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View article: Editorial: Genetics of non-syndromic hearing loss
Editorial: Genetics of non-syndromic hearing loss Open
View article: Gene therapy of rare diseases as a milestone in medicine - overview of the field and report on initial experiences in Slovenia
Gene therapy of rare diseases as a milestone in medicine - overview of the field and report on initial experiences in Slovenia Open
Gene therapy has transitioned from a long-awaited promise to a clinical reality, offering transformative treatments for rare congenital diseases and certain cancers, which have a significant impact on patients’ lives. Current approaches fo…
View article: Enhancing the Outcomes of Temporalis Fascia Tympanoplasty Using Autologous Platelet-Rich Plasma and Gel: A Randomized Controlled Trial
Enhancing the Outcomes of Temporalis Fascia Tympanoplasty Using Autologous Platelet-Rich Plasma and Gel: A Randomized Controlled Trial Open
Objectives: This study aimed to investigate the impact of platelet-rich plasma (PRP) and platelet-rich gel (PRG) on tympanic membrane closure rates, hearing improvement, and quality of life following tympanoplasty. Methods: Seventy-two pat…
View article: Let’s See If You Can Hear: The Effect of Stimulus Type and Intensity to Pupil Diameter Response in Infants and Adults
Let’s See If You Can Hear: The Effect of Stimulus Type and Intensity to Pupil Diameter Response in Infants and Adults Open
Objectives: Pupil dilation can serve as a measure of auditory attention. It has been proposed as an objective measure for adjusting hearing aid configurations, and as a measure of hearing threshold in the pediatric population. Here we expl…
View article: 6468 Once-Weekly Semaglutide and Taste Perception in Women with Obesity
6468 Once-Weekly Semaglutide and Taste Perception in Women with Obesity Open
Disclosure: M. Jensterle Sever: None. J. Kovac: None. A. Vovk: None. S. Battelino: None. T. Battelino: None. A. Janez: None. Objective: Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue that causes weight loss by reducing appetite …
View article: Prirojena okužba s citomegalovirusom: priporočila za usmerjeno presejanje novorojenčkov in protokol obravnave
Prirojena okužba s citomegalovirusom: priporočila za usmerjeno presejanje novorojenčkov in protokol obravnave Open
Prirojena okužba s citomegalovirusom (pCMV) je v razvitih državah najpogostejša prirojena okužba ter najpogostejši vzrok za senzorinevralno okvaro sluha in razvojnonevrološke motnje. Le manjši delež otrok s pCMV ima ob rojstvu izražene zna…
View article: A Multidisciplinary Skull Base Board for Tumour and Non-Tumour Diseases: Initial Experiences
A Multidisciplinary Skull Base Board for Tumour and Non-Tumour Diseases: Initial Experiences Open
The skull base is the area where various cancerous and non-cancerous diseases occur and represents the intersection of several medical fields. The key is an integrated treatment by specialists of multiple disciplines. We prospectively anal…
View article: Appropriate Vestibular Stimulation in Children and Adolescents—A Prerequisite for Normal Cognitive, Motor Development and Bodily Homeostasis—A Review
Appropriate Vestibular Stimulation in Children and Adolescents—A Prerequisite for Normal Cognitive, Motor Development and Bodily Homeostasis—A Review Open
The structural development of the vestibular part of the inner ear is completed by birth but its central connections continue to develop until adolescence. Their development is dependent on vestibular stimulation—vestibular experience. Stu…
View article: Genetic Evaluation of Prelingual Hearing Impairment: Recommendations of an European Network for Genetic Hearing Impairment
Genetic Evaluation of Prelingual Hearing Impairment: Recommendations of an European Network for Genetic Hearing Impairment Open
The cause of childhood hearing impairment (excluding infectious pathology of the middle ear) can be extrinsic (embryofoetopathy, meningitis, trauma, drug ototoxicity, noise trauma, etc [...]
