Sabah Akhtar
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View article: Interleukin-31: The Inflammatory Cytokine Connecting Pruritus and Cancer
Interleukin-31: The Inflammatory Cytokine Connecting Pruritus and Cancer Open
Interleukin 31 (IL-31) is a proinflammatory cytokine, mainly secreted by Type II helper T cells. It signals through a heterodimeric receptor complex composed of IL-31 receptor α and oncostatin-M receptor β chain. The hallmark feature of IL…
View article: Corrigendum: Curcumin-mediated degradation of S-phase kinase protein 2 induces cytotoxic effects in human papillomavirus-positive and negative squamous carcinoma cells
Corrigendum: Curcumin-mediated degradation of S-phase kinase protein 2 induces cytotoxic effects in human papillomavirus-positive and negative squamous carcinoma cells Open
[This corrects the article DOI: 10.3389/fonc.2018.00399.].
View article: Role of HMGB1 and its associated signaling pathways in human malignancies
Role of HMGB1 and its associated signaling pathways in human malignancies Open
The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 has been reporte…
View article: Epigenetic control of inflammation in Atopic Dermatitis
Epigenetic control of inflammation in Atopic Dermatitis Open
View article: Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway Open
Multiple myeloma (MM) is a hematological disorder characterized by the abnormal expansion of plasma cells in the bone marrow. Despite great advances over the past three decades in discovering the efficacious therapies for MM, the disease r…
View article: Dysregulated FOXM1 signaling in the regulation of cancer stem cells
Dysregulated FOXM1 signaling in the regulation of cancer stem cells Open
Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have been made in understanding the functional and biological plasticity of these elusive components in malignancies. Endowed with self-renewing abilities …
View article: Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents Open
View article: Genetics of glutamate and its receptors in autism spectrum disorder
Genetics of glutamate and its receptors in autism spectrum disorder Open
View article: Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis
Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis Open
Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like chemotherapy, radiothera…
View article: Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids
Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids Open
View article: The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance
The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance Open
View article: Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy Open
View article: Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases
Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases Open
Skin is the largest human organ and is continuously exposed to various exogenous and endogenous trigger factors affecting body homeostasis. A number of mechanisms, including genetic, inflammatory and autoimmune ones, have been implicated i…
View article: Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway
Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway Open
View article: Cytokine-Mediated Dysregulation of Signaling Pathways in the Pathogenesis of Multiple Myeloma
Cytokine-Mediated Dysregulation of Signaling Pathways in the Pathogenesis of Multiple Myeloma Open
Multiple myeloma (MM) is a hematologic disorder of B lymphocytes characterized by the accumulation of malignant plasma cells (PCs) in the bone marrow. The altered plasma cells overproduce abnormal monoclonal immunoglobulins and also stimul…
View article: Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia
Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia Open
Acute lymphoblastic leukemia (ALL) is a significant cancer of children resulting from the clonal proliferation of lymphoid precursors with arrested maturation. Although chemotherapeutic approaches have been achieving successful remission f…
View article: Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling Open
Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and in vitro studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a mostl…
View article: Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells
Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells Open
S-phase kinase-associated protein2 (Skp2), a proto-oncoprotein, plays an important role in development and progression of human malignancies. Skp2 is frequently overexpressed in many human malignancies. It targets cell cycle progression th…
View article: UNCOVERING THE DEVELOPMENT OF CONTENT KNOWLEDGE, PEDAGOGICAL KNOWLEDGE AND PEDAGOGICAL CONTENT KNOWLEDGE: PROSPECTIVE TEACHERS’ PERCEPTIONS
UNCOVERING THE DEVELOPMENT OF CONTENT KNOWLEDGE, PEDAGOGICAL KNOWLEDGE AND PEDAGOGICAL CONTENT KNOWLEDGE: PROSPECTIVE TEACHERS’ PERCEPTIONS Open
The purpose of the current study was to compare the perceptions of prospective teachers with respect to their Content Knowledge (CK), Pedagogical Knowledge (PK), and Pedagogical Content Knowledge (PCK) in the subject areas of mathematics, …