George R. Saade
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View article: Childhood sexual abuse and post‐cesarean pain
Childhood sexual abuse and post‐cesarean pain Open
Background Sexual abuse before the age of 10 is reported by 2.7% of US women. Chronic pain has been linked to sexual abuse, but little is known about acute postoperative pain in those with a sexual abuse history and no history of chronic p…
View article: Association of Mean Arterial, Systolic, and Diastolic Blood Pressure Trends in Early Pregnancy With Superimposed Preeclampsia With Severe Features in Pregnancies Complicated by Chronic Hypertension
Association of Mean Arterial, Systolic, and Diastolic Blood Pressure Trends in Early Pregnancy With Superimposed Preeclampsia With Severe Features in Pregnancies Complicated by Chronic Hypertension Open
OBJECTIVE: To evaluate the association of longitudinal systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) in early pregnancy with later development of superimposed preeclampsia with severe featu…
View article: Maternal mortality according to state abortion legislative climate following the US Supreme Court's <i>Dobbs v. Jackson Women's Health Organization</i> ruling
Maternal mortality according to state abortion legislative climate following the US Supreme Court's <i>Dobbs v. Jackson Women's Health Organization</i> ruling Open
Objective We aimed to evaluate how maternal mortality rates have evolved across US states following the Dobbs ruling, while accounting for the confounding influence of the coronavirus disease 2019 (COVID‐19) pandemic. Study design We condu…
View article: Pulse Pressure and Adverse Maternal and Perinatal Outcomes in Patients With Mild Chronic Hypertension During Pregnancy
Pulse Pressure and Adverse Maternal and Perinatal Outcomes in Patients With Mild Chronic Hypertension During Pregnancy Open
OBJECTIVE: To evaluate associations among antepartum pulse pressure and maternal and perinatal outcomes in women with mild chronic hypertension. METHODS: Secondary analysis of the CHAP (Chronic Hypertension and Pregnancy) trial, an open-la…
View article: Use of a Maternal Genetic Risk Score to Derive and Test a Genetically Customized Fetal Growth Curve
Use of a Maternal Genetic Risk Score to Derive and Test a Genetically Customized Fetal Growth Curve Open
OBJECTIVE: Our aim was to determine whether using a maternal genetic risk score for birth weight (GRS BW ) to genetically customize a fetal growth curve would improve model fit and identification of perinatal morbidity. METHODS: We perform…
View article: Association between adverse pregnancy outcomes and awareness of cardiovascular risk factors: A nuMoM2b‐HHS secondary analysis
Association between adverse pregnancy outcomes and awareness of cardiovascular risk factors: A nuMoM2b‐HHS secondary analysis Open
Background Adverse pregnancy outcomes (APOs) affect 10%–20% of pregnancies and are associated with increased risk of cardiovascular disease. Objective To determine whether the history of APO is associated with a person's awareness of their…
View article: Small-for-Gestational-Age Birth Weight Risk Stratification Using First-Trimester Fetal Cardiac Parameters
Small-for-Gestational-Age Birth Weight Risk Stratification Using First-Trimester Fetal Cardiac Parameters Open
OBJECTIVE: To apply unsupervised machine learning techniques to first-trimester fetal cardiac data to enhance early risk stratification of small-for-gestational-age (SGA) birth weight. METHODS: This was a prospective cohort study that enro…
View article: Variability and Longitudinal Trajectories of Phthalate and Replacement Biomarkers across Pregnancy in the Human Placenta and Phthalates Study
Variability and Longitudinal Trajectories of Phthalate and Replacement Biomarkers across Pregnancy in the Human Placenta and Phthalates Study Open
Human exposure to phthalates is widespread, but assessment of variability across pregnancy has been hampered by short half-lives of phthalate biomarkers and a few repeated measures in prior studies. We aimed to characterize the variability…
View article: Early Postnatal Polymerase Chain Reaction Testing in the Identification of Perinatal Transmission of Hepatitis C Virus
Early Postnatal Polymerase Chain Reaction Testing in the Identification of Perinatal Transmission of Hepatitis C Virus Open
In this study, a single hepatitis C virus (HCV) RNA at 2–6 months was sensitive and specific (86.7% and 95% confidence interval [CI], 62.1%–96.3% and 100% and 95% CI, 98.8%–100%, respectively) in identifying perinatal transmission of HCV. …
View article: Post–Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) After Infection During Pregnancy
Post–Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) After Infection During Pregnancy Open
OBJECTIVE: To estimate the prevalence of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) after infection with SARS-CoV-2 during pregnancy and to characterize associated risk factors. MET…
View article: Maternal Vulnerability Index and Severe Maternal Morbidity
Maternal Vulnerability Index and Severe Maternal Morbidity Open
Importance Few studies have investigated the association of composite measures of neighborhood social determinants of health with severe maternal morbidity (SMM), and no research has examined this association for indices tailored to matern…
View article: Outpatient or Inpatient Setting for Cervical Ripening Before Induction of Labour: An Individual Participant Data Meta‐Analysis
Outpatient or Inpatient Setting for Cervical Ripening Before Induction of Labour: An Individual Participant Data Meta‐Analysis Open
