Ashraf Dar
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View article: Integrating in-silico and experimental validation approaches to unveil the therapeutic mechanism of naringenin against breast cancer
Integrating in-silico and experimental validation approaches to unveil the therapeutic mechanism of naringenin against breast cancer Open
Naringenin (NAR), a flavanone abundant in citrus fruits, has shown antiproliferative effects in several cancers, including breast cancer. However, its precise molecular mechanisms remain unclear. This study integrates network pharmacology,…
View article: Naringenin Inhibits Cellular Proliferation, Arrests Cell Cycle and Induces Pro‐Apoptotic Autophagy in <scp>MCF</scp>‐7 Breast Cancer Cells
Naringenin Inhibits Cellular Proliferation, Arrests Cell Cycle and Induces Pro‐Apoptotic Autophagy in <span>MCF</span>‐7 Breast Cancer Cells Open
The global incidence of breast cancer has significantly increased, highlighting the need for novel therapeutic strategies. Current treatment options are often limited by drug resistance and adverse effects, necessitating the exploration of…
View article: Mdm2 restrains the activity of the CRL4<sup>Cdt2</sup> E3 ubiquitin ligase to promote cell cycle progression through the G2/M phase
Mdm2 restrains the activity of the CRL4<sup>Cdt2</sup> E3 ubiquitin ligase to promote cell cycle progression through the G2/M phase Open
The canonical function of the Mdm2 oncoprotein is widely recognized as the negative regulation of the p53 tumor suppressor. However, growing evidence indicates that its physiological activities extend far beyond p53. Here, we show that Mdm…
View article: Plasmodium falciparum topoisomerases: Emerging targets for anti-malarial therapy
Plasmodium falciparum topoisomerases: Emerging targets for anti-malarial therapy Open
View article: Flavonoids as promising molecules in the cancer therapy: An insight
Flavonoids as promising molecules in the cancer therapy: An insight Open
View article: Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer
Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer Open
Mechanistic target of rapamycin (mTOR) is a protein kinase that regulates cellular growth, development, survival, and metabolism through integration of diverse extracellular and intracellular stimuli. Additionally, mTOR is involved in inte…
View article: The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers
The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers Open