View article: Storage of Platelet-Rich Products
Storage of Platelet-Rich Products Open
Platelets are a natural source of signaling molecules, growth factors, cytokines and extracellular vesicles that modify the pericellular microenvironment in favor of tissue healing and regeneration. Autologous platelet-rich products, such …
View article: Atypical Skull-Base Osteomyelitis: Comprehensive Review and Multidisciplinary Management Viewpoints
Atypical Skull-Base Osteomyelitis: Comprehensive Review and Multidisciplinary Management Viewpoints Open
Atypical skull-base osteomyelitis is a rare but fatal disease that usually involves infection of the ethmoid, sphenoid, occipital, or temporal bones that form the skull base. Unlike typical (so-called otogenic), atypical skull-base osteomy…
View article: Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review
Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review Open
The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the func…
View article: Management of Choanal Atresia: National Recommendations with a Comprehensive Literature Review
Management of Choanal Atresia: National Recommendations with a Comprehensive Literature Review Open
Choanal atresia is the most common congenital anatomical abnormality of the nasal cavities, manifested with a clinical picture of neonatal respiratory distress. The treatment requires interdisciplinary management based mainly on tertiary r…
View article: Facial Nerve Reconstructive Surgery in Otorhinolaryngology and its Enhancement by Platelet- and Extracellular Vesicle-Rich Plasma Therapy
Facial Nerve Reconstructive Surgery in Otorhinolaryngology and its Enhancement by Platelet- and Extracellular Vesicle-Rich Plasma Therapy Open
The facial nerve and its reconstructive surgical procedures are complex and challenging. The main function of facial nerve is namely motor innervation of facial muscles and its dysfunction presents as facial paralysis. Depending on the ext…
View article: Surface-Based Total Blood Volume Calculation for Platelet and Extracellular Vesicle-Rich Plasma and Gel Preparation by Us-ing a Mathematical Model
Surface-Based Total Blood Volume Calculation for Platelet and Extracellular Vesicle-Rich Plasma and Gel Preparation by Us-ing a Mathematical Model Open
Platelet- and extracellular vesicle-rich plasma (PVRP) and platelet- and extracellular vesicle-rich gel (PVRG) are blood-derived products gaining attraction in regenerative medicine. However, despite their reported good efficacy, their pre…
View article: Socratic Lectures 7
Socratic Lectures 7 Open
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View article: Vector-Borne Tularemia: A Re-Emerging Cause of Cervical Lymphadenopathy
Vector-Borne Tularemia: A Re-Emerging Cause of Cervical Lymphadenopathy Open
Tularemia is a zoonosis caused by the highly invasive bacterium Francisella tularensis. It is transmitted to humans by direct contact with infected animals or by vectors, such as ticks, mosquitos, and flies. Even though it is well-known as…
View article: Indicators of pediatric peripheral vestibular disorder: A retrospective study in a tertiary referral center
Indicators of pediatric peripheral vestibular disorder: A retrospective study in a tertiary referral center Open
Unlike adults, peripheral vestibular causes of vertigo and dizziness in children may be rare but have the same typical signs and symptoms. The detailed history and careful clinical examination are crucial in differentiating between periphe…
View article: Consequences of Stapes Surgery on Tongue Morphological Characteristics in Narrow Band Imaging, Gustatory Function and General Sensation: A Prospective Tertiary Center Study
Consequences of Stapes Surgery on Tongue Morphological Characteristics in Narrow Band Imaging, Gustatory Function and General Sensation: A Prospective Tertiary Center Study Open
(1) Background: Chorda tympani (CT) manipulation during stapes surgery affects its functions. We hypothesized that this alters tongue morphology and sensory functions. (2) Methods: Patients undergoing stapes surgery were tested 1 day preop…
View article: Attention to Speech and Music in Young Children with Bilateral Cochlear Implants: A Pupillometry Study
Attention to Speech and Music in Young Children with Bilateral Cochlear Implants: A Pupillometry Study Open
Early bilateral cochlear implants (CIs) may enhance attention to speech, and reduce cognitive load in noisy environments. However, it is sometimes difficult to measure speech perception and listening effort, especially in very young childr…
