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View article: Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective
Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective Open
View article: Overexpressing the ClpC AAA+ unfoldase accelerates developmental cycle progression in <i>Chlamydia trachomatis</i>
Overexpressing the ClpC AAA+ unfoldase accelerates developmental cycle progression in <i>Chlamydia trachomatis</i> Open
Chlamydia is an obligate intracellular bacterium that undergoes a complex biphasic developmental cycle, alternating between the smaller, infectious, non-dividing elementary body (EB) and the larger, non-infectious but dividing reticulate b…
View article: Dengue virus IgG and serotype-specific neutralizing antibody titers measured with standard and mature viruses are associated with protection
Dengue virus IgG and serotype-specific neutralizing antibody titers measured with standard and mature viruses are associated with protection Open
Recent work demonstrates the limitations of the standard dengue virus (DENV) neutralization assay to predict protection against dengue. We perform studies to compare how a commercial IgG ELISA, envelope domain III (EDIII) or non-structural…
View article: Phase 1 trial to model primary, secondary, and tertiary dengue using a monovalent vaccine
Phase 1 trial to model primary, secondary, and tertiary dengue using a monovalent vaccine Open
View article: Detection of envelope-dimer epitope-like broadly protective antibodies in dengue-immune children in the Philippines following vaccination and natural infection
Detection of envelope-dimer epitope-like broadly protective antibodies in dengue-immune children in the Philippines following vaccination and natural infection Open
The dengue vaccine, Dengvaxia, has been described as eliciting antibody-dependent enhancement (ADE) in dengue-naive individuals. There is an urgent need to develop an effective dengue virus (DENV) vaccine that elicits protective, cross-rea…
View article: Rapid pathogen-specific recruitment of immune effector cells in the skin by secreted toxins
Rapid pathogen-specific recruitment of immune effector cells in the skin by secreted toxins Open
View article: A Chlamydial Plasmid-Dependent Secretion System for the Delivery of Virulence Factors to the Host Cytosol
A Chlamydial Plasmid-Dependent Secretion System for the Delivery of Virulence Factors to the Host Cytosol Open
The Chlamydia trachomatis plasmid regulates the expression and secretion of immune evasion virulence factors to the host cytosol by an unknown mechanism. In this study, we identified a novel plasmid gene protein 4 (Pgp4)-dependent secretio…