Søren Molin
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View article: The <i>Pseudomonas aeruginosa sirB2</i> gene is a fitness determinant of anaerobic growth and its inactivation affects virulence and rugose small colony variants emergence
The <i>Pseudomonas aeruginosa sirB2</i> gene is a fitness determinant of anaerobic growth and its inactivation affects virulence and rugose small colony variants emergence Open
Pseudomonas aeruginosa is the leading cause of death in cystic fibrosis (CF) patients, yet the genetic mechanisms driving its fitness in the host remain poorly defined. Previously collected transcriptomic data of clinical samples showed th…
View article: Occurrence of type VI secretion system effector genes in longitudinal isolates of P. aeruginosa from people with cystic fibrosis
Occurrence of type VI secretion system effector genes in longitudinal isolates of P. aeruginosa from people with cystic fibrosis Open
Pseudomonas aeruginosa uses multiple type VI secretion systems (T6SSs) to manipulate eukaryotic cells, kill competing microbes and take up nutrients. Bacterial strains are known to differ in their T6SS apparatus and the toxic effector prot…
View article: Pseudomonas aeruginosa: persistence beyond antibiotic resistance
Pseudomonas aeruginosa: persistence beyond antibiotic resistance Open
The persistence of Pseudomonas aeruginosa in chronic infections extends beyond the issue of antibiotic resistance. A critical, yet unresolved question is why antibiotics fail to eradicate all infecting bacteria, despite P. aeruginosa often…
View article: Infection dynamics and virulence potential of clinical <i>Pseudomonas aeruginosa</i> isolates in human airway epithelial models
Infection dynamics and virulence potential of clinical <i>Pseudomonas aeruginosa</i> isolates in human airway epithelial models Open
Persistent bacterial infections constitute an increasing health problem, often associated with antibiotic resistance. However, despite extensive antibiotic treatment, Pseudomonas aeruginosa persists for decades in people with cystic fibros…
View article: <i>Pseudomonas aeruginosa</i> maintains an inducible array of novel and diverse prophages over lengthy persistence in cystic fibrosis lungs
<i>Pseudomonas aeruginosa</i> maintains an inducible array of novel and diverse prophages over lengthy persistence in cystic fibrosis lungs Open
Pseudomonas aeruginosa has increasing clinical relevance and commonly occupies the cystic fibrosis (CF) airways. Its ability to colonize and persist in diverse niches is attributed to its large accessory genome, where prophages represent a…
View article: Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa
Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa Open
Macrolides are widely used antibiotics for the treatment of bacterial airway infections. Due to its elevated minimum inhibitory concentration in standardized culture media, Pseudomonas aeruginosa is considered intrinsically resistant and, …
View article: Metabolic specialization drives reduced pathogenicity in Pseudomonas aeruginosa isolates from cystic fibrosis patients
Metabolic specialization drives reduced pathogenicity in Pseudomonas aeruginosa isolates from cystic fibrosis patients Open
Metabolism provides the foundation for all cellular functions. During persistent infections, in adapted pathogenic bacteria metabolism functions radically differently compared with more naïve strains. Whether this is simply a necessary acc…
View article: A concept for international societally relevant microbiology education and microbiology knowledge promulgation in society
A concept for international societally relevant microbiology education and microbiology knowledge promulgation in society Open
Executive summary Microbes are all pervasive in their distribution and influence on the functioning and well‐being of humans, life in general and the planet. Microbially‐based technologies contribute hugely to the supply of important goods…
View article: Macrolide resistance through uL4 and uL22 ribosomal mutations in<i>Pseudomonas aeruginosa</i>
Macrolide resistance through uL4 and uL22 ribosomal mutations in<i>Pseudomonas aeruginosa</i> Open
Macrolides are widely used antibiotics for the treatment of bacterial airway infections. Due to its elevated minimum inhibitory concentration in standardized culture media, Pseudomonas aeruginosa is considered intrinsically resistant and, …
View article: Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance
Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance Open
Mutations in mexZ , encoding a negative regulator of the expression of the mexXY efflux pump genes, are frequently acquired by Pseudomonas aeruginosa at early stages of lung infection. Although traditionally related to resistance to the fi…
View article: Adaptive Evolution of <i>Pseudomonas aeruginosa</i> in Human Airways Shows Phenotypic Convergence Despite Diverse Patterns of Genomic Changes