View article: Malignant Syphilis in a Female Patient: A Case Report and Mini-Review
Malignant Syphilis in a Female Patient: A Case Report and Mini-Review Open
Malignant syphilis (MS) is a rare form of secondary syphilis with grotesque skin lesions, systemic manifestation and life-threatening complications. This article presents a case of MS in an immunocompetent 41-year-old female, who initially…
View article: GENSKO ZDRAVLJENJE PRI MUKOPOLISAHARIDOZI TIPA IIIA: PREDSTAVITEV PRIMEROV
GENSKO ZDRAVLJENJE PRI MUKOPOLISAHARIDOZI TIPA IIIA: PREDSTAVITEV PRIMEROV Open
Mukopolisaharidoze so lizosomske bolezni kopičenja, pri katerih se klinična slika razvija postopno. Bolezni napredujejo in prizadenejo številne organe. S trenutno dostopnimi možnostmi zdravljenja bolnikov ne moremo ozdraviti, a s prihodom …
View article: GENE THERAPY IN MUCOPOLYSACCHARIDOSIS TYPE IIIA: CASE REPORTS
GENE THERAPY IN MUCOPOLYSACCHARIDOSIS TYPE IIIA: CASE REPORTS Open
Mucopolysaccharidoses are a group of rare lysosomal storage diseases. The clinical signs develop gradually, the impairment is progressive and multiple organs are affected. With the currently known treatment options, the patient cannot be c…
View article: Prospects of Extracellular Vesicles in Otorhinolaryngology, Head and Neck Surgery
Prospects of Extracellular Vesicles in Otorhinolaryngology, Head and Neck Surgery Open
The diagnostic and therapeutic potential of extracellular vesicles (EVs) has been recognised in many fields of medicine for several years. More recently, it has become a topic of increasing interest in otorhinolaryngology, head and neck su…
View article: Enrichment of plasma in platelets and extracellular vesicles by the counterflow to erythrocyte settling
Enrichment of plasma in platelets and extracellular vesicles by the counterflow to erythrocyte settling Open
In order to prepare optimal platelet and extracellular vesicle (EV)-rich plasma for the treatment of chronic temporal bone inflammation, we studied effects of centrifugation parameters on redistribution of blood constituents in blood sampl…
View article: Does intervention with GLP-1 receptor agonist semaglutide modulate perception of sweet taste in women with obesity: study protocol of a randomized, single-blinded, placebo-controlled clinical trial
Does intervention with GLP-1 receptor agonist semaglutide modulate perception of sweet taste in women with obesity: study protocol of a randomized, single-blinded, placebo-controlled clinical trial Open
View article: Autologous Platelet- and Extracellular Vesicle-Rich Plasma Is an Effective Treatment Modality for Chronic Postoperative Temporal Bone Cavity Inflammation: Randomized Controlled Clinical Trial
Autologous Platelet- and Extracellular Vesicle-Rich Plasma Is an Effective Treatment Modality for Chronic Postoperative Temporal Bone Cavity Inflammation: Randomized Controlled Clinical Trial Open
Purpose To determine the efficacy of autologous platelet- and extracellular vesicle-rich plasma (PVRP) to treat chronic postoperative temporal bone cavity inflammation (CPTBCI) after exhausting surgical and standard conservative therapies.…
View article: Priporočila za obravnavo bolnikov z rakom glave in vratu v Sloveniji
Priporočila za obravnavo bolnikov z rakom glave in vratu v Sloveniji Open
Priporočila za obravnavo rakov glave in vratu (RGV) v Sloveniji sledijo priporočilom in usmeritvam, povzetim v publikaciji neprofitne mreže 30 vodilnih severnoameriških inštitucij za obravnavo raka, National Comprehensive Cancer Network, i…
View article: Reliability of parental assessment of auditory skills in young children: a cross-sectional study in Italian language
Reliability of parental assessment of auditory skills in young children: a cross-sectional study in Italian language Open
Objective Hearing impairments (HIs) that progress or have later onset may have specific effects on language and cognitive development, but are difficult to suspect during routine primary care visits. Family concern regarding hearing is tho…
View article: Unraveling the Etiology of Pediatric Vertigo and Dizziness: A Tertiary Pediatric Center Experience
Unraveling the Etiology of Pediatric Vertigo and Dizziness: A Tertiary Pediatric Center Experience Open
Background and Objectives: Numerous authors have reported that the commonest type of vertigo in children is migraine-associated vertigo (vestibular migraine and benign paroxysmal vertigo of childhood—BPV). We aimed to provide the possible …