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View article: Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome
Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome Open
View article: A cellular and spatial map of salivary glands at single cell resolution reveals the functional basis of tertiary lymphoid structure formation in Sjogren’s syndrome
A cellular and spatial map of salivary glands at single cell resolution reveals the functional basis of tertiary lymphoid structure formation in Sjogren’s syndrome Open
The key role of tertiary lymphoid structures in autoimmune and non-autoimmune conditions has been recently appreciated. While many of the molecular mechanisms involved in tertiary lymphoid structure (TLS) formation have been identified, th…
View article: Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction
Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction Open
View article: Stromal cells in tertiary lymphoid structures: Architects of autoimmunity
Stromal cells in tertiary lymphoid structures: Architects of autoimmunity Open
The molecular mediators present within the inflammatory microenvironment are able, in certain conditions, to favor the initiation of tertiary lymphoid structure (TLS) development. TLS is organized lymphocyte clusters able to support antige…
View article: Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology
Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology Open
Significance TLS, which are clusters of lymphocytes and stromal cells observed at sites of chronic inflammation, play a key role in sustaining disease progression in autoimmune conditions. While the role of lymphocytes in these structures …