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View article: Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology
Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology Open
Growing evidence highlights sex‐related differences in the pathogenesis of Alzheimer's disease (AD). Yet, early impact of sex on neuronal activity and microglia in the hippocampus, a main site of memory formation and one of the most vulner…
View article: IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter
IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter Open
Regulation of firing rate homeostasis constitutes a fundamental property of central neural circuits. While intracellular Ca 2+ has long been hypothesized to be a feedback control signal, the molecular machinery enabling a network-wide home…
View article: IGF1 Receptor Regulates Upward Firing Rate Homeostasis via the Mitochondrial Calcium Uniporter
IGF1 Receptor Regulates Upward Firing Rate Homeostasis via the Mitochondrial Calcium Uniporter Open
Regulation of firing rate homeostasis constitutes a fundamental property of central neural circuits. While intracellular Ca 2+ has long been hypothesized to be a feedback control signal, the molecular machinery enabling network-wide homeos…
View article: Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction
Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction Open
Significance Energy homeostasis is fundamental for the survival of living organisms and contributes to their health, longevity, and aging. When food resources are scarce, and during experimental calorie restriction, endothermic animals can…
View article: The Alzheimer’s disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons
The Alzheimer’s disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons Open
Seminal studies using post-mortem brains of patients with Alzheimer's disease evidenced aberrant insulin-like growth factor 1 receptor (IGF1R) signalling. Addressing causality, work in animal models recently demonstrated that long-term sup…
View article: Disrupting IGF Signaling in Adult Mice Conditions Leanness, Resilient Energy Metabolism, and High Growth Hormone Pulses
Disrupting IGF Signaling in Adult Mice Conditions Leanness, Resilient Energy Metabolism, and High Growth Hormone Pulses Open
Growth hormone (GH) and insulinlike growth factor (IGF) promote aging and age-related pathologies. Inhibiting this pathway by targeting IGF receptor (IGF-1R) is a promising strategy to extend life span, alleviate age-related diseases, and …
View article: O2‐07‐03: Regulatory T Cells Delay Disease Progression in Alzheimer's‐Like Pathology
O2‐07‐03: Regulatory T Cells Delay Disease Progression in Alzheimer's‐Like Pathology Open
Recent studies highlight the implication of innate and adaptive immunity in the pathophysiology of Alzheimer's disease (AD), and foster immunotherapy as a promising strategy for its treatment. Vaccines targeting amyloid-beta (Abeta) peptid…
View article: Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin
Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin Open
Insulin-like growth factors control numerous processes, namely somatic growth, metabolism and stress resistance, connecting this pathway to aging and age-related diseases. Insulin-like growth factor signaling also impacts on neurogenesis, …