscape and impact of clonal hematopoiesis of indeterminate potential in severe aortic valve stenosis Open
Background Clonal hematopoiesis of indeterminate potential (CHIP) has been progressively established as a risk factor for cardiovascular disease and associated with worsened outcomes in patients with aortic valve stenosis (AVS). This cohor…
View article: Transcatheter Edge-to-Edge Repair in Patients With Primary Tricuspid Regurgitation
Transcatheter Edge-to-Edge Repair in Patients With Primary Tricuspid Regurgitation Open
TEER is a safe and effective option for primary TR, promoting right heart reverse remodeling and symptomatic relief, offering a vital alternative to surgery in selected patients.
View article: ASO Author Reflections: The Role of Beta-Blockers in Gastric Cancer—A Pathway to Personalized Therapy?
ASO Author Reflections: The Role of Beta-Blockers in Gastric Cancer—A Pathway to Personalized Therapy? Open
View article: A novel approach to studying infective endocarditis: Ultrasound-guided wire injury and bacterial challenge in mice
A novel approach to studying infective endocarditis: Ultrasound-guided wire injury and bacterial challenge in mice Open
Background Infective endocarditis (IE) is frequently caused by Staphylococcus aureus (S. aureus) and most commonly affects the aortic valve. Early diagnosis and treatment initiation are challenging because the involved immunological proces…
View article: The role of placental growth factor as a biomarker in patients with resectable gastric cancer
The role of placental growth factor as a biomarker in patients with resectable gastric cancer Open
The association of elevated PlGF expression with disease-specific survival despite no correlation with other tumor-specific prognostic factors may indicate that PlGF could be used as an independent prognostic biomarker in gastric cancer. T…
View article: β-Blockers Influence Oncological Outcomes in Gastric Cancer Patients Treated with Neoadjuvant Chemotherapy Based on the Pathological Subtype: A Retrospective Cohort Study
β-Blockers Influence Oncological Outcomes in Gastric Cancer Patients Treated with Neoadjuvant Chemotherapy Based on the Pathological Subtype: A Retrospective Cohort Study Open
View article: Tricuspid regurgitation: Innovation, current landscape, and future perspective of transcatheter tricuspid valve interventions
Tricuspid regurgitation: Innovation, current landscape, and future perspective of transcatheter tricuspid valve interventions Open
Tricuspid regurgitation (TR) is a prevalent cardiovascular disease necessitating innovative treatments. Assessing comorbidities, such as right ventricular dysfunction, is pivotal for the therapeutic strategy. Preprocedural echocardiographi…
View article: The interplay between COVID-19 and heart disease: Unravelling a complex connection
The interplay between COVID-19 and heart disease: Unravelling a complex connection Open
The intersection of coronavirus (COVID-19) and heart disease has emerged as a critical nexus in the landscape of global health. Individuals with heart disease face elevated risks when infected with Severe Acute Respiratory-Syndrome Coronav…
View article: Secondary sclerosing cholangitis in patients suffering cardiogenic shock
Secondary sclerosing cholangitis in patients suffering cardiogenic shock Open
Aims Cardiogenic shock (CS) patients suffer from severe organ hypoperfusion, yet the incidence of secondary sclerosing cholangitis in critically ill patients (SSC‐CIP) in CS is poorly described. Given the limited evidence and severity of t…
View article: Management of high-risk acute pulmonary embolism: an emulated target trial analysis
Management of high-risk acute pulmonary embolism: an emulated target trial analysis Open