Background The optimal methods and settings for induction of labour (IOL) in terms of effectiveness, safety, and women's experience are still not elucidated. Objective To compare the effectiveness and safety of outpatient versus inpatient …
View article: Racial and Ethnic Inequities in Cesarean Birth and Maternal Morbidity in a Low-Risk, Nulliparous Cohort
Racial and Ethnic Inequities in Cesarean Birth and Maternal Morbidity in a Low-Risk, Nulliparous Cohort Open
OBJECTIVE: To evaluate race and ethnicity differences in cesarean birth and maternal morbidity in low-risk nulliparous people at term. METHODS: We conducted a secondary analysis of a randomized trial of expectant management compared with i…
View article: Racial and Ethnic Disparities in Adverse Perinatal Outcomes at Term
Racial and Ethnic Disparities in Adverse Perinatal Outcomes at Term Open
OBJECTIVE: This study aimed to evaluate whether racial and ethnic disparities in adverse perinatal outcomes exist at term. STUDY DESIGN: We performed a secondary analysis of a multicenter observational study of 115,502 pregnant patients an…
View article: Associations of prenatal concentrations of environmental phthalates and phenols with preeclampsia
Associations of prenatal concentrations of environmental phthalates and phenols with preeclampsia Open
Introduction Endocrine‐disrupting chemicals (EDCs) like phthalates and phenols are ubiquitous in consumer products, raising concerns about fetal development and pregnancy complications such as hypertensive disorders of pregnancy (HDP). Whi…
View article: Exposure to phthalates and replacements during pregnancy in association with gestational blood pressure and hypertensive disorders of pregnancy
Exposure to phthalates and replacements during pregnancy in association with gestational blood pressure and hypertensive disorders of pregnancy Open
Exposure to endocrine-disrupting chemicals such as phthalates may increase risk of hypertensive disorders of pregnancy (HDP). Prior studies lack investigation of chemical mixtures, phthalate replacements, or key periods of susceptibility i…
View article: Association Between Giving Birth During the Early Coronavirus Disease 2019 (COVID-19) Pandemic and Serious Maternal Morbidity
Association Between Giving Birth During the Early Coronavirus Disease 2019 (COVID-19) Pandemic and Serious Maternal Morbidity Open
OBJECTIVE: To evaluate whether delivering during the early the coronavirus disease 2019 (COVID-19) pandemic was associated with increased risk of maternal death or serious morbidity from common obstetric complications compared with a histo…
View article: The Association of Race and Ethnicity with Severe Maternal Morbidity among Individuals Diagnosed with Hypertensive Disorders of Pregnancy
The Association of Race and Ethnicity with Severe Maternal Morbidity among Individuals Diagnosed with Hypertensive Disorders of Pregnancy Open
OBJECTIVE: This study aimed to examine whether there are racial disparities in severe maternal morbidity (SMM) in patients with hypertensive disorders of pregnancy (HDP). STUDY DESIGN: Secondary analysis of an observational study of 115,50…
View article: Development of a Risk-Scoring System for Prediction of Blood Transfusion During Hospitalization for Delivery
Development of a Risk-Scoring System for Prediction of Blood Transfusion During Hospitalization for Delivery Open
OBJECTIVE: To develop and internally validate a practical and data-driven risk-scoring system to predict blood transfusion during hospitalization for delivery in a contemporary U.S. cohort. METHODS: This was a secondary analysis of a multi…
View article: Racial and Ethnic Inequalities in Actual vs Nearest Delivery Hospitals
Racial and Ethnic Inequalities in Actual vs Nearest Delivery Hospitals Open
Importance Minoritized racial and ethnic groups, such as American Indian and Black individuals, often receive lower quality health care compared with White individuals. There is limited understanding of how these disparities extend to obst…
View article: Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication
Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication Open
This practice guideline provides updated evidence-based conclusions and recommendations regarding the effects of antiseizure medications (ASMs) and folic acid supplementation on the prevalence of major congenital malformations (MCMs), adve…
View article: The Effect of Maternal Antioxidant Vitamin Supplementation on Maternal and Cord Blood Adiponectin Concentrations
The Effect of Maternal Antioxidant Vitamin Supplementation on Maternal and Cord Blood Adiponectin Concentrations Open
Adiponectin is a hormone that modulates glucose regulation and fatty acid oxidation. Low adiponectin concentration has been associated with increased insulin resistance. Studies show a beneficial effect of vitamin E supplementation on insu…
View article: Medical‐legal claims in obstetrics and gynecology: Japan versus the United States
Medical‐legal claims in obstetrics and gynecology: Japan versus the United States Open
This study investigates the factors contributing to the decline in obstetrics and gynecology (OB/GYN) malpractice claims in Japan and highlights professional attitudes, institutional support systems, clinical practices, and policies that c…
View article: A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions
A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions Open
Post-Acute Sequelae of SARS-CoV-2 infection (PASC or “Long COVID”), includes numerous chronic conditions associated with widespread morbidity and rising healthcare costs. PASC has highly variable clinical presentations, and likely includes…