Salman Siddiqui
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View article: Clinical relevance of CompEx Asthma and impact on disease trajectory: benralizumab effect
Clinical relevance of CompEx Asthma and impact on disease trajectory: benralizumab effect Open
Background Severe exacerbations (SevEx), the typical endpoint when evaluating asthma therapies, may provide incomplete assessment, as it relies on patient perception of disease and physician action. CompEx includes SevEx and acute worsenin…
View article: The European Respiratory Society Clinical Research Collaboration Programme: advancing respiratory science through successful collaboration
The European Respiratory Society Clinical Research Collaboration Programme: advancing respiratory science through successful collaboration Open
Overview and guidance on how to run a successful clinical research collaboration within the @EuroRespSoc https://bit.ly/3He8mTp.
View article: Detecting Small Airways Dysfunction in Asthma: Rationale, Findings, and Future of ATLANTIS
Detecting Small Airways Dysfunction in Asthma: Rationale, Findings, and Future of ATLANTIS Open
Small airway dysfunction (SAD) is both common and clinically relevant in patients with asthma. However, there is no recognized "gold standard" approach for the identification of SAD in clinical practice. The ATLANTIS (AssessmenT of smalL A…
View article: Interpreting respiratory oscillometry in adults with asthma or COPD: findings of an international Delphi study
Interpreting respiratory oscillometry in adults with asthma or COPD: findings of an international Delphi study Open
Background Respiratory oscillometry measures the physiological effort and mechanics of moving air in and out of the lungs during normal breathing. It provides complementary information to spirometry. Uncertainty regarding the interpretatio…
View article: TruthLens: AI-Powered Fake News and Misinformation Detection Using Multimodal Analysis
TruthLens: AI-Powered Fake News and Misinformation Detection Using Multimodal Analysis Open
—The spread of misinformation and fake news poses a significant challenge in today’s digital landscape. This research presents TruthLens, an AI-powered framework integrating Nat- ural Language Processing (NLP), Computer Vision (CV), and Fa…
View article: Pre-biologic assessment of adherence in severe asthma and association with biologic continuation: a UK Severe Asthma Registry Study
Pre-biologic assessment of adherence in severe asthma and association with biologic continuation: a UK Severe Asthma Registry Study Open
Background Biologic therapies are approved for uncontrolled severe asthma despite good adherence to inhaled corticosteroids (ICS) and additional controllers. We examined the adherence assessments used across UK Severe Asthma Centres (SACs)…
View article: ”Treat-to-Target”: A Call for Earlier Targeted Intervention in Asthma
”Treat-to-Target”: A Call for Earlier Targeted Intervention in Asthma Open
The treat-to-target approach is a concept that has been successfully implemented in many disease areas such as rheumatoid arthritis and cardiovascular disease and more recently is being discussed in asthma. Currently, asthma management is …
View article: Speech Recognition Technologies: Design, Challenges, and Real-World Applications
Speech Recognition Technologies: Design, Challenges, and Real-World Applications Open
This paper presents an automated speech recognition (ASR) system that transcribes audio from YouTube videos into accurate text using OpenAI's Whisper model. Leveraging tools such as yt_dlp, FFmpeg, and PyTorch, the system creates a robust …
View article: Assessment of an Oral Corticosteroid Withdrawal Pathway for Severe Asthma Patients Receiving Biologic Therapies
Assessment of an Oral Corticosteroid Withdrawal Pathway for Severe Asthma Patients Receiving Biologic Therapies Open
Most clinically stable patients with asthma receiving biologics successfully withdrew mOCS without requiring dynamic adrenal function testing.
View article: PRIMARY POSTPARTUM HEMORRHAGE IN AUGMENTED LABOUR: A STUDY OF NORMAL VAGINAL DELIVERIES
PRIMARY POSTPARTUM HEMORRHAGE IN AUGMENTED LABOUR: A STUDY OF NORMAL VAGINAL DELIVERIES Open
Background: One of the important and life-threatening complications encountered during labor is bleeding. This study is to estimate the frequency of Primary Postpartum Hemorrhage after augmented labor in normal vaginal delivery in our popu…
View article: Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission-Longitudinal (UNIVERSAL) study: a prospective observational cohort study protocol
Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission-Longitudinal (UNIVERSAL) study: a prospective observational cohort study protocol Open
Background Respiratory viral infections (RVIs) are a significant cause of morbidity and hospital admission worldwide. However, the management of most viral infection-associated diseases remains primarily supportive. The recent COVID-19 pan…
View article: Long-term clinical outcomes of pancreatic cystic lesions in liver transplant patients
Long-term clinical outcomes of pancreatic cystic lesions in liver transplant patients Open
There is a low incidence of malignant transformation of PCL in OLT patients and no survival disadvantage at long-term follow up despite immunosuppression. PCL in OLT patients should be managed under similar guidelines as immunocompetent pa…
View article: Readability and complexity of written information presented to hospitalised patients for trial consent during the COVID-19 pandemic in the UK: a retrospective document analysis
Readability and complexity of written information presented to hospitalised patients for trial consent during the COVID-19 pandemic in the UK: a retrospective document analysis Open
Objectives Patient information sheets (PISs) and informed consent forms (ICFs) are essential tools to communicate and document informed consent for clinical trial participation. These documents need to be easily understandable, especially …
View article: Oscillometry to assess ventilation heterogeneity during hospital admission for acute cardiorespiratory illness
Oscillometry to assess ventilation heterogeneity during hospital admission for acute cardiorespiratory illness Open
Rationale Hospitalisation due to exacerbations of cardiorespiratory disease results in reduced lung function and increased airways obstruction. However, traditional measures of lung function require maximal effort which is difficult when p…
View article: Ramadan fasting for patients with chronic respiratory diseases: a systematic review and consensus recommendations for healthcare professionals
Ramadan fasting for patients with chronic respiratory diseases: a systematic review and consensus recommendations for healthcare professionals Open
Background Ramadan, observed by nearly 2 billion Muslims worldwide, involves fasting from dawn to sunset, which can present challenges for individuals with chronic respiratory diseases due to altered medication regimens and oral intake res…
View article: Atmosclear (Ai-Ml De-Haze/De-Smoking Algorithm)
Atmosclear (Ai-Ml De-Haze/De-Smoking Algorithm) Open
Surveillance footage quality is often degraded by environmental factors like noise and fog, impacting monitoring accuracy. AtmosClear is an AI-ML solution designed to enhance video clarity in challenging conditions. It employs deep learnin…
View article: Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci
Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci Open
Asthma is a genetically complex inflammatory airway disease associated with more than 200 SNPs. However, the functional effects of many asthma-associated SNPs in lung and airway epithelial samples are unknown. Here, we aimed to conduct exp…
View article: Comparative Analysis of Efficient Adapter-Based Fine-Tuning of State-of-the-Art Transformer Models
Comparative Analysis of Efficient Adapter-Based Fine-Tuning of State-of-the-Art Transformer Models Open
In this work, we investigate the efficacy of various adapter architectures on supervised binary classification tasks from the SuperGLUE benchmark as well as a supervised multi-class news category classification task from Kaggle. Specifical…
View article: Mathematical modelling of polyvinyl chloride embedded tin tungsto phosphate composite membrane for industrial water separation
Mathematical modelling of polyvinyl chloride embedded tin tungsto phosphate composite membrane for industrial water separation Open
A novel tin tungstophosphate (TTP) composite ion‐exchange membrane was made with casting a polyvinyl chloride (PVC) by co‐precipitation method. The electrochemical characterization and intermolecular interactions between the components in …
View article: Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma
Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma Open
Background We have previously developed Core Outcome Measures sets for Severe Asthma (COMSA) by multi-stakeholder consensus. There are no patient-centred tools to quantify response to biological therapies for severe asthma. We aimed to dev…
View article: Neutrophilic inflammation in sputum or blood does not define a clinically distinct asthma phenotype in ATLANTIS
Neutrophilic inflammation in sputum or blood does not define a clinically distinct asthma phenotype in ATLANTIS Open
Introduction Neutrophilic asthma has been suggested to be a clinically distinct phenotype characterised by more severe airflow obstruction and higher exacerbation risk. However, this has only been assessed in few and smaller studies, using…
View article: Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics
Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics Open
Background Lung quantitative computed tomography (qCT) severe asthma clusters have been reported, but their replication and underlying disease mechanisms are unknown. We identified and replicated qCT clusters of severe asthma in two indepe…
View article: Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils
Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils Open
Interleukin (IL)‐5 is the key cytokine in the maturation, activation, proliferation, migration and survival of eosinophils, which are key effector cells in many upper and lower airway diseases. Through its effects on eosinophils, IL‐5 indi…
View article: Multivariate time series approaches to extract predictive asthma biomarkers from prospectively patient-collected diary data: a systematic review
Multivariate time series approaches to extract predictive asthma biomarkers from prospectively patient-collected diary data: a systematic review Open
Objectives Longitudinal data are common in asthma studies, to assess asthma progression in patients and identify predictors of future outcomes, including asthma exacerbations and asthma control. Different methods can quantify temporal beha…
View article: Nasal epithelial gene expression identifies relevant asthma endotypes in the ATLANTIS study
Nasal epithelial gene expression identifies relevant asthma endotypes in the ATLANTIS study Open
Introduction Asthma is an inflammatory airways disease encompassing multiple phenotypes and endotypes. Several studies suggested gene expression in nasal epithelium to serve as a proxy for bronchial epithelium, being a non-invasive approac…
View article: Fulfilling the Promise of Breathomics: Considerations for the Discovery and Validation of Exhaled Volatile Biomarkers
Fulfilling the Promise of Breathomics: Considerations for the Discovery and Validation of Exhaled Volatile Biomarkers Open
The exhaled breath represents an ideal matrix for noninvasive biomarker discovery, and exhaled metabolomics have the potential to be clinically useful in the era of precision medicine. In this concise translational review, we specifically …
View article: Sex differences in asthma control, lung function and exacerbations: the ATLANTIS study
Sex differences in asthma control, lung function and exacerbations: the ATLANTIS study Open
Background Asthma is a heterogeneous disease with a prevalence and severity that differs between male and female patients. Question What are differences between male and female patients with asthma with regard to asthma control, lung funct…