Adaptive Evolution of <i>Pseudomonas aeruginosa</i> in Human Airways Shows Phenotypic Convergence Despite Diverse Patterns of Genomic Changes Open
Selective forces in the environment drive bacterial adaptation to novel niches, choosing the fitter variants in the population. However, in dynamic and changing environments, the evolutionary processes controlling bacterial adaptation are …
View article: Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs
Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs Open
Pseudomonas aeruginosa is a bacterium with increasing relevance in clinical settings and among the most common bacteria occupying the cystic fibrosis (CF) lung niche. Its ability to colonize and persist in diverse niches is attributed to t…
View article: Establishment of a 3D-Printed Tissue-on-a-Chip Model for Live Imaging of Bacterial Infections
Establishment of a 3D-Printed Tissue-on-a-Chip Model for Live Imaging of Bacterial Infections Open
Despite advances in healthcare, bacterial pathogens remain a severe global health threat, exacerbated by rising antibiotic resistance. Lower respiratory tract infections, with their high death toll, are of particular concern. Accurately re…
View article: Likely intact but uninduced prophages of Pseudomonas aeruginosa clinical CF isolates
Likely intact but uninduced prophages of Pseudomonas aeruginosa clinical CF isolates Open
The dataset is deposited as part of the research article "Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs".
View article: Long-term evolution of antibiotic tolerance in <i>Pseudomonas aeruginosa</i> lung infections
Long-term evolution of antibiotic tolerance in <i>Pseudomonas aeruginosa</i> lung infections Open
Pathogenic bacteria respond to antibiotic pressure with the evolution of resistance but survival can also depend on their ability to tolerate antibiotic treatment, known as tolerance. While a variety of resistance mechanisms and underlying…
View article: Cystic fibrosis systemic immune profile is associated with lung microbes and characterized by widespread alterations in the innate and adaptive immune compartments
Cystic fibrosis systemic immune profile is associated with lung microbes and characterized by widespread alterations in the innate and adaptive immune compartments Open
Polymicrobial airway infections and detrimental inflammation characterize patients with cystic fibrosis (CF), a disease with heterogeneous clinical outcomes. How the overall immune response is affected in CF, its relationships with the lun…
View article: Efflux pump mutations in<i>Pseudomonas aeruginosa</i>cause low-level clinical resistance and high-level tolerance to antibiotics in patients
Efflux pump mutations in<i>Pseudomonas aeruginosa</i>cause low-level clinical resistance and high-level tolerance to antibiotics in patients Open
Pseudomonas aeruginosa is one of the microorganisms with high-risk regarding antimicrobial resistance, since it has an overwhelming capacity to acquire antibiotic resistance, mainly by mutations during persistent lung infections. Mutations…
View article: Adaptive evolution of<i>P. aeruginosa</i>in human airways shows phenotypic convergence despite diverse patterns of genomic changes
Adaptive evolution of<i>P. aeruginosa</i>in human airways shows phenotypic convergence despite diverse patterns of genomic changes Open
Selective forces in the environment drive bacterial adaptation to novel niches, choosing the fitter variants in the population. However, in dynamic and changing environments, the evolutionary processes controlling bacterial adaptation are …
View article: Detuning of the Ribosome Conformational Landscape Promotes Antibiotic Resistance and Collateral Sensitivity
Detuning of the Ribosome Conformational Landscape Promotes Antibiotic Resistance and Collateral Sensitivity Open
SUMMARY Around 50% of the current antibiotic arsenal targets the ribosome, thus resistance to ribosome-targeting antibiotics poses severe challenges to antimicrobial treatments. Here, we characterize a 12-nucleotide deletion in the rplF ge…
View article: Metabolic specialization drives reduced pathogenicity in<i>Pseudomonas aeruginosa</i>CF clinical isolates
Metabolic specialization drives reduced pathogenicity in<i>Pseudomonas aeruginosa</i>CF clinical isolates Open
Metabolism provides the foundation for all cellular functions. During persistent infections, in adapted pathogenic bacteria metabolism functions radically differently compared with more naïve strains. Whether this is simply a necessary acc…
View article: Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs
Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs Open
The dataset is deposited as part of the research article "Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs".
View article: Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs
Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs Open
The dataset is deposited as part of the research article "Